ENSG00000070961

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261173 ENSG00000070961 HEK293_OSMI2_6hA HEK293_TMG_6hB ATP2B1 protein_coding protein_coding 20.35954 6.090922 40.75291 1.419954 1.792628 2.740158 3.1671487 1.8599911 6.6653209 0.7863128 0.8171575 1.8358058 0.29414583 0.32126667 0.16380000 -0.15746667 6.806774e-01 8.483329e-10 FALSE TRUE
ENST00000393164 ENSG00000070961 HEK293_OSMI2_6hA HEK293_TMG_6hB ATP2B1 protein_coding protein_coding 20.35954 6.090922 40.75291 1.419954 1.792628 2.740158 2.0915511 1.4079949 4.3793910 0.5381896 0.7754240 1.6301684 0.09780833 0.21646667 0.10853333 -0.10793333 2.764017e-01 8.483329e-10 FALSE TRUE
ENST00000428670 ENSG00000070961 HEK293_OSMI2_6hA HEK293_TMG_6hB ATP2B1 protein_coding protein_coding 20.35954 6.090922 40.75291 1.419954 1.792628 2.740158 3.0817188 0.3956490 4.6234523 0.2979542 0.9133542 3.5137838 0.11545833 0.05750000 0.11330000 0.05580000 7.077296e-01 8.483329e-10 FALSE TRUE
ENST00000635033 ENSG00000070961 HEK293_OSMI2_6hA HEK293_TMG_6hB ATP2B1 protein_coding protein_coding 20.35954 6.090922 40.75291 1.419954 1.792628 2.740158 3.6790365 1.3673915 6.9919021 0.4116102 1.2195689 2.3458082 0.20292083 0.22133333 0.16966667 -0.05166667 7.235403e-01 8.483329e-10 FALSE TRUE
MSTRG.7745.3 ENSG00000070961 HEK293_OSMI2_6hA HEK293_TMG_6hB ATP2B1 protein_coding   20.35954 6.090922 40.75291 1.419954 1.792628 2.740158 0.4071324 0.6404394 0.9626294 0.4429418 0.9626294 0.5804755 0.03302917 0.08163333 0.02576667 -0.05586667 5.612747e-01 8.483329e-10 FALSE TRUE
MSTRG.7745.6 ENSG00000070961 HEK293_OSMI2_6hA HEK293_TMG_6hB ATP2B1 protein_coding   20.35954 6.090922 40.75291 1.419954 1.792628 2.740158 3.4044498 0.0000000 7.0215402 0.0000000 1.2916541 9.4576969 0.09206250 0.00000000 0.17240000 0.17240000 8.483329e-10 8.483329e-10 FALSE TRUE
MSTRG.7745.7 ENSG00000070961 HEK293_OSMI2_6hA HEK293_TMG_6hB ATP2B1 protein_coding   20.35954 6.090922 40.75291 1.419954 1.792628 2.740158 3.6306071 0.2074947 7.7250345 0.2074947 1.4693490 5.1523553 0.11003750 0.05756667 0.18750000 0.12993333 3.009228e-01 8.483329e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000070961 E001 0.1426347 0.0320863908 1.0000000000   12 89588049 89588050 2 - 0.054 0.000 -9.460
ENSG00000070961 E002 274.0520277 1.6838660028 0.3414316683 0.579319732 12 89588051 89590527 2477 - 2.175 2.659 1.612
ENSG00000070961 E003 143.5520211 1.4733479445 0.3844863553 0.616056783 12 89590528 89590841 314 - 1.926 2.317 1.307
ENSG00000070961 E004 172.2013837 1.5477069625 0.4412398085 0.659618556 12 89590842 89591102 261 - 2.021 2.352 1.108
ENSG00000070961 E005 151.0168139 1.5025336164 0.4343577266 0.654503883 12 89591103 89591295 193 - 1.969 2.285 1.057
ENSG00000070961 E006 0.1614157 0.0353686458 1.0000000000   12 89598590 89598656 67 - 0.054 0.000 -9.452
ENSG00000070961 E007 0.1614157 0.0353686458 1.0000000000   12 89598657 89598743 87 - 0.054 0.000 -9.452
ENSG00000070961 E008 169.4307164 0.0070159318 0.0470955534 0.172763385 12 89599117 89599299 183 - 2.052 2.240 0.628
ENSG00000070961 E009 122.7060253 0.0072007297 0.7740203690 0.881156099 12 89601326 89601403 78 - 1.932 2.013 0.272
ENSG00000070961 E010 77.9488682 0.0006270126 0.8930508141 0.948180785 12 89601404 89601433 30 - 1.736 1.839 0.347
ENSG00000070961 E011 153.4919760 0.0108222188 0.7258946461 0.851648784 12 89603043 89603254 212 - 2.027 2.107 0.266
