ENSG00000072571

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000353866 ENSG00000072571 HEK293_OSMI2_6hA HEK293_TMG_6hB HMMR protein_coding protein_coding 18.81295 3.499039 37.15348 0.1902748 0.4790395 3.404738 0.6345393 0.3430171 1.0828791 0.14986739 0.7556778 1.630324 0.05217500 0.09456667 0.02953333 -0.06503333 4.840007e-01 3.253173e-08 FALSE TRUE
ENST00000358715 ENSG00000072571 HEK293_OSMI2_6hA HEK293_TMG_6hB HMMR protein_coding protein_coding 18.81295 3.499039 37.15348 0.1902748 0.4790395 3.404738 0.4688472 0.5597192 0.9791306 0.40589186 0.5120380 0.795910 0.03250833 0.16313333 0.02620000 -0.13693333 8.512733e-01 3.253173e-08 FALSE TRUE
ENST00000393915 ENSG00000072571 HEK293_OSMI2_6hA HEK293_TMG_6hB HMMR protein_coding protein_coding 18.81295 3.499039 37.15348 0.1902748 0.4790395 3.404738 11.3817523 0.9670418 19.4541585 0.48427064 0.2438804 4.316256 0.48499583 0.27126667 0.52393333 0.25266667 7.090551e-01 3.253173e-08 FALSE TRUE
ENST00000432118 ENSG00000072571 HEK293_OSMI2_6hA HEK293_TMG_6hB HMMR protein_coding protein_coding 18.81295 3.499039 37.15348 0.1902748 0.4790395 3.404738 2.8263166 1.6027047 7.1966126 0.07951422 0.6440579 2.159839 0.31340417 0.46296667 0.19336667 -0.26960000 9.409441e-04 3.253173e-08 FALSE TRUE
ENST00000517936 ENSG00000072571 HEK293_OSMI2_6hA HEK293_TMG_6hB HMMR protein_coding retained_intron 18.81295 3.499039 37.15348 0.1902748 0.4790395 3.404738 1.7310051 0.0000000 3.8586426 0.00000000 0.3348107 8.595684 0.06136250 0.00000000 0.10366667 0.10366667 3.253173e-08 3.253173e-08 FALSE TRUE
ENST00000522094 ENSG00000072571 HEK293_OSMI2_6hA HEK293_TMG_6hB HMMR protein_coding protein_coding 18.81295 3.499039 37.15348 0.1902748 0.4790395 3.404738 1.6381795 0.0000000 4.5170172 0.00000000 0.6792150 8.822417 0.04760833 0.00000000 0.12153333 0.12153333 2.242520e-07 3.253173e-08 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000072571 E001 1.2449456 0.0138156888 9.730283e-03   5 163460203 163460341 139 + 0.167 0.659 2.928
ENSG00000072571 E002 0.9417030 0.0160957305 1.757420e-01   5 163460342 163460365 24 + 0.167 0.444 1.929
ENSG00000072571 E003 0.9417030 0.0160957305 1.757420e-01   5 163460366 163460366 1 + 0.167 0.444 1.929
ENSG00000072571 E004 0.9417030 0.0160957305 1.757420e-01   5 163460367 163460422 56 + 0.167 0.444 1.929
ENSG00000072571 E005 0.8925621 0.0226521484 1.772842e-01   5 163460423 163460631 209 + 0.166 0.444 1.929
ENSG00000072571 E006 0.7499275 0.0172671820 1.148059e-01   5 163460632 163460633 2 + 0.130 0.444 2.343
ENSG00000072571 E007 9.4039872 0.0036253678 9.205319e-01 0.962506909 5 163460634 163460652 19 + 0.857 0.859 0.008
ENSG00000072571 E008 11.2723841 0.0047028425 8.042559e-01 0.898772448 5 163460653 163460656 4 + 0.928 0.909 -0.071
ENSG00000072571 E009 12.5161123 0.0140942325 8.439045e-01 0.921539869 5 163460657 163460659 3 + 0.967 0.954 -0.046
ENSG00000072571 E010 37.1027561 0.0073161521 4.174838e-01 0.641706884 5 163460660 163460738 79 + 1.409 1.349 -0.210
ENSG00000072571 E011 60.7610633 0.0007078915 4.752254e-02 0.173834065 5 163463856 163463954 99 + 1.619 1.495 -0.424
ENSG00000072571 E012 71.6592496 0.0052328971 2.704539e-03 0.021595431 5 163464723 163464802 80 + 1.696 1.481 -0.734
ENSG00000072571 E013 0.5117739 0.0222127737 3.009677e-01   5 163464803 163465208 406 + 0.091 0.277 1.928
ENSG00000072571 E014 14.0290080 0.0026727190 3.637778e-03 0.027136005 5 163467701 163467703 3 + 1.044 0.564 -1.914
ENSG00000072571 E015 25.1662679 0.0021529947 1.679811e-02 0.084720413 5 163467704 163467748 45 + 1.263 0.995 -0.961
ENSG00000072571 E016 133.2348996 0.0033178312 1.440555e-02 0.075905916 5 163469641 163469829 189 + 1.952 1.836 -0.390
ENSG00000072571 E017 0.7721051 0.0232829484 6.033495e-01   5 163469830 163469910 81 + 0.167 0.276 0.925
ENSG00000072571 E018 95.0488638 0.0059392519 1.394813e-01 0.346709313 5 163471185 163471271 87 + 1.803 1.722 -0.273
ENSG00000072571 E019 117.5452703 0.0012883611 2.999456e-02 0.127321866 5 163471363 163471463 101 + 1.897 1.801 -0.323
ENSG00000072571 E020 87.7211721 0.0073204220 1.873973e-01 0.413588239 5 163473179 163473253 75 + 1.770 1.697 -0.246
ENSG00000072571 E021 148.0920387 0.0008607308 7.877732e-02 0.242376026 5 163473379 163473557 179 + 1.993 1.932 -0.204
ENSG00000072571 E022 154.7989299 0.0012710375 8.255190e-01 0.911245908 5 163474057 163474205 149 + 2.004 2.014 0.036
ENSG00000072571 E023 175.2952568 0.0071200378 9.061454e-01 0.955155030 5 163475458 163475672 215 + 2.056 2.068 0.041
ENSG00000072571 E024 109.9736284 0.0029394716 7.895152e-01 0.890237926 5 163478684 163478800 117 + 1.854 1.889 0.118
ENSG00000072571 E025 105.9323510 0.0019924462 4.857884e-02 0.176345424 5 163482642 163482788 147 + 1.830 1.949 0.402
ENSG00000072571 E026 102.9686503 0.1863839090 3.326478e-01 0.571347486 5 163483020 163483172 153 + 1.811 1.955 0.487
ENSG00000072571 E027 88.3783432 0.0583295372 5.485232e-01 0.735279786 5 163483268 163483367 100 + 1.757 1.831 0.249
ENSG00000072571 E028 136.1165406 0.0077908808 9.694746e-01 0.986583506 5 163484069 163484245 177 + 1.951 1.968 0.058
ENSG00000072571 E029 136.6481286 0.0008194423 2.989052e-01 0.539372000 5 163490390 163490552 163 + 1.945 2.010 0.220
ENSG00000072571 E030 293.2783211 0.0038862306 6.725173e-05 0.001072888 5 163491112 163491941 830 + 2.257 2.422 0.552