ENSG00000070061

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000537196 ENSG00000070061 HEK293_OSMI2_6hA HEK293_TMG_6hB ELP1 protein_coding protein_coding 34.32196 19.91044 43.91596 3.21685 1.713174 1.140825 12.3951540 10.2738716 13.8495885 1.9499186 0.5051469 0.4305009 0.39531250 0.51010000 0.31546667 -0.19463333 7.661874e-06 3.799136e-13 FALSE TRUE
ENST00000674535 ENSG00000070061 HEK293_OSMI2_6hA HEK293_TMG_6hB ELP1 protein_coding protein_coding 34.32196 19.91044 43.91596 3.21685 1.713174 1.140825 6.7644387 2.8447461 11.1835366 0.5158911 0.4653042 1.9712316 0.17750833 0.14246667 0.25483333 0.11236667 7.098471e-04 3.799136e-13 FALSE TRUE
ENST00000675052 ENSG00000070061 HEK293_OSMI2_6hA HEK293_TMG_6hB ELP1 protein_coding protein_coding 34.32196 19.91044 43.91596 3.21685 1.713174 1.140825 2.1791514 1.5211522 2.5740416 0.3994710 0.4042567 0.7550116 0.06365417 0.07336667 0.05866667 -0.01470000 8.205239e-01 3.799136e-13 FALSE TRUE
ENST00000675321 ENSG00000070061 HEK293_OSMI2_6hA HEK293_TMG_6hB ELP1 protein_coding nonsense_mediated_decay 34.32196 19.91044 43.91596 3.21685 1.713174 1.140825 2.2129243 0.0000000 2.5518406 0.0000000 0.2962656 8.0010369 0.04886250 0.00000000 0.05820000 0.05820000 3.799136e-13 3.799136e-13 TRUE TRUE
ENST00000675335 ENSG00000070061 HEK293_OSMI2_6hA HEK293_TMG_6hB ELP1 protein_coding nonsense_mediated_decay 34.32196 19.91044 43.91596 3.21685 1.713174 1.140825 2.0672441 0.4445291 4.2006686 0.4445291 0.5839767 3.2116048 0.04962083 0.03296667 0.09523333 0.06226667 2.893196e-01 3.799136e-13 FALSE TRUE
ENST00000676162 ENSG00000070061 HEK293_OSMI2_6hA HEK293_TMG_6hB ELP1 protein_coding processed_transcript 34.32196 19.91044 43.91596 3.21685 1.713174 1.140825 1.4044571 0.0000000 0.1468945 0.0000000 0.1468945 3.9717226 0.05659167 0.00000000 0.00320000 0.00320000 9.381889e-01 3.799136e-13 FALSE TRUE
MSTRG.33210.3 ENSG00000070061 HEK293_OSMI2_6hA HEK293_TMG_6hB ELP1 protein_coding   34.32196 19.91044 43.91596 3.21685 1.713174 1.140825 0.9366884 1.5315320 0.0000000 0.7759223 0.0000000 -7.2682210 0.03228333 0.06633333 0.00000000 -0.06633333 1.805770e-01 3.799136e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000070061 E001 0.5352391 0.2556594020 2.146460e-01   9 108866898 108867515 618 - 0.091 0.357 2.459
ENSG00000070061 E002 0.1308682 0.0326491905 2.664887e-01   9 108867516 108867516 1 - 0.000 0.159 12.701
ENSG00000070061 E003 0.1308682 0.0326491905 2.664887e-01   9 108867517 108867537 21 - 0.000 0.159 12.701
ENSG00000070061 E004 0.3336024 0.0244411696 8.080839e-02   9 108867538 108867539 2 - 0.000 0.276 13.705
ENSG00000070061 E005 14.7449848 0.0568132207 3.290497e-01 5.680614e-01 9 108867540 108868172 633 - 1.119 1.266 0.521
ENSG00000070061 E006 52.1017431 0.0007035001 3.724181e-02 1.475959e-01 9 108868173 108868445 273 - 1.663 1.779 0.393
ENSG00000070061 E007 53.8069638 0.0015450517 9.776514e-03 5.715607e-02 9 108868446 108868549 104 - 1.667 1.812 0.491
ENSG00000070061 E008 57.5289190 0.0067927243 1.967919e-03 1.685315e-02 9 108868550 108868640 91 - 1.666 1.870 0.690
ENSG00000070061 E009 39.4814630 0.0093673127 3.633156e-02 1.451442e-01 9 108868641 108868650 10 - 1.519 1.684 0.563
