ENSG00000070413

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263196 ENSG00000070413 HEK293_OSMI2_6hA HEK293_TMG_6hB DGCR2 protein_coding protein_coding 87.65974 121.3785 65.67142 11.47481 1.693953 -0.8860743 63.694992 89.054525 45.709726 8.311362 1.7128881 -0.9620341 0.72446667 0.73393333 0.69696667 -0.03696667 0.818619911 0.001138152 FALSE TRUE
ENST00000537045 ENSG00000070413 HEK293_OSMI2_6hA HEK293_TMG_6hB DGCR2 protein_coding protein_coding 87.65974 121.3785 65.67142 11.47481 1.693953 -0.8860743 8.189805 10.716069 4.291725 2.244310 0.3208514 -1.3181341 0.08883750 0.08646667 0.06546667 -0.02100000 0.735427218 0.001138152 FALSE TRUE
ENST00000608548 ENSG00000070413 HEK293_OSMI2_6hA HEK293_TMG_6hB DGCR2 protein_coding processed_transcript 87.65974 121.3785 65.67142 11.47481 1.693953 -0.8860743 3.786281 2.611535 7.462165 0.602372 2.0544652 1.5111147 0.04972917 0.02103333 0.11290000 0.09186667 0.001138152 0.001138152 FALSE FALSE
MSTRG.21611.6 ENSG00000070413 HEK293_OSMI2_6hA HEK293_TMG_6hB DGCR2 protein_coding   87.65974 121.3785 65.67142 11.47481 1.693953 -0.8860743 8.647531 14.488067 5.843973 1.135534 0.5297183 -1.3083727 0.09723750 0.12020000 0.08870000 -0.03150000 0.359746282 0.001138152 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000070413 E001 0.9113432 0.016045780 0.03298638   22 19036282 19036285 4 - 0.466 0.156 -2.150
ENSG00000070413 E002 152.9469847 0.453544158 0.21639988 0.44916371 22 19036286 19036357 72 - 1.899 2.229 1.105
ENSG00000070413 E003 294.0594232 0.977662025 0.40570000 0.63283289 22 19036358 19036391 34 - 2.237 2.499 0.875
ENSG00000070413 E004 372.6790521 1.082406873 0.43621925 0.65597591 22 19036392 19036418 27 - 2.352 2.599 0.822
ENSG00000070413 E005 358.4970936 1.069796214 0.43838333 0.65752180 22 19036419 19036424 6 - 2.339 2.581 0.808
ENSG00000070413 E006 4011.8364541 1.926176579 0.50844169 0.70680475 22 19036425 19037836 1412 - 3.364 3.634 0.899
ENSG00000070413 E007 1965.1491760 1.687622605 0.51523201 0.71181924 22 19037837 19038566 730 - 3.075 3.319 0.810
ENSG00000070413 E008 1425.6739508 1.594393494 0.53725347 0.72715123 22 19038567 19039121 555 - 2.962 3.173 0.701
ENSG00000070413 E009 756.8011399 1.377842673 0.52128827 0.71576668 22 19041058 19041294 237 - 2.695 2.896 0.668
ENSG00000070413 E010 21.4706410 0.007979756 0.08544769 0.25542109 22 19041295 19041806 512 - 1.097 1.394 1.048
ENSG00000070413 E011 597.9565158 1.294785917 0.51459128 0.71140283 22 19041807 19041959 153 - 2.596 2.793 0.656
ENSG00000070413 E012 6.7725004 0.004902393 0.03041167 0.12858460 22 19045258 19045362 105 - 0.962 0.807 -0.591
ENSG00000070413 E013 4.4430498 0.143188232 0.27514841 0.51517672 22 19048379 19048439 61 - 0.768 0.682 -0.354
ENSG00000070413 E014 783.0829783 0.025479262 0.04191524 0.15971484 22 19048440 19048643 204 - 2.841 2.867 0.086
ENSG00000070413 E015 14.6737526 0.106027780 0.07500222 0.23482423 22 19052481 19052605 125 - 1.255 1.114 -0.502
ENSG00000070413 E016 278.1755418 0.088515804 0.10755554 0.29497440 22 19056986 19056993 8 - 2.446 2.394 -0.173
ENSG00000070413 E017 251.9101387 0.091624234 0.11234134 0.30303451 22 19056994 19056994 1 - 2.404 2.350 -0.180
ENSG00000070413 E018 794.3836472 0.089599091 0.10529488 0.29120106 22 19056995 19057162 168 - 2.892 2.852 -0.132
ENSG00000070413 E019 7.6706651 0.004174130 0.05221415 0.18486524 22 19060566 19060955 390 - 0.985 0.875 -0.414
ENSG00000070413 E020 448.4968134 0.099901569 0.19239656 0.41997237 22 19063202 19063278 77 - 2.627 2.613 -0.049
ENSG00000070413 E021 656.2290691 0.089979613 0.23337797 0.46901610 22 19064848 19065058 211 - 2.769 2.788 0.061
ENSG00000070413 E022 172.5106164 0.056666008 0.03907453 0.15237442 22 19065059 19065067 9 - 2.246 2.185 -0.203
ENSG00000070413 E023 0.3337900 0.029212681 0.40798960   22 19065185 19065189 5 - 0.170 0.085 -1.150
ENSG00000070413 E024 8.1517897 0.191131382 0.01510501 0.07849862 22 19065756 19065904 149 - 1.141 0.781 -1.349
ENSG00000070413 E025 1.4045579 0.012824919 0.05401227 0.18909866 22 19068096 19068099 4 - 0.000 0.469 16.293
ENSG00000070413 E026 508.8673138 0.071928327 0.09477204 0.27255669 22 19068100 19068222 123 - 2.691 2.663 -0.094
ENSG00000070413 E027 253.3692563 0.085494639 0.07528013 0.23539492 22 19068223 19068225 3 - 2.418 2.347 -0.238
ENSG00000070413 E028 508.0384357 0.081458973 0.18531637 0.41097173 22 19089368 19089490 123 - 2.666 2.673 0.023
ENSG00000070413 E029 734.9215307 0.089401654 0.47658526 0.68468867 22 19122128 19122454 327 - 2.767 2.857 0.298