ENSG00000069667

1 Isoform Switch

Summary Plot
Results

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Rows: 1-6 / 6
Columns:
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isoform_id
gene_id
condition_1
condition_2
gene_name
gene_biotype
iso_biotype
gene_overall_mean
gene_value_1
gene_value_2
gene_stderr_1
gene_stderr_2
gene_log2_fold_change
iso_overall_mean
iso_value_1
iso_value_2
iso_stderr_1
iso_stderr_2
iso_log2_fold_change
IF_overall
IF1
IF2
dIF
isoform_switch_q_value
gene_switch_q_value
PTC
codingPotential
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isoform_id	gene_id	condition_1	condition_2	gene_name	gene_biotype	iso_biotype	gene_overall_mean	gene_value_1	gene_value_2	gene_stderr_1	gene_stderr_2	gene_log2_fold_change	iso_overall_mean	iso_value_1	iso_value_2	iso_stderr_1	iso_stderr_2	iso_log2_fold_change	IF_overall	IF1	IF2	dIF	isoform_switch_q_value	gene_switch_q_value	PTC	codingPotential

ENST00000335670	ENSG00000069667	HEK293_OSMI2_6hA	HEK293_TMG_6hB	RORA	protein_coding	protein_coding	1.298774	0.6830831	1.761146	0.07068334	0.4160402	1.353583	0.38611405	0.13479210	0.84731275	0.03192722	0.07360180	2.5658387	0.28763333	0.20693333	0.54693333	0.34000000	0.33204044	0.01782194	FALSE	TRUE
ENST00000449337	ENSG00000069667	HEK293_OSMI2_6hA	HEK293_TMG_6hB	RORA	protein_coding	protein_coding	1.298774	0.6830831	1.761146	0.07068334	0.4160402	1.353583	0.31955296	0.06137690	0.40534850	0.03083994	0.13485214	2.5407931	0.20357083	0.08163333	0.22546667	0.14383333	0.47697833	0.01782194	FALSE	TRUE
ENST00000558904	ENSG00000069667	HEK293_OSMI2_6hA	HEK293_TMG_6hB	RORA	protein_coding	protein_coding	1.298774	0.6830831	1.761146	0.07068334	0.4160402	1.353583	0.43085816	0.36902596	0.15242682	0.05362424	0.07972299	-1.2225068	0.41605833	0.55403333	0.07873333	-0.47530000	0.01782194	0.01782194		FALSE
ENST00000559343	ENSG00000069667	HEK293_OSMI2_6hA	HEK293_TMG_6hB	RORA	protein_coding	protein_coding	1.298774	0.6830831	1.761146	0.07068334	0.4160402	1.353583	0.04196477	0.05999393	0.04186946	0.03115092	0.04186946	-0.4323446	0.02864583	0.07993333	0.01616667	-0.06376667	0.58914116	0.01782194		FALSE
ENST00000559587	ENSG00000069667	HEK293_OSMI2_6hA	HEK293_TMG_6hB	RORA	protein_coding	processed_transcript	1.298774	0.6830831	1.761146	0.07068334	0.4160402	1.353583	0.05185377	0.00000000	0.27840550	0.00000000	0.27840550	4.8500268	0.02101250	0.00000000	0.10753333	0.10753333	0.92959126	0.01782194	FALSE	FALSE
ENST00000560300	ENSG00000069667	HEK293_OSMI2_6hA	HEK293_TMG_6hB	RORA	protein_coding	processed_transcript	1.298774	0.6830831	1.761146	0.07068334	0.4160402	1.353583	0.01428145	0.05394950	0.00000000	0.05394950	0.00000000	-2.6769330	0.01253750	0.07016667	0.00000000	-0.07016667	0.70729412	0.01782194		FALSE

Note:
- The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

All exons whithin this gene region are shown and numbering below.

All isoforms whithin this gene region are shown below.

Rows: 1-10 / 35
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featureID
exonBaseMean
dispersion
pvalue
padj
seqnames
start
end
width
strand
HEK293_TMG_6hB
HEK293_OSMI2_6hA
log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
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groupID	featureID	exonBaseMean	dispersion	pvalue	padj	seqnames	start	end	width	strand	HEK293_TMG_6hB	HEK293_OSMI2_6hA	log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB

