ENSG00000075240

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361034 ENSG00000075240 HEK293_OSMI2_6hA HEK293_TMG_6hB GRAMD4 protein_coding protein_coding 10.33026 14.40464 8.702234 0.07021543 0.6542505 -0.7264197 3.9540178 6.722525 4.2471774 1.0585154 0.1711084 -0.6612504 0.36998750 0.4659667 0.49116667 0.025200000 9.679191e-01 9.45664e-13 FALSE TRUE
ENST00000408031 ENSG00000075240 HEK293_OSMI2_6hA HEK293_TMG_6hB GRAMD4 protein_coding protein_coding 10.33026 14.40464 8.702234 0.07021543 0.6542505 -0.7264197 1.3390661 1.795921 0.0000000 0.9202111 0.0000000 -7.4965909 0.11327083 0.1250000 0.00000000 -0.125000000 3.825389e-01 9.45664e-13 FALSE FALSE
ENST00000456069 ENSG00000075240 HEK293_OSMI2_6hA HEK293_TMG_6hB GRAMD4 protein_coding protein_coding 10.33026 14.40464 8.702234 0.07021543 0.6542505 -0.7264197 0.7645103 1.135847 0.6219258 0.1757801 0.3189914 -0.8585876 0.07328333 0.0789000 0.06733333 -0.011566667 8.971191e-01 9.45664e-13 FALSE FALSE
ENST00000490378 ENSG00000075240 HEK293_OSMI2_6hA HEK293_TMG_6hB GRAMD4 protein_coding processed_transcript 10.33026 14.40464 8.702234 0.07021543 0.6542505 -0.7264197 0.1606504 0.000000 1.0258417 0.0000000 0.2499366 6.6946598 0.01810000 0.0000000 0.11566667 0.115666667 9.456640e-13 9.45664e-13   FALSE
MSTRG.22342.2 ENSG00000075240 HEK293_OSMI2_6hA HEK293_TMG_6hB GRAMD4 protein_coding   10.33026 14.40464 8.702234 0.07021543 0.6542505 -0.7264197 4.1041148 4.750343 2.8072893 0.6579863 0.1427612 -0.7567578 0.42452083 0.3301333 0.32590000 -0.004233333 1.000000e+00 9.45664e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000075240 E001 0.0000000       22 46576012 46576078 67 +      
ENSG00000075240 E002 0.0000000       22 46577100 46577128 29 +      
ENSG00000075240 E003 16.1903590 0.0024044456 9.728215e-01 9.883890e-01 22 46577129 46577290 162 + 1.198 1.207 0.031
ENSG00000075240 E004 0.0000000       22 46620386 46620565 180 +      
ENSG00000075240 E005 18.0853321 0.0038883726 7.766160e-01 8.826807e-01 22 46626751 46626760 10 + 1.256 1.244 -0.042
ENSG00000075240 E006 37.8564377 0.0068474908 6.249809e-01 7.873250e-01 22 46626761 46626842 82 + 1.572 1.554 -0.062
ENSG00000075240 E007 49.4988412 0.0027062744 3.398664e-02 1.388332e-01 22 46626843 46626916 74 + 1.743 1.639 -0.352
ENSG00000075240 E008 46.7329400 0.0087368101 5.379222e-01 7.275646e-01 22 46626917 46626961 45 + 1.671 1.644 -0.092
ENSG00000075240 E009 62.7517688 0.0009571439 2.026355e-01 4.328652e-01 22 46637840 46637960 121 + 1.808 1.761 -0.158
ENSG00000075240 E010 67.0133104 0.0005899991 7.389875e-01 8.597849e-01 22 46658187 46658307 121 + 1.808 1.806 -0.006
ENSG00000075240 E011 48.1801602 0.0007942456 2.434669e-01 4.804887e-01 22 46661381 46661442 62 + 1.616 1.693 0.259
ENSG00000075240 E012 42.5464717 0.0015603430 9.268491e-01 9.654946e-01 22 46663040 46663106 67 + 1.612 1.619 0.025
ENSG00000075240 E013 49.4228740 0.0010382669 2.454459e-01 4.828914e-01 22 46663107 46663172 66 + 1.709 1.661 -0.164
ENSG00000075240 E014 48.6157248 0.0026568246 3.236917e-01 5.629954e-01 22 46663838 46663863 26 + 1.698 1.655 -0.147
ENSG00000075240 E015 82.5352286 0.0017385347 3.787779e-01 6.112248e-01 22 46664026 46664117 92 + 1.917 1.892 -0.083
ENSG00000075240 E016 84.9108388 0.0005429668 2.255959e-02 1.044305e-01 22 46665615 46665706 92 + 1.957 1.880 -0.261
ENSG00000075240 E017 64.2245560 0.0017678686 1.512854e-02 7.858005e-02 22 46666825 46666873 49 + 1.851 1.746 -0.353
ENSG00000075240 E018 67.7487968 0.0006204268 2.148855e-02 1.009335e-01 22 46668096 46668167 72 + 1.870 1.781 -0.299
ENSG00000075240 E019 51.1556917 0.0007255126 3.407869e-02 1.390754e-01 22 46668689 46668732 44 + 1.753 1.659 -0.319
ENSG00000075240 E020 64.7193598 0.0007915252 4.279641e-01 6.494526e-01 22 46668799 46668908 110 + 1.808 1.785 -0.078
ENSG00000075240 E021 4.7949238 0.0088771330 1.448455e-01 3.547257e-01 22 46671050 46671167 118 + 0.567 0.803 0.990
ENSG00000075240 E022 79.9902181 0.0005213413 2.546322e-01 4.931337e-01 22 46672843 46672997 155 + 1.905 1.872 -0.113
ENSG00000075240 E023 90.7203361 0.0008589944 4.813032e-01 6.879296e-01 22 46673670 46673814 145 + 1.910 1.952 0.142
ENSG00000075240 E024 0.3503582 0.0273348019 6.144123e-01   22 46674608 46674656 49 + 0.161 0.091 -0.949
ENSG00000075240 E025 83.7476932 0.0007573263 7.103000e-01 8.419749e-01 22 46674657 46674750 94 + 1.905 1.903 -0.007
ENSG00000075240 E026 91.2673448 0.0005372299 1.556753e-01 3.704357e-01 22 46675468 46675552 85 + 1.964 1.922 -0.142
ENSG00000075240 E027 84.8476686 0.0005270501 6.215939e-03 4.079335e-02 22 46676600 46676668 69 + 1.966 1.870 -0.322
ENSG00000075240 E028 727.4947780 0.0009967966 1.743501e-10 1.174388e-08 22 46677147 46679790 2644 + 2.760 2.871 0.371