ENSG00000071462

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265758 ENSG00000071462 HEK293_OSMI2_6hA HEK293_TMG_6hB BUD23 protein_coding protein_coding 183.3458 199.8688 149.586 25.02361 2.601584 -0.4180533 135.30863 147.10096 100.19196 22.4521516 3.8549843 -0.5539940 0.72610000 0.7303333 0.6693333 -0.06100000 0.55800610 0.04458366 FALSE TRUE
ENST00000428163 ENSG00000071462 HEK293_OSMI2_6hA HEK293_TMG_6hB BUD23 protein_coding nonsense_mediated_decay 183.3458 199.8688 149.586 25.02361 2.601584 -0.4180533 14.36346 13.03691 20.79206 0.6422568 0.5414061 0.6730178 0.08796667 0.0683000 0.1392333 0.07093333 0.04458366 0.04458366 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000071462 E001 2.9572531 4.076222e-01 0.9279569817 0.966004838 7 73682135 73682992 858 + 0.588 0.594 0.027
ENSG00000071462 E002 0.8395791 1.689644e-02 0.0633511227   7 73683025 73683383 359 + 0.000 0.350 10.891
ENSG00000071462 E003 2.2556139 3.700882e-02 0.4426179190 0.660452003 7 73683558 73683568 11 + 0.428 0.568 0.683
ENSG00000071462 E004 2.2556139 3.700882e-02 0.4426179190 0.660452003 7 73683569 73683570 2 + 0.428 0.568 0.683
ENSG00000071462 E005 2.2556139 3.700882e-02 0.4426179190 0.660452003 7 73683571 73683572 2 + 0.428 0.568 0.683
ENSG00000071462 E006 55.6858273 9.971924e-03 0.7402208467 0.860561526 7 73683573 73683591 19 + 1.728 1.749 0.073
ENSG00000071462 E007 62.0411092 5.093013e-03 0.3331816883 0.571787334 7 73683592 73683596 5 + 1.751 1.806 0.185
ENSG00000071462 E008 64.9993448 4.397971e-03 0.3470458699 0.584576030 7 73683597 73683600 4 + 1.774 1.825 0.172
ENSG00000071462 E009 75.7668057 5.679847e-03 0.3594991861 0.595435867 7 73683601 73683606 6 + 1.839 1.890 0.171
ENSG00000071462 E010 88.9295550 2.938069e-03 0.0731961314 0.231219989 7 73683607 73683608 2 + 1.884 1.969 0.283
ENSG00000071462 E011 335.5357551 7.479889e-04 0.2249770977 0.459404907 7 73683609 73683625 17 + 2.529 2.500 -0.094
ENSG00000071462 E012 404.9497159 8.115042e-04 0.9023963340 0.953062301 7 73683626 73683630 5 + 2.590 2.593 0.011
ENSG00000071462 E013 618.9775709 5.110411e-04 0.1272340867 0.327457366 7 73683631 73683673 43 + 2.758 2.786 0.092
ENSG00000071462 E014 752.6859899 4.054754e-04 0.1973660845 0.426346940 7 73683767 73683804 38 + 2.846 2.867 0.069
ENSG00000071462 E015 65.6104593 2.506978e-03 0.9154376934 0.959851668 7 73683805 73683901 97 + 1.810 1.806 -0.014
ENSG00000071462 E016 19.4212828 2.046505e-03 0.8755171033 0.939016547 7 73683902 73683923 22 + 1.309 1.296 -0.045
ENSG00000071462 E017 23.4514171 8.611757e-03 0.7012558426 0.836415212 7 73683924 73684000 77 + 1.398 1.368 -0.104
ENSG00000071462 E018 1134.3314976 7.175637e-05 0.6672199090 0.814450498 7 73686636 73686731 96 + 3.041 3.035 -0.019
ENSG00000071462 E019 3.8981802 4.972763e-02 0.0683900220 0.221471724 7 73686732 73686734 3 + 0.430 0.759 1.489
ENSG00000071462 E020 637.3844459 1.156261e-04 0.1380456463 0.344526795 7 73686818 73686819 2 + 2.801 2.778 -0.077
ENSG00000071462 E021 1150.3585556 7.725753e-05 0.6357211882 0.794081021 7 73686820 73686900 81 + 3.046 3.040 -0.021
ENSG00000071462 E022 1183.3367298 6.808829e-05 0.0736485680 0.232057828 7 73686999 73687095 97 + 3.044 3.062 0.061
ENSG00000071462 E023 903.9326354 1.006384e-03 0.0026076939 0.021010884 7 73690916 73691012 97 + 2.900 2.960 0.196
ENSG00000071462 E024 943.0247446 5.459473e-04 0.3753525044 0.608459911 7 73692596 73692646 51 + 2.947 2.962 0.049
ENSG00000071462 E025 54.1640813 1.152032e-01 0.2600598724 0.499044943 7 73692647 73693328 682 + 1.807 1.669 -0.467
ENSG00000071462 E026 1243.2987213 3.081170e-04 0.0558901850 0.193392531 7 73693329 73693414 86 + 3.092 3.067 -0.081
ENSG00000071462 E027 3.8113050 1.595737e-01 0.6988258125 0.834863602 7 73693415 73693551 137 + 0.599 0.699 0.426
ENSG00000071462 E028 992.8827422 6.608708e-04 0.0017890399 0.015624588 7 73693624 73693669 46 + 3.010 2.960 -0.167
ENSG00000071462 E029 1011.4669735 3.640766e-04 0.0005156322 0.005819513 7 73693992 73694050 59 + 3.018 2.969 -0.163
ENSG00000071462 E030 16.8995101 9.084071e-02 0.3529798197 0.590008857 7 73694051 73694113 63 + 1.315 1.185 -0.455
ENSG00000071462 E031 254.6437750 1.297471e-01 0.5700757537 0.750334679 7 73694114 73696405 2292 + 2.412 2.379 -0.110
ENSG00000071462 E032 155.6641115 1.062847e-01 0.4759611430 0.684213767 7 73696406 73697465 1060 + 2.216 2.155 -0.203
ENSG00000071462 E033 32.5004445 9.059772e-02 0.3598315587 0.595637816 7 73697466 73697516 51 + 1.581 1.463 -0.404
ENSG00000071462 E034 33.7622979 8.429865e-02 0.3523629958 0.589422401 7 73697517 73697604 88 + 1.592 1.480 -0.382
ENSG00000071462 E035 1057.6274440 8.092882e-05 0.5641091225 0.746217867 7 73697605 73697694 90 + 3.003 3.009 0.019
ENSG00000071462 E036 973.4686090 1.174530e-03 0.0147804775 0.077247031 7 73697832 73698212 381 + 2.939 2.989 0.166
ENSG00000071462 E037 6.7768726 2.321917e-02 0.7445588699 0.863422387 7 73703379 73705161 1783 + 0.840 0.886 0.176