ENSG00000070961 E012 9.8506180 0.0143506541 0.1136279170 0.305200926 12 89603255 89603711 457 - 0.923 0.759 -0.639
ENSG00000070961 E013 109.1576654 0.0151484434 0.5842225002 0.759832874 12 89603712 89603795 84 - 1.884 1.941 0.190
ENSG00000070961 E014 92.3528012 0.0097075589 0.5138303091 0.710802152 12 89603796 89603837 42 - 1.814 1.872 0.194
ENSG00000070961 E015 117.2054435 0.0179593892 0.3929929661 0.622811591 12 89603838 89603925 88 - 1.919 1.957 0.129
ENSG00000070961 E016 4.4064153 0.0111014447 0.6844555981 0.825592221 12 89603926 89604154 229 - 0.619 0.619 0.001
ENSG00000070961 E017 165.6664248 0.0068816661 0.7844489620 0.887193826 12 89604155 89604346 192 - 2.060 2.147 0.292
ENSG00000070961 E018 124.0960094 0.0058336874 0.6755216339 0.819875593 12 89609937 89610043 107 - 1.937 2.008 0.242
ENSG00000070961 E019 124.4983939 0.0142221858 0.6556151410 0.807110920 12 89610421 89610508 88 - 1.940 1.999 0.200
ENSG00000070961 E020 5.8812799 0.1325371169 0.0877166135 0.259478926 12 89610509 89610705 197 - 0.746 0.407 -1.558
ENSG00000070961 E021 163.0998266 0.0193125128 0.5952678850 0.767202160 12 89611193 89611372 180 - 2.059 2.106 0.159
ENSG00000070961 E022 2.4111280 0.0104596470 0.0402676666 0.155405467 12 89611373 89612147 775 - 0.339 0.759 2.002
ENSG00000070961 E023 204.6910074 0.0031469620 0.0018274909 0.015894192 12 89616802 89617039 238 - 2.170 2.134 -0.121
ENSG00000070961 E024 192.1034808 0.0075613629 0.0103035745 0.059429540 12 89619999 89620240 242 - 2.142 2.102 -0.134
ENSG00000070961 E025 169.8756091 0.0082855128 0.0019842717 0.016964958 12 89621549 89621791 243 - 2.094 2.013 -0.273
ENSG00000070961 E026 139.4459681 0.0043760383 0.0001711579 0.002347105 12 89624183 89624397 215 - 2.013 1.914 -0.332
ENSG00000070961 E027 113.4834978 0.0025467791 0.0094052984 0.055556034 12 89626454 89626615 162 - 1.918 1.884 -0.114
ENSG00000070961 E028 64.6358209 0.0184075472 0.1691360329 0.389421787 12 89627678 89627716 39 - 1.674 1.645 -0.099
ENSG00000070961 E029 105.5006022 0.0152371256 0.0050110241 0.034678966 12 89630505 89630645 141 - 1.895 1.766 -0.436
ENSG00000070961 E030 0.4632531 0.0250604501 0.8789114934   12 89630646 89630754 109 - 0.144 0.000 -11.036
ENSG00000070961 E031 124.1761256 0.0104476421 0.0014167586 0.013020792 12 89634778 89634903 126 - 1.965 1.845 -0.403
ENSG00000070961 E032 197.4951917 0.0142627628 0.0005015223 0.005689760 12 89634997 89635251 255 - 2.167 2.025 -0.475
ENSG00000070961 E033 0.3040503 0.0244411696 1.0000000000   12 89641823 89642157 335 - 0.101 0.000 -10.451
ENSG00000070961 E034 134.4641286 0.0068967132 0.0005138727 0.005803511 12 89642158 89642355 198 - 1.999 1.883 -0.388
ENSG00000070961 E035 0.3393995 0.0271786217 1.0000000000   12 89655583 89655678 96 - 0.102 0.000 -10.454
ENSG00000070961 E036 151.1065030 0.0136427879 0.0036747911 0.027341251 12 89655679 89656107 429 - 2.049 1.931 -0.396
ENSG00000070961 E037 0.1426347 0.0320863908 1.0000000000   12 89656108 89656111 4 - 0.054 0.000 -9.450
ENSG00000070961 E038 0.8545700 0.5369086567 0.6286792119   12 89708394 89708595 202 - 0.225 0.000 -11.822
ENSG00000070961 E039 14.5582058 0.0601941376 0.1618476283 0.379502241 12 89708596 89708838 243 - 1.075 0.940 -0.499
ENSG00000070961 E040 20.4748181 0.7247809340 0.5964362034 0.767971758 12 89709219 89709484 266 - 1.174 1.276 0.359