ENSG00000074603

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000300141 ENSG00000074603 HEK293_OSMI2_6hA HEK293_TMG_6hB DPP8 protein_coding protein_coding 8.919611 3.608532 13.4669 0.4624902 0.7693237 1.897012 4.33867115 1.84026258 6.67651079 0.47023197 0.37913326 1.8535235 0.46760833 0.493100000 0.495833333 0.002733333 1.0000000000 7.97406e-05 FALSE TRUE
ENST00000321147 ENSG00000074603 HEK293_OSMI2_6hA HEK293_TMG_6hB DPP8 protein_coding protein_coding 8.919611 3.608532 13.4669 0.4624902 0.7693237 1.897012 0.92495654 0.17546101 1.55074711 0.03022034 0.09531589 3.0730490 0.08116250 0.048100000 0.115966667 0.067866667 0.1144637562 7.97406e-05 FALSE TRUE
ENST00000558786 ENSG00000074603 HEK293_OSMI2_6hA HEK293_TMG_6hB DPP8 protein_coding protein_coding 8.919611 3.608532 13.4669 0.4624902 0.7693237 1.897012 0.07146912 0.16557844 0.08486521 0.16557844 0.08486521 -0.8881647 0.01104583 0.060366667 0.005766667 -0.054600000 0.9275680081 7.97406e-05 FALSE TRUE
ENST00000559526 ENSG00000074603 HEK293_OSMI2_6hA HEK293_TMG_6hB DPP8 protein_coding protein_coding 8.919611 3.608532 13.4669 0.4624902 0.7693237 1.897012 0.18144548 0.25607054 0.09555628 0.25607054 0.09555628 -1.3337963 0.01868333 0.059233333 0.007033333 -0.052200000 0.9035668198 7.97406e-05 FALSE FALSE
ENST00000560194 ENSG00000074603 HEK293_OSMI2_6hA HEK293_TMG_6hB DPP8 protein_coding processed_transcript 8.919611 3.608532 13.4669 0.4624902 0.7693237 1.897012 1.57351867 0.76702122 1.44025553 0.07381435 0.17289659 0.9002812 0.23960833 0.221533333 0.108533333 -0.113000000 0.2369153265 7.97406e-05 FALSE TRUE
MSTRG.11056.8 ENSG00000074603 HEK293_OSMI2_6hA HEK293_TMG_6hB DPP8 protein_coding   8.919611 3.608532 13.4669 0.4624902 0.7693237 1.897012 0.44097799 0.01360996 1.30195451 0.01360996 0.08849632 5.7961785 0.03389583 0.004966667 0.097633333 0.092666667 0.0000797406 7.97406e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000074603 E001 0.1308682 0.032649190 0.1301539638   15 65442463 65442466 4 - 0.000 0.227 14.241
ENSG00000074603 E002 343.2222418 1.714543581 0.3720155246 0.605605756 15 65442467 65446616 4150 - 2.319 2.722 1.343
ENSG00000074603 E003 7.5700317 0.298421481 0.3872212797 0.618309586 15 65446617 65446620 4 - 0.789 1.017 0.871
ENSG00000074603 E004 9.4771584 0.349760958 0.4948791257 0.697341847 15 65446621 65446636 16 - 0.888 1.053 0.615
ENSG00000074603 E005 6.9990817 0.364539273 0.4078127026 0.634316798 15 65446637 65446651 15 - 0.751 1.014 1.005
ENSG00000074603 E006 19.8320782 0.515240014 0.3584847471 0.594570536 15 65446652 65446739 88 - 1.163 1.388 0.791
ENSG00000074603 E007 12.1235437 0.435535104 0.4600166889 0.673158706 15 65446740 65446740 1 - 0.975 1.164 0.685
ENSG00000074603 E008 53.3315388 0.841512781 0.4140435494 0.639027543 15 65446741 65447006 266 - 1.574 1.804 0.782
ENSG00000074603 E009 0.9287192 0.015600690 0.1717650494   15 65450739 65450998 260 - 0.280 0.000 -12.496
ENSG00000074603 E010 40.3792283 0.020335010 0.4371734271 0.656581532 15 65450999 65451110 112 - 1.478 1.651 0.592
ENSG00000074603 E011 38.5902939 0.005876558 0.2156724093 0.448261906 15 65451960 65452043 84 - 1.491 1.514 0.080
ENSG00000074603 E012 36.7172089 0.020656464 0.5768129289 0.755006403 15 65452044 65452102 59 - 1.456 1.531 0.256
ENSG00000074603 E013 43.1436772 0.004130698 0.5055570416 0.704666963 15 65454263 65454415 153 - 1.503 1.673 0.580
