ENSG00000073921

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000393346 ENSG00000073921 HEK293_OSMI2_6hA HEK293_TMG_6hB PICALM protein_coding protein_coding 35.15825 15.72791 54.94867 4.669845 3.271463 1.804103 2.8278430 1.9642798 3.421750 0.8959114 0.1180384 0.7976179 0.10223333 0.10706667 0.06246667 -0.04460000 6.883307e-01 9.081393e-12 FALSE TRUE
ENST00000526033 ENSG00000073921 HEK293_OSMI2_6hA HEK293_TMG_6hB PICALM protein_coding protein_coding 35.15825 15.72791 54.94867 4.669845 3.271463 1.804103 8.1594430 4.1231853 12.800820 1.0946142 0.9340211 1.6320369 0.23781667 0.27173333 0.23406667 -0.03766667 7.846321e-01 9.081393e-12 FALSE TRUE
ENST00000529760 ENSG00000073921 HEK293_OSMI2_6hA HEK293_TMG_6hB PICALM protein_coding protein_coding 35.15825 15.72791 54.94867 4.669845 3.271463 1.804103 0.2763819 1.0533788 0.000000 0.5502069 0.0000000 -6.7325117 0.01744583 0.05166667 0.00000000 -0.05166667 6.612017e-02 9.081393e-12 FALSE TRUE
ENST00000530542 ENSG00000073921 HEK293_OSMI2_6hA HEK293_TMG_6hB PICALM protein_coding protein_coding 35.15825 15.72791 54.94867 4.669845 3.271463 1.804103 2.7404400 0.7771752 4.345297 0.4757586 1.4167320 2.4680143 0.06519583 0.06280000 0.07680000 0.01400000 9.146295e-01 9.081393e-12 FALSE FALSE
ENST00000532317 ENSG00000073921 HEK293_OSMI2_6hA HEK293_TMG_6hB PICALM protein_coding protein_coding 35.15825 15.72791 54.94867 4.669845 3.271463 1.804103 9.9210803 5.1166930 14.030698 1.5821071 1.1184336 1.4535143 0.30440417 0.32180000 0.25470000 -0.06710000 2.736822e-01 9.081393e-12 FALSE TRUE
ENST00000532603 ENSG00000073921 HEK293_OSMI2_6hA HEK293_TMG_6hB PICALM protein_coding protein_coding 35.15825 15.72791 54.94867 4.669845 3.271463 1.804103 3.4853047 1.0949785 6.041072 0.3992410 1.6963184 2.4531725 0.09226250 0.06446667 0.10716667 0.04270000 6.470942e-01 9.081393e-12 FALSE FALSE
MSTRG.6128.17 ENSG00000073921 HEK293_OSMI2_6hA HEK293_TMG_6hB PICALM protein_coding   35.15825 15.72791 54.94867 4.669845 3.271463 1.804103 2.8188829 0.0000000 5.259381 0.0000000 0.6654722 9.0414898 0.05357917 0.00000000 0.09746667 0.09746667 9.081393e-12 9.081393e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000073921 E001 17.0260443 0.3408006211 0.114355428 0.30640384 11 85957175 85957683 509 - 1.051 1.472 1.484
ENSG00000073921 E002 9.1510493 0.0852923945 0.002667544 0.02138657 11 85957684 85957687 4 - 0.745 1.283 1.995
ENSG00000073921 E003 444.9034050 1.6939876210 0.397743142 0.62658087 11 85957688 85958626 939 - 2.486 2.809 1.074
ENSG00000073921 E004 163.8466351 1.4094914802 0.515304316 0.71187267 11 85958627 85958754 128 - 2.121 2.282 0.539
ENSG00000073921 E005 143.2883730 1.3801314811 0.571081413 0.75109266 11 85958755 85958810 56 - 2.083 2.187 0.350
ENSG00000073921 E006 88.8712650 1.2048263420 0.531398324 0.72299037 11 85958811 85958816 6 - 1.868 1.999 0.439
