ENSG00000067445

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000173898 ENSG00000067445 HEK293_OSMI2_6hA HEK293_TMG_6hB TRO protein_coding protein_coding 20.32637 27.4547 12.35563 1.979036 0.4156365 -1.151243 5.793431 8.349367 3.7759231 0.7615586 0.3061739 -1.142749 0.28643333 0.31083333 0.30800000 -0.002833333 1.000000000 3.571172e-05 FALSE TRUE
ENST00000375022 ENSG00000067445 HEK293_OSMI2_6hA HEK293_TMG_6hB TRO protein_coding protein_coding 20.32637 27.4547 12.35563 1.979036 0.4156365 -1.151243 3.183838 2.404954 2.6298770 0.3777128 0.5823048 0.128475 0.17118750 0.08950000 0.21496667 0.125466667 0.271645142 3.571172e-05 FALSE TRUE
ENST00000445561 ENSG00000067445 HEK293_OSMI2_6hA HEK293_TMG_6hB TRO protein_coding nonsense_mediated_decay 20.32637 27.4547 12.35563 1.979036 0.4156365 -1.151243 1.823393 3.075941 0.8735152 1.0395824 0.7341085 -1.804384 0.08704583 0.10900000 0.06813333 -0.040866667 0.718002341 3.571172e-05 TRUE TRUE
ENST00000492706 ENSG00000067445 HEK293_OSMI2_6hA HEK293_TMG_6hB TRO protein_coding retained_intron 20.32637 27.4547 12.35563 1.979036 0.4156365 -1.151243 3.954568 5.845218 2.5438039 1.6407185 0.2646680 -1.197075 0.18883333 0.20696667 0.20566667 -0.001300000 1.000000000 3.571172e-05 FALSE TRUE
MSTRG.34318.24 ENSG00000067445 HEK293_OSMI2_6hA HEK293_TMG_6hB TRO protein_coding   20.32637 27.4547 12.35563 1.979036 0.4156365 -1.151243 1.079437 2.048447 0.0000000 0.7753630 0.0000000 -7.685412 0.04501250 0.07916667 0.00000000 -0.079166667 0.001529845 3.571172e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000067445 E001 0.1723744 0.0310883573 1.000000e+00   X 54920462 54920562 101 + 0.001 0.075 7.088
ENSG00000067445 E002 0.1723744 0.0310883573 1.000000e+00   X 54920563 54920795 233 + 0.000 0.075 9.383
ENSG00000067445 E003 0.0000000       X 54920796 54920806 11 +      
ENSG00000067445 E004 0.5668842 0.4151284919 7.666086e-01   X 54920807 54920810 4 + 0.192 0.144 -0.498
ENSG00000067445 E005 4.6659610 0.0642911786 9.327069e-01 9.685107e-01 X 54920811 54920815 5 + 0.691 0.685 -0.026
ENSG00000067445 E006 7.8835772 0.0571055675 8.760703e-01 9.392539e-01 X 54920816 54920823 8 + 0.855 0.888 0.127
ENSG00000067445 E007 7.8835772 0.0571055675 8.760703e-01 9.392539e-01 X 54920824 54920824 1 + 0.855 0.888 0.127
ENSG00000067445 E008 37.7067855 0.0018879405 3.922000e-02 1.527431e-01 X 54920825 54920850 26 + 1.624 1.489 -0.461
ENSG00000067445 E009 53.1094719 0.0023870696 1.064511e-01 2.930862e-01 X 54920851 54920878 28 + 1.743 1.648 -0.324
ENSG00000067445 E010 4.6410931 0.0067291401 7.100916e-01 8.418671e-01 X 54920879 54920888 10 + 0.736 0.677 -0.242
ENSG00000067445 E011 2.4931449 0.0093966013 2.241003e-01 4.582776e-01 X 54920889 54920965 77 + 0.637 0.430 -0.981
ENSG00000067445 E012 2.4636949 0.0384070130 8.063029e-01 8.999271e-01 X 54920966 54921059 94 + 0.509 0.462 -0.230
ENSG00000067445 E013 2.2268289 0.0096765512 1.031073e-01 2.873837e-01 X 54921084 54921177 94 + 0.192 0.512 2.020
ENSG00000067445 E014 1.9747815 0.2059919002 5.346812e-01 7.254285e-01 X 54921388 54921446 59 + 0.512 0.398 -0.586
ENSG00000067445 E015 1.0727588 0.0261604221 1.305306e-02   X 54921977 54922087 111 + 0.577 0.138 -2.889
ENSG00000067445 E016 14.8706195 0.0085443617 2.713343e-01 5.112823e-01 X 54922203 54922217 15 + 1.233 1.118 -0.409
ENSG00000067445 E017 74.2061130 0.0031057921 2.669040e-01 5.064726e-01 X 54922218 54922291 74 + 1.861 1.801 -0.204