ENSG00000069667	E001	104.3108951	0.019224160	4.693487e-02	1.724123e-01	15	60488284	60497263	8980	-	1.939	1.829	-0.368
ENSG00000069667	E002	1.3309947	0.015724838	6.798154e-01		15	60497264	60497284	21	-	0.320	0.223	-0.700
ENSG00000069667	E003	8.6125853	0.003960207	5.490148e-01	7.356308e-01	15	60497285	60497619	335	-	0.903	0.804	-0.382
ENSG00000069667	E004	6.5142535	0.006250071	5.404300e-02	1.891694e-01	15	60499892	60500004	113	-	0.829	0.479	-1.514
ENSG00000069667	E005	5.1439089	0.006303726	1.639891e-01	3.826162e-01	15	60500959	60501069	111	-	0.741	0.479	-1.164
ENSG00000069667	E006	4.2737457	0.007710989	3.544312e-01	5.912223e-01	15	60502760	60502867	108	-	0.661	0.479	-0.832
ENSG00000069667	E007	5.5905573	0.006179886	7.224703e-01	8.496158e-01	15	60503535	60503667	133	-	0.716	0.755	0.161
ENSG00000069667	E008	5.2454469	0.006069684	3.938462e-01	6.234154e-01	15	60505508	60505605	98	-	0.689	0.803	0.463
ENSG00000069667	E009	3.8217799	0.111802956	6.253026e-01	7.875026e-01	15	60505606	60505629	24	-	0.595	0.691	0.411
ENSG00000069667	E010	6.5038379	0.067116280	3.599773e-01	5.957165e-01	15	60511226	60511293	68	-	0.764	0.913	0.578
ENSG00000069667	E011	8.0556171	0.031362471	6.427616e-01	7.986836e-01	15	60511294	60511456	163	-	0.865	0.920	0.209
ENSG00000069667	E012	4.6015714	0.019650157	5.519569e-01	7.376700e-01	15	60511457	60511591	135	-	0.688	0.567	-0.527
ENSG00000069667	E013	2.4703406	0.010092561	1.654875e-01	3.845293e-01	15	60511592	60511621	30	-	0.522	0.223	-1.798
ENSG00000069667	E014	0.1779838	0.033295494	1.000000e+00		15	60512033	60512097	65	-	0.063	0.000	-9.302
ENSG00000069667	E015	4.1127601	0.006988559	8.936270e-01	9.484912e-01	15	60514616	60514757	142	-	0.629	0.638	0.039
ENSG00000069667	E016	0.7366858	0.518070913	6.268477e-01		15	60528073	60531527	3455	-	0.172	0.229	0.517
ENSG00000069667	E017	0.3206185	0.027442404	1.000000e+00		15	60531528	60531765	238	-	0.117	0.000	-10.266
ENSG00000069667	E018	2.0032590	0.011610106	9.168980e-02	2.668375e-01	15	60531766	60531851	86	-	0.351	0.638	1.429
ENSG00000069667	E019	0.0000000				15	60556853	60556928	76	-
ENSG00000069667	E020	0.0000000				15	60558225	60558306	82	-
ENSG00000069667	E021	0.9091303	0.044272794	3.849613e-01		15	60592387	60592541	155	-	0.209	0.369	1.111
ENSG00000069667	E022	0.4458772	0.023603869	6.504101e-02		15	60592808	60593126	319	-	0.063	0.369	3.109
ENSG00000069667	E023	0.0000000				15	60614894	60615027	134	-
ENSG00000069667	E024	0.0000000				15	60627238	60627463	226	-
ENSG00000069667	E025	0.0000000				15	60650621	60650708	88	-
ENSG00000069667	E026	0.0000000				15	60677109	60677150	42	-
ENSG00000069667	E027	0.0000000				15	60677151	60677232	82	-
ENSG00000069667	E028	0.0000000				15	60677233	60677272	40	-
ENSG00000069667	E029	0.0000000				15	60678224	60678656	433	-
ENSG00000069667	E030	0.4868358	0.142008757	5.230439e-01		15	60678657	60678686	30	-	0.119	0.221	1.081
ENSG00000069667	E031	0.0000000				15	60706232	60706352	121	-
ENSG00000069667	E032	0.0000000				15	61038826	61039127	302	-
ENSG00000069667	E033	0.1723744	0.040075087	8.867553e-02		15	61041104	61041134	31	-	0.000	0.223	12.149
ENSG00000069667	E034	2.3489176	0.033511787	1.783271e-03	1.558784e-02	15	61176068	61176456	389	-	0.286	0.805	2.531
ENSG00000069667	E035	3.0754319	0.009029604	5.166416e-08	2.053303e-06	15	61229053	61229302	250	-	0.250	1.042	3.689

Isoforom Switch Analysis

WANG Ziyi

Date: 19 5月 2022

ENSG00000069667

1 Isoform Switch

TableFilter v0.7.3

2 Differential Exon Usage

TableFilter v0.7.3