ENSG00000071967

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000321348 ENSG00000071967 HEK293_OSMI2_6hA HEK293_TMG_6hB CYBRD1 protein_coding protein_coding 1.902458 1.422745 1.377605 0.2913693 0.1571006 -0.04618498 0.92204446 0.4193987 0.96949119 0.06767673 0.04407793 1.1897146 0.48753333 0.3041333 0.7213000 0.4171667 0.01564182 0.01564182 FALSE TRUE
ENST00000468308 ENSG00000071967 HEK293_OSMI2_6hA HEK293_TMG_6hB CYBRD1 protein_coding processed_transcript 1.902458 1.422745 1.377605 0.2913693 0.1571006 -0.04618498 0.73652869 0.6897005 0.30069463 0.21409931 0.15232124 -1.1712402 0.37219167 0.4659667 0.1974667 -0.2685000 0.50468032 0.01564182 FALSE TRUE
ENST00000474182 ENSG00000071967 HEK293_OSMI2_6hA HEK293_TMG_6hB CYBRD1 protein_coding processed_transcript 1.902458 1.422745 1.377605 0.2913693 0.1571006 -0.04618498 0.02579045 0.1306535 0.00000000 0.06983652 0.00000000 -3.8140730 0.01374167 0.0788000 0.0000000 -0.0788000 0.26157982 0.01564182 FALSE FALSE
ENST00000494587 ENSG00000071967 HEK293_OSMI2_6hA HEK293_TMG_6hB CYBRD1 protein_coding processed_transcript 1.902458 1.422745 1.377605 0.2913693 0.1571006 -0.04618498 0.19314153 0.1600654 0.08359525 0.08198474 0.04181610 -0.8615822 0.11276667 0.1387000 0.0651000 -0.0736000 0.93725024 0.01564182 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000071967 E001 0.1723744 0.045693628 3.754508e-01   2 171522247 171522291 45 + 0.000 0.135 9.409
ENSG00000071967 E002 1.5418434 0.013752155 1.059841e-01 0.2923407615 2 171522348 171522473 126 + 0.269 0.549 1.569
ENSG00000071967 E003 1.3638596 0.015118422 4.347607e-02   2 171522474 171522476 3 + 0.196 0.549 2.154
ENSG00000071967 E004 3.4101024 0.019385037 3.827137e-01 0.6144745206 2 171522477 171522509 33 + 0.587 0.728 0.601
ENSG00000071967 E005 3.2792343 0.011533587 4.733511e-01 0.6823623965 2 171522510 171522510 1 + 0.586 0.698 0.482
ENSG00000071967 E006 13.3526463 0.003053038 5.248549e-03 0.0359332541 2 171522511 171522738 228 + 1.041 1.283 0.862
ENSG00000071967 E007 0.1779838 0.035085778 6.389544e-01   2 171523079 171523312 234 + 0.109 0.000 -11.181
ENSG00000071967 E008 0.2027342 0.046631851 3.754303e-01   2 171539824 171539871 48 + 0.000 0.135 11.139
ENSG00000071967 E009 1.0708357 0.182109282 2.836984e-01   2 171540808 171541128 321 + 0.196 0.398 1.395
ENSG00000071967 E010 17.6997992 0.002108184 1.759217e-01 0.3983554066 2 171541585 171541793 209 + 1.230 1.330 0.349
ENSG00000071967 E011 1.6486963 0.021638914 2.055808e-01 0.4365596858 2 171550978 171551140 163 + 0.331 0.549 1.154
ENSG00000071967 E012 13.5172862 0.036993178 7.561096e-01 0.8702872539 2 171553346 171553500 155 + 1.189 1.151 -0.137
ENSG00000071967 E013 58.1242334 0.001257167 6.471308e-06 0.0001440526 2 171554524 171558129 3606 + 1.835 1.680 -0.523