ENSG00000070367

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000340918 ENSG00000070367 HEK293_OSMI2_6hA HEK293_TMG_6hB EXOC5 protein_coding protein_coding 17.97361 2.921844 32.64192 0.6630876 1.150498 3.477288 2.2310271 0.0000000 4.618585 0.00000000 0.64257009 8.854427 0.06930000 0.00000000 0.14073333 0.140733333 5.168913e-08 5.168913e-08 FALSE TRUE
ENST00000555148 ENSG00000070367 HEK293_OSMI2_6hA HEK293_TMG_6hB EXOC5 protein_coding nonsense_mediated_decay 17.97361 2.921844 32.64192 0.6630876 1.150498 3.477288 1.4934833 0.1126199 2.031804 0.07252852 0.45425149 4.057579 0.05354167 0.06023333 0.06146667 0.001233333 8.834184e-01 5.168913e-08 FALSE TRUE
ENST00000555749 ENSG00000070367 HEK293_OSMI2_6hA HEK293_TMG_6hB EXOC5 protein_coding retained_intron 17.97361 2.921844 32.64192 0.6630876 1.150498 3.477288 2.4945865 0.3427902 2.730558 0.34279023 0.25467495 2.957587 0.09288750 0.09293333 0.08420000 -0.008733333 6.845086e-01 5.168913e-08 FALSE TRUE
ENST00000621441 ENSG00000070367 HEK293_OSMI2_6hA HEK293_TMG_6hB EXOC5 protein_coding protein_coding 17.97361 2.921844 32.64192 0.6630876 1.150498 3.477288 0.7987542 0.2356668 1.111448 0.05606617 0.02037904 2.190588 0.07121667 0.08120000 0.03410000 -0.047100000 6.136079e-02 5.168913e-08 FALSE TRUE
MSTRG.9608.3 ENSG00000070367 HEK293_OSMI2_6hA HEK293_TMG_6hB EXOC5 protein_coding   17.97361 2.921844 32.64192 0.6630876 1.150498 3.477288 9.0042842 1.9651476 17.867840 0.38034712 0.31707664 3.178140 0.60084583 0.69033333 0.54823333 -0.142100000 3.192058e-01 5.168913e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000070367 E001 25.8224863 0.012527676 7.573657e-03 0.0473714093 14 57200507 57202482 1976 - 1.138 1.532 1.375
ENSG00000070367 E002 169.6907228 0.029754505 7.751523e-01 0.8818185614 14 57202483 57206793 4311 - 1.963 2.140 0.595
ENSG00000070367 E003 286.0922038 1.727395193 3.555355e-01 0.5921878662 14 57206794 57208159 1366 - 2.142 2.597 1.519
ENSG00000070367 E004 46.2411535 0.882539594 2.795783e-01 0.5197013094 14 57208160 57208281 122 - 1.373 1.786 1.411
ENSG00000070367 E005 87.8294786 1.340898146 4.096493e-01 0.6357701037 14 57208282 57208473 192 - 1.655 2.006 1.184
ENSG00000070367 E006 73.7374801 1.297934502 4.649761e-01 0.6765601689 14 57208474 57208544 71 - 1.591 1.880 0.977
ENSG00000070367 E007 119.4616702 0.617668020 2.570936e-01 0.4958918712 14 57208545 57208797 253 - 1.788 2.130 1.149
ENSG00000070367 E008 138.0150942 0.003622012 5.193398e-01 0.7146050606 14 57209567 57209782 216 - 1.881 2.033 0.511
ENSG00000070367 E009 109.6449877 0.009848683 1.705257e-01 0.3911499469 14 57209953 57210061 109 - 1.792 1.820 0.096
ENSG00000070367 E010 0.6190593 0.021182445 3.857413e-01   14 57211699 57211703 5 - 0.111 0.316 1.881
ENSG00000070367 E011 0.1426347 0.032055599 6.753909e-01   14 57217978 57217981 4 - 0.040 0.000 -9.144
ENSG00000070367 E012 88.0832950 0.023272085 4.308488e-01 0.6517770260 14 57217982 57218068 87 - 1.695 1.751 0.188
ENSG00000070367 E013 107.5270265 0.010787547 1.578668e-01 0.3735348527 14 57219322 57219442 121 - 1.785 1.804 0.066
ENSG00000070367 E014 111.5322016 0.005009321 3.053155e-02 0.1289341700 14 57222308 57222416 109 - 1.804 1.784 -0.066
ENSG00000070367 E015 151.1191233 0.011597656 1.987454e-02 0.0954349895 14 57229734 57229881 148 - 1.934 1.902 -0.109
