ENSG00000068878

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000404125 ENSG00000068878 HEK293_OSMI2_6hA HEK293_TMG_6hB PSME4 protein_coding protein_coding 25.60365 16.15837 38.1456 4.438289 2.394595 1.23872 3.609184 2.322014 4.966685 0.7815402 0.3096327 1.0936083 0.1436042 0.1379667 0.1319000 -0.006066667 9.660093e-01 6.692288e-05 FALSE TRUE
ENST00000476586 ENSG00000068878 HEK293_OSMI2_6hA HEK293_TMG_6hB PSME4 protein_coding processed_transcript 25.60365 16.15837 38.1456 4.438289 2.394595 1.23872 10.720862 8.578937 11.709134 2.5864443 1.2189457 0.4483144 0.4569542 0.5197000 0.3053667 -0.214333333 6.692288e-05 6.692288e-05 FALSE TRUE
MSTRG.18404.5 ENSG00000068878 HEK293_OSMI2_6hA HEK293_TMG_6hB PSME4 protein_coding   25.60365 16.15837 38.1456 4.438289 2.394595 1.23872 3.307766 1.048897 6.628446 0.1689940 0.5888351 2.6482830 0.1134417 0.0736000 0.1733667 0.099766667 3.896097e-02 6.692288e-05 FALSE TRUE
MSTRG.18404.6 ENSG00000068878 HEK293_OSMI2_6hA HEK293_TMG_6hB PSME4 protein_coding   25.60365 16.15837 38.1456 4.438289 2.394595 1.23872 6.877812 3.166297 13.310554 0.6585416 0.7140181 2.0682366 0.2421792 0.2062333 0.3496333 0.143400000 1.552274e-02 6.692288e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000068878 E001 19.7452503 0.4508560890 1.028621e-01 2.868932e-01 2 53864069 53864433 365 - 1.085 1.556 1.647
ENSG00000068878 E002 22.8857783 0.5166320805 1.348317e-01 3.394137e-01 2 53864434 53864860 427 - 1.155 1.606 1.566
ENSG00000068878 E003 7.8756089 0.2995575095 8.520260e-02 2.550026e-01 2 53864861 53864869 9 - 0.683 1.216 2.014
ENSG00000068878 E004 24.2131466 0.5900183568 2.234590e-01 4.575195e-01 2 53864870 53864913 44 - 1.199 1.608 1.417
ENSG00000068878 E005 73.3179511 0.9085169438 2.391587e-01 4.756258e-01 2 53864914 53864978 65 - 1.652 2.092 1.481
ENSG00000068878 E006 177.7002994 1.4761336244 3.609851e-01 5.964601e-01 2 53864979 53865152 174 - 2.049 2.455 1.356
ENSG00000068878 E007 316.2544412 1.6699764793 3.891723e-01 6.198398e-01 2 53865153 53865573 421 - 2.305 2.697 1.306
ENSG00000068878 E008 16.7997757 0.0819897458 5.111479e-01 7.088545e-01 2 53865574 53866084 511 - 1.155 1.298 0.505
ENSG00000068878 E009 133.9459190 0.0663158880 1.049135e-02 6.022217e-02 2 53866085 53866147 63 - 1.955 2.301 1.159
ENSG00000068878 E010 145.2312216 0.0131020631 1.005446e-04 1.502137e-03 2 53866148 53866223 76 - 2.013 2.305 0.978
ENSG00000068878 E011 178.7514313 0.0003593407 4.208014e-09 2.148579e-07 2 53866747 53866880 134 - 2.126 2.352 0.753
ENSG00000068878 E012 7.0828143 0.0396054728 3.626308e-01 5.978530e-01 2 53869364 53869375 12 - 0.791 0.989 0.756
ENSG00000068878 E013 172.6819404 0.0037067522 7.815813e-04 8.130006e-03 2 53869376 53869538 163 - 2.119 2.321 0.676
ENSG00000068878 E014 10.7905242 0.1375918037 5.764885e-01 7.547746e-01 2 53869539 53870960 1422 - 0.974 1.132 0.577
ENSG00000068878 E015 182.5471656 0.0046088618 4.278713e-03 3.071626e-02 2 53874339 53874494 156 - 2.150 2.332 0.608
