ENSG00000072803

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000296933 ENSG00000072803 HEK293_OSMI2_6hA HEK293_TMG_6hB FBXW11 protein_coding protein_coding 22.95062 14.57044 29.35483 3.651225 1.708436 1.010055 15.9158459 11.30296128 16.711647 3.59081736 3.8875568 0.5637403 0.7259250 0.7358000 0.5579667 -0.17783333 0.630921906 0.002583382 FALSE TRUE
ENST00000393802 ENSG00000072803 HEK293_OSMI2_6hA HEK293_TMG_6hB FBXW11 protein_coding protein_coding 22.95062 14.57044 29.35483 3.651225 1.708436 1.010055 3.3241696 1.54583775 5.127411 0.62545783 0.3139453 1.7233500 0.1214500 0.1008667 0.1755000 0.07463333 0.370489717 0.002583382 FALSE TRUE
MSTRG.27291.5 ENSG00000072803 HEK293_OSMI2_6hA HEK293_TMG_6hB FBXW11 protein_coding   22.95062 14.57044 29.35483 3.651225 1.708436 1.010055 0.9325964 0.02867844 4.312664 0.02867844 2.1822487 6.8042473 0.0322625 0.0016000 0.1564667 0.15486667 0.002583382 0.002583382 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000072803 E001 1.4179401 0.013696863 0.8046421698 0.898974015 5 171861549 171861551 3 - 0.339 0.440 0.569
ENSG00000072803 E002 579.4685159 1.739542837 0.4351987111 0.655118220 5 171861552 171863104 1553 - 2.599 2.926 1.087
ENSG00000072803 E003 243.8081529 1.444041259 0.4307823466 0.651736322 5 171863105 171863620 516 - 2.239 2.538 0.996
ENSG00000072803 E004 184.0942361 1.368497778 0.4753645708 0.683752798 5 171863621 171863926 306 - 2.150 2.384 0.781
ENSG00000072803 E005 149.6181750 1.293748070 0.4804054672 0.687346434 5 171863927 171864101 175 - 2.062 2.293 0.772
ENSG00000072803 E006 0.9299365 0.015378759 0.6401415806   5 171867778 171867834 57 - 0.233 0.365 0.888
ENSG00000072803 E007 5.9040999 0.161279335 0.2564906590 0.495262519 5 171867835 171868044 210 - 0.685 0.992 1.196
ENSG00000072803 E008 6.0065271 0.303796508 0.5262968994 0.719402404 5 171868045 171868149 105 - 0.705 0.991 1.113
ENSG00000072803 E009 166.8928747 0.008808549 0.6089101411 0.776158998 5 171868610 171868796 187 - 2.163 2.280 0.393
ENSG00000072803 E010 114.7740660 0.005227195 0.5540185501 0.739139239 5 171869729 171869807 79 - 2.016 2.095 0.266
ENSG00000072803 E011 171.1419655 0.016413411 0.3850174580 0.616522508 5 171870748 171870858 111 - 2.195 2.254 0.197
ENSG00000072803 E012 208.1674510 0.031442270 0.2192674091 0.452535253 5 171872872 171872990 119 - 2.303 2.301 -0.007
ENSG00000072803 E013 205.4176283 0.023645476 0.3841608570 0.615726952 5 171876285 171876401 117 - 2.282 2.321 0.128
ENSG00000072803 E014 194.5445114 0.024773575 0.2582160353 0.496957374 5 171876402 171876534 133 - 2.266 2.285 0.063
ENSG00000072803 E015 149.3857691 0.018712220 0.0322600894 0.134004480 5 171878011 171878129 119 - 2.172 2.133 -0.129
ENSG00000072803 E016 129.9815754 0.015855847 0.0068553317 0.043969974 5 171891467 171891604 138 - 2.124 2.049 -0.251
ENSG00000072803 E017 100.4016153 0.007312939 0.0003119461 0.003850532 5 171899004 171899094 91 - 2.020 1.928 -0.310
ENSG00000072803 E018 71.1488433 0.006846356 0.0066498958 0.042945895 5 171899914 171899932 19 - 1.862 1.803 -0.200
ENSG00000072803 E019 190.1749130 0.017848115 0.0070486563 0.044854627 5 171899933 171900100 168 - 2.288 2.215 -0.244
ENSG00000072803 E020 0.0000000       5 171908709 171908859 151 -      
ENSG00000072803 E021 121.7257051 0.015833418 0.0254146386 0.113486108 5 171910572 171910630 59 - 2.086 2.042 -0.147
ENSG00000072803 E022 103.3305839 0.014331779 0.0107261314 0.061222190 5 171910631 171910671 41 - 2.021 1.957 -0.213
ENSG00000072803 E023 114.5630869 0.022406771 0.0376764514 0.148784485 5 171910672 171910733 62 - 2.060 2.015 -0.150
ENSG00000072803 E024 97.9160819 0.020584565 0.0623477810 0.208026082 5 171910734 171910797 64 - 1.988 1.955 -0.111
ENSG00000072803 E025 35.1207672 0.051201993 0.0764861321 0.237717180 5 171914343 171914405 63 - 1.569 1.477 -0.315
ENSG00000072803 E026 0.5171231 1.401436022 0.3653806458   5 171957597 171957698 102 - 0.000 0.375 12.894
ENSG00000072803 E027 0.1779838 0.104429446 0.7224237456   5 171977636 171977756 121 - 0.093 0.000 -9.515
ENSG00000072803 E028 13.8769471 0.022427538 0.2263331139 0.461037696 5 171996890 171997051 162 - 1.169 1.124 -0.159
ENSG00000072803 E029 1.8989942 0.012677716 0.2715672581 0.511435119 5 172003181 172003310 130 - 0.496 0.365 -0.699
ENSG00000072803 E030 64.5412202 0.024953295 0.8236324928 0.910060450 5 172006458 172006873 416 - 1.746 1.879 0.448