ENSG00000070061 E010 78.0359489 0.0024557275 8.757696e-03 5.274560e-02 9 108868651 108868670 20 - 1.823 1.957 0.450
ENSG00000070061 E011 95.3276676 0.0076074438 7.950317e-03 4.909446e-02 9 108868671 108868720 50 - 1.897 2.061 0.552
ENSG00000070061 E012 414.4724665 0.0070639987 6.612370e-05 1.057574e-03 9 108868721 108869030 310 - 2.519 2.714 0.648
ENSG00000070061 E013 260.4404884 0.0046309642 4.853610e-07 1.508243e-05 9 108869031 108869114 84 - 2.308 2.523 0.716
ENSG00000070061 E014 253.5547029 0.0065651981 5.108764e-04 5.776587e-03 9 108869115 108869182 68 - 2.315 2.491 0.588
ENSG00000070061 E015 6.8752358 0.0971236018 3.262141e-02 1.350331e-01 9 108870454 108870553 100 - 0.701 1.074 1.430
ENSG00000070061 E016 3.1596847 0.0078871060 8.410712e-03 5.120572e-02 9 108872661 108872801 141 - 0.421 0.830 1.815
ENSG00000070061 E017 232.2151238 0.0009488794 7.338793e-08 2.815215e-06 9 108874895 108874963 69 - 2.284 2.445 0.537
ENSG00000070061 E018 133.0392023 0.0003442587 2.899987e-05 5.239755e-04 9 108874964 108874970 7 - 2.050 2.194 0.485
ENSG00000070061 E019 0.7392585 0.0854015962 1.191893e-01   9 108874971 108875632 662 - 0.091 0.371 2.528
ENSG00000070061 E020 0.5067846 0.0206879980 1.000000e+00   9 108875633 108875735 103 - 0.167 0.160 -0.074
ENSG00000070061 E021 0.7860845 0.0170622932 7.723284e-02   9 108875736 108876701 966 - 0.337 0.000 -13.216
ENSG00000070061 E022 0.1779838 0.0359444683 9.086873e-01   9 108876898 108876986 89 - 0.092 0.000 -10.896
ENSG00000070061 E023 0.3447487 0.6521373335 1.927750e-01   9 108876987 108877612 626 - 0.000 0.281 13.731
ENSG00000070061 E024 0.5587019 0.3462794319 1.000000e+00   9 108877613 108877800 188 - 0.170 0.163 -0.073
ENSG00000070061 E025 1.3089191 0.4083671494 1.533459e-01   9 108877801 108877994 194 - 0.170 0.529 2.309
ENSG00000070061 E026 293.6675755 0.0002550197 1.282666e-08 5.869744e-07 9 108877995 108878149 155 - 2.397 2.533 0.455
ENSG00000070061 E027 267.7735317 0.0002265727 1.769555e-08 7.863664e-07 9 108878623 108878750 128 - 2.357 2.497 0.465
ENSG00000070061 E028 0.0000000       9 108878751 108878988 238 -      
ENSG00000070061 E029 148.8498108 0.0011722461 7.458264e-03 4.682903e-02 9 108879446 108879460 15 - 2.121 2.223 0.341
ENSG00000070061 E030 235.5092925 0.0024341118 2.094884e-02 9.916933e-02 9 108879461 108879557 97 - 2.322 2.414 0.308
ENSG00000070061 E031 225.1997837 0.0002476137 5.860070e-04 6.456723e-03 9 108880052 108880165 114 - 2.299 2.397 0.325
ENSG00000070061 E032 3.6198617 0.4088933101 9.725758e-01 9.882499e-01 9 108880166 108880943 778 - 0.641 0.659 0.077
ENSG00000070061 E033 1.4209042 0.0132410403 9.136241e-01 9.589181e-01 9 108880944 108881662 719 - 0.381 0.368 -0.077
ENSG00000070061 E034 5.4474771 0.0055010828 3.670169e-01 6.015230e-01 9 108881663 108881704 42 - 0.755 0.884 0.506
ENSG00000070061 E035 151.7215874 0.0004290535 3.953325e-02 1.535497e-01 9 108881705 108881765 61 - 2.138 2.213 0.251
ENSG00000070061 E036 150.0000079 0.0011099285 8.595988e-02 2.563520e-01 9 108882125 108882187 63 - 2.135 2.204 0.230
ENSG00000070061 E037 2.4651229 0.1421704642 3.846652e-01 6.162231e-01 9 108882188 108882562 375 - 0.421 0.629 0.994
ENSG00000070061 E038 0.8030126 0.3015590261 7.144467e-01   9 108884796 108884912 117 - 0.227 0.282 0.412
