ENSG00000072786

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000176763 ENSG00000072786 HEK293_OSMI2_6hA HEK293_TMG_6hB STK10 protein_coding protein_coding 15.77487 24.86622 8.251309 2.979684 0.6647984 -1.590325 2.433369 3.360309 1.3645512 0.2842038 0.13104934 -1.2939200 0.1572875 0.13770000 0.16510000 0.027400000 0.7594242860 0.0001372593 FALSE TRUE
ENST00000517360 ENSG00000072786 HEK293_OSMI2_6hA HEK293_TMG_6hB STK10 protein_coding retained_intron 15.77487 24.86622 8.251309 2.979684 0.6647984 -1.590325 4.361787 8.768796 0.5300032 1.7854059 0.30369084 -4.0229833 0.2378667 0.34470000 0.06453333 -0.280166667 0.2161036657 0.0001372593 FALSE FALSE
MSTRG.27299.2 ENSG00000072786 HEK293_OSMI2_6hA HEK293_TMG_6hB STK10 protein_coding   15.77487 24.86622 8.251309 2.979684 0.6647984 -1.590325 1.869264 1.332823 2.2642559 0.1895752 0.16295702 0.7601257 0.1373833 0.05743333 0.27803333 0.220600000 0.0001372593 0.0001372593 FALSE TRUE
MSTRG.27299.4 ENSG00000072786 HEK293_OSMI2_6hA HEK293_TMG_6hB STK10 protein_coding   15.77487 24.86622 8.251309 2.979684 0.6647984 -1.590325 5.505899 9.513603 3.0215078 1.9984363 0.07664884 -1.6514719 0.3504333 0.37656667 0.36943333 -0.007133333 1.0000000000 0.0001372593 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000072786 E001 43.0886362 0.0042220134 2.903785e-01 0.5310233191 5 172042079 172043110 1032 - 1.626 1.559 -0.230
ENSG00000072786 E002 59.5080324 0.0008337743 8.689035e-01 0.9353672508 5 172043111 172043737 627 - 1.716 1.714 -0.008
ENSG00000072786 E003 91.5986261 0.0069767570 9.578120e-03 0.0563083257 5 172043738 172043831 94 - 1.766 1.930 0.553
ENSG00000072786 E004 352.3893176 0.0022783764 3.533062e-05 0.0006201501 5 172043832 172044580 749 - 2.375 2.507 0.440
ENSG00000072786 E005 98.9276145 0.0008498888 8.761413e-02 0.2592819332 5 172044581 172044667 87 - 1.870 1.949 0.268
ENSG00000072786 E006 62.0473140 0.0040415774 1.243370e-01 0.3226268636 5 172044668 172044685 18 - 1.655 1.752 0.328
ENSG00000072786 E007 188.7058285 0.0003139847 8.670813e-04 0.0088258422 5 172044686 172045022 337 - 2.129 2.239 0.367
ENSG00000072786 E008 0.5767453 0.0194193985 1.000000e+00   5 172045426 172045480 55 - 0.195 0.190 -0.041
ENSG00000072786 E009 87.7776403 0.0006238324 7.616403e-01 0.8736123427 5 172052929 172053042 114 - 1.892 1.885 -0.023
ENSG00000072786 E010 0.3206185 0.0244411696 3.288410e-02   5 172053043 172053200 158 - 0.329 0.000 -13.874
ENSG00000072786 E011 95.7763987 0.0004339114 3.033489e-01 0.5439015430 5 172054569 172054694 126 - 1.948 1.913 -0.120
ENSG00000072786 E012 107.0011004 0.0005150113 6.138527e-01 0.7794467586 5 172055588 172055721 134 - 1.980 1.967 -0.044
ENSG00000072786 E013 76.2661772 0.0008116030 9.779571e-01 0.9907489984 5 172055722 172055776 55 - 1.820 1.829 0.028
ENSG00000072786 E014 0.5885118 0.0335069705 2.781075e-01   5 172057012 172057348 337 - 0.328 0.136 -1.622
ENSG00000072786 E015 102.3012465 0.0034747787 3.570059e-01 0.5932735135 5 172057349 172057463 115 - 1.980 1.944 -0.121
ENSG00000072786 E016 62.5866962 0.0022414935 9.266303e-01 0.9653969020 5 172057464 172057473 10 - 1.734 1.745 0.038
ENSG00000072786 E017 115.1909232 0.0067603001 7.785470e-01 0.8838740196 5 172061139 172061268 130 - 1.984 2.007 0.079
ENSG00000072786 E018 1.7263595 0.0245960796 3.837414e-02 0.1505524225 5 172061269 172061533 265 - 0.643 0.283 -1.888
ENSG00000072786 E019 0.6544085 0.0189415887 3.503211e-02   5 172061534 172061630 97 - 0.431 0.073 -3.208
