ENSG00000073417

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000394553 ENSG00000073417 HEK293_OSMI2_6hA HEK293_TMG_6hB PDE8A protein_coding protein_coding 6.594154 5.975108 7.365378 0.5334573 0.303063 0.3013398 1.4137809 0.2888418 0.5467576 0.2034345 0.20279546 0.8976674 0.1936083 0.05046667 0.07226667 0.02180000 0.84506600 0.03776709 FALSE TRUE
ENST00000557957 ENSG00000073417 HEK293_OSMI2_6hA HEK293_TMG_6hB PDE8A protein_coding protein_coding 6.594154 5.975108 7.365378 0.5334573 0.303063 0.3013398 2.6691991 1.7264873 3.6181787 0.8784285 0.27259726 1.0630737 0.4073125 0.28496667 0.49003333 0.20506667 0.78259207 0.03776709 FALSE TRUE
ENST00000558543 ENSG00000073417 HEK293_OSMI2_6hA HEK293_TMG_6hB PDE8A protein_coding retained_intron 6.594154 5.975108 7.365378 0.5334573 0.303063 0.3013398 0.6116160 1.4239400 0.6080523 0.3458265 0.30326049 -1.2141838 0.0924750 0.23273333 0.08023333 -0.15250000 0.19295468 0.03776709   FALSE
ENST00000559086 ENSG00000073417 HEK293_OSMI2_6hA HEK293_TMG_6hB PDE8A protein_coding nonsense_mediated_decay 6.594154 5.975108 7.365378 0.5334573 0.303063 0.3013398 0.1146866 0.0000000 0.4210302 0.0000000 0.27677612 5.4297171 0.0168625 0.00000000 0.05760000 0.05760000 0.36177062 0.03776709 TRUE FALSE
ENST00000561024 ENSG00000073417 HEK293_OSMI2_6hA HEK293_TMG_6hB PDE8A protein_coding retained_intron 6.594154 5.975108 7.365378 0.5334573 0.303063 0.3013398 0.5848542 0.9374094 0.2849222 0.3219378 0.04690642 -1.6836537 0.0970125 0.15026667 0.03936667 -0.11090000 0.03776709 0.03776709 FALSE TRUE
MSTRG.11455.2 ENSG00000073417 HEK293_OSMI2_6hA HEK293_TMG_6hB PDE8A protein_coding   6.594154 5.975108 7.365378 0.5334573 0.303063 0.3013398 0.6528240 0.9383954 0.9250648 0.9383954 0.54899736 -0.0204223 0.1132167 0.17263333 0.13220000 -0.04043333 0.75032102 0.03776709 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000073417 E001 0.6907378 0.5835070795 0.8559500686   15 84980440 84980502 63 + 0.194 0.247 0.448
ENSG00000073417 E002 0.9995898 0.0416678758 0.8318047164   15 84980507 84980512 6 + 0.271 0.318 0.316
ENSG00000073417 E003 4.8735083 0.0055164311 0.4308130245 0.651765316 15 84980513 84980685 173 + 0.813 0.725 -0.356
ENSG00000073417 E004 1.4119707 0.0125601299 0.4535342637 0.668360691 15 84980686 84980690 5 + 0.438 0.317 -0.691
ENSG00000073417 E005 2.3682167 0.0087635128 0.1344176163 0.338756173 15 84981856 84981973 118 + 0.622 0.387 -1.150
ENSG00000073417 E006 0.6002783 0.4403980497 0.6259802441   15 84981974 84981980 7 + 0.265 0.134 -1.213
ENSG00000073417 E007 3.5311070 0.0474557404 0.2158268201 0.448445628 15 84981981 84982225 245 + 0.555 0.777 0.942
ENSG00000073417 E008 5.8885526 0.0169660947 0.6710292667 0.817007479 15 84982226 84982348 123 + 0.867 0.827 -0.152
ENSG00000073417 E009 1.9086971 0.0108198748 0.0084214984 0.051251178 15 85062497 85064369 1873 + 0.199 0.662 2.630
ENSG00000073417 E010 5.4157122 0.0058213897 0.3102071124 0.550686289 15 85064370 85064373 4 + 0.868 0.753 -0.451
ENSG00000073417 E011 11.3822338 0.0032230034 0.2462061516 0.483831560 15 85064374 85064426 53 + 1.138 1.043 -0.344
ENSG00000073417 E012 10.3193225 0.0099559547 0.3751696888 0.608327004 15 85067014 85067027 14 + 1.090 1.013 -0.282
ENSG00000073417 E013 28.6525405 0.0032186106 0.0242339604 0.109801869 15 85067028 85067204 177 + 1.532 1.398 -0.460