ENSG00000073921 E007 80.5760008 0.9235220135 0.498492822 0.69975984 11 85958817 85958817 1 - 1.830 1.950 0.403
ENSG00000073921 E008 99.4685017 1.2395718981 0.510852723 0.70860966 11 85958818 85958838 21 - 1.912 2.056 0.483
ENSG00000073921 E009 123.8347283 1.3182681009 0.508495949 0.70684304 11 85958839 85958882 44 - 2.009 2.145 0.453
ENSG00000073921 E010 162.3871512 1.4061993678 0.506998886 0.70564657 11 85958883 85958986 104 - 2.118 2.275 0.524
ENSG00000073921 E011 97.3539383 1.2139762574 0.454667056 0.66926924 11 85958987 85959022 36 - 1.885 2.078 0.647
ENSG00000073921 E012 83.9366340 1.1730036600 0.493145177 0.69607934 11 85959023 85959036 14 - 1.831 1.997 0.558
ENSG00000073921 E013 92.4496373 1.1969209691 0.461190960 0.67396905 11 85959037 85959060 24 - 1.863 2.054 0.640
ENSG00000073921 E014 1.5879293 0.0118379910 0.475967787 0.68421377 11 85960675 85960777 103 - 0.417 0.308 -0.638
ENSG00000073921 E015 146.6918767 0.0128939808 0.214189845 0.44659614 11 85974708 85974781 74 - 2.098 2.196 0.328
ENSG00000073921 E016 117.1009512 0.0004014904 0.556882741 0.74110367 11 85974782 85974812 31 - 2.016 2.081 0.215
ENSG00000073921 E017 94.5916408 0.0045886842 0.239680446 0.47629830 11 85976623 85976648 26 - 1.908 2.013 0.354
ENSG00000073921 E018 100.0207901 0.0071749191 0.148534143 0.36020424 11 85976649 85976682 34 - 1.921 2.055 0.448
ENSG00000073921 E019 6.4880207 0.1187088695 0.376824357 0.60969147 11 85976683 85977005 323 - 0.779 0.949 0.655
ENSG00000073921 E020 14.3949165 0.0027075076 0.092167266 0.26774529 11 85978070 85978093 24 - 1.081 1.281 0.710
ENSG00000073921 E021 9.1980217 0.2657050154 0.238721009 0.47513939 11 85978094 85978715 622 - 1.034 0.722 -1.197
ENSG00000073921 E022 129.5630591 0.0005873301 0.358561702 0.59462226 11 85981129 85981183 55 - 2.054 2.131 0.261
ENSG00000073921 E023 166.7943742 0.0023789800 0.226814328 0.46152350 11 85981184 85981228 45 - 2.183 2.188 0.018
ENSG00000073921 E024 159.9873233 0.0034602326 0.060772731 0.20457507 11 85981745 85981775 31 - 2.173 2.146 -0.093
ENSG00000073921 E025 223.6561195 0.0067026828 0.166678173 0.38612666 11 85981872 85981988 117 - 2.314 2.299 -0.047
ENSG00000073921 E026 61.0457668 0.0085991956 0.251545846 0.48960207 11 85981989 85982003 15 - 1.761 1.740 -0.071
ENSG00000073921 E027 0.6412370 0.1161796659 0.233637715   11 85982004 85982185 182 - 0.256 0.000 -11.110
ENSG00000073921 E028 181.3682440 0.0143114980 0.722011653 0.84928797 11 85983866 85983973 108 - 2.208 2.241 0.109
ENSG00000073921 E029 86.9502966 0.0128093986 0.191156896 0.41834632 11 85990250 85990378 129 - 1.911 1.872 -0.131
ENSG00000073921 E030 40.9199713 0.0099002539 0.151862190 0.36500358 11 85990379 85990399 21 - 1.595 1.539 -0.193
ENSG00000073921 E031 185.0602028 0.0173062295 0.354484244 0.59128756 11 85996826 85996929 104 - 2.230 2.215 -0.050
