ENSG00000071794

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000310053 ENSG00000071794 HEK293_OSMI2_6hA HEK293_TMG_6hB HLTF protein_coding protein_coding 22.21276 4.622547 42.68362 0.2387307 1.481151 3.204143 8.4376541 2.1094262 14.942456 0.03943004 0.3037635 2.818637 0.45657500 0.45940000 0.35060000 -0.10880000 2.893192e-01 2.250216e-05 FALSE TRUE
ENST00000392912 ENSG00000071794 HEK293_OSMI2_6hA HEK293_TMG_6hB HLTF protein_coding protein_coding 22.21276 4.622547 42.68362 0.2387307 1.481151 3.204143 0.7824245 0.0000000 2.191526 0.00000000 0.2384756 7.782360 0.01935417 0.00000000 0.05153333 0.05153333 2.250216e-05 2.250216e-05 FALSE TRUE
ENST00000465259 ENSG00000071794 HEK293_OSMI2_6hA HEK293_TMG_6hB HLTF protein_coding protein_coding 22.21276 4.622547 42.68362 0.2387307 1.481151 3.204143 4.2434792 0.8250709 9.678199 0.27325167 0.2464634 3.536258 0.15032917 0.17743333 0.22740000 0.04996667 8.015562e-01 2.250216e-05 FALSE TRUE
MSTRG.23881.4 ENSG00000071794 HEK293_OSMI2_6hA HEK293_TMG_6hB HLTF protein_coding   22.21276 4.622547 42.68362 0.2387307 1.481151 3.204143 6.0661132 0.5868976 10.834220 0.29749570 1.2083159 4.183299 0.19664583 0.13010000 0.25256667 0.12246667 7.434584e-01 2.250216e-05 FALSE TRUE
MSTRG.23881.5 ENSG00000071794 HEK293_OSMI2_6hA HEK293_TMG_6hB HLTF protein_coding   22.21276 4.622547 42.68362 0.2387307 1.481151 3.204143 0.2592030 0.2792570 0.000000 0.27925703 0.0000000 -4.854280 0.01339583 0.05746667 0.00000000 -0.05746667 5.894996e-01 2.250216e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000071794 E001 0.000000       3 149030001 149030126 126 -      
ENSG00000071794 E002 28.800257 0.6057850702 4.885333e-02 1.768960e-01 3 149030127 149030396 270 - 1.117 1.815 2.410
ENSG00000071794 E003 17.636574 0.4058548941 1.496191e-02 7.794491e-02 3 149030397 149030397 1 - 0.907 1.639 2.590
ENSG00000071794 E004 174.144207 1.5036677924 2.891578e-01 5.296750e-01 3 149030398 149030684 287 - 1.935 2.450 1.720
ENSG00000071794 E005 277.703219 1.6742567755 3.892835e-01 6.199354e-01 3 149030685 149030994 310 - 2.163 2.568 1.350
ENSG00000071794 E006 180.953551 1.5289630769 3.768794e-01 6.097479e-01 3 149030995 149031360 366 - 1.979 2.382 1.350
ENSG00000071794 E007 33.625259 0.7338390972 2.707231e-01 5.106406e-01 3 149031361 149031363 3 - 1.274 1.638 1.256
ENSG00000071794 E008 222.721662 1.6126982425 4.578316e-01 6.716279e-01 3 149031364 149032200 837 - 2.086 2.404 1.062
ENSG00000071794 E009 139.717444 0.4537857302 2.474164e-01 4.852071e-01 3 149032201 149032372 172 - 1.889 2.187 1.000
ENSG00000071794 E010 60.144777 0.2495804851 2.026039e-01 4.328334e-01 3 149034918 149034922 5 - 1.529 1.837 1.046
ENSG00000071794 E011 102.505448 0.0288667268 8.746782e-02 2.590532e-01 3 149034923 149034988 66 - 1.767 2.019 0.848
ENSG00000071794 E012 65.647887 0.0007220748 2.195342e-01 4.528561e-01 3 149034989 149034998 10 - 1.593 1.782 0.642
ENSG00000071794 E013 160.645806 0.0003088361 4.711612e-01 6.809877e-01 3 149039049 149039229 181 - 1.977 2.123 0.488
ENSG00000071794 E014 126.385539 0.0083555858 9.205510e-01 9.625100e-01 3 149039581 149039693 113 - 1.874 1.990 0.392
ENSG00000071794 E015 137.193497 0.0157964780 7.865229e-01 8.884259e-01 3 149040031 149040141 111 - 1.911 2.015 0.351