ENSG00000073417 E014 19.8493360 0.0022176918 0.0051533545 0.035422034 15 85075862 85075918 57 + 1.399 1.196 -0.708
ENSG00000073417 E015 21.0056278 0.0150030343 0.0097465054 0.057030549 15 85076733 85076787 55 + 1.436 1.212 -0.779
ENSG00000073417 E016 29.6658681 0.0092752946 0.0415773373 0.158837157 15 85083556 85083644 89 + 1.545 1.405 -0.483
ENSG00000073417 E017 26.2110050 0.0076003979 0.5409628163 0.729707049 15 85089338 85089416 79 + 1.438 1.408 -0.101
ENSG00000073417 E018 1.5767104 0.0130591701 0.7147461362 0.844772571 15 85090718 85090915 198 + 0.437 0.387 -0.274
ENSG00000073417 E019 38.4054914 0.0011593000 0.1722131635 0.393472169 15 85091044 85091181 138 + 1.616 1.559 -0.195
ENSG00000073417 E020 5.6899885 0.0382208922 0.0007434587 0.007808063 15 85097803 85097947 145 + 0.482 1.033 2.268
ENSG00000073417 E021 36.8259168 0.0011589947 0.1912079135 0.418388361 15 85097948 85098036 89 + 1.600 1.545 -0.188
ENSG00000073417 E022 0.8080019 0.0987052348 0.8069674739   15 85099757 85099978 222 + 0.271 0.236 -0.263
ENSG00000073417 E023 0.0000000       15 85099979 85100014 36 +      
ENSG00000073417 E024 25.4884802 0.0025105233 0.2302283554 0.465392270 15 85100015 85100066 52 + 1.451 1.386 -0.224
ENSG00000073417 E025 25.3341967 0.0017681087 0.2201623129 0.453729653 15 85100156 85100198 43 + 1.446 1.380 -0.228
ENSG00000073417 E026 0.1614157 0.0321248555 0.5708714888   15 85100199 85100258 60 + 0.111 0.000 -10.760
ENSG00000073417 E027 32.7699662 0.0010624637 0.9980338601 1.000000000 15 85109053 85109130 78 + 1.517 1.537 0.068
ENSG00000073417 E028 32.6004488 0.0016524688 0.8782281591 0.940403800 15 85113377 85113447 71 + 1.525 1.536 0.039
ENSG00000073417 E029 49.5556905 0.0007530646 0.3830396598 0.614767212 15 85113873 85114037 165 + 1.711 1.688 -0.078
ENSG00000073417 E030 0.6566214 0.5486479218 0.6556138979   15 85114038 85114038 1 + 0.273 0.135 -1.266
ENSG00000073417 E031 0.6785387 0.4591784340 0.4635012113   15 85115256 85115438 183 + 0.111 0.323 1.926
ENSG00000073417 E032 26.1789847 0.0018792520 0.7337963303 0.856505084 15 85115439 85115487 49 + 1.428 1.424 -0.015
ENSG00000073417 E033 0.5474829 0.0404678166 0.0630994344   15 85115769 85115983 215 + 0.000 0.319 12.365
ENSG00000073417 E034 47.6438613 0.0009858793 0.0720088622 0.228818760 15 85115984 85116119 136 + 1.716 1.644 -0.243
ENSG00000073417 E035 0.1723744 0.0316299394 0.4144598423   15 85116120 85116309 190 + 0.000 0.133 10.852
ENSG00000073417 E036 58.2478866 0.0175237048 0.4861263637 0.691349592 15 85117641 85117839 199 + 1.788 1.750 -0.128
ENSG00000073417 E037 11.0519683 0.0501131011 0.0120499479 0.066647939 15 85120191 85120796 606 + 0.852 1.253 1.470
ENSG00000073417 E038 52.7953843 0.0008615369 0.6539066145 0.806030129 15 85120797 85121014 218 + 1.709 1.751 0.141
ENSG00000073417 E039 40.4621179 0.0014364500 0.2239931515 0.458187555 15 85123061 85123193 133 + 1.577 1.665 0.298
ENSG00000073417 E040 41.5452471 0.0012297900 0.0740133136 0.232801107 15 85126207 85126374 168 + 1.571 1.688 0.399
ENSG00000073417 E041 41.0305810 0.0259836731 0.0614780774 0.206091544 15 85136534 85136663 130 + 1.513 1.723 0.714
ENSG00000073417 E042 177.6017444 0.0093084120 0.0089593040 0.053633086 15 85137797 85139145 1349 + 2.182 2.319 0.457