ENSG00000070061 E039 0.2922838 0.0264064403 6.559737e-01   9 108885768 108885872 105 - 0.091 0.159 0.920
ENSG00000070061 E040 157.7155111 0.0003146636 4.740485e-02 1.735269e-01 9 108889332 108889393 62 - 2.156 2.226 0.236
ENSG00000070061 E041 0.0000000       9 108889645 108889684 40 -      
ENSG00000070061 E042 299.8275202 0.0001607148 2.512940e-04 3.234218e-03 9 108891203 108891404 202 - 2.425 2.515 0.300
ENSG00000070061 E043 227.7699905 0.0001998134 1.698488e-02 8.541378e-02 9 108892986 108893083 98 - 2.314 2.385 0.235
ENSG00000070061 E044 1.0843377 0.0180211479 7.175338e-01   9 108893084 108893942 859 - 0.336 0.276 -0.397
ENSG00000070061 E045 225.6318390 0.0019768119 9.923088e-02 2.804314e-01 9 108893943 108894066 124 - 2.311 2.375 0.215
ENSG00000070061 E046 0.3641499 0.0308295091 6.524851e-01   9 108894067 108894088 22 - 0.091 0.160 0.926
ENSG00000070061 E047 240.3069941 0.0002098283 2.472729e-02 1.113745e-01 9 108896496 108896644 149 - 2.338 2.404 0.220
ENSG00000070061 E048 2.3599643 0.0977325846 3.667859e-01 6.013272e-01 9 108896645 108896890 246 - 0.558 0.369 -0.969
ENSG00000070061 E049 4.4074221 0.0089014948 2.420831e-01 4.789068e-01 9 108896891 108896952 62 - 0.655 0.830 0.712
ENSG00000070061 E050 181.2481052 0.0003206307 2.911024e-01 5.316773e-01 9 108896953 108897038 86 - 2.228 2.270 0.138
ENSG00000070061 E051 206.9459336 0.0003703009 7.362440e-01 8.581176e-01 9 108897148 108897283 136 - 2.299 2.302 0.009
ENSG00000070061 E052 83.3189607 0.0004770631 9.074380e-02 2.651295e-01 9 108897284 108897285 2 - 1.924 1.866 -0.196
ENSG00000070061 E053 1.6202418 0.0849340732 3.656863e-01 6.004984e-01 9 108897286 108898135 850 - 0.336 0.510 0.938
ENSG00000070061 E054 0.0000000       9 108898136 108898234 99 -      
ENSG00000070061 E055 0.4536995 0.2030283929 1.000000e+00   9 108898235 108898501 267 - 0.167 0.158 -0.100
ENSG00000070061 E056 130.9757645 0.0006278495 1.295187e-01 3.310659e-01 9 108898502 108898581 80 - 2.113 2.073 -0.136
ENSG00000070061 E057 162.1291578 0.0004961276 1.014551e-01 2.844327e-01 9 108898671 108898749 79 - 2.205 2.167 -0.130
ENSG00000070061 E058 169.3668309 0.0010459525 4.515714e-01 6.667815e-01 9 108899822 108899895 74 - 2.216 2.202 -0.046
ENSG00000070061 E059 210.2090883 0.0003202238 5.278632e-01 7.205185e-01 9 108900260 108900375 116 - 2.306 2.301 -0.017
ENSG00000070061 E060 186.0115226 0.0002425815 7.199825e-02 2.288022e-01 9 108901425 108901530 106 - 2.264 2.226 -0.126
ENSG00000070061 E061 135.9559525 0.0003446310 5.722506e-04 6.328556e-03 9 108901628 108901681 54 - 2.148 2.046 -0.342
ENSG00000070061 E062 181.9603032 0.0003222274 1.245474e-04 1.793827e-03 9 108902839 108902942 104 - 2.277 2.179 -0.328
ENSG00000070061 E063 188.0918217 0.0002445813 1.594895e-02 8.161571e-02 9 108903563 108903658 96 - 2.276 2.222 -0.182
ENSG00000070061 E064 98.3074718 0.0007574568 7.322926e-02 2.312902e-01 9 108903659 108903669 11 - 1.997 1.938 -0.197
ENSG00000070061 E065 229.9943007 0.0019547522 1.072833e-01 2.944916e-01 9 108906303 108906485 183 - 2.359 2.316 -0.142
ENSG00000070061 E066 10.8726809 0.2682579643 3.547199e-01 5.914714e-01 9 108906486 108908304 1819 - 1.100 0.951 -0.547
