ENSG00000068615

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000165698 ENSG00000068615 HEK293_OSMI2_6hA HEK293_TMG_6hB REEP1 protein_coding protein_coding 7.74461 4.996875 8.098562 0.7818736 0.1018912 0.6955356 3.664582 1.436741 5.5757621 0.4397087 0.2244795 1.94894753 0.4493375 0.2770667 0.6891667 0.4121000 0.003650555 0.003650555 FALSE TRUE
ENST00000489855 ENSG00000068615 HEK293_OSMI2_6hA HEK293_TMG_6hB REEP1 protein_coding protein_coding 7.74461 4.996875 8.098562 0.7818736 0.1018912 0.6955356 2.709493 2.081583 2.0195237 0.2055010 0.1089739 -0.04345377 0.3608792 0.4258667 0.2491333 -0.1767333 0.032790494 0.003650555 FALSE TRUE
MSTRG.18793.21 ENSG00000068615 HEK293_OSMI2_6hA HEK293_TMG_6hB REEP1 protein_coding   7.74461 4.996875 8.098562 0.7818736 0.1018912 0.6955356 1.086023 1.149008 0.3368426 0.4417182 0.1686136 -1.74053762 0.1488542 0.2248000 0.0412000 -0.1836000 0.290265230 0.003650555 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000068615 E001 25.7682238 0.019496043 4.636041e-01 6.755355e-01 2 86213993 86214250 258 - 1.371 1.460 0.309
ENSG00000068615 E002 90.4723868 0.010285025 7.546787e-01 8.694889e-01 2 86214251 86215038 788 - 1.933 1.933 -0.001
ENSG00000068615 E003 6.8148638 0.074824620 8.733790e-01 9.378369e-01 2 86215039 86215056 18 - 0.873 0.828 -0.175
ENSG00000068615 E004 7.1534554 0.124025938 8.304000e-01 9.140101e-01 2 86215057 86215063 7 - 0.877 0.885 0.031
ENSG00000068615 E005 7.3148711 0.129065404 8.760545e-01 9.392539e-01 2 86215064 86215067 4 - 0.890 0.885 -0.018
ENSG00000068615 E006 8.1224453 0.158033452 6.968885e-01 8.335420e-01 2 86215068 86215095 28 - 0.916 0.968 0.194
ENSG00000068615 E007 11.7788475 0.038105931 8.342830e-01 9.161701e-01 2 86215096 86215155 60 - 1.067 1.091 0.087
ENSG00000068615 E008 25.5076288 0.045913725 8.691576e-02 2.580922e-01 2 86215156 86215318 163 - 1.450 1.257 -0.670
ENSG00000068615 E009 35.6760152 0.021039937 1.205572e-02 6.667117e-02 2 86215319 86215617 299 - 1.596 1.387 -0.719
ENSG00000068615 E010 107.1619399 0.002287162 3.028359e-13 3.430854e-11 2 86215618 86216516 899 - 2.081 1.781 -1.010
ENSG00000068615 E011 17.0805647 0.002724762 2.371260e-04 3.078704e-03 2 86216517 86216553 37 - 1.312 0.958 -1.273
ENSG00000068615 E012 14.2658352 0.005436454 5.049012e-03 3.489068e-02 2 86216554 86216580 27 - 1.225 0.935 -1.055
ENSG00000068615 E013 24.1231261 0.003151841 7.490949e-04 7.853173e-03 2 86216581 86216793 213 - 1.440 1.169 -0.946
ENSG00000068615 E014 10.3391898 0.003279249 7.671938e-02 2.382022e-01 2 86216794 86216839 46 - 1.077 0.884 -0.718
ENSG00000068615 E015 27.2781743 0.001637484 7.526618e-03 4.715013e-02 2 86216840 86217110 271 - 1.479 1.290 -0.653
ENSG00000068615 E016 0.4458772 0.021768165 2.236765e-01   2 86219970 86220121 152 - 0.086 0.290 2.117
ENSG00000068615 E017 0.0000000       2 86220122 86220140 19 -      
ENSG00000068615 E018 0.1723744 0.050496204 2.264943e-01   2 86223075 86223268 194 - 0.000 0.169 13.184
ENSG00000068615 E019 0.0000000       2 86223269 86223275 7 -      
ENSG00000068615 E020 0.3751086 0.030152589 6.314080e-02   2 86223489 86223785 297 - 0.000 0.291 14.286
ENSG00000068615 E021 1.0175630 0.015575284 1.047240e-02   2 86224700 86225347 648 - 0.086 0.529 3.439
ENSG00000068615 E022 0.4644705 0.021768165 1.811179e-02   2 86225348 86225589 242 - 0.000 0.384 14.898
ENSG00000068615 E023 0.5171231 1.088549847 2.170966e-01   2 86227363 86227398 36 - 0.000 0.394 13.053
ENSG00000068615 E024 14.3844553 0.003470905 2.207514e-01 4.543474e-01 2 86232625 86232675 51 - 1.201 1.093 -0.387
ENSG00000068615 E025 13.2346280 0.002429609 5.430999e-01 7.312629e-01 2 86232676 86232733 58 - 1.144 1.093 -0.181
ENSG00000068615 E026 16.7017049 0.002353155 7.800292e-01 8.847642e-01 2 86232734 86232802 69 - 1.225 1.209 -0.055
ENSG00000068615 E027 0.0000000       2 86239922 86240020 99 -      
ENSG00000068615 E028 0.0000000       2 86240021 86240071 51 -      
ENSG00000068615 E029 3.0475797 0.206868616 3.197240e-02 1.331319e-01 2 86247943 86248071 129 - 0.323 0.849 2.459
ENSG00000068615 E030 30.8879163 0.001338745 6.874062e-11 5.029616e-09 2 86251352 86251956 605 - 1.297 1.711 1.418
ENSG00000068615 E031 45.2368805 0.010026344 8.207170e-04 8.449995e-03 2 86251957 86252070 114 - 1.544 1.773 0.779
ENSG00000068615 E032 47.6738474 0.012698574 2.919575e-03 2.291814e-02 2 86254694 86254814 121 - 1.578 1.790 0.717
ENSG00000068615 E033 0.1308682 0.032649190 2.278411e-01   2 86254815 86255018 204 - 0.000 0.169 13.299
ENSG00000068615 E034 26.1480529 0.010181125 4.264197e-02 1.616354e-01 2 86263965 86263993 29 - 1.342 1.511 0.585
ENSG00000068615 E035 25.9016155 0.012307662 1.180897e-02 6.567013e-02 2 86263994 86264041 48 - 1.315 1.532 0.748
ENSG00000068615 E036 20.5261893 0.005782832 3.589819e-04 4.326930e-03 2 86282170 86282242 73 - 1.188 1.484 1.030
ENSG00000068615 E037 0.3503582 0.042471151 5.774495e-01   2 86336722 86337065 344 - 0.086 0.169 1.117
ENSG00000068615 E038 0.0000000       2 86337348 86337478 131 -      
ENSG00000068615 E039 12.4588128 0.004226954 5.479230e-05 9.009481e-04 2 86337479 86337658 180 - 0.938 1.331 1.414
ENSG00000068615 E040 0.0000000       2 86338024 86338083 60 -