ENSG00000075142

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265729 ENSG00000075142 HEK293_OSMI2_6hA HEK293_TMG_6hB SRI protein_coding protein_coding 166.7205 117.1 157.5157 10.02114 5.89486 0.4277239 12.09309 3.983288 16.59118 0.7030256 1.16880910 2.055636734 0.07544583 0.0339000 0.10506667 0.07116667 9.593103e-06 9.593103e-06 FALSE  
ENST00000472930 ENSG00000075142 HEK293_OSMI2_6hA HEK293_TMG_6hB SRI protein_coding retained_intron 166.7205 117.1 157.5157 10.02114 5.89486 0.4277239 15.61585 12.504101 12.44724 1.4747944 0.04800895 -0.006570676 0.08973750 0.1066333 0.07926667 -0.02736667 3.196186e-01 9.593103e-06 FALSE  
MSTRG.30195.1 ENSG00000075142 HEK293_OSMI2_6hA HEK293_TMG_6hB SRI protein_coding   166.7205 117.1 157.5157 10.02114 5.89486 0.4277239 132.56649 96.845844 118.83964 8.1812295 6.89508653 0.295226534 0.79310000 0.8271333 0.75326667 -0.07386667 9.745543e-02 9.593103e-06 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000075142 E001 5.7358403 1.0288017821 4.812221e-02 1.752801e-01 7 88201626 88201715 90 - 1.070 0.000 -15.145
ENSG00000075142 E002 18.4667220 0.6447456806 7.355120e-01 8.576294e-01 7 88203625 88203750 126 - 1.300 1.270 -0.103
ENSG00000075142 E003 104.0797462 0.0081067646 5.294451e-16 9.202862e-14 7 88205115 88205657 543 - 2.175 1.740 -1.463
ENSG00000075142 E004 140.4664994 0.0189394134 1.574639e-13 1.877879e-11 7 88205658 88206285 628 - 2.322 1.798 -1.758
ENSG00000075142 E005 273.2943235 0.0121696821 4.093034e-01 6.355179e-01 7 88206286 88206404 119 - 2.439 2.433 -0.023
ENSG00000075142 E006 403.6128664 0.0086671735 7.797172e-01 8.845285e-01 7 88206405 88206437 33 - 2.591 2.620 0.097
ENSG00000075142 E007 392.9609352 0.0079403032 9.791515e-01 9.913343e-01 7 88206438 88206455 18 - 2.573 2.616 0.144
ENSG00000075142 E008 478.8414770 0.0051846193 9.386051e-01 9.716134e-01 7 88206456 88206504 49 - 2.661 2.699 0.127
ENSG00000075142 E009 48.6682049 0.0602042427 2.154611e-05 4.070105e-04 7 88207676 88208488 813 - 1.867 1.342 -1.792
ENSG00000075142 E010 6.0135352 0.0105708407 2.334223e-02 1.070238e-01 7 88208489 88208506 18 - 0.957 0.683 -1.077
ENSG00000075142 E011 780.7351647 0.0074052509 2.807163e-01 5.209756e-01 7 88208507 88208565 59 - 2.893 2.891 -0.007
ENSG00000075142 E012 1.9576887 0.0110336396 2.532191e-02 1.131911e-01 7 88208860 88209338 479 - 0.601 0.230 -2.100
ENSG00000075142 E013 1105.4481317 0.0044387879 1.636795e-01 3.821986e-01 7 88209339 88209432 94 - 3.043 3.042 -0.004
ENSG00000075142 E014 637.2332495 0.0058044673 1.822480e-01 4.069379e-01 7 88209433 88209452 20 - 2.808 2.798 -0.034
ENSG00000075142 E015 977.2022812 0.0018021267 3.419138e-01 5.796340e-01 7 88209983 88210082 100 - 2.980 2.998 0.059
ENSG00000075142 E016 615.9395092 0.0005660307 1.853433e-02 9.083076e-02 7 88210083 88210130 48 - 2.753 2.826 0.243
ENSG00000075142 E017 17.8065181 0.0388763262 1.315007e-03 1.227028e-02 7 88210131 88210493 363 - 1.410 1.044 -1.297
ENSG00000075142 E018 6.0182010 0.0047538710 1.154226e-02 6.457391e-02 7 88210555 88210567 13 - 0.957 0.652 -1.208
ENSG00000075142 E019 12.6478923 0.0346644032 1.250329e-02 6.844238e-02 7 88210568 88210881 314 - 1.243 0.956 -1.035
ENSG00000075142 E020 607.2253959 0.0133575648 1.019697e-01 2.853277e-01 7 88210882 88210925 44 - 2.726 2.841 0.383
ENSG00000075142 E021 2.0368272 0.0100427688 1.524401e-02 7.899616e-02 7 88214795 88214936 142 - 0.632 0.230 -2.237
ENSG00000075142 E022 677.7645614 0.0659481611 1.720195e-01 3.932170e-01 7 88217122 88217191 70 - 2.751 2.907 0.519
ENSG00000075142 E023 505.7384636 1.7102545105 5.026770e-01 7.026350e-01 7 88218859 88218942 84 - 2.584 2.809 0.749
ENSG00000075142 E024 274.2464647 0.3299988551 1.927083e-01 4.203925e-01 7 88219976 88220065 90 - 2.303 2.555 0.838
ENSG00000075142 E025 0.1308682 0.0315096554 4.540689e-01   7 88226909 88226993 85 - 0.000 0.130 10.392