ENSG00000071626

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000233078 ENSG00000071626 HEK293_OSMI2_6hA HEK293_TMG_6hB DAZAP1 protein_coding protein_coding 152.6134 189.7495 109.681 19.65066 3.507228 -0.7907274 63.43804 80.445724 35.117362 16.970450 0.8209292 -1.1955998 0.40155417 0.41366667 0.32050000 -0.09316667 6.054405e-01 1.579163e-05 FALSE TRUE
ENST00000585485 ENSG00000071626 HEK293_OSMI2_6hA HEK293_TMG_6hB DAZAP1 protein_coding retained_intron 152.6134 189.7495 109.681 19.65066 3.507228 -0.7907274 7.79955 9.379178 7.917718 1.863101 0.1455673 -0.2440934 0.05332083 0.05293333 0.07233333 0.01940000 7.153581e-01 1.579163e-05 FALSE FALSE
ENST00000586579 ENSG00000071626 HEK293_OSMI2_6hA HEK293_TMG_6hB DAZAP1 protein_coding processed_transcript 152.6134 189.7495 109.681 19.65066 3.507228 -0.7907274 10.81502 10.146576 13.853418 1.938181 0.3721086 0.4488688 0.08490833 0.05260000 0.12653333 0.07393333 1.394197e-04 1.579163e-05 FALSE TRUE
ENST00000587079 ENSG00000071626 HEK293_OSMI2_6hA HEK293_TMG_6hB DAZAP1 protein_coding protein_coding 152.6134 189.7495 109.681 19.65066 3.507228 -0.7907274 20.34883 28.594735 6.752592 5.051056 0.3195926 -2.0806058 0.11402083 0.14813333 0.06160000 -0.08653333 1.579163e-05 1.579163e-05 FALSE TRUE
ENST00000592453 ENSG00000071626 HEK293_OSMI2_6hA HEK293_TMG_6hB DAZAP1 protein_coding protein_coding 152.6134 189.7495 109.681 19.65066 3.507228 -0.7907274 14.95543 15.562696 22.948472 2.298719 2.0745501 0.5600079 0.11550000 0.08603333 0.20846667 0.12243333 4.625295e-02 1.579163e-05 FALSE TRUE
ENST00000592522 ENSG00000071626 HEK293_OSMI2_6hA HEK293_TMG_6hB DAZAP1 protein_coding protein_coding 152.6134 189.7495 109.681 19.65066 3.507228 -0.7907274 16.60566 20.506305 8.059161 3.579787 0.6995212 -1.3462804 0.10310833 0.10630000 0.07403333 -0.03226667 4.404848e-01 1.579163e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000071626 E001 0.3337900 0.0294233078 5.101452e-01   19 1407419 1407542 124 + 0.179 0.081 -1.323
ENSG00000071626 E002 0.1723744 0.0357805177 1.000000e+00   19 1407543 1407554 12 + 0.000 0.081 10.490
ENSG00000071626 E003 0.1723744 0.0357805177 1.000000e+00   19 1407555 1407568 14 + 0.000 0.081 10.490
ENSG00000071626 E004 0.1723744 0.0357805177 1.000000e+00   19 1407569 1407585 17 + 0.000 0.081 10.490
ENSG00000071626 E005 0.1723744 0.0357805177 1.000000e+00   19 1407586 1407612 27 + 0.000 0.081 10.490
ENSG00000071626 E006 0.1723744 0.0357805177 1.000000e+00   19 1407613 1407616 4 + 0.000 0.081 10.490
ENSG00000071626 E007 1.4213137 0.0127007887 2.083333e-01 4.398172e-01 19 1407617 1407624 8 + 0.179 0.420 1.673
ENSG00000071626 E008 1.7135976 0.0122618548 4.291623e-01 6.503862e-01 19 1407625 1407626 2 + 0.306 0.452 0.842
ENSG00000071626 E009 2.9872874 0.0083461488 5.898964e-02 2.005003e-01 19 1407627 1407632 6 + 0.306 0.649 1.760
ENSG00000071626 E010 10.9580597 0.0030238808 3.653285e-03 2.721582e-02 19 1407633 1407647 15 + 0.748 1.108 1.364
ENSG00000071626 E011 11.9286946 0.0026821501 2.892101e-03 2.275540e-02 19 1407648 1407649 2 + 0.786 1.141 1.331
ENSG00000071626 E012 58.5749132 0.0327332138 4.644620e-02 1.711247e-01 19 1407650 1407676 27 + 1.584 1.773 0.642
ENSG00000071626 E013 66.2955229 0.0265394600 1.167064e-02 6.511623e-02 19 1407677 1407679 3 + 1.606 1.833 0.771
ENSG00000071626 E014 216.1980640 0.0137533901 2.006023e-01 4.304696e-01 19 1407680 1407734 55 + 2.234 2.309 0.251
ENSG00000071626 E015 457.9114628 0.0071202636 4.509438e-01 6.663299e-01 19 1407735 1407802 68 + 2.640 2.604 -0.118