ENSG00000070367 E016 108.6243827 0.020000723 5.895811e-02 0.2004212399 14 57231506 57231570 65 - 1.793 1.758 -0.115
ENSG00000070367 E017 85.0248580 0.021494855 4.763842e-02 0.1741416783 14 57231571 57231612 42 - 1.691 1.627 -0.218
ENSG00000070367 E018 100.3028905 0.015413113 2.610825e-01 0.5001219613 14 57231613 57231715 103 - 1.753 1.779 0.089
ENSG00000070367 E019 2.5340245 0.009376690 1.192723e-01 0.3146730224 14 57231716 57232139 424 - 0.407 0.000 -13.145
ENSG00000070367 E020 1.0713538 0.015382688 5.212332e-01   14 57232140 57232215 76 - 0.225 0.000 -11.951
ENSG00000070367 E021 0.7860845 0.016895491 9.024657e-01   14 57232216 57232372 157 - 0.172 0.000 -11.467
ENSG00000070367 E022 91.1373776 0.024102790 6.516286e-01 0.8045640311 14 57232667 57232749 83 - 1.706 1.792 0.291
ENSG00000070367 E023 0.1426347 0.032055599 6.753909e-01   14 57232750 57233223 474 - 0.040 0.000 -9.144
ENSG00000070367 E024 110.9367452 0.015960332 6.371694e-01 0.7951413912 14 57233743 57233883 141 - 1.790 1.875 0.285
ENSG00000070367 E025 63.3977801 0.013308284 5.086782e-01 0.7069401075 14 57233988 57234032 45 - 1.555 1.611 0.191
ENSG00000070367 E026 93.7656825 0.009448262 2.162095e-02 0.1013640804 14 57235711 57235820 110 - 1.731 1.673 -0.197
ENSG00000070367 E027 56.0153779 0.004201127 4.604495e-02 0.1701454156 14 57237338 57237358 21 - 1.512 1.461 -0.177
ENSG00000070367 E028 45.9253871 0.002190466 5.205493e-02 0.1845190745 14 57237359 57237366 8 - 1.430 1.371 -0.203
ENSG00000070367 E029 0.9662812 0.059708638 6.630506e-01   14 57237367 57237506 140 - 0.200 0.000 -11.732
ENSG00000070367 E030 0.0000000       14 57237674 57237677 4 -      
ENSG00000070367 E031 0.3228314 0.350212423 1.000000e+00   14 57239528 57239590 63 - 0.077 0.000 -10.151
ENSG00000070367 E032 0.3228314 0.350212423 1.000000e+00   14 57239591 57239594 4 - 0.077 0.000 -10.151
ENSG00000070367 E033 68.7781675 0.005200294 2.935360e-02 0.1254382773 14 57239595 57239659 65 - 1.601 1.547 -0.184
ENSG00000070367 E034 0.1426347 0.032055599 6.753909e-01   14 57243248 57243636 389 - 0.040 0.000 -9.144
ENSG00000070367 E035 0.4820342 0.021660538 1.000000e+00   14 57244113 57244164 52 - 0.111 0.000 -10.730
ENSG00000070367 E036 84.7418253 0.014671965 7.586130e-02 0.2364980222 14 57244165 57244278 114 - 1.687 1.660 -0.094
ENSG00000070367 E037 70.8815140 0.006785747 8.563763e-03 0.0518864024 14 57244279 57244359 81 - 1.616 1.520 -0.328
ENSG00000070367 E038 92.0745002 0.012036216 7.177290e-06 0.0001572328 14 57246711 57246827 117 - 1.737 1.443 -1.003
ENSG00000070367 E039 48.6828104 0.014844234 3.726494e-04 0.0044646626 14 57246828 57246850 23 - 1.469 1.172 -1.036
ENSG00000070367 E040 39.6274528 0.005691813 2.116208e-04 0.0028035014 14 57246851 57246858 8 - 1.384 1.068 -1.118
ENSG00000070367 E041 61.2034393 0.014379919 4.437934e-03 0.0315935152 14 57247618 57247712 95 - 1.557 1.391 -0.570
ENSG00000070367 E042 0.1723744 0.079049475 3.780932e-02   14 57268247 57268507 261 - 0.000 0.317 16.039
ENSG00000070367 E043 2.6954402 0.008390417 1.033141e-01 0.2877660950 14 57268508 57268621 114 - 0.423 0.000 -13.232
ENSG00000070367 E044 59.7882680 0.020828335 7.377685e-01 0.8591102850 14 57268622 57268905 284 - 1.526 1.621 0.325