ENSG00000067167

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262213 ENSG00000067167 HEK293_OSMI2_6hA HEK293_TMG_6hB TRAM1 protein_coding protein_coding 76.76757 8.529381 120.2169 2.005624 2.484062 3.815484 38.973727 8.1801939 54.65407 2.00381722 1.911212 2.738623 0.68682917 0.95456667 0.4544333 -0.5001333 2.625233e-13 8.240681e-17 FALSE TRUE
ENST00000520700 ENSG00000067167 HEK293_OSMI2_6hA HEK293_TMG_6hB TRAM1 protein_coding processed_transcript 76.76757 8.529381 120.2169 2.005624 2.484062 3.815484 9.121304 0.0000000 17.53254 0.00000000 4.955650 10.776642 0.06710833 0.00000000 0.1443000 0.1443000 2.386846e-07 8.240681e-17 FALSE FALSE
MSTRG.31616.4 ENSG00000067167 HEK293_OSMI2_6hA HEK293_TMG_6hB TRAM1 protein_coding   76.76757 8.529381 120.2169 2.005624 2.484062 3.815484 14.902516 0.0000000 30.38637 0.00000000 3.277701 11.569683 0.11879167 0.00000000 0.2541333 0.2541333 8.240681e-17 8.240681e-17 FALSE TRUE
MSTRG.31616.7 ENSG00000067167 HEK293_OSMI2_6hA HEK293_TMG_6hB TRAM1 protein_coding   76.76757 8.529381 120.2169 2.005624 2.484062 3.815484 12.313211 0.1154355 17.06887 0.06012066 1.495928 7.089123 0.09128333 0.01606667 0.1424333 0.1263667 1.294074e-02 8.240681e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000067167 E001 4.4969922 0.0088637406 3.744567e-01 6.077010e-01 8 70573218 70573441 224 - 0.518 0.715 0.867
ENSG00000067167 E002 131.8203735 0.0151505249 1.681056e-07 5.915498e-06 8 70573442 70573529 88 - 1.817 2.252 1.458
ENSG00000067167 E003 180.7872765 0.0092234584 1.999423e-13 2.344145e-11 8 70573530 70573551 22 - 1.945 2.414 1.571
ENSG00000067167 E004 369.6295773 0.0143340974 7.257734e-08 2.786638e-06 8 70573552 70573764 213 - 2.271 2.663 1.306
ENSG00000067167 E005 1326.0700716 0.0056075708 9.088382e-01 9.565049e-01 8 70573765 70575005 1241 - 2.875 2.910 0.114
ENSG00000067167 E006 661.1022778 0.0001028286 2.587788e-02 1.149021e-01 8 70583164 70583324 161 - 2.577 2.562 -0.051
ENSG00000067167 E007 485.1328005 0.0001686957 1.983896e-02 9.533584e-02 8 70583650 70583705 56 - 2.445 2.417 -0.094
ENSG00000067167 E008 550.7505424 0.0001901233 1.093759e-02 6.210770e-02 8 70583706 70583793 88 - 2.499 2.469 -0.101
ENSG00000067167 E009 557.0717223 0.0004322407 3.987545e-02 1.543916e-01 8 70586895 70586999 105 - 2.502 2.483 -0.064
ENSG00000067167 E010 473.9998711 0.0001342136 4.452661e-02 1.664277e-01 8 70587106 70587176 71 - 2.433 2.413 -0.065
ENSG00000067167 E011 0.1614157 0.0343546269 5.963716e-01   8 70587517 70587680 164 - 0.041 0.000 -6.864
ENSG00000067167 E012 1.1420522 0.0143314545 6.176553e-01   8 70594501 70594505 5 - 0.230 0.000 -9.672
ENSG00000067167 E013 511.7499789 0.0001635445 5.012588e-02 1.799776e-01 8 70594506 70594590 85 - 2.466 2.450 -0.054
ENSG00000067167 E014 514.8081572 0.0002397124 9.809506e-03 5.730383e-02 8 70596263 70596321 59 - 2.472 2.437 -0.115
ENSG00000067167 E015 1.5831277 0.0117580088 1.000000e+00 1.000000e+00 8 70597891 70597894 4 - 0.278 0.311 0.221
ENSG00000067167 E016 607.1668136 0.0009167023 1.533092e-03 1.383686e-02 8 70597895 70598011 117 - 2.545 2.490 -0.182
ENSG00000067167 E017 535.7901616 0.0009846126 8.210109e-05 1.269014e-03 8 70598134 70598252 119 - 2.493 2.408 -0.285
ENSG00000067167 E018 214.6288358 0.0013735256 4.586755e-02 1.697214e-01 8 70598253 70598255 3 - 2.096 2.040 -0.190
ENSG00000067167 E019 343.7070853 0.0012044974 1.186594e-02 6.587476e-02 8 70600019 70600082 64 - 2.300 2.241 -0.195
ENSG00000067167 E020 1.5618075 0.1486690938 1.008004e-01 2.832034e-01 8 70606877 70606979 103 - 0.230 0.612 2.141
ENSG00000067167 E021 1.4976421 0.2961316853 3.316908e-02 1.365049e-01 8 70606980 70607525 546 - 0.199 0.708 2.816
ENSG00000067167 E022 0.4986023 0.0295999749 1.000000e+00   8 70607526 70607778 253 - 0.114 0.000 -8.450
ENSG00000067167 E023 280.5254804 0.0001939354 5.523934e-02 1.918818e-01 8 70608077 70608136 60 - 2.208 2.174 -0.114
ENSG00000067167 E024 202.1703716 0.0005747963 6.366823e-01 7.948197e-01 8 70608137 70608219 83 - 2.060 2.116 0.187
ENSG00000067167 E025 117.3406475 0.0016807606 1.062053e-01 2.926989e-01 8 70608220 70608262 43 - 1.818 1.943 0.419
ENSG00000067167 E026 87.6108023 0.0018825374 2.105070e-01 4.424154e-01 8 70608263 70608416 154 - 1.696 1.811 0.389