ENSG00000071626 E016 3.9434607 0.0955005350 4.487619e-01 6.648280e-01 19 1407803 1407971 169 + 0.549 0.703 0.671
ENSG00000071626 E017 10.2912254 0.0151881237 1.183938e-01 3.132361e-01 19 1409824 1409882 59 + 0.853 1.051 0.743
ENSG00000071626 E018 23.5057798 0.0478011283 5.873188e-01 7.618469e-01 19 1409883 1410079 197 + 1.389 1.324 -0.225
ENSG00000071626 E019 21.7746223 0.1286111003 2.379834e-01 4.742771e-01 19 1415740 1415940 201 + 1.135 1.368 0.820
ENSG00000071626 E020 36.5523068 0.0872327632 3.498041e-01 5.870768e-01 19 1415970 1416235 266 + 1.397 1.570 0.595
ENSG00000071626 E021 36.8863806 0.0705719113 2.399933e-01 4.766271e-01 19 1416236 1416456 221 + 1.387 1.577 0.651
ENSG00000071626 E022 23.5875550 0.0267911985 1.935750e-02 9.370740e-02 19 1416457 1416555 99 + 1.138 1.408 0.949
ENSG00000071626 E023 22.0458496 0.0425010816 2.434837e-01 4.804966e-01 19 1416556 1416703 148 + 1.202 1.352 0.528
ENSG00000071626 E024 56.0852715 0.0614996120 1.035117e-01 2.880520e-01 19 1416704 1417499 796 + 1.556 1.758 0.685
ENSG00000071626 E025 552.1471569 0.0008186963 8.075697e-04 8.343609e-03 19 1417500 1417540 41 + 2.746 2.673 -0.244
ENSG00000071626 E026 1371.3497467 0.0006627869 2.600596e-07 8.698859e-06 19 1418204 1418370 167 + 3.147 3.065 -0.273
ENSG00000071626 E027 1156.3952856 0.0005579120 3.421022e-04 4.160324e-03 19 1418666 1418731 66 + 3.057 2.999 -0.194
ENSG00000071626 E028 595.5676392 0.0004739828 2.110001e-02 9.967038e-02 19 1421148 1421150 3 + 2.760 2.713 -0.155
ENSG00000071626 E029 1608.6870441 0.0001584922 6.804688e-10 4.092042e-08 19 1421151 1421258 108 + 3.208 3.138 -0.231
ENSG00000071626 E030 1183.9313470 0.0009018347 1.087704e-05 2.258156e-04 19 1422348 1422396 49 + 3.082 3.002 -0.267
ENSG00000071626 E031 131.8901706 0.0302935036 5.048634e-06 1.160810e-04 19 1422397 1422585 189 + 2.332 1.914 -1.400
ENSG00000071626 E032 1396.4191177 0.0006457756 2.030520e-07 6.988831e-06 19 1425878 1425960 83 + 3.155 3.073 -0.274
ENSG00000071626 E033 48.3363723 0.0601858718 7.805557e-04 8.120831e-03 19 1425961 1425962 2 + 1.909 1.478 -1.462
ENSG00000071626 E034 667.1639086 0.0643875367 3.116339e-02 1.308282e-01 19 1426349 1428841 2493 + 2.940 2.694 -0.819
ENSG00000071626 E035 1325.3634460 0.0014137974 9.304958e-01 9.672356e-01 19 1428842 1428995 154 + 3.076 3.076 -0.001
ENSG00000071626 E036 33.1358650 0.0354433431 2.178995e-02 1.018898e-01 19 1429835 1429966 132 + 1.279 1.546 0.924
ENSG00000071626 E037 459.4644876 0.0014986048 2.892378e-03 2.275542e-02 19 1429967 1429996 30 + 2.561 2.636 0.253
ENSG00000071626 E038 934.9839805 0.0017113152 6.638359e-08 2.574437e-06 19 1430222 1430362 141 + 2.831 2.956 0.416
ENSG00000071626 E039 11.8069451 0.0096240229 4.369640e-03 3.120510e-02 19 1432043 1432513 471 + 0.785 1.142 1.335
ENSG00000071626 E040 1602.7755187 0.0014857805 4.837777e-12 4.426540e-10 19 1432514 1432690 177 + 3.055 3.193 0.459
ENSG00000071626 E041 53.1948412 0.0799545178 7.931957e-02 2.434448e-01 19 1432691 1433738 1048 + 1.455 1.753 1.016
ENSG00000071626 E042 35.9683380 0.0351183187 1.937240e-02 9.375546e-02 19 1433739 1433827 89 + 1.318 1.588 0.929
ENSG00000071626 E043 60.1001231 0.0983890400 7.436942e-02 2.335017e-01 19 1433828 1434736 909 + 1.486 1.809 1.099
ENSG00000071626 E044 751.1034484 0.0014097282 5.906318e-08 2.316999e-06 19 1434737 1434739 3 + 2.737 2.860 0.411
ENSG00000071626 E045 3073.1194119 0.0001939518 3.814133e-21 1.287729e-18 19 1434740 1435981 1242 + 3.381 3.461 0.265