ENSG00000070366

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263073 ENSG00000070366 HEK293_OSMI2_6hA HEK293_TMG_6hB SMG6 protein_coding protein_coding 20.17403 29.47846 10.41564 4.393377 0.2901171 -1.500014 8.568279 11.108349 7.041516 1.5554703 0.22040703 -0.6569371 0.47748750 0.37916667 0.6759667 0.2968000 7.719107e-08 7.719107e-08 FALSE TRUE
ENST00000570756 ENSG00000070366 HEK293_OSMI2_6hA HEK293_TMG_6hB SMG6 protein_coding processed_transcript 20.17403 29.47846 10.41564 4.393377 0.2901171 -1.500014 6.311019 9.710832 1.131571 1.7478570 0.28485057 -3.0900591 0.26744167 0.32576667 0.1082333 -0.2175333 2.266446e-03 7.719107e-08 FALSE TRUE
ENST00000575454 ENSG00000070366 HEK293_OSMI2_6hA HEK293_TMG_6hB SMG6 protein_coding protein_coding 20.17403 29.47846 10.41564 4.393377 0.2901171 -1.500014 1.276225 3.297429 0.000000 2.0754581 0.00000000 -8.3695665 0.04775833 0.10930000 0.0000000 -0.1093000 4.385651e-01 7.719107e-08 FALSE FALSE
MSTRG.13391.10 ENSG00000070366 HEK293_OSMI2_6hA HEK293_TMG_6hB SMG6 protein_coding   20.17403 29.47846 10.41564 4.393377 0.2901171 -1.500014 2.007747 2.803138 1.748213 0.4282802 0.05328576 -0.6780707 0.11546250 0.09553333 0.1683333 0.0728000 6.158744e-02 7.719107e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000070366 E001 0.0000000       17 2059766 2059838 73 -      
ENSG00000070366 E002 0.0000000       17 2059839 2059842 4 -      
ENSG00000070366 E003 1.1013154 0.0149198748 0.0754831329   17 2059843 2059845 3 - 0.000 0.388 13.767
ENSG00000070366 E004 1.5354261 0.0128400684 0.0258864215 0.114933979 17 2059846 2059849 4 - 0.000 0.486 14.278
ENSG00000070366 E005 2.2856433 0.0090992391 0.0063209124 0.041300308 17 2059850 2059875 26 - 0.000 0.590 14.767
ENSG00000070366 E006 646.1264114 1.5201746190 0.4090706902 0.635295947 17 2059876 2061373 1498 - 2.533 2.834 1.002
ENSG00000070366 E007 78.7256483 0.4264273747 0.1294545371 0.330937319 17 2061374 2061404 31 - 1.555 1.938 1.296
ENSG00000070366 E008 82.1178292 0.4908876990 0.2031788570 0.433562165 17 2061405 2061451 47 - 1.630 1.946 1.067
ENSG00000070366 E009 85.4977523 0.4917930646 0.1862498687 0.412105529 17 2061452 2061550 99 - 1.634 1.966 1.122
ENSG00000070366 E010 98.6274604 0.5717094727 0.2334883698 0.469150896 17 2061551 2061622 72 - 1.724 2.022 1.003
ENSG00000070366 E011 11.2847183 0.1706353094 0.4161500631 0.640723954 17 2061623 2062257 635 - 0.900 1.100 0.740
ENSG00000070366 E012 109.2515332 0.0410987766 0.0670247093 0.218445807 17 2065073 2065154 82 - 1.840 2.051 0.708
ENSG00000070366 E013 180.3901777 0.0006215018 0.1501865263 0.362642162 17 2065468 2065679 212 - 2.152 2.245 0.312
ENSG00000070366 E014 1.5886988 0.0116688188 0.1917845670 0.419125837 17 2066003 2066089 87 - 0.177 0.456 1.885
ENSG00000070366 E015 129.5229355 0.0004022193 0.6536350965 0.805859224 17 2068778 2068886 109 - 2.026 2.091 0.216
ENSG00000070366 E016 93.1325041 0.0027644729 0.8819047437 0.942334949 17 2068887 2068931 45 - 1.898 1.939 0.137
ENSG00000070366 E017 0.4952057 0.2410519464 0.2229288570   17 2071923 2072003 81 - 0.303 0.082 -2.280
ENSG00000070366 E018 136.9580948 0.0183322689 0.7615778684 0.873570258 17 2081810 2081915 106 - 2.044 2.113 0.232
ENSG00000070366 E019 101.2362747 0.0168123067 0.3747214504 0.607902920 17 2081916 2081956 41 - 1.977 1.960 -0.059
ENSG00000070366 E020 0.1426347 0.0317727168 0.1733020986   17 2082227 2082243 17 - 0.177 0.000 -13.563
ENSG00000070366 E021 0.5177432 0.0241846261 0.8013284890   17 2082244 2082310 67 - 0.177 0.151 -0.280
ENSG00000070366 E022 105.1861195 0.0126313623 0.4527900186 0.667743267 17 2085725 2085782 58 - 1.981 1.981 -0.001
ENSG00000070366 E023 136.4843266 0.0061029714 0.7940699289 0.892772417 17 2085783 2085901 119 - 2.065 2.105 0.134
ENSG00000070366 E024 1.9226765 0.0751364635 0.8744925315 0.938462707 17 2087075 2088761 1687 - 0.399 0.456 0.303
