ENSG00000071189

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000409076 ENSG00000071189 HEK293_OSMI2_6hA HEK293_TMG_6hB SNX13 protein_coding nonsense_mediated_decay 7.663145 1.390181 15.33091 0.1597862 0.909977 3.453699 2.1877124 0.3732046 4.8825321 0.24379834 0.48344271 3.674395 0.24901667 0.2746333 0.31726667 0.04263333 9.139337e-01 3.050171e-05 FALSE TRUE
ENST00000428135 ENSG00000071189 HEK293_OSMI2_6hA HEK293_TMG_6hB SNX13 protein_coding protein_coding 7.663145 1.390181 15.33091 0.1597862 0.909977 3.453699 1.9434864 0.5207698 3.4860744 0.14121351 0.19801010 2.719578 0.32675417 0.3630667 0.23036667 -0.13270000 4.633965e-01 3.050171e-05 FALSE TRUE
ENST00000496855 ENSG00000071189 HEK293_OSMI2_6hA HEK293_TMG_6hB SNX13 protein_coding processed_transcript 7.663145 1.390181 15.33091 0.1597862 0.909977 3.453699 0.4569859 0.2983919 0.8435021 0.18171776 0.84350209 1.468630 0.10467917 0.2137000 0.04926667 -0.16443333 5.393331e-01 3.050171e-05 FALSE TRUE
ENST00000611725 ENSG00000071189 HEK293_OSMI2_6hA HEK293_TMG_6hB SNX13 protein_coding protein_coding 7.663145 1.390181 15.33091 0.1597862 0.909977 3.453699 0.5535091 0.1355875 1.4019016 0.02534513 0.03858061 3.277681 0.08068333 0.1044667 0.09206667 -0.01240000 9.838403e-01 3.050171e-05 FALSE TRUE
MSTRG.29530.4 ENSG00000071189 HEK293_OSMI2_6hA HEK293_TMG_6hB SNX13 protein_coding   7.663145 1.390181 15.33091 0.1597862 0.909977 3.453699 1.5391633 0.0000000 3.0023327 0.00000000 0.39362095 8.234737 0.12119583 0.0000000 0.19946667 0.19946667 3.050171e-05 3.050171e-05 FALSE TRUE
MSTRG.29530.6 ENSG00000071189 HEK293_OSMI2_6hA HEK293_TMG_6hB SNX13 protein_coding   7.663145 1.390181 15.33091 0.1597862 0.909977 3.453699 0.5717073 0.0000000 1.1577290 0.00000000 0.33844758 6.867562 0.04844167 0.0000000 0.07736667 0.07736667 4.028512e-02 3.050171e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000071189 E001 79.1336140 0.0005720046 3.319985e-03 0.0253204195 7 17790761 17792841 2081 - 1.669 1.840 0.577
ENSG00000071189 E002 38.7285733 0.0536339949 1.710996e-01 0.3919741438 7 17792842 17793419 578 - 1.366 1.546 0.621
ENSG00000071189 E003 87.7508047 0.0005140642 7.828256e-02 0.2413744123 7 17793420 17793763 344 - 1.725 1.827 0.346
ENSG00000071189 E004 94.1132689 0.0026160112 1.288691e-01 0.3300034746 7 17793764 17794026 263 - 1.755 1.846 0.307
ENSG00000071189 E005 90.2456627 0.0004703732 3.603430e-01 0.5959789931 7 17794027 17794292 266 - 1.740 1.795 0.188
ENSG00000071189 E006 47.0585865 0.0009039021 5.796296e-01 0.7569434331 7 17794293 17796826 2534 - 1.467 1.514 0.161
ENSG00000071189 E007 58.2872420 0.0041485038 2.729936e-01 0.5128317530 7 17796827 17796939 113 - 1.553 1.636 0.284
ENSG00000071189 E008 50.4223267 0.0117698871 5.186961e-01 0.7141642989 7 17798690 17798758 69 - 1.496 1.552 0.193
ENSG00000071189 E009 60.4326134 0.0020922181 1.973480e-01 0.4263192666 7 17799009 17799154 146 - 1.569 1.663 0.320
ENSG00000071189 E010 49.1742746 0.0009599909 1.749397e-01 0.3970860895 7 17801588 17801659 72 - 1.480 1.585 0.359
ENSG00000071189 E011 68.6201417 0.0005617966 9.950813e-01 0.9991007960 7 17803419 17803580 162 - 1.632 1.636 0.011
ENSG00000071189 E012 58.2069590 0.0006436304 5.540437e-01 0.7391441901 7 17814834 17814944 111 - 1.567 1.527 -0.139
ENSG00000071189 E013 31.2600993 0.0023684444 3.174314e-01 0.5573994512 7 17816182 17816219 38 - 1.315 1.213 -0.356
ENSG00000071189 E014 43.0566553 0.0011020719 7.703598e-01 0.8788706733 7 17816220 17816289 70 - 1.432 1.460 0.096
ENSG00000071189 E015 57.3976696 0.0006488961 1.615692e-01 0.3790849744 7 17821509 17821648 140 - 1.566 1.460 -0.364
