ENSG00000071073

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000393487 ENSG00000071073 HEK293_OSMI2_6hA HEK293_TMG_6hB MGAT4A protein_coding protein_coding 3.863157 0.8244226 6.520745 0.2044649 0.2009038 2.968397 1.9836237 0.4972681 3.8222878 0.10628986 0.08000585 2.9173855 0.4748083 0.6285333 0.5866000 -0.04193333 9.765150e-01 5.289306e-08 FALSE TRUE
ENST00000409391 ENSG00000071073 HEK293_OSMI2_6hA HEK293_TMG_6hB MGAT4A protein_coding protein_coding 3.863157 0.8244226 6.520745 0.2044649 0.2009038 2.968397 0.8958581 0.0000000 2.3367578 0.00000000 0.17415408 7.8745251 0.1360542 0.0000000 0.3580333 0.35803333 5.289306e-08 5.289306e-08 FALSE TRUE
ENST00000414521 ENSG00000071073 HEK293_OSMI2_6hA HEK293_TMG_6hB MGAT4A protein_coding protein_coding 3.863157 0.8244226 6.520745 0.2044649 0.2009038 2.968397 0.4002047 0.1820561 0.2056127 0.12052669 0.10341917 0.1669145 0.1759417 0.2020333 0.0322000 -0.16983333 5.723249e-01 5.289306e-08 FALSE TRUE
ENST00000495056 ENSG00000071073 HEK293_OSMI2_6hA HEK293_TMG_6hB MGAT4A protein_coding protein_coding 3.863157 0.8244226 6.520745 0.2044649 0.2009038 2.968397 0.4069338 0.1450984 0.1339208 0.04975452 0.06780877 -0.1079089 0.1733958 0.1694333 0.0199000 -0.14953333 2.072198e-02 5.289306e-08   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000071073 E001 0.0000000       2 98619106 98619107 2 -      
ENSG00000071073 E002 154.3358852 0.0004588342 3.023724e-06 7.483211e-05 2 98619108 98621505 2398 - 2.004 2.162 0.528
ENSG00000071073 E003 187.6423903 0.0034444255 5.673528e-01 7.482998e-01 2 98621506 98625504 3999 - 2.115 2.085 -0.100
ENSG00000071073 E004 12.0103103 0.0047132449 2.886748e-01 5.293796e-01 2 98625505 98625592 88 - 0.986 0.831 -0.589
ENSG00000071073 E005 17.5880018 0.0025144561 9.071812e-01 9.557264e-01 2 98625723 98625835 113 - 1.113 1.099 -0.052
ENSG00000071073 E006 20.9819994 0.0019032244 8.793013e-01 9.409474e-01 2 98635222 98635288 67 - 1.184 1.200 0.058
ENSG00000071073 E007 24.7758223 0.0078208335 9.836617e-01 9.936554e-01 2 98636517 98636595 79 - 1.254 1.261 0.025
ENSG00000071073 E008 35.9706785 0.0015429375 2.316571e-01 4.670494e-01 2 98639808 98640001 194 - 1.421 1.318 -0.360
ENSG00000071073 E009 24.8471378 0.0015523432 6.826472e-01 8.243736e-01 2 98640121 98640228 108 - 1.262 1.222 -0.143
ENSG00000071073 E010 24.5412574 0.0014627026 2.759094e-01 5.159901e-01 2 98643923 98644053 131 - 1.265 1.152 -0.400
ENSG00000071073 E011 12.0217505 0.0051323620 4.821805e-01 6.885171e-01 2 98645428 98645455 28 - 0.981 0.881 -0.377
ENSG00000071073 E012 19.1685585 0.0017835394 5.786682e-01 7.562500e-01 2 98645456 98645542 87 - 1.161 1.098 -0.225
ENSG00000071073 E013 17.4798971 0.0089009533 1.982320e-01 4.273861e-01 2 98655445 98655520 76 - 1.137 0.966 -0.624
ENSG00000071073 E014 0.4952057 0.2971774837 3.387348e-01   2 98655862 98656351 490 - 0.098 0.263 1.716
ENSG00000071073 E015 22.2750741 0.0021726586 6.814871e-01 8.235935e-01 2 98656352 98656465 114 - 1.221 1.177 -0.157
ENSG00000071073 E016 17.4162400 0.0028234308 2.535516e-01 4.918598e-01 2 98658218 98658264 47 - 1.100 1.222 0.432
ENSG00000071073 E017 16.0939227 0.0022025809 8.578012e-01 9.292295e-01 2 98663046 98663077 32 - 1.078 1.098 0.073
ENSG00000071073 E018 25.0172335 0.0015475158 5.047381e-01 7.041323e-01 2 98663078 98663179 102 - 1.268 1.200 -0.240
ENSG00000071073 E019 0.0000000       2 98663341 98663473 133 -      
ENSG00000071073 E020 30.5818672 0.0016124178 3.360703e-02 1.377863e-01 2 98675035 98675175 141 - 1.365 1.152 -0.749
ENSG00000071073 E021 28.5114034 0.0014929072 1.818775e-01 4.064513e-01 2 98678304 98678420 117 - 1.331 1.200 -0.460
ENSG00000071073 E022 20.1812356 0.0017576017 2.615611e-02 1.157922e-01 2 98678421 98678471 51 - 1.201 0.925 -1.005
ENSG00000071073 E023 1.5184484 0.0123382803 5.989069e-03 3.967556e-02 2 98725939 98726238 300 - 0.212 0.709 2.709
ENSG00000071073 E024 31.2672798 0.0012409998 8.631076e-01 9.320670e-01 2 98726239 98726567 329 - 1.351 1.367 0.053
ENSG00000071073 E025 0.0000000       2 98726568 98726696 129 -      
ENSG00000071073 E026 0.0000000       2 98726719 98726832 114 -      
ENSG00000071073 E027 0.0000000       2 98726854 98726881 28 -      
ENSG00000071073 E028 0.3337900 0.0348811827 1.694944e-01   2 98730195 98730248 54 - 0.052 0.261 2.710
ENSG00000071073 E029 4.7652657 0.0073122942 3.220009e-01 5.614509e-01 2 98731048 98731132 85 - 0.605 0.774 0.705