ENSG00000067334

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000359208 ENSG00000067334 HEK293_OSMI2_6hA HEK293_TMG_6hB DNTTIP2 protein_coding nonsense_mediated_decay 46.82812 17.35258 70.31299 1.803578 3.017392 2.018015 24.854619 7.2051039 38.807287 0.9070390 2.3333635 2.427607 0.4766292 0.41353333 0.5512667 0.13773333 0.007482483 0.007482483 TRUE TRUE
ENST00000496535 ENSG00000067334 HEK293_OSMI2_6hA HEK293_TMG_6hB DNTTIP2 protein_coding processed_transcript 46.82812 17.35258 70.31299 1.803578 3.017392 2.018015 1.630592 0.9039758 1.831751 0.1909392 0.2583728 1.010850 0.0567500 0.05383333 0.0259000 -0.02793333 0.356324360 0.007482483 FALSE FALSE
MSTRG.1627.2 ENSG00000067334 HEK293_OSMI2_6hA HEK293_TMG_6hB DNTTIP2 protein_coding   46.82812 17.35258 70.31299 1.803578 3.017392 2.018015 19.521743 8.8164889 28.359734 1.1216379 1.0984698 1.684441 0.4455500 0.50610000 0.4040667 -0.10203333 0.251211211 0.007482483 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000067334 E001 14.888839 0.0034483238 4.750974e-01 6.836380e-01 1 93866284 93869638 3355 - 1.133 1.199 0.236
ENSG00000067334 E002 6.185933 0.0055319844 3.709497e-01 6.046909e-01 1 93869639 93869779 141 - 0.835 0.698 -0.548
ENSG00000067334 E003 15.304872 0.0022145565 4.358430e-01 6.556284e-01 1 93869780 93869797 18 - 1.177 1.094 -0.300
ENSG00000067334 E004 161.090703 0.0003035805 9.545252e-02 2.737950e-01 1 93869798 93869944 147 - 2.135 2.182 0.159
ENSG00000067334 E005 249.784166 0.0002461785 1.310985e-03 1.224248e-02 1 93870683 93870792 110 - 2.316 2.391 0.251
ENSG00000067334 E006 1.393307 0.1294871363 9.176629e-01 9.610449e-01 1 93870793 93870997 205 - 0.324 0.334 0.059
ENSG00000067334 E007 356.973712 0.0005747629 3.534060e-06 8.556668e-05 1 93872072 93872236 165 - 2.466 2.564 0.328
ENSG00000067334 E008 264.450815 0.0006374777 2.134863e-05 4.041343e-04 1 93873119 93873214 96 - 2.334 2.438 0.345
ENSG00000067334 E009 14.371562 0.0105845558 2.486285e-01 4.863765e-01 1 93873215 93873422 208 - 1.097 1.214 0.419
ENSG00000067334 E010 178.726440 0.0003798889 1.970018e-04 2.640941e-03 1 93875645 93875665 21 - 2.164 2.269 0.352
ENSG00000067334 E011 308.877424 0.0001713795 7.983682e-06 1.726490e-04 1 93875666 93875783 118 - 2.404 2.497 0.311
ENSG00000067334 E012 780.764329 0.0001058616 9.067941e-01 9.554774e-01 1 93876268 93876758 491 - 2.833 2.826 -0.023
ENSG00000067334 E013 826.991190 0.0001273516 2.517867e-14 3.507726e-12 1 93876759 93877472 714 - 2.881 2.769 -0.372
ENSG00000067334 E014 133.484199 0.0014565070 5.040237e-03 3.484827e-02 1 93877473 93877489 17 - 2.093 1.973 -0.402
ENSG00000067334 E015 448.009132 0.0026847465 2.232755e-04 2.928883e-03 1 93877490 93877862 373 - 2.616 2.495 -0.402
ENSG00000067334 E016 2.049929 0.3396718147 8.327193e-01 9.153186e-01 1 93877863 93877883 21 - 0.429 0.442 0.072
ENSG00000067334 E017 4.223826 0.1603252529 2.567134e-01 4.954692e-01 1 93878548 93879076 529 - 0.578 0.837 1.076
ENSG00000067334 E018 157.961157 0.0024815769 6.439449e-02 2.125618e-01 1 93879077 93879330 254 - 2.158 2.077 -0.272
ENSG00000067334 E019 4.824435 0.0063304412 7.370192e-01 8.585970e-01 1 93879331 93879918 588 - 0.700 0.746 0.187