ENSG00000072786 E020 0.9872031 0.0157381559 6.610473e-01   5 172063463 172063600 138 - 0.195 0.283 0.697
ENSG00000072786 E021 1.5776202 0.0600723816 2.323908e-01 0.4679642722 5 172064365 172064719 355 - 0.513 0.286 -1.277
ENSG00000072786 E022 77.9583508 0.0021751823 7.729992e-01 0.8804861920 5 172064720 172064812 93 - 1.820 1.842 0.075
ENSG00000072786 E023 103.2984760 0.0003772092 7.977034e-02 0.2443557366 5 172082326 172082505 180 - 2.000 1.938 -0.209
ENSG00000072786 E024 93.9775378 0.0028343708 9.476137e-01 0.9761232251 5 172082961 172083084 124 - 1.908 1.907 -0.001
ENSG00000072786 E025 101.1476143 0.0015945461 4.682749e-01 0.6788997394 5 172090232 172090362 131 - 1.911 1.948 0.124
ENSG00000072786 E026 5.1216315 0.0349440517 2.874455e-01 0.5281999323 5 172092428 172092912 485 - 0.584 0.774 0.803
ENSG00000072786 E027 137.4719234 0.0003303550 4.800887e-02 0.1750119125 5 172093412 172093696 285 - 2.015 2.092 0.259
ENSG00000072786 E028 129.5929983 0.0005216146 6.979364e-01 0.8342119004 5 172093697 172093960 264 - 2.058 2.051 -0.025
ENSG00000072786 E029 39.7323698 0.0074283612 6.372474e-01 0.7951978038 5 172096426 172096437 12 - 1.565 1.532 -0.114
ENSG00000072786 E030 79.8413535 0.0006333623 7.219721e-01 0.8492644827 5 172096438 172096560 123 - 1.849 1.839 -0.036
ENSG00000072786 E031 0.2027342 0.0371396152 1.000000e+00   5 172105571 172105655 85 - 0.000 0.073 9.782
ENSG00000072786 E032 37.8299928 0.0010042260 3.024462e-01 0.5430339006 5 172105656 172105657 2 - 1.571 1.511 -0.206
ENSG00000072786 E033 62.3464104 0.0006731231 1.116248e-02 0.0630602818 5 172105658 172105737 80 - 1.824 1.704 -0.405
ENSG00000072786 E034 51.6572136 0.0007409665 9.896332e-04 0.0098335148 5 172106620 172106661 42 - 1.777 1.608 -0.576
ENSG00000072786 E035 56.5412533 0.0006893288 1.732653e-03 0.0152473981 5 172106662 172106709 48 - 1.805 1.651 -0.523
ENSG00000072786 E036 73.5520735 0.0006426484 2.448593e-03 0.0200006430 5 172106710 172106802 93 - 1.905 1.774 -0.442
ENSG00000072786 E037 42.0809786 0.0098446768 2.480822e-01 0.4859404775 5 172106803 172106814 12 - 1.631 1.553 -0.265
ENSG00000072786 E038 0.1308682 0.0326491905 1.000000e+00   5 172106815 172106815 1 - 0.000 0.073 9.813
ENSG00000072786 E039 0.6238610 0.0193874923 2.712831e-01   5 172106816 172107034 219 - 0.329 0.136 -1.625
ENSG00000072786 E040 0.1308682 0.0326491905 1.000000e+00   5 172107035 172107073 39 - 0.000 0.073 9.813
ENSG00000072786 E041 56.3932486 0.0008977758 6.297791e-02 0.2094039715 5 172107780 172107852 73 - 1.765 1.674 -0.307
ENSG00000072786 E042 0.8148287 0.0169639596 8.363874e-01   5 172107853 172108288 436 - 0.195 0.239 0.374
ENSG00000072786 E043 0.0000000       5 172114597 172114800 204 -      
ENSG00000072786 E044 0.1779838 0.0344611439 1.470805e-01   5 172114996 172115144 149 - 0.195 0.000 -12.736
ENSG00000072786 E045 107.1262857 0.0003948991 4.067182e-02 0.1564796322 5 172117481 172117630 150 - 2.022 1.950 -0.242
ENSG00000072786 E046 66.4914538 0.0005888897 3.736222e-01 0.6070342723 5 172127373 172127421 49 - 1.794 1.756 -0.127
ENSG00000072786 E047 103.4369545 0.0007953741 2.984355e-03 0.0233049242 5 172156624 172156788 165 - 2.036 1.924 -0.374
ENSG00000072786 E048 77.7355073 0.0053839860 8.042363e-01 0.8987689121 5 172187887 172188077 191 - 1.838 1.829 -0.031
ENSG00000072786 E049 31.2755773 0.0011623005 2.082148e-03 0.0176155357 5 172188078 172188185 108 - 1.241 1.493 0.875
ENSG00000072786 E050 13.6364252 0.0392028898 1.578797e-01 0.3735455581 5 172188186 172188255 70 - 0.924 1.134 0.769