ENSG00000067596

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262415 ENSG00000067596 HEK293_OSMI2_6hA HEK293_TMG_6hB DHX8 protein_coding protein_coding 44.73687 54.69255 36.48185 7.143267 1.45493 -0.5840338 15.272829 20.705389 11.107429 2.9254553 0.8449401 -0.8978797 0.3361292 0.37750000 0.3037000 -0.07380000 1.925561e-01 8.414656e-08 FALSE TRUE
ENST00000587574 ENSG00000067596 HEK293_OSMI2_6hA HEK293_TMG_6hB DHX8 protein_coding protein_coding 44.73687 54.69255 36.48185 7.143267 1.45493 -0.5840338 15.431549 21.793723 7.802882 1.6708968 0.5961586 -1.4806477 0.3252500 0.40406667 0.2132667 -0.19080000 2.423406e-05 8.414656e-08   FALSE
MSTRG.14413.14 ENSG00000067596 HEK293_OSMI2_6hA HEK293_TMG_6hB DHX8 protein_coding   44.73687 54.69255 36.48185 7.143267 1.45493 -0.5840338 3.495771 2.280862 4.378959 0.3934107 0.1137586 0.9379879 0.0849625 0.04136667 0.1205000 0.07913333 8.414656e-08 8.414656e-08 FALSE TRUE
MSTRG.14413.7 ENSG00000067596 HEK293_OSMI2_6hA HEK293_TMG_6hB DHX8 protein_coding   44.73687 54.69255 36.48185 7.143267 1.45493 -0.5840338 7.841633 7.424937 9.230553 1.5029949 0.2795462 0.3136588 0.1869625 0.13316667 0.2533667 0.12020000 2.029801e-04 8.414656e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000067596 E001 1.0289696 0.1103553239 2.304375e-01   17 43483865 43483950 86 + 0.413 0.185 -1.585
ENSG00000067596 E002 2.3103618 0.1832135815 4.519315e-01 6.670847e-01 17 43483951 43483959 9 + 0.581 0.423 -0.772
ENSG00000067596 E003 2.4412300 0.1150576468 5.349941e-01 7.256038e-01 17 43483960 43483962 3 + 0.579 0.460 -0.566
ENSG00000067596 E004 2.4412300 0.1150576468 5.349941e-01 7.256038e-01 17 43483963 43483963 1 + 0.579 0.460 -0.566
ENSG00000067596 E005 4.8208150 0.0062328447 8.739812e-01 9.381750e-01 17 43483964 43483972 9 + 0.757 0.741 -0.068
ENSG00000067596 E006 4.9931893 0.0058120787 9.925441e-01 9.979386e-01 17 43483973 43483974 2 + 0.757 0.761 0.015
ENSG00000067596 E007 4.9931893 0.0058120787 9.925441e-01 9.979386e-01 17 43483975 43483976 2 + 0.757 0.761 0.015
ENSG00000067596 E008 9.5807749 0.0086180587 8.506878e-01 9.254186e-01 17 43483977 43483983 7 + 0.985 1.013 0.103
ENSG00000067596 E009 146.2280097 0.0003305018 1.503526e-06 4.054839e-05 17 43483984 43484139 156 + 2.234 2.096 -0.463
ENSG00000067596 E010 141.8953330 0.0003563657 2.116021e-05 4.008802e-04 17 43484140 43484185 46 + 2.215 2.091 -0.414
ENSG00000067596 E011 138.5259833 0.0003969967 8.000579e-05 1.241599e-03 17 43489449 43489534 86 + 2.199 2.083 -0.389
ENSG00000067596 E012 122.3122963 0.0051596266 6.154625e-03 4.048483e-02 17 43490391 43490463 73 + 2.147 2.029 -0.396
ENSG00000067596 E013 0.3453689 0.0265809031 7.676973e-01   17 43490464 43490493 30 + 0.144 0.102 -0.565
ENSG00000067596 E014 93.1286012 0.0008103152 2.138083e-05 4.046085e-04 17 43491165 43491193 29 + 2.049 1.891 -0.528
ENSG00000067596 E015 117.0375587 0.0015631696 1.751434e-05 3.412112e-04 17 43491194 43491250 57 + 2.144 1.990 -0.516
ENSG00000067596 E016 170.3900613 0.0003300336 1.992068e-07 6.871806e-06 17 43492183 43492292 110 + 2.299 2.160 -0.467
ENSG00000067596 E017 94.0328918 0.0005301446 7.301081e-05 1.150071e-03 17 43492681 43492686 6 + 2.046 1.903 -0.479
ENSG00000067596 E018 327.8983174 0.0001697114 1.979036e-12 1.931528e-10 17 43492687 43493040 354 + 2.580 2.445 -0.449
