ENSG00000071537

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000336735 ENSG00000071537 HEK293_OSMI2_6hA HEK293_TMG_6hB SEL1L protein_coding protein_coding 10.92005 3.552104 19.35431 1.391553 0.5912928 2.442598 5.454537 2.930697 8.999822 1.246074 0.2553591 1.615340 0.6574917 0.7592667 0.4651667 -0.2941 0.02631531 0.02631531 FALSE TRUE
MSTRG.10016.2 ENSG00000071537 HEK293_OSMI2_6hA HEK293_TMG_6hB SEL1L protein_coding   10.92005 3.552104 19.35431 1.391553 0.5912928 2.442598 5.013942 0.523917 9.763124 0.144010 0.4413578 4.194132 0.3061500 0.2221000 0.5041000 0.2820 0.14034551 0.02631531 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000071537 E001 235.7842197 1.10100601 0.23632071 0.47231911 14 81471547 81473929 2383 - 2.098 2.635 1.794
ENSG00000071537 E002 685.4634451 1.96660272 0.51715477 0.71310653 14 81473930 81477181 3252 - 2.644 2.928 0.946
ENSG00000071537 E003 1.2541393 0.03383910 0.57472853   14 81479278 81479611 334 - 0.297 0.240 -0.413
ENSG00000071537 E004 62.7440376 0.01973184 0.97533871 0.98950250 14 81479612 81479740 129 - 1.657 1.777 0.409
ENSG00000071537 E005 87.1957462 0.01759670 0.02011001 0.09625813 14 81484225 81484397 173 - 1.819 1.803 -0.052
ENSG00000071537 E006 0.5173834 0.35351935 0.73545428   14 81484398 81484528 131 - 0.156 0.000 -14.698
ENSG00000071537 E007 62.7156214 0.03853349 0.03305435 0.13622745 14 81485672 81485746 75 - 1.686 1.601 -0.291
ENSG00000071537 E008 84.2930155 0.04186280 0.14537626 0.35545652 14 81486289 81486454 166 - 1.797 1.824 0.092
ENSG00000071537 E009 69.0367819 0.05530803 0.24454291 0.48170269 14 81487390 81487538 149 - 1.706 1.766 0.201
ENSG00000071537 E010 51.8435253 0.04830735 0.27728075 0.51730822 14 81487855 81487942 88 - 1.588 1.633 0.155
ENSG00000071537 E011 1.9137814 0.03819004 0.04814806 0.17534791 14 81488797 81489251 455 - 0.429 0.000 -16.667
ENSG00000071537 E012 51.4609055 0.04617749 0.15103337 0.36378379 14 81489252 81489314 63 - 1.592 1.604 0.039
ENSG00000071537 E013 63.8882836 0.05696489 0.32999572 0.56895134 14 81490388 81490465 78 - 1.675 1.726 0.172
ENSG00000071537 E014 0.3040503 0.02444117 1.00000000   14 81490466 81490473 8 - 0.107 0.000 -14.081
ENSG00000071537 E015 53.9369193 0.03554764 0.46825715 0.67888772 14 81492480 81492548 69 - 1.597 1.692 0.322
ENSG00000071537 E016 59.6828075 0.02560476 0.13602523 0.34138076 14 81495081 81495137 57 - 1.651 1.669 0.062
ENSG00000071537 E017 95.3529910 0.03416805 0.05985984 0.20245720 14 81497892 81498046 155 - 1.858 1.836 -0.074
ENSG00000071537 E018 0.2027342 0.04441180 0.10868513   14 81498358 81498412 55 - 0.000 0.241 17.848
ENSG00000071537 E019 68.5975574 0.04589476 0.19147528 0.41875217 14 81498413 81498494 82 - 1.713 1.723 0.034
ENSG00000071537 E020 0.1779838 0.31513339 1.00000000   14 81498808 81499458 651 - 0.058 0.000 -13.098
ENSG00000071537 E021 56.1917127 0.05484428 0.31019262 0.55067228 14 81499459 81499518 60 - 1.626 1.650 0.082
ENSG00000071537 E022 48.2229958 0.02518805 0.10304881 0.28725123 14 81499609 81499662 54 - 1.568 1.558 -0.033
ENSG00000071537 E023 89.8217181 0.02342142 0.07967539 0.24417082 14 81502721 81502883 163 - 1.828 1.831 0.012
ENSG00000071537 E024 68.0313940 0.03100972 0.09575293 0.27434357 14 81504201 81504262 62 - 1.712 1.694 -0.060
ENSG00000071537 E025 63.0184676 0.04044372 0.06939728 0.22355700 14 81504263 81504306 44 - 1.687 1.627 -0.206
ENSG00000071537 E026 71.8681690 0.09552334 0.22120749 0.45494435 14 81506074 81506178 105 - 1.746 1.666 -0.273
ENSG00000071537 E027 49.0754372 0.13397218 0.13939497 0.34659404 14 81506179 81506241 63 - 1.591 1.464 -0.433
ENSG00000071537 E028 86.2426502 0.04600719 0.05591797 0.19344381 14 81526733 81526964 232 - 1.823 1.742 -0.275
ENSG00000071537 E029 38.5948048 0.04364492 0.03963568 0.15379785 14 81527701 81527738 38 - 1.485 1.388 -0.334
ENSG00000071537 E030 39.6261098 0.03654856 0.04434460 0.16593367 14 81533675 81533853 179 - 1.492 1.417 -0.258