ENSG00000074603 E014 3.5767131 0.013734273 0.6343901700 0.793175428 15 65455394 65455653 260 - 0.570 0.576 0.026
ENSG00000074603 E015 6.2740063 0.017461851 0.0040757307 0.029595622 15 65455654 65455711 58 - 0.819 0.377 -2.018
ENSG00000074603 E016 7.5801650 0.086262224 0.2072179770 0.438493713 15 65455712 65455841 130 - 0.851 0.716 -0.537
ENSG00000074603 E017 34.7223920 0.020348896 0.6556983003 0.807137231 15 65456225 65456286 62 - 1.425 1.524 0.339
ENSG00000074603 E018 42.6319052 0.021435451 0.5220879947 0.716381114 15 65456287 65456371 85 - 1.514 1.593 0.270
ENSG00000074603 E019 50.6112072 0.029600969 0.1786537870 0.402178363 15 65463761 65463906 146 - 1.604 1.604 0.001
ENSG00000074603 E020 46.3397388 0.026030179 0.1166023152 0.310153575 15 65466678 65466813 136 - 1.572 1.547 -0.084
ENSG00000074603 E021 43.2287477 0.029212968 0.0779969987 0.240804354 15 65467071 65467223 153 - 1.546 1.494 -0.180
ENSG00000074603 E022 28.7708365 0.053815672 0.2298939013 0.465059405 15 65474209 65474288 80 - 1.366 1.355 -0.040
ENSG00000074603 E023 49.6200573 0.042355966 0.1977802000 0.426840180 15 65478880 65479039 160 - 1.594 1.585 -0.033
ENSG00000074603 E024 59.2430186 0.023168381 0.0056230775 0.037851907 15 65480222 65480399 178 - 1.689 1.564 -0.424
ENSG00000074603 E025 41.2626405 0.006681075 0.0054535788 0.036984245 15 65481515 65481615 101 - 1.535 1.436 -0.341
ENSG00000074603 E026 33.6557942 0.001303460 0.0284569695 0.122670558 15 65485099 65485160 62 - 1.445 1.400 -0.154
ENSG00000074603 E027 46.2086580 0.010039130 0.0048067068 0.033568671 15 65487690 65487818 129 - 1.584 1.485 -0.339
ENSG00000074603 E028 48.9601492 0.015113938 0.0002894445 0.003623081 15 65490189 65490299 111 - 1.620 1.423 -0.678
ENSG00000074603 E029 40.0455711 0.018914302 0.0002156235 0.002848307 15 65497864 65497916 53 - 1.543 1.292 -0.867
ENSG00000074603 E030 34.6190570 0.004372635 0.0001373471 0.001949247 15 65497917 65497950 34 - 1.480 1.277 -0.705
ENSG00000074603 E031 47.1410232 0.001145684 0.0001523093 0.002126058 15 65497951 65498032 82 - 1.599 1.466 -0.455
ENSG00000074603 E032 57.9055236 0.019594795 0.0123758124 0.067934757 15 65500606 65500779 174 - 1.675 1.596 -0.267
ENSG00000074603 E033 31.3708972 0.031166052 0.1068287545 0.293730645 15 65507243 65507302 60 - 1.413 1.379 -0.117
ENSG00000074603 E034 30.1828928 0.004472661 0.2166638083 0.449516759 15 65507303 65507355 53 - 1.387 1.411 0.084
ENSG00000074603 E035 6.0034138 0.028715731 0.1247183830 0.323305246 15 65511961 65512108 148 - 0.665 1.000 1.311
ENSG00000074603 E036 27.0862162 0.012073834 0.7961105369 0.894068714 15 65512295 65512301 7 - 1.316 1.464 0.515
ENSG00000074603 E037 69.7349565 0.022176736 0.9344719756 0.969412923 15 65512302 65512564 263 - 1.713 1.855 0.481
ENSG00000074603 E038 1.0230998 0.258824284 0.0008343939   15 65512565 65512831 267 - 0.000 0.717 16.873
ENSG00000074603 E039 8.8073728 0.076589215 0.6035787915 0.772570481 15 65515656 65515791 136 - 0.849 1.052 0.762
ENSG00000074603 E040 4.8713632 0.054423570 0.6519914738 0.804764601 15 65515792 65517205 1414 - 0.636 0.816 0.740
ENSG00000074603 E041 0.5283420 0.640271697 0.6719565219   15 65517206 65517338 133 - 0.118 0.230 1.163
ENSG00000074603 E042 0.7664957 0.018697839 0.3878292674   15 65517381 65517485 105 - 0.162 0.376 1.607
ENSG00000074603 E043 31.1126922 0.060876918 0.2113830705 0.443411487 15 65517486 65517704 219 - 1.325 1.636 1.067