ENSG00000067596 E019 204.5078141 0.0009103317 1.699719e-04 2.333856e-03 17 43493445 43493589 145 + 2.359 2.258 -0.337
ENSG00000067596 E020 265.6257727 0.0002019452 6.594818e-06 1.464947e-04 17 43493683 43493886 204 + 2.468 2.373 -0.316
ENSG00000067596 E021 163.6814219 0.0041724043 5.342143e-02 1.877058e-01 17 43496181 43496268 88 + 2.242 2.175 -0.224
ENSG00000067596 E022 183.8026092 0.0004340470 1.647058e-03 1.464901e-02 17 43498862 43498959 98 + 2.297 2.216 -0.271
ENSG00000067596 E023 246.3241589 0.0002038550 2.031653e-06 5.293364e-05 17 43499956 43500103 148 + 2.439 2.334 -0.347
ENSG00000067596 E024 262.8821734 0.0006322170 1.080766e-04 1.595019e-03 17 43504644 43504825 182 + 2.462 2.374 -0.296
ENSG00000067596 E025 312.7226074 0.0002179853 2.219500e-03 1.852015e-02 17 43507003 43507197 195 + 2.517 2.459 -0.194
ENSG00000067596 E026 315.7291436 0.0002888368 1.294289e-02 7.022588e-02 17 43507503 43507688 186 + 2.514 2.467 -0.156
ENSG00000067596 E027 312.9790972 0.0007551488 1.095589e-01 2.983392e-01 17 43507809 43508019 211 + 2.501 2.470 -0.103
ENSG00000067596 E028 262.9776797 0.0006162764 9.572875e-01 9.804858e-01 17 43508339 43508520 182 + 2.401 2.410 0.029
ENSG00000067596 E029 269.3448153 0.0002175470 8.404864e-01 9.196942e-01 17 43513362 43513502 141 + 2.416 2.417 0.004
ENSG00000067596 E030 291.6435853 0.0002236447 9.450535e-02 2.720984e-01 17 43517167 43517322 156 + 2.426 2.468 0.141
ENSG00000067596 E031 4.0188632 0.3090361821 2.482534e-01 4.860403e-01 17 43517323 43520129 2807 + 0.814 0.579 -0.981
ENSG00000067596 E032 262.5637652 0.0001917357 8.810880e-02 2.602379e-01 17 43520130 43520267 138 + 2.379 2.423 0.149
ENSG00000067596 E033 210.3254094 0.0005494162 1.525586e-01 3.659938e-01 17 43520751 43520879 129 + 2.283 2.328 0.151
ENSG00000067596 E034 143.6281799 0.0003826591 5.225703e-02 1.849729e-01 17 43521369 43521395 27 + 2.106 2.172 0.223
ENSG00000067596 E035 292.3051235 0.0001983689 6.754139e-05 1.076801e-03 17 43521396 43521565 170 + 2.396 2.489 0.310
ENSG00000067596 E036 237.1656352 0.0002154924 2.409265e-04 3.119937e-03 17 43522047 43522151 105 + 2.304 2.399 0.317
ENSG00000067596 E037 216.0609765 0.0030305693 5.161539e-03 3.546256e-02 17 43522152 43522226 75 + 2.257 2.368 0.368
ENSG00000067596 E038 551.9557153 0.0001257053 1.320442e-06 3.616214e-05 17 43523628 43524185 558 + 2.677 2.760 0.274
ENSG00000067596 E039 606.3866722 0.0008583878 4.272428e-34 4.869507e-31 17 43524186 43525670 1485 + 2.601 2.855 0.846
ENSG00000067596 E040 132.4736981 0.0003597703 3.386030e-13 3.803081e-11 17 43526218 43526386 169 + 1.942 2.194 0.846
ENSG00000067596 E041 103.0471510 0.0038896480 4.573553e-09 2.317108e-07 17 43526387 43526495 109 + 1.810 2.100 0.974
ENSG00000067596 E042 137.5394316 0.0033505820 1.455328e-13 1.750341e-11 17 43526496 43526803 308 + 1.905 2.234 1.102
ENSG00000067596 E043 5.3930371 0.2192176534 3.852917e-01 6.167130e-01 17 43536412 43536498 87 + 0.659 0.867 0.839
ENSG00000067596 E044 7.3787325 0.0368067521 3.179327e-01 5.578865e-01 17 43544162 43544463 302 + 0.813 0.974 0.614
ENSG00000067596 E045 0.0000000       17 43544785 43544815 31 +      
ENSG00000067596 E046 0.0000000       17 43590088 43590165 78 +      
ENSG00000067596 E047 0.1723744 0.0341148708 6.985671e-01   17 43590166 43590741 576 + 0.000 0.102 9.692
ENSG00000067596 E048 0.3447487 0.5378048184 4.752681e-01   17 43609887 43610338 452 + 0.000 0.188 9.172