ENSG00000072501

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000322213 ENSG00000072501 HEK293_OSMI2_6hA HEK293_TMG_6hB SMC1A protein_coding protein_coding 113.1318 87.04822 150.2065 17.95774 5.663399 0.7869905 17.595632 18.424920 16.939112 4.997817 1.7148201 -0.121231472 0.16876667 0.20603333 0.1128667 -0.09316667 4.815897e-02 1.92447e-25 FALSE TRUE
ENST00000675504 ENSG00000072501 HEK293_OSMI2_6hA HEK293_TMG_6hB SMC1A protein_coding protein_coding 113.1318 87.04822 150.2065 17.95774 5.663399 0.7869905 9.095770 8.996609 9.048454 1.971911 1.6341517 0.008280792 0.10310000 0.10390000 0.0605000 -0.04340000 3.287386e-01 1.92447e-25 FALSE TRUE
MSTRG.34295.10 ENSG00000072501 HEK293_OSMI2_6hA HEK293_TMG_6hB SMC1A protein_coding   113.1318 87.04822 150.2065 17.95774 5.663399 0.7869905 4.009398 0.000000 7.721947 0.000000 1.0220487 9.594688022 0.02630417 0.00000000 0.0510000 0.05100000 1.924470e-25 1.92447e-25 FALSE TRUE
MSTRG.34295.4 ENSG00000072501 HEK293_OSMI2_6hA HEK293_TMG_6hB SMC1A protein_coding   113.1318 87.04822 150.2065 17.95774 5.663399 0.7869905 54.662546 45.260646 74.123049 9.938457 3.9764939 0.711540965 0.48592917 0.51593333 0.4928667 -0.02306667 8.205886e-01 1.92447e-25 FALSE TRUE
MSTRG.34295.9 ENSG00000072501 HEK293_OSMI2_6hA HEK293_TMG_6hB SMC1A protein_coding   113.1318 87.04822 150.2065 17.95774 5.663399 0.7869905 12.021427 2.155374 21.242221 1.234343 0.4552331 3.294925734 0.08208333 0.02816667 0.1416333 0.11346667 4.961557e-01 1.92447e-25 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000072501 E001 2344.234283 3.585712e-03 2.775663e-14 3.826146e-12 X 53374149 53378563 4415 - 3.237 3.494 0.853
ENSG00000072501 E002 5403.810688 1.931473e-03 1.260751e-08 5.777239e-07 X 53378564 53380053 1490 - 3.660 3.805 0.484
ENSG00000072501 E003 1139.280345 2.056299e-03 4.968384e-03 3.446111e-02 X 53380054 53380182 129 - 3.003 3.108 0.348
ENSG00000072501 E004 462.869442 3.602761e-04 3.038889e-01 5.444730e-01 X 53380183 53380186 4 - 2.636 2.689 0.174
ENSG00000072501 E005 954.026034 8.655991e-05 1.182947e-03 1.130129e-02 X 53380620 53380730 111 - 2.942 3.014 0.240
ENSG00000072501 E006 749.085676 1.097538e-04 1.952933e-02 9.428729e-02 X 53381018 53381087 70 - 2.841 2.905 0.215
ENSG00000072501 E007 40.256771 2.172995e-01 9.163120e-01 9.603724e-01 X 53381678 53382231 554 - 1.546 1.684 0.468
ENSG00000072501 E008 1074.149023 1.084487e-04 1.172195e-03 1.121876e-02 X 53382232 53382383 152 - 2.995 3.067 0.237
ENSG00000072501 E009 1099.111336 4.892367e-04 3.731469e-02 1.477820e-01 X 53382506 53382660 155 - 3.008 3.073 0.216
ENSG00000072501 E010 1107.218055 1.355224e-03 6.993000e-01 8.351263e-01 X 53383097 53383253 157 - 3.028 3.055 0.090
ENSG00000072501 E011 901.503496 8.051068e-04 4.210250e-02 1.601660e-01 X 53394778 53394888 111 - 2.952 2.950 -0.006