ENSG00000070366 E025 0.0000000       17 2094785 2095112 328 -      
ENSG00000070366 E026 71.9024108 0.0073598034 0.9549389610 0.979367941 17 2172658 2172667 10 - 1.788 1.838 0.168
ENSG00000070366 E027 97.0617505 0.0005243908 0.9494307570 0.976777837 17 2172668 2172711 44 - 1.917 1.963 0.156
ENSG00000070366 E028 75.3689843 0.0005131930 0.4911271022 0.694743716 17 2172712 2172736 25 - 1.829 1.846 0.058
ENSG00000070366 E029 97.4934625 0.0005674847 0.9134525137 0.958814967 17 2172737 2172796 60 - 1.917 1.961 0.147
ENSG00000070366 E030 53.8104316 0.0007309016 0.8123761359 0.903649031 17 2172797 2172801 5 - 1.670 1.706 0.120
ENSG00000070366 E031 55.1672242 0.0007266192 0.6910982930 0.829785813 17 2172802 2172803 2 - 1.689 1.716 0.093
ENSG00000070366 E032 92.3586099 0.0005169572 0.0868947623 0.258047935 17 2172804 2172859 56 - 1.942 1.921 -0.071
ENSG00000070366 E033 0.0000000       17 2172860 2173071 212 -      
ENSG00000070366 E034 0.0000000       17 2173098 2173178 81 -      
ENSG00000070366 E035 88.5960677 0.0006069045 0.0260302377 0.115408876 17 2186663 2186724 62 - 1.942 1.899 -0.146
ENSG00000070366 E036 52.5306868 0.0009631725 0.0144894782 0.076204041 17 2186725 2186736 12 - 1.747 1.667 -0.272
ENSG00000070366 E037 88.8385154 0.0013229907 0.0081279515 0.049911882 17 2186737 2186831 95 - 1.957 1.894 -0.214
ENSG00000070366 E038 87.9017787 0.0129703781 0.3192637820 0.558983690 17 2188399 2188515 117 - 1.918 1.902 -0.052
ENSG00000070366 E039 0.3503582 0.0475192733 0.4672701197   17 2212615 2212737 123 - 0.177 0.082 -1.285
ENSG00000070366 E040 0.0000000       17 2214139 2214349 211 -      
ENSG00000070366 E041 0.1308682 0.0326491905 1.0000000000   17 2229323 2229464 142 - 0.000 0.081 10.957
ENSG00000070366 E042 89.2920385 0.0016940013 0.0470520781 0.172656116 17 2236492 2236637 146 - 1.940 1.900 -0.133
ENSG00000070366 E043 0.3447487 0.6358079831 0.8228623802   17 2236797 2237037 241 - 0.000 0.153 11.994
ENSG00000070366 E044 0.0000000       17 2237299 2237391 93 -      
ENSG00000070366 E045 0.1779838 0.0467286149 0.1734779305   17 2237495 2237580 86 - 0.177 0.000 -13.567
ENSG00000070366 E046 0.3393995 0.0254454294 0.0419218173   17 2240003 2240191 189 - 0.303 0.000 -14.566
ENSG00000070366 E047 55.7419337 0.0007670118 0.1215740620 0.318333963 17 2244658 2244719 62 - 1.735 1.704 -0.106
ENSG00000070366 E048 0.0000000       17 2244873 2244912 40 -      
ENSG00000070366 E049 0.0000000       17 2265930 2265967 38 -      
ENSG00000070366 E050 0.0000000       17 2265968 2266199 232 -      
ENSG00000070366 E051 141.1487685 0.0004638689 0.0079782894 0.049207651 17 2282647 2282859 213 - 2.138 2.099 -0.131
ENSG00000070366 E052 122.6712382 0.0018554712 0.2142451605 0.446656631 17 2283625 2283735 111 - 2.052 2.052 -0.001
ENSG00000070366 E053 100.8190012 0.0004219137 0.5863254762 0.761192197 17 2292552 2292630 79 - 1.947 1.975 0.092
ENSG00000070366 E054 108.2189465 0.0081732418 0.0704134472 0.225521431 17 2292871 2292977 107 - 2.031 1.983 -0.161
ENSG00000070366 E055 95.5316597 0.0004148973 0.0029028247 0.022818292 17 2297243 2297353 111 - 1.990 1.921 -0.230
ENSG00000070366 E056 98.0486796 0.0004504938 0.0001753320 0.002396411 17 2297863 2298055 193 - 2.020 1.925 -0.321
ENSG00000070366 E057 541.1389313 0.0116535631 0.0001181667 0.001717514 17 2298906 2300664 1759 - 2.783 2.647 -0.454
ENSG00000070366 E058 25.8196046 0.0033551110 0.0827255720 0.250146092 17 2303014 2303152 139 - 1.443 1.356 -0.298
ENSG00000070366 E059 11.7761073 0.0398638897 0.7715086190 0.879505325 17 2303153 2303156 4 - 1.005 1.081 0.281
ENSG00000070366 E060 26.4324444 0.0013581678 0.3630199132 0.598169379 17 2303157 2303354 198 - 1.315 1.432 0.406
ENSG00000070366 E061 29.1925042 0.0249774483 0.0411450256 0.157723004 17 2303633 2303916 284 - 1.543 1.395 -0.507