ENSG00000072518

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000350490 ENSG00000072518 HEK293_OSMI2_6hA HEK293_TMG_6hB MARK2 protein_coding protein_coding 31.06732 46.09331 23.27307 8.272546 1.046236 -0.9855894 2.231245 3.403595 0.2355553 0.7529618 0.2355553 -3.7971718 0.06927083 0.0732000 0.01103333 -0.06216667 1.657911e-01 6.844466e-44 FALSE TRUE
ENST00000408948 ENSG00000072518 HEK293_OSMI2_6hA HEK293_TMG_6hB MARK2 protein_coding protein_coding 31.06732 46.09331 23.27307 8.272546 1.046236 -0.9855894 11.566587 17.767546 5.9120819 4.3264862 0.1535518 -1.5858798 0.34653333 0.3741667 0.25490000 -0.11926667 2.255774e-01 6.844466e-44 FALSE TRUE
ENST00000502399 ENSG00000072518 HEK293_OSMI2_6hA HEK293_TMG_6hB MARK2 protein_coding protein_coding 31.06732 46.09331 23.27307 8.272546 1.046236 -0.9855894 6.876469 11.067176 5.9962379 1.7351457 0.5525920 -0.8830566 0.22936667 0.2427000 0.25653333 0.01383333 9.191591e-01 6.844466e-44 FALSE TRUE
ENST00000508192 ENSG00000072518 HEK293_OSMI2_6hA HEK293_TMG_6hB MARK2 protein_coding protein_coding 31.06732 46.09331 23.27307 8.272546 1.046236 -0.9855894 1.521612 2.653937 0.6937603 0.7428114 0.3755063 -1.9204040 0.05310833 0.0595000 0.02890000 -0.03060000 7.384065e-01 6.844466e-44 FALSE TRUE
ENST00000513765 ENSG00000072518 HEK293_OSMI2_6hA HEK293_TMG_6hB MARK2 protein_coding protein_coding 31.06732 46.09331 23.27307 8.272546 1.046236 -0.9855894 2.960928 5.418889 2.3764208 0.4253479 0.3137163 -1.1858084 0.08392917 0.1235333 0.10370000 -0.01983333 8.703298e-01 6.844466e-44 FALSE TRUE
ENST00000543220 ENSG00000072518 HEK293_OSMI2_6hA HEK293_TMG_6hB MARK2 protein_coding protein_coding 31.06732 46.09331 23.27307 8.272546 1.046236 -0.9855894 1.613645 0.000000 4.9214487 0.0000000 0.3797221 8.9458677 0.06823750 0.0000000 0.21086667 0.21086667 6.844466e-44 6.844466e-44 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000072518 E001 1.1595774 0.0264030021 4.328545e-01   11 63838928 63839004 77 + 0.185 0.338 1.155
ENSG00000072518 E002 3.4744831 0.0075148705 4.103131e-02 1.573892e-01 11 63839005 63839092 88 + 0.314 0.692 1.890
ENSG00000072518 E003 3.9979557 0.0097103014 1.663306e-02 8.410768e-02 11 63839093 63839109 17 + 0.314 0.756 2.149
ENSG00000072518 E004 12.2672315 0.0051701719 4.829833e-03 3.369138e-02 11 63839110 63839137 28 + 0.799 1.150 1.311
ENSG00000072518 E005 25.4676134 0.0024753167 1.323826e-04 1.890800e-03 11 63839138 63839294 157 + 1.102 1.451 1.224
ENSG00000072518 E006 36.7258872 0.0181962676 3.187913e-02 1.328510e-01 11 63839295 63839429 135 + 1.368 1.572 0.702
ENSG00000072518 E007 44.1749762 0.0056043181 1.186263e-01 3.135990e-01 11 63839430 63839463 34 + 1.522 1.635 0.385
ENSG00000072518 E008 111.5245104 0.0004861317 4.398772e-01 6.586194e-01 11 63839464 63839560 97 + 2.018 1.995 -0.078
ENSG00000072518 E009 0.3032425 0.0274424043 6.470384e-01   11 63849963 63850029 67 + 0.000 0.144 10.465
ENSG00000072518 E010 0.0000000       11 63868470 63868909 440 +      
ENSG00000072518 E011 0.0000000       11 63869276 63869372 97 +      
ENSG00000072518 E012 0.3393995 0.0250059152 4.225829e-02   11 63880148 63880228 81 + 0.314 0.000 -12.773
ENSG00000072518 E013 0.0000000       11 63888547 63888695 149 +      
ENSG00000072518 E014 0.3088520 0.0263514761 4.615397e-01   11 63888696 63888964 269 + 0.185 0.078 -1.433
ENSG00000072518 E015 0.0000000       11 63890222 63890295 74 +      
ENSG00000072518 E016 109.5765488 0.0004711323 8.373466e-03 5.103934e-02 11 63895159 63895185 27 + 2.060 1.968 -0.308
ENSG00000072518 E017 204.7564520 0.0007249914 1.009522e-03 9.984865e-03 11 63895186 63895281 96 + 2.328 2.238 -0.300
ENSG00000072518 E018 190.9788948 0.0002509702 1.566879e-04 2.179475e-03 11 63895282 63895338 57 + 2.305 2.206 -0.330