ENSG00000072501 E012 1229.717775 6.092366e-04 5.263282e-03 3.600219e-02 X 53396227 53396380 154 - 3.090 3.080 -0.035
ENSG00000072501 E013 1238.763827 2.144626e-04 1.534568e-03 1.384577e-02 X 53396472 53396614 143 - 3.091 3.086 -0.019
ENSG00000072501 E014 548.445267 8.448338e-04 2.571262e-03 2.079133e-02 X 53396615 53396617 3 - 2.748 2.718 -0.101
ENSG00000072501 E015 1030.224493 1.768047e-04 2.434000e-02 1.101379e-01 X 53399589 53399730 142 - 3.007 3.011 0.015
ENSG00000072501 E016 10.106790 2.323667e-01 3.878975e-01 6.188423e-01 X 53402287 53402379 93 - 0.890 1.190 1.097
ENSG00000072501 E017 912.673227 1.440126e-03 2.034298e-01 4.338346e-01 X 53403566 53403672 107 - 2.954 2.956 0.007
ENSG00000072501 E018 899.418248 6.480404e-04 3.281106e-03 2.507909e-02 X 53403777 53403893 117 - 2.956 2.939 -0.057
ENSG00000072501 E019 9.592570 1.250330e-01 6.646991e-01 8.128259e-01 X 53404799 53405011 213 - 0.966 1.077 0.408
ENSG00000072501 E020 937.887827 1.149621e-04 4.685814e-05 7.866341e-04 X 53405012 53405149 138 - 2.976 2.958 -0.060
ENSG00000072501 E021 780.628783 1.245101e-04 9.728799e-05 1.461219e-03 X 53405245 53405391 147 - 2.897 2.876 -0.067
ENSG00000072501 E022 844.295061 1.027676e-04 6.038224e-05 9.788366e-04 X 53405493 53405672 180 - 2.930 2.911 -0.063
ENSG00000072501 E023 791.060958 2.448072e-04 8.010104e-06 1.731984e-04 X 53405771 53405956 186 - 2.908 2.875 -0.109
ENSG00000072501 E024 785.476409 1.601000e-04 1.823397e-05 3.532049e-04 X 53409062 53409269 208 - 2.902 2.876 -0.089
ENSG00000072501 E025 609.096483 1.146699e-03 1.700915e-04 2.335121e-03 X 53409421 53409503 83 - 2.802 2.749 -0.174
ENSG00000072501 E026 809.976151 5.127118e-04 3.824736e-07 1.221607e-05 X 53411761 53411901 141 - 2.925 2.871 -0.178
ENSG00000072501 E027 1291.892183 3.766847e-04 9.800647e-20 2.764743e-17 X 53411995 53412253 259 - 3.143 3.051 -0.305
ENSG00000072501 E028 1084.924565 3.442364e-03 2.035510e-07 7.003169e-06 X 53412900 53413138 239 - 3.081 2.952 -0.429
ENSG00000072501 E029 869.074456 3.610503e-03 2.537779e-07 8.512210e-06 X 53413232 53413435 204 - 2.987 2.850 -0.455
ENSG00000072501 E030 560.121221 9.982763e-04 2.222526e-14 3.109028e-12 X 53414758 53414870 113 - 2.797 2.660 -0.453
ENSG00000072501 E031 654.218031 1.102853e-03 1.367323e-10 9.430584e-09 X 53414981 53415169 189 - 2.853 2.747 -0.352
ENSG00000072501 E032 15.683506 2.595411e-03 3.703574e-02 1.469960e-01 X 53421895 53422013 119 - 1.277 1.122 -0.551
ENSG00000072501 E033 10.987488 2.737489e-03 1.690403e-02 8.510128e-02 X 53422014 53422040 27 - 1.156 0.937 -0.798
ENSG00000072501 E034 7.509908 3.855112e-03 9.189364e-01 9.616617e-01 X 53422041 53422194 154 - 0.921 0.937 0.062
ENSG00000072501 E035 427.114777 9.687295e-04 2.507889e-11 2.016559e-09 X 53422492 53423150 659 - 2.674 2.550 -0.414