ENSG00000073921 E032 125.2986792 0.0148798221 0.686957785 0.82716974 11 86000643 86000680 38 - 2.055 2.069 0.047
ENSG00000073921 E033 163.4363545 0.0123341814 0.326135489 0.56531772 11 86000681 86000779 99 - 2.180 2.158 -0.073
ENSG00000073921 E034 0.1614157 0.0361904387 1.000000000   11 86001031 86001034 4 - 0.080 0.000 -9.110
ENSG00000073921 E035 181.2028801 0.0133844414 0.396328807 0.62539193 11 86001035 86001158 124 - 2.222 2.204 -0.060
ENSG00000073921 E036 149.2343917 0.0128646116 0.357994042 0.59415402 11 86003366 86003451 86 - 2.136 2.132 -0.013
ENSG00000073921 E037 0.2922838 0.0274424043 0.530871219   11 86003452 86003778 327 - 0.080 0.181 1.360
ENSG00000073921 E038 0.9688700 0.1061052956 0.467731671   11 86007369 86007541 173 - 0.304 0.180 -0.980
ENSG00000073921 E039 119.2232576 0.0157405279 0.583163634 0.75908211 11 86007542 86007583 42 - 2.032 2.050 0.062
ENSG00000073921 E040 133.1039854 0.0152804591 0.176104781 0.39859873 11 86011030 86011111 82 - 2.096 2.053 -0.144
ENSG00000073921 E041 71.9587585 0.0208429449 0.467588884 0.67844990 11 86011112 86011136 25 - 1.822 1.815 -0.023
ENSG00000073921 E042 127.9728863 0.0241103274 0.105144948 0.29089763 11 86012281 86012328 48 - 2.089 2.003 -0.289
ENSG00000073921 E043 109.0390553 0.0261963722 0.096746729 0.27602888 11 86012329 86012342 14 - 2.022 1.927 -0.320
ENSG00000073921 E044 143.9425817 0.0234250175 0.045418417 0.16863272 11 86012343 86012392 50 - 2.146 2.037 -0.365
ENSG00000073921 E045 190.6461757 0.0248416533 0.059991559 0.20279363 11 86014870 86014963 94 - 2.268 2.155 -0.375
ENSG00000073921 E046 97.3728574 0.0369634756 0.113039398 0.30422646 11 86022367 86022377 11 - 1.980 1.860 -0.401
ENSG00000073921 E047 168.5999818 0.0293889698 0.025073265 0.11245254 11 86022378 86022469 92 - 2.224 2.071 -0.511
ENSG00000073921 E048 1.1765935 0.4525974981 0.930603642   11 86023416 86023541 126 - 0.311 0.305 -0.039
ENSG00000073921 E049 146.3517159 0.0298871938 0.044516332 0.16640824 11 86026292 86026367 76 - 2.158 2.025 -0.445
ENSG00000073921 E050 175.0434562 0.0165968171 0.018863616 0.09198254 11 86031469 86031611 143 - 2.233 2.116 -0.389
ENSG00000073921 E051 120.8160296 0.0110891664 0.052100251 0.18462963 11 86068651 86068733 83 - 2.066 1.984 -0.276
ENSG00000073921 E052 68.5200980 0.0149452830 0.161986049 0.37971147 11 86068734 86068738 5 - 1.818 1.756 -0.210
ENSG00000073921 E053 125.2322456 0.0364424552 0.630641194 0.79082925 11 86068739 86069022 284 - 2.064 2.040 -0.082
ENSG00000073921 E054 45.3392882 0.1018034507 0.983655651 0.99365522 11 86069023 86069097 75 - 1.621 1.629 0.029
ENSG00000073921 E055 0.1426347 0.0339265095 1.000000000   11 86069246 86069457 212 - 0.080 0.000 -9.108
ENSG00000073921 E056 0.0000000       11 86069458 86069719 262 -      
ENSG00000073921 E057 0.6246688 0.0193798627 0.212958811   11 86069720 86069915 196 - 0.256 0.000 -11.109