ENSG00000071189 E016 3.2883235 0.0551576527 4.238314e-01 0.6464319321 7 17821649 17821681 33 - 0.489 0.291 -1.124
ENSG00000071189 E017 0.1779838 0.0342069700 6.451010e-01   7 17821682 17821697 16 - 0.045 0.000 -7.146
ENSG00000071189 E018 42.1318514 0.0008634572 7.691456e-04 0.0080207930 7 17826022 17826091 70 - 1.451 1.097 -1.241
ENSG00000071189 E019 24.2496678 0.0188957063 9.670658e-02 0.2759704520 7 17830010 17830047 38 - 1.221 0.984 -0.855
ENSG00000071189 E020 52.9343566 0.0007824668 2.070156e-05 0.0003934640 7 17834052 17834184 133 - 1.549 1.129 -1.464
ENSG00000071189 E021 47.8893871 0.0111287915 3.465993e-01 0.5842003774 7 17834761 17834865 105 - 1.488 1.396 -0.316
ENSG00000071189 E022 68.9903539 0.0008854470 9.785197e-01 0.9910372748 7 17839807 17840000 194 - 1.634 1.635 0.006
ENSG00000071189 E023 44.4024309 0.0008343933 2.783103e-01 0.5184338357 7 17845595 17845694 100 - 1.437 1.527 0.307
ENSG00000071189 E024 42.3061951 0.0018636158 5.670818e-02 0.1953141326 7 17850347 17850435 89 - 1.442 1.262 -0.628
ENSG00000071189 E025 57.7861710 0.0038796759 6.291692e-01 0.7899583244 7 17850826 17850964 139 - 1.562 1.526 -0.122
ENSG00000071189 E026 0.0000000       7 17868282 17868406 125 -      
ENSG00000071189 E027 42.2524744 0.0021104104 4.133749e-01 0.6386247958 7 17868407 17868490 84 - 1.434 1.363 -0.245
ENSG00000071189 E028 37.7265343 0.0012088526 1.043541e-01 0.2894665661 7 17873528 17873616 89 - 1.395 1.238 -0.549
ENSG00000071189 E029 44.1342366 0.0008093538 3.028832e-02 0.1282258741 7 17875480 17875581 102 - 1.462 1.262 -0.697
ENSG00000071189 E030 54.0038825 0.0009172825 6.760806e-02 0.2197145365 7 17875669 17875790 122 - 1.546 1.398 -0.510
ENSG00000071189 E031 8.9447283 0.0209754053 3.134719e-05 0.0005610007 7 17879427 17882943 3517 - 0.699 1.265 2.121
ENSG00000071189 E032 0.0000000       7 17888156 17888559 404 -      
ENSG00000071189 E033 0.2735028 0.0258445368 1.178746e-01   7 17888560 17888722 163 - 0.045 0.292 3.144
ENSG00000071189 E034 0.9688700 0.0180449627 6.205248e-01   7 17888723 17890362 1640 - 0.188 0.292 0.819
ENSG00000071189 E035 64.0621849 0.0006134090 1.747422e-01 0.3968402110 7 17890363 17890484 122 - 1.611 1.514 -0.331
ENSG00000071189 E036 34.2148293 0.0022888813 7.958049e-01 0.8939467585 7 17891546 17891561 16 - 1.335 1.363 0.096
ENSG00000071189 E037 45.1786518 0.0007937942 2.415063e-01 0.4782617271 7 17891562 17891628 67 - 1.444 1.539 0.326
ENSG00000071189 E038 25.9104116 0.0016646369 3.879940e-01 0.6189266577 7 17891629 17891635 7 - 1.215 1.305 0.318
ENSG00000071189 E039 31.6323216 0.0013700557 9.564032e-01 0.9800836773 7 17893332 17893347 16 - 1.308 1.305 -0.008
ENSG00000071189 E040 42.9644800 0.0036144691 3.684500e-01 0.6027684326 7 17893348 17893434 87 - 1.442 1.363 -0.276
ENSG00000071189 E041 39.6650380 0.0009170616 4.693120e-01 0.6795874513 7 17897334 17897446 113 - 1.407 1.344 -0.217
ENSG00000071189 E042 0.0000000       7 17897844 17897884 41 -      
ENSG00000071189 E043 0.0000000       7 17898217 17898300 84 -      
ENSG00000071189 E044 0.1614157 0.0330661289 6.448553e-01   7 17898827 17898973 147 - 0.045 0.000 -7.144
ENSG00000071189 E045 0.1614157 0.0330661289 6.448553e-01   7 17898974 17900106 1133 - 0.045 0.000 -7.144
ENSG00000071189 E046 0.0000000       7 17900124 17900248 125 -      
ENSG00000071189 E047 0.6434498 0.0194922896 1.000000e+00   7 17907249 17907340 92 - 0.157 0.000 -9.144
ENSG00000071189 E048 32.1945839 0.0014720067 7.477011e-01 0.8653209607 7 17940284 17940501 218 - 1.310 1.344 0.119