ENSG00000071794 E016 83.874287 0.0202149987 4.185540e-01 6.425320e-01 3 149040142 149040156 15 - 1.706 1.760 0.180
ENSG00000071794 E017 3.517831 0.0067909728 6.797913e-02 2.205491e-01 3 149040157 149040259 103 - 0.432 0.836 1.778
ENSG00000071794 E018 177.788531 0.0310581046 1.592218e-01 3.755802e-01 3 149041490 149041668 179 - 2.034 2.032 -0.009
ENSG00000071794 E019 13.541821 0.0356465430 4.239370e-01 6.464885e-01 3 149041669 149041680 12 - 0.961 0.945 -0.060
ENSG00000071794 E020 11.251747 0.0307818892 5.102421e-01 7.081747e-01 3 149041681 149042044 364 - 0.889 0.893 0.015
ENSG00000071794 E021 158.304354 0.0422917790 1.840841e-01 4.092650e-01 3 149042166 149042290 125 - 1.985 1.979 -0.021
ENSG00000071794 E022 186.451258 0.0361972185 1.357003e-01 3.408877e-01 3 149046080 149046259 180 - 2.056 2.042 -0.048
ENSG00000071794 E023 134.382596 0.0155098424 7.294440e-02 2.307209e-01 3 149048028 149048163 136 - 1.915 1.906 -0.030
ENSG00000071794 E024 135.762221 0.0151243770 1.325757e-01 3.358685e-01 3 149048863 149049001 139 - 1.916 1.926 0.033
ENSG00000071794 E025 79.145328 0.0162503477 5.797000e-02 1.982169e-01 3 149050232 149050269 38 - 1.691 1.644 -0.161
ENSG00000071794 E026 112.368093 0.0167329086 1.457847e-01 3.560387e-01 3 149050270 149050375 106 - 1.836 1.841 0.019
ENSG00000071794 E027 2.356450 0.0090048146 4.004662e-02 1.548460e-01 3 149052045 149052144 100 - 0.315 0.769 2.192
ENSG00000071794 E028 124.179620 0.0145428921 1.505710e-02 7.829516e-02 3 149055303 149055400 98 - 1.886 1.821 -0.220
ENSG00000071794 E029 101.729028 0.0178584664 5.816944e-02 1.986668e-01 3 149059718 149059804 87 - 1.798 1.760 -0.130
ENSG00000071794 E030 40.524881 0.0019475689 1.327163e-01 3.360713e-01 3 149059805 149059807 3 - 1.407 1.388 -0.065
ENSG00000071794 E031 101.117791 0.0177412304 3.896189e-02 1.520784e-01 3 149060643 149060687 45 - 1.797 1.740 -0.191
ENSG00000071794 E032 132.529811 0.0311051868 3.588916e-02 1.439151e-01 3 149060779 149060858 80 - 1.915 1.827 -0.296
ENSG00000071794 E033 141.540936 0.0295163860 1.180542e-02 6.566547e-02 3 149063431 149063524 94 - 1.946 1.823 -0.415
ENSG00000071794 E034 123.886524 0.0298048425 1.066100e-03 1.042005e-02 3 149064791 149064866 76 - 1.896 1.692 -0.689
ENSG00000071794 E035 118.558346 0.0485979708 1.296452e-02 7.030282e-02 3 149068240 149068335 96 - 1.874 1.712 -0.547
ENSG00000071794 E036 156.664338 0.0178580623 1.112668e-03 1.076737e-02 3 149071252 149071443 192 - 1.992 1.852 -0.470
ENSG00000071794 E037 93.192396 0.0143270451 7.695752e-04 8.023794e-03 3 149071583 149071657 75 - 1.771 1.602 -0.575
ENSG00000071794 E038 82.075420 0.0171357492 9.381760e-03 5.546177e-02 3 149073225 149073322 98 - 1.712 1.594 -0.401
ENSG00000071794 E039 115.307692 0.0349617379 1.523876e-03 1.377564e-02 3 149074215 149074348 134 - 1.865 1.652 -0.722
ENSG00000071794 E040 160.673298 0.0091241640 4.925514e-07 1.528072e-05 3 149075881 149076047 167 - 2.009 1.783 -0.761
ENSG00000071794 E041 3.100813 0.3006573486 7.945180e-02 2.437317e-01 3 149083632 149083735 104 - 0.315 0.998 3.070
ENSG00000071794 E042 145.479968 0.0023232501 9.176280e-05 1.390633e-03 3 149084682 149084889 208 - 1.961 1.864 -0.324
ENSG00000071794 E043 78.366631 0.4846696697 6.584487e-01 8.089689e-01 3 149086317 149086554 238 - 1.675 1.751 0.258