ENSG00000070061 E067 170.5868553 0.0004261594 9.908014e-04 9.841543e-03 9 108908305 108908404 100 - 2.244 2.157 -0.291
ENSG00000070061 E068 236.0381584 0.0005339499 2.012501e-06 5.251521e-05 9 108911010 108911180 171 - 2.394 2.279 -0.385
ENSG00000070061 E069 0.1614157 0.0338335063 9.087376e-01   9 108911181 108911211 31 - 0.091 0.000 -10.895
ENSG00000070061 E070 256.9566523 0.0057072787 4.742885e-03 3.323777e-02 9 108912264 108912494 231 - 2.430 2.315 -0.383
ENSG00000070061 E071 142.5417028 0.0003383924 1.518080e-03 1.373934e-02 9 108916204 108916297 94 - 2.168 2.078 -0.302
ENSG00000070061 E072 0.8040577 0.0210759196 8.268959e-01   9 108916298 108917546 1249 - 0.231 0.276 0.335
ENSG00000070061 E073 168.1635912 0.0004933624 1.151146e-06 3.209507e-05 9 108917547 108917662 116 - 2.255 2.116 -0.463
ENSG00000070061 E074 104.7134659 0.0035429382 1.217173e-03 1.156063e-02 9 108917663 108917670 8 - 2.050 1.906 -0.484
ENSG00000070061 E075 73.5809192 0.1645315419 5.002564e-01 7.009365e-01 9 108917671 108918810 1140 - 1.870 1.818 -0.176
ENSG00000070061 E076 156.5127128 0.0002953011 2.407367e-06 6.136689e-05 9 108918811 108918901 91 - 2.221 2.087 -0.449
ENSG00000070061 E077 20.3947700 0.1621048883 2.173836e-01 4.502772e-01 9 108918902 108919252 351 - 1.370 1.169 -0.709
ENSG00000070061 E078 157.9020459 0.0002616613 9.432124e-06 1.993766e-04 9 108919253 108919349 97 - 2.221 2.097 -0.415
ENSG00000070061 E079 0.5767453 0.0199518516 1.097831e-01   9 108920316 108920690 375 - 0.091 0.367 2.506
ENSG00000070061 E080 0.5963342 0.0226449284 6.737173e-01   9 108920691 108920783 93 - 0.231 0.159 -0.664
ENSG00000070061 E081 2.0974743 0.3577415672 9.337416e-01 9.689631e-01 9 108920784 108922841 2058 - 0.487 0.454 -0.164
ENSG00000070061 E082 163.4851472 0.0002595634 1.505479e-04 2.104932e-03 9 108922842 108922927 86 - 2.228 2.127 -0.341
ENSG00000070061 E083 178.4500546 0.0003465718 1.723536e-08 7.670234e-07 9 108926523 108926595 73 - 2.282 2.126 -0.519
ENSG00000070061 E084 116.2670443 0.0025764844 2.366034e-05 4.408680e-04 9 108926596 108926603 8 - 2.103 1.932 -0.573
ENSG00000070061 E085 185.6286024 0.0014401496 1.034315e-05 2.159460e-04 9 108927372 108927453 82 - 2.295 2.160 -0.450
ENSG00000070061 E086 211.1561969 0.0005342539 3.320108e-10 2.109355e-08 9 108929769 108929921 153 - 2.360 2.194 -0.554
ENSG00000070061 E087 131.2965103 0.0003303214 1.780229e-13 2.109165e-11 9 108930997 108931056 60 - 2.175 1.929 -0.824
ENSG00000070061 E088 76.9840138 0.0005316083 3.646828e-07 1.171171e-05 9 108931057 108931080 24 - 1.938 1.720 -0.735
ENSG00000070061 E089 117.2644121 0.0005511391 6.656236e-07 1.995026e-05 9 108931081 108931199 119 - 2.106 1.936 -0.573
ENSG00000070061 E090 47.3233406 0.0009100959 4.844180e-04 5.533790e-03 9 108931200 108931201 2 - 1.721 1.535 -0.631
ENSG00000070061 E091 37.3160768 0.1916121511 2.784800e-01 5.185727e-01 9 108931202 108933863 2662 - 1.611 1.461 -0.513
ENSG00000070061 E092 146.4479284 0.0002873082 1.690430e-06 4.505947e-05 9 108933864 108934063 200 - 2.194 2.053 -0.473
ENSG00000070061 E093 46.1005724 0.0009028090 3.333896e-02 1.369948e-01 9 108934064 108934328 265 - 1.686 1.578 -0.368
ENSG00000070061 E094 0.1614157 0.0338335063 9.087376e-01   9 108934367 108934449 83 - 0.091 0.000 -10.895