ENSG00000071994

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000167218 ENSG00000071994 HEK293_OSMI2_6hA HEK293_TMG_6hB PDCD2 protein_coding nonsense_mediated_decay 121.7042 89.80198 125.449 8.872054 7.865495 0.4822358 8.856291 7.232429 6.294545 0.7157156 0.8007414 -0.2000814 0.07307917 0.08066667 0.05006667 -0.030600000 1.139408e-01 6.801069e-27 TRUE TRUE
ENST00000392090 ENSG00000071994 HEK293_OSMI2_6hA HEK293_TMG_6hB PDCD2 protein_coding protein_coding 121.7042 89.80198 125.449 8.872054 7.865495 0.4822358 38.355708 24.005884 33.717961 2.8484691 1.3088853 0.4899562 0.31547083 0.26683333 0.27160000 0.004766667 1.000000e+00 6.801069e-27 FALSE TRUE
ENST00000453163 ENSG00000071994 HEK293_OSMI2_6hA HEK293_TMG_6hB PDCD2 protein_coding protein_coding 121.7042 89.80198 125.449 8.872054 7.865495 0.4822358 7.400461 5.364365 9.612845 0.2299336 0.5762823 0.8403691 0.06179167 0.06053333 0.07663333 0.016100000 4.875272e-01 6.801069e-27 FALSE TRUE
ENST00000537445 ENSG00000071994 HEK293_OSMI2_6hA HEK293_TMG_6hB PDCD2 protein_coding protein_coding 121.7042 89.80198 125.449 8.872054 7.865495 0.4822358 4.224178 0.000000 25.767420 0.0000000 6.4826952 11.3318922 0.03224167 0.00000000 0.20060000 0.200600000 1.175427e-24 6.801069e-27 FALSE TRUE
ENST00000544866 ENSG00000071994 HEK293_OSMI2_6hA HEK293_TMG_6hB PDCD2 protein_coding nonsense_mediated_decay 121.7042 89.80198 125.449 8.872054 7.865495 0.4822358 29.082080 27.403135 25.511403 2.9450222 3.6371029 -0.1031597 0.23871250 0.30483333 0.20126667 -0.103566667 3.963343e-02 6.801069e-27 FALSE TRUE
ENST00000614056 ENSG00000071994 HEK293_OSMI2_6hA HEK293_TMG_6hB PDCD2 protein_coding protein_coding 121.7042 89.80198 125.449 8.872054 7.865495 0.4822358 20.566014 17.808696 8.727950 2.8044892 4.7197841 -1.0280250 0.17019583 0.19636667 0.07480000 -0.121566667 7.415545e-01 6.801069e-27 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000071994 E001 1.024528 2.3587351736 4.985951e-01   6 170575295 170575327 33 - 0.304 0.301 -0.023
ENSG00000071994 E002 220.525311 0.0044116067 4.642673e-10 2.870159e-08 6 170575328 170577435 2108 - 2.473 2.214 -0.866
ENSG00000071994 E003 194.079481 0.0002914765 2.993035e-07 9.837163e-06 6 170577436 170577558 123 - 2.370 2.229 -0.471
ENSG00000071994 E004 183.028174 0.0002648836 2.749493e-01 5.149498e-01 6 170577559 170577593 35 - 2.291 2.253 -0.126
ENSG00000071994 E005 294.624111 0.0014420076 8.520525e-01 9.262359e-01 6 170577594 170577717 124 - 2.477 2.468 -0.028
ENSG00000071994 E006 1.499957 2.4163403397 1.000000e+00 1.000000e+00 6 170578482 170578488 7 - 0.221 0.501 1.711
ENSG00000071994 E007 1.924207 1.8795699952 1.000000e+00 1.000000e+00 6 170578489 170578506 18 - 0.228 0.589 2.060
ENSG00000071994 E008 140.049797 0.0033189282 1.406953e-07 5.047168e-06 6 170578507 170578656 150 - 2.010 2.235 0.755
ENSG00000071994 E009 306.606190 0.0020619088 1.123081e-02 6.331753e-02 6 170578857 170578882 26 - 2.444 2.521 0.257
ENSG00000071994 E010 404.939536 0.0015126833 1.995089e-04 2.669656e-03 6 170578883 170578970 88 - 2.553 2.649 0.321
ENSG00000071994 E011 30.520081 0.0015143988 2.778478e-03 2.205213e-02 6 170578971 170579721 751 - 1.604 1.405 -0.682
ENSG00000071994 E012 419.104660 0.0006027970 1.321547e-05 2.672729e-04 6 170580002 170580092 91 - 2.576 2.661 0.284
ENSG00000071994 E013 248.730940 0.0002236259 2.451671e-05 4.542828e-04 6 170580093 170580105 13 - 2.349 2.438 0.297
ENSG00000071994 E014 96.936218 0.0004635339 2.682366e-05 4.898144e-04 6 170581089 170581744 656 - 2.080 1.919 -0.540
ENSG00000071994 E015 20.625265 0.0021147345 1.180140e-01 3.125921e-01 6 170581745 170581746 2 - 1.404 1.278 -0.440
ENSG00000071994 E016 21.606859 0.0020773954 2.819877e-01 5.223111e-01 6 170581747 170581747 1 - 1.404 1.317 -0.305
ENSG00000071994 E017 59.058772 0.0007616554 3.467329e-03 2.614360e-02 6 170581748 170581791 44 - 1.857 1.713 -0.487
ENSG00000071994 E018 514.409705 0.0016299503 2.223313e-12 2.156308e-10 6 170581792 170582265 474 - 2.804 2.629 -0.583
ENSG00000071994 E019 210.541306 0.0185832014 1.178024e-02 6.555543e-02 6 170582266 170582848 583 - 2.415 2.236 -0.596
ENSG00000071994 E020 97.462536 0.0053394712 9.706062e-05 1.458302e-03 6 170582849 170583056 208 - 2.099 1.893 -0.692
ENSG00000071994 E021 756.649471 0.0001842995 9.911581e-01 9.973178e-01 6 170583057 170583188 132 - 2.888 2.881 -0.024
ENSG00000071994 E022 629.627500 0.0002396347 3.642878e-01 5.992450e-01 6 170583505 170583623 119 - 2.801 2.808 0.023
ENSG00000071994 E023 450.518844 0.0008881545 6.111478e-01 7.777078e-01 6 170583624 170583747 124 - 2.656 2.663 0.025
ENSG00000071994 E024 3.188019 0.9686908482 4.030029e-01 6.307524e-01 6 170584055 170584298 244 - 0.682 0.565 -0.509
ENSG00000071994 E025 225.304056 0.0037884620 7.391742e-04 7.774124e-03 6 170584299 170584392 94 - 2.278 2.415 0.458
ENSG00000071994 E026 102.097800 0.0106439949 2.764902e-11 2.202364e-09 6 170584393 170584491 99 - 1.707 2.166 1.543
ENSG00000071994 E027 62.033179 0.0104231325 3.853348e-19 9.945092e-17 6 170584492 170584692 201 - 1.284 1.997 2.432