ENSG00000068878 E016 172.9625024 0.0039623337 9.279578e-04 9.321228e-03 2 53875627 53875755 129 - 2.122 2.317 0.653
ENSG00000068878 E017 0.0000000       2 53881456 53881508 53 -      
ENSG00000068878 E018 147.4238333 0.0008432383 5.948182e-02 2.016405e-01 2 53885690 53885775 86 - 2.080 2.200 0.403
ENSG00000068878 E019 193.5900105 0.0003309891 6.696322e-01 8.160554e-01 2 53887259 53887416 158 - 2.214 2.283 0.233
ENSG00000068878 E020 115.8583627 0.0059527997 9.945967e-01 9.988905e-01 2 53887417 53887467 51 - 1.992 2.059 0.223
ENSG00000068878 E021 161.9283583 0.0104478921 9.736291e-01 9.887435e-01 2 53887858 53887989 132 - 2.134 2.214 0.267
ENSG00000068878 E022 0.9806365 0.0178949934 9.538094e-02   2 53887990 53888320 331 - 0.331 0.000 -11.568
ENSG00000068878 E023 129.6395389 0.0010775088 3.060644e-01 5.467269e-01 2 53888721 53888812 92 - 2.035 2.132 0.325
ENSG00000068878 E024 123.3479111 0.0038789383 5.009217e-02 1.798973e-01 2 53890104 53890208 105 - 1.993 2.147 0.517
ENSG00000068878 E025 158.8851602 0.0017175973 7.460679e-02 2.339917e-01 2 53892808 53892960 153 - 2.113 2.238 0.420
ENSG00000068878 E026 116.2884299 0.0003684240 3.908491e-01 6.210212e-01 2 53893674 53893799 126 - 2.009 2.034 0.085
ENSG00000068878 E027 105.4241111 0.0004368868 1.420723e-01 3.505324e-01 2 53895007 53895076 70 - 1.976 1.975 -0.002
ENSG00000068878 E028 179.9970697 0.0006986802 2.401246e-01 4.767429e-01 2 53895583 53895736 154 - 2.197 2.219 0.072
ENSG00000068878 E029 128.5758177 0.0037378613 9.628110e-02 2.752234e-01 2 53896804 53896885 82 - 2.060 2.044 -0.052
ENSG00000068878 E030 144.1427819 0.0084708230 6.456664e-01 8.005974e-01 2 53897870 53897999 130 - 2.096 2.128 0.108
ENSG00000068878 E031 92.0883337 0.0044391720 6.542156e-01 8.062120e-01 2 53898301 53898354 54 - 1.902 1.936 0.115
ENSG00000068878 E032 139.8802819 0.0023733202 1.874185e-02 9.152933e-02 2 53899881 53900017 137 - 2.101 2.061 -0.134
ENSG00000068878 E033 172.4848344 0.0059766036 1.258627e-01 3.252522e-01 2 53901350 53901559 210 - 2.189 2.171 -0.061
ENSG00000068878 E034 132.8321955 0.0155177051 9.308343e-02 2.694453e-01 2 53904025 53904156 132 - 2.088 2.020 -0.229
ENSG00000068878 E035 125.6323954 0.0061249933 5.928618e-04 6.516606e-03 2 53906598 53906693 96 - 2.076 1.952 -0.415
ENSG00000068878 E036 113.2995656 0.0065939618 1.502099e-02 7.815767e-02 2 53906806 53906868 63 - 2.020 1.945 -0.250
ENSG00000068878 E037 0.4466850 0.0226926641 3.635731e-01   2 53907973 53908319 347 - 0.196 0.000 -10.565
ENSG00000068878 E038 127.4491732 0.0015855200 1.241441e-04 1.788626e-03 2 53908320 53908418 99 - 2.077 1.978 -0.331
ENSG00000068878 E039 101.8297320 0.0055412946 1.444455e-02 7.604808e-02 2 53908510 53908565 56 - 1.972 1.896 -0.256
ENSG00000068878 E040 111.0749239 0.0283575980 3.980968e-01 6.268111e-01 2 53908784 53908840 57 - 2.000 1.972 -0.093
ENSG00000068878 E041 0.5255656 0.2095814024 8.338532e-01   2 53908841 53908843 3 - 0.140 0.192 0.541