ENSG00000072518 E019 227.1755870 0.0012171842 3.240387e-04 3.974090e-03 11 63895580 63895633 54 + 2.378 2.275 -0.342
ENSG00000072518 E020 0.3447487 0.7127174692 8.184155e-01   11 63895880 63895949 70 + 0.000 0.147 9.396
ENSG00000072518 E021 5.6312149 0.1392994052 2.216549e-01 4.554839e-01 11 63895950 63898086 2137 + 0.948 0.695 -0.994
ENSG00000072518 E022 0.5530924 0.0295822860 7.989926e-01   11 63898087 63898231 145 + 0.185 0.144 -0.427
ENSG00000072518 E023 219.1417869 0.0003037318 1.609822e-03 1.439562e-02 11 63898232 63898280 49 + 2.346 2.268 -0.259
ENSG00000072518 E024 6.2197739 0.2402838270 2.776466e-01 5.177238e-01 11 63898281 63898607 327 + 0.985 0.720 -1.025
ENSG00000072518 E025 196.3523743 0.0003018759 2.469321e-04 3.185563e-03 11 63898608 63898659 52 + 2.312 2.217 -0.319
ENSG00000072518 E026 149.1613200 0.0003235786 1.918714e-03 1.652777e-02 11 63898660 63898673 14 + 2.192 2.100 -0.309
ENSG00000072518 E027 3.7769561 0.0076454662 2.618126e-01 5.009199e-01 11 63898674 63898762 89 + 0.761 0.596 -0.696
ENSG00000072518 E028 215.1940602 0.0004865553 4.498087e-03 3.193072e-02 11 63898763 63898833 71 + 2.336 2.264 -0.242
ENSG00000072518 E029 1.4176096 0.0827209440 3.383051e-01 5.764996e-01 11 63898834 63899051 218 + 0.185 0.380 1.402
ENSG00000072518 E030 181.4853996 0.0023233185 5.310837e-02 1.870235e-01 11 63899052 63899108 57 + 2.254 2.191 -0.211
ENSG00000072518 E031 1.9338954 0.0104892020 2.747111e-01 5.147100e-01 11 63899109 63899873 765 + 0.562 0.376 -0.945
ENSG00000072518 E032 381.1228674 0.0016263593 6.786050e-02 2.202919e-01 11 63899874 63900110 237 + 2.561 2.516 -0.150
ENSG00000072518 E033 4.8469791 0.2371267763 5.288208e-01 7.211914e-01 11 63900111 63900558 448 + 0.800 0.686 -0.463
ENSG00000072518 E034 327.1311421 0.0001834051 4.788356e-03 3.346818e-02 11 63900559 63900678 120 + 2.504 2.449 -0.183
ENSG00000072518 E035 279.2671636 0.0003530768 1.280985e-01 3.287753e-01 11 63900780 63900879 100 + 2.417 2.386 -0.105
ENSG00000072518 E036 253.5310405 0.0002352074 1.619106e-01 3.795817e-01 11 63900957 63901069 113 + 2.374 2.346 -0.095
ENSG00000072518 E037 230.7066106 0.0002479256 4.868277e-01 6.917966e-01 11 63902198 63902330 133 + 2.324 2.312 -0.037
ENSG00000072518 E038 10.9984656 0.0466699182 4.913596e-01 6.948700e-01 11 63902601 63902603 3 + 1.106 0.999 -0.390
ENSG00000072518 E039 171.4362196 0.0011025698 9.413102e-01 9.728713e-01 11 63902604 63902686 83 + 2.179 2.190 0.037
ENSG00000072518 E040 169.7810651 0.0002626252 7.514078e-01 8.676513e-01 11 63902687 63902782 96 + 2.169 2.186 0.056
ENSG00000072518 E041 182.0535022 0.0004194527 3.569847e-01 5.932548e-01 11 63903061 63903132 72 + 2.189 2.224 0.117
ENSG00000072518 E042 119.5522333 0.0008184318 4.521203e-02 1.681421e-01 11 63903133 63903158 26 + 1.969 2.054 0.287
ENSG00000072518 E043 1.6836654 0.5607652179 7.850781e-01 8.876039e-01 11 63903159 63903403 245 + 0.407 0.389 -0.097
ENSG00000072518 E044 88.7456477 0.0006607984 3.988955e-01 6.273244e-01 11 63903986 63904097 112 + 1.927 1.899 -0.095
ENSG00000072518 E045 62.1641166 0.0006959939 7.596533e-01 8.723619e-01 11 63904098 63904147 50 + 1.761 1.752 -0.028
ENSG00000072518 E046 2.0775256 0.0380971349 3.336080e-03 2.539982e-02 11 63904148 63904354 207 + 0.761 0.252 -2.598
ENSG00000072518 E047 391.8519982 0.0002111201 5.524122e-04 6.151976e-03 11 63904786 63905043 258 + 2.485 2.564 0.265
ENSG00000072518 E048 16.0437154 0.0021017029 5.369961e-01 7.270148e-01 11 63906088 63906114 27 + 1.137 1.202 0.233
ENSG00000072518 E049 44.6132749 0.1102496359 3.796962e-01 6.119438e-01 11 63906115 63907567 1453 + 1.701 1.567 -0.458
ENSG00000072518 E050 218.2122529 0.0014791856 4.936635e-01 6.964115e-01 11 63908260 63908304 45 + 2.268 2.294 0.086
ENSG00000072518 E051 1789.2153826 0.0003425948 7.092308e-22 2.579094e-19 11 63908877 63911020 2144 + 3.118 3.228 0.367