ENSG00000067445 E018 25.3781189 0.0035789472 3.676434e-02 1.462966e-01 X 54922292 54922577 286 + 1.476 1.312 -0.567
ENSG00000067445 E019 52.3000875 0.0009594070 5.593149e-01 7.428095e-01 X 54922578 54922623 46 + 1.693 1.657 -0.122
ENSG00000067445 E020 188.0704277 0.0012137033 3.654182e-03 2.722131e-02 X 54922624 54923060 437 + 2.284 2.189 -0.317
ENSG00000067445 E021 167.0528937 0.0002817689 9.984900e-04 9.902682e-03 X 54923061 54923356 296 + 2.236 2.133 -0.343
ENSG00000067445 E022 204.3210171 0.0002913210 4.627522e-02 1.707314e-01 X 54923357 54923768 412 + 2.290 2.231 -0.197
ENSG00000067445 E023 3.3855642 0.1568246906 3.706468e-01 6.044379e-01 X 54923830 54923946 117 + 0.690 0.546 -0.633
ENSG00000067445 E024 2.8774945 0.1442056588 7.103350e-01 8.419911e-01 X 54924378 54924450 73 + 0.578 0.535 -0.197
ENSG00000067445 E025 67.2950469 0.0066388069 5.665310e-01 7.476732e-01 X 54924451 54924487 37 + 1.801 1.761 -0.135
ENSG00000067445 E026 70.4667214 0.0101013716 1.856165e-01 4.113681e-01 X 54924488 54924555 68 + 1.859 1.767 -0.312
ENSG00000067445 E027 66.2689208 0.0073145533 2.689429e-01 5.087009e-01 X 54924670 54924733 64 + 1.820 1.749 -0.242
ENSG00000067445 E028 86.7893995 0.0079887665 9.202372e-02 2.674701e-01 X 54924989 54925068 80 + 1.956 1.854 -0.341
ENSG00000067445 E029 95.7388964 0.0144996974 1.729931e-01 3.944655e-01 X 54925592 54925683 92 + 1.997 1.893 -0.350
ENSG00000067445 E030 89.8214463 0.0080249407 1.057562e-01 2.919207e-01 X 54926410 54926489 80 + 1.967 1.865 -0.341
ENSG00000067445 E031 70.5709604 0.0066022830 5.505642e-01 7.367513e-01 X 54926583 54926625 43 + 1.820 1.782 -0.130
ENSG00000067445 E032 38.0808861 0.0709645788 1.989889e-01 4.284577e-01 X 54926626 54926821 196 + 1.618 1.496 -0.419
ENSG00000067445 E033 43.4138524 0.0781731745 4.628903e-01 6.750577e-01 X 54926822 54927042 221 + 1.617 1.574 -0.143
ENSG00000067445 E034 86.4750295 0.0046615486 4.801922e-01 6.872439e-01 X 54927043 54927105 63 + 1.906 1.867 -0.131
ENSG00000067445 E035 2.7551709 0.0098644208 5.351451e-01 7.256888e-01 X 54927285 54927304 20 + 0.426 0.537 0.550
ENSG00000067445 E036 7.7734562 0.1041114953 4.625482e-01 6.748511e-01 X 54927305 54927666 362 + 0.737 0.920 0.715
ENSG00000067445 E037 128.3094381 0.0028459593 4.135076e-01 6.386636e-01 X 54927667 54927781 115 + 2.074 2.039 -0.119
ENSG00000067445 E038 129.9171674 0.0018299758 8.765303e-01 9.394544e-01 X 54928603 54928710 108 + 2.051 2.055 0.014
ENSG00000067445 E039 249.0162626 0.0002282376 1.044782e-01 2.897341e-01 X 54928711 54929275 565 + 2.304 2.343 0.128
ENSG00000067445 E040 102.5740239 0.0004546947 6.585115e-02 2.158430e-01 X 54929276 54929395 120 + 1.896 1.969 0.243
ENSG00000067445 E041 93.5766302 0.0010828073 3.847104e-01 6.162568e-01 X 54929396 54929515 120 + 1.884 1.918 0.117
ENSG00000067445 E042 194.5353975 0.0023444266 2.481934e-02 1.116765e-01 X 54929516 54930034 519 + 2.167 2.245 0.262
ENSG00000067445 E043 181.4495172 0.0004352293 1.801341e-03 1.571101e-02 X 54930035 54930394 360 + 2.121 2.216 0.319
ENSG00000067445 E044 234.6773250 0.0056726445 2.530658e-03 2.053139e-02 X 54930395 54930740 346 + 2.205 2.335 0.434
ENSG00000067445 E045 230.6227733 0.0003132359 4.749276e-08 1.904454e-06 X 54930741 54931031 291 + 2.179 2.331 0.510
ENSG00000067445 E046 118.6598684 0.0004013895 2.305008e-04 3.006940e-03 X 54931204 54931444 241 + 1.902 2.044 0.476