ENSG00000068878 E042 107.9726671 0.0182474536 1.865394e-01 4.124828e-01 2 53910075 53910130 56 - 1.994 1.940 -0.180
ENSG00000068878 E043 128.6343813 0.0049260599 1.261123e-02 6.889189e-02 2 53919151 53919246 96 - 2.072 2.004 -0.228
ENSG00000068878 E044 154.2265255 0.0041172060 1.886234e-02 9.198201e-02 2 53920193 53920350 158 - 2.148 2.101 -0.157
ENSG00000068878 E045 137.0868561 0.0028153497 2.922185e-05 5.275372e-04 2 53920889 53921104 216 - 2.115 1.992 -0.414
ENSG00000068878 E046 65.6570950 0.0005462043 2.573624e-02 1.144977e-01 2 53922517 53922584 68 - 1.783 1.728 -0.186
ENSG00000068878 E047 56.7438894 0.0007726719 2.527882e-02 1.130576e-01 2 53923049 53923118 70 - 1.727 1.661 -0.222
ENSG00000068878 E048 72.8876868 0.0007236905 3.717229e-02 1.473605e-01 2 53923321 53923419 99 - 1.827 1.783 -0.150
ENSG00000068878 E049 122.5390290 0.0030798756 2.587787e-03 2.088721e-02 2 53925539 53925689 151 - 2.056 1.973 -0.279
ENSG00000068878 E050 88.1564506 0.0045728761 2.352815e-03 1.939527e-02 2 53925959 53926023 65 - 1.920 1.808 -0.380
ENSG00000068878 E051 101.7598845 0.0004831313 6.761152e-06 1.494856e-04 2 53927394 53927483 90 - 1.987 1.855 -0.445
ENSG00000068878 E052 129.9203081 0.0003782000 7.789258e-08 2.969904e-06 2 53928117 53928303 187 - 2.098 1.955 -0.479
ENSG00000068878 E053 117.2228563 0.0034722689 1.267434e-06 3.487919e-05 2 53931835 53932055 221 - 2.059 1.885 -0.587
ENSG00000068878 E054 48.0093808 0.0008575689 1.756629e-04 2.399775e-03 2 53932056 53932100 45 - 1.679 1.507 -0.586
ENSG00000068878 E055 57.6411800 0.0007638552 1.685736e-08 7.523697e-07 2 53932668 53932760 93 - 1.774 1.500 -0.931
ENSG00000068878 E056 0.1614157 0.0338175126 1.000000e+00   2 53932761 53933169 409 - 0.076 0.000 -8.983
ENSG00000068878 E057 75.0402434 0.0010957064 1.876238e-05 3.619542e-04 2 53934605 53934727 123 - 1.867 1.710 -0.532
ENSG00000068878 E058 38.9676461 0.0011031930 4.790513e-03 3.347898e-02 2 53936087 53936094 8 - 1.583 1.452 -0.449
ENSG00000068878 E059 66.6623894 0.0056740512 1.600963e-06 4.290364e-05 2 53936095 53936161 67 - 1.831 1.574 -0.870
ENSG00000068878 E060 71.3521916 0.0067134120 2.331778e-07 7.886667e-06 2 53936764 53936827 64 - 1.866 1.579 -0.970
ENSG00000068878 E061 93.6164388 0.0075701024 2.579704e-04 3.303371e-03 2 53937391 53937540 150 - 1.963 1.791 -0.579
ENSG00000068878 E062 53.3534953 0.0021933707 1.579593e-04 2.194643e-03 2 53939956 53940000 45 - 1.726 1.549 -0.602
ENSG00000068878 E063 0.7499275 0.0177290849 5.778284e-01   2 53942159 53942224 66 - 0.196 0.321 0.939
ENSG00000068878 E064 74.2332003 0.0005611302 2.194755e-09 1.198841e-07 2 53948421 53948537 117 - 1.877 1.629 -0.840
ENSG00000068878 E065 66.3333187 0.0014986933 1.138345e-05 2.343238e-04 2 53949143 53949283 141 - 1.816 1.634 -0.617
ENSG00000068878 E066 46.9908247 0.0008360992 7.024705e-01 8.371307e-01 2 53970543 53971017 475 - 1.622 1.656 0.115