ENSG00000073712

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000341590 ENSG00000073712 HEK293_OSMI2_6hA HEK293_TMG_6hB FERMT2 protein_coding protein_coding 17.2809 5.256771 28.88996 0.9305554 0.7461976 2.456077 13.312705 4.481737 22.04021 0.9207884 0.9893036 2.295447 0.79185000 0.8428 0.7623333 -0.08046667 5.211799e-01 1.515558e-13 FALSE TRUE
ENST00000553373 ENSG00000073712 HEK293_OSMI2_6hA HEK293_TMG_6hB FERMT2 protein_coding protein_coding 17.2809 5.256771 28.88996 0.9305554 0.7461976 2.456077 2.658018 0.000000 4.95073 0.0000000 0.3165246 8.954409 0.09011667 0.0000 0.1720000 0.17200000 1.515558e-13 1.515558e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000073712 E001 0.0000000       14 52857268 52857270 3 -      
ENSG00000073712 E002 0.0000000       14 52857271 52857271 1 -      
ENSG00000073712 E003 0.0000000       14 52857272 52857272 1 -      
ENSG00000073712 E004 0.0000000       14 52857273 52857274 2 -      
ENSG00000073712 E005 80.9014158 0.0006683250 5.730215e-05 0.0009369558 14 52857275 52857530 256 - 1.772 1.956 0.622
ENSG00000073712 E006 337.8391608 0.0002123144 4.789431e-04 0.0054856375 14 52857531 52858376 846 - 2.412 2.491 0.264
ENSG00000073712 E007 162.0943492 0.0011493735 5.656211e-01 0.7471063744 14 52858377 52858550 174 - 2.109 2.132 0.079
ENSG00000073712 E008 2.4804915 0.0091336494 5.565012e-01 0.7408288885 14 52858551 52859305 755 - 0.458 0.565 0.516
ENSG00000073712 E009 0.2852693 0.3331800674 1.000000e+00   14 52859306 52859487 182 - 0.116 0.000 -9.360
ENSG00000073712 E010 0.6648197 0.5167070452 7.166367e-01   14 52859488 52859572 85 - 0.172 0.217 0.415
ENSG00000073712 E011 178.1521177 0.0002974022 9.386253e-03 0.0554782697 14 52859573 52859714 142 - 2.135 2.218 0.279
ENSG00000073712 E012 2.3350102 0.0105846348 3.903005e-01 0.6206819683 14 52859715 52860340 626 - 0.408 0.565 0.779
ENSG00000073712 E013 152.2383290 0.0003398795 9.083087e-02 0.2652536771 14 52860341 52860465 125 - 2.071 2.131 0.202
ENSG00000073712 E014 8.3560736 0.1413765486 7.672772e-02 0.2382195378 14 52860466 52861013 548 - 0.777 1.136 1.346
ENSG00000073712 E015 8.7621077 0.0479483379 9.312533e-01 0.9676817891 14 52861014 52861034 21 - 0.890 0.889 -0.005
ENSG00000073712 E016 5.6095242 0.0055567392 8.317599e-02 0.2511404956 14 52861035 52861586 552 - 0.676 0.922 0.975
ENSG00000073712 E017 1.9554759 0.0287988818 8.412484e-01 0.9201667555 14 52861587 52861610 24 - 0.408 0.369 -0.223
ENSG00000073712 E018 6.4735482 0.0558387324 3.652768e-01 0.6001712754 14 52861611 52862184 574 - 0.813 0.636 -0.727
ENSG00000073712 E019 10.6269198 0.3241911598 6.156867e-01 0.7807946121 14 52862591 52863677 1087 - 0.984 0.906 -0.293
ENSG00000073712 E020 149.6604403 0.0004583303 5.294793e-01 0.7216700978 14 52864401 52864622 222 - 2.071 2.095 0.080
ENSG00000073712 E021 100.5237706 0.0008107993 6.442123e-01 0.7996191035 14 52864747 52864853 107 - 1.910 1.891 -0.065
ENSG00000073712 E022 133.2112138 0.0003830750 9.795863e-02 0.2781929690 14 52872799 52872923 125 - 2.039 1.975 -0.213
ENSG00000073712 E023 0.2852693 0.3331800674 1.000000e+00   14 52873662 52873710 49 - 0.116 0.000 -9.360
ENSG00000073712 E024 90.8507274 0.0004730159 1.429891e-02 0.0755204012 14 52874177 52874226 50 - 1.881 1.762 -0.401
ENSG00000073712 E025 133.8182398 0.0023019395 2.692936e-02 0.1181040439 14 52875223 52875357 135 - 2.044 1.941 -0.346
ENSG00000073712 E026 104.1073629 0.0004406285 1.487326e-02 0.0776077227 14 52878582 52878689 108 - 1.937 1.827 -0.371
ENSG00000073712 E027 98.5577007 0.0004309444 6.905269e-02 0.2228781618 14 52881036 52881108 73 - 1.913 1.831 -0.276
ENSG00000073712 E028 71.8233863 0.0006675170 2.162889e-02 0.1013907487 14 52881109 52881138 30 - 1.785 1.660 -0.424
ENSG00000073712 E029 159.6541641 0.0002693389 1.321815e-02 0.0713229009 14 52881244 52881469 226 - 2.121 2.033 -0.294
ENSG00000073712 E030 1.4638881 0.0136968632 3.181898e-01 0.5581244985 14 52881796 52881828 33 - 0.287 0.477 1.098
ENSG00000073712 E031 0.0000000       14 52893288 52893292 5 -      
ENSG00000073712 E032 72.2092471 0.0023058305 2.413403e-01 0.4780888788 14 52893293 52893358 66 - 1.778 1.713 -0.218
ENSG00000073712 E033 47.1856613 0.0009138124 9.019964e-02 0.2641450968 14 52893359 52893375 17 - 1.605 1.492 -0.385
ENSG00000073712 E034 58.9243118 0.0007116622 2.218891e-01 0.4557886734 14 52893376 52893427 52 - 1.691 1.621 -0.241
ENSG00000073712 E035 105.7649017 0.0004959784 2.801852e-02 0.1213112278 14 52919123 52919356 234 - 1.946 1.848 -0.329
ENSG00000073712 E036 0.0000000       14 52928020 52928345 326 -      
ENSG00000073712 E037 0.0000000       14 52928346 52928420 75 -      
ENSG00000073712 E038 0.1426347 0.0327938791 1.000000e+00   14 52948562 52948580 19 - 0.063 0.000 -9.696
ENSG00000073712 E039 89.5084214 0.0009169081 2.576689e-01 0.4964180298 14 52950412 52950577 166 - 1.845 1.898 0.181
ENSG00000073712 E040 1.7907834 0.0160569225 1.976441e-02 0.0950890192 14 52950828 52950920 93 - 0.287 0.698 2.093
ENSG00000073712 E041 31.3486296 0.0152454486 9.234802e-03 0.0548484805 14 52950921 52951050 130 - 1.355 1.594 0.820
ENSG00000073712 E042 0.0000000       14 52952318 52952435 118 -