ENSG00000068438

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000348411 ENSG00000068438 HEK293_OSMI2_6hA HEK293_TMG_6hB FTSJ1 protein_coding protein_coding 54.50053 63.29581 34.52003 6.828348 0.4762218 -0.8744864 27.995539 25.829833 18.799063 1.9249325 0.4628084 -0.45816875 0.51854583 0.4133000 0.54516667 0.13186667 2.047294e-01 2.683724e-18 FALSE TRUE
ENST00000466371 ENSG00000068438 HEK293_OSMI2_6hA HEK293_TMG_6hB FTSJ1 protein_coding processed_transcript 54.50053 63.29581 34.52003 6.828348 0.4762218 -0.8744864 8.328371 12.716531 2.026889 2.5517998 0.4028871 -2.64339992 0.13810417 0.1964333 0.05850000 -0.13793333 1.806845e-03 2.683724e-18 FALSE TRUE
ENST00000467954 ENSG00000068438 HEK293_OSMI2_6hA HEK293_TMG_6hB FTSJ1 protein_coding processed_transcript 54.50053 63.29581 34.52003 6.828348 0.4762218 -0.8744864 5.182677 4.329208 4.521017 0.9029869 0.2650455 0.06240291 0.09967083 0.0688000 0.13110000 0.06230000 1.375273e-01 2.683724e-18 TRUE FALSE
MSTRG.34199.1 ENSG00000068438 HEK293_OSMI2_6hA HEK293_TMG_6hB FTSJ1 protein_coding   54.50053 63.29581 34.52003 6.828348 0.4762218 -0.8744864 2.441279 1.083770 3.299943 0.2470336 0.3560160 1.59749730 0.05010417 0.0183000 0.09556667 0.07726667 2.371765e-03 2.683724e-18 FALSE TRUE
MSTRG.34199.4 ENSG00000068438 HEK293_OSMI2_6hA HEK293_TMG_6hB FTSJ1 protein_coding   54.50053 63.29581 34.52003 6.828348 0.4762218 -0.8744864 3.400525 9.901742 0.000000 2.8099129 0.0000000 -9.95299485 0.05593750 0.1509000 0.00000000 -0.15090000 2.683724e-18 2.683724e-18 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000068438 E001 0.1779838 0.0340522648 2.383065e-01   X 48475967 48476020 54 + 0.169 0.000 -9.556
ENSG00000068438 E002 2.4206114 0.0963678669 4.856612e-02 0.1763128982 X 48476021 48476152 132 + 0.725 0.326 -1.943
ENSG00000068438 E003 4.5339889 0.0056278731 2.061924e-04 0.0027424972 X 48476153 48476160 8 + 1.000 0.474 -2.187
ENSG00000068438 E004 22.3929118 0.0014996369 1.188939e-02 0.0659725899 X 48476161 48476198 38 + 1.469 1.264 -0.713
ENSG00000068438 E005 24.0465118 0.0014245268 8.276476e-02 0.2502378567 X 48476199 48476202 4 + 1.462 1.317 -0.501
ENSG00000068438 E006 65.1925835 0.0006733687 1.530387e-02 0.0792169163 X 48476203 48476217 15 + 1.875 1.745 -0.436
ENSG00000068438 E007 172.9424187 0.0035477029 2.884225e-01 0.5291509833 X 48476218 48476259 42 + 2.193 2.218 0.083
ENSG00000068438 E008 313.3354328 0.0034556592 9.734883e-01 0.9886652253 X 48476260 48476396 137 + 2.478 2.461 -0.056
ENSG00000068438 E009 5.1315698 0.0059515404 2.972606e-01 0.5377601023 X 48476563 48476668 106 + 0.855 0.695 -0.638
ENSG00000068438 E010 227.3015170 0.0025991698 6.754396e-01 0.8198327609 X 48477961 48478009 49 + 2.350 2.317 -0.110
ENSG00000068438 E011 358.7291223 0.0004017022 2.626167e-01 0.5018340096 X 48478010 48478168 159 + 2.522 2.527 0.015
ENSG00000068438 E012 19.7427614 0.1507457116 2.331937e-01 0.4688417391 X 48478169 48478448 280 + 1.404 1.218 -0.650
ENSG00000068438 E013 221.7260806 0.0008919067 1.333501e-01 0.3370274578 X 48478449 48478518 70 + 2.299 2.323 0.081
ENSG00000068438 E014 206.4178047 0.0002474023 6.590039e-01 0.8094020264 X 48478617 48478680 64 + 2.289 2.281 -0.025
ENSG00000068438 E015 162.7680280 0.0003567584 1.410900e-01 0.3491635871 X 48478681 48478707 27 + 2.166 2.192 0.086
ENSG00000068438 E016 211.2659477 0.0015228092 5.876138e-02 0.1999886590 X 48479038 48479116 79 + 2.265 2.307 0.139
ENSG00000068438 E017 138.9224778 0.0003600282 2.558371e-01 0.4945253088 X 48481151 48481164 14 + 2.102 2.121 0.061
ENSG00000068438 E018 153.5786748 0.0002980303 1.512555e-03 0.0137017469 X 48481165 48481203 39 + 2.099 2.180 0.270
ENSG00000068438 E019 167.3164040 0.0003015751 7.064156e-03 0.0449208476 X 48481289 48481342 54 + 2.150 2.212 0.207
ENSG00000068438 E020 195.6241861 0.0002551333 9.558068e-03 0.0562212857 X 48481426 48481481 56 + 2.222 2.275 0.175
ENSG00000068438 E021 206.0367467 0.0003080262 2.497786e-02 0.1121550074 X 48481482 48481528 47 + 2.252 2.294 0.139
ENSG00000068438 E022 31.2446253 0.0223261832 9.858374e-01 0.9947415846 X 48481529 48481631 103 + 1.489 1.470 -0.066
ENSG00000068438 E023 247.2292566 0.0002140544 2.219346e-01 0.4558249937 X 48481632 48481715 84 + 2.354 2.364 0.035
ENSG00000068438 E024 106.5369177 0.0003736885 6.360877e-01 0.7943518628 X 48482403 48482408 6 + 1.998 1.996 -0.006
ENSG00000068438 E025 151.9110639 0.0003176408 4.428441e-01 0.6606327048 X 48482409 48482419 11 + 2.147 2.152 0.015
ENSG00000068438 E026 244.7646308 0.0002007113 8.932942e-01 0.9482968681 X 48482420 48482506 87 + 2.368 2.352 -0.054
ENSG00000068438 E027 371.2945442 0.0002251192 2.042140e-01 0.4349530236 X 48482597 48482794 198 + 2.533 2.539 0.019
ENSG00000068438 E028 126.6129718 0.0014571023 4.092767e-03 0.0296913975 X 48482795 48482985 191 + 2.006 2.098 0.307
ENSG00000068438 E029 146.4637484 0.0096594591 1.185336e-02 0.0658350648 X 48482986 48483027 42 + 2.237 2.077 -0.535
ENSG00000068438 E030 7.3539247 0.1115558223 1.751378e-03 0.0153798771 X 48483241 48483252 12 + 1.197 0.617 -2.231
ENSG00000068438 E031 12.1499525 0.2047370760 6.120666e-03 0.0403145420 X 48483253 48483341 89 + 1.392 0.821 -2.073
ENSG00000068438 E032 465.2604390 0.0064502254 3.586293e-05 0.0006281301 X 48485736 48486364 629 + 2.752 2.568 -0.610