ENSG00000067141

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000560328 ENSG00000067141 HEK293_OSMI2_6hA HEK293_TMG_6hB NEO1 protein_coding protein_coding 17.63303 18.58345 17.30311 2.114095 0.8363493 -0.1029301 5.183997 7.845715 3.243023 1.1480458 0.5467215 -1.2719614 0.29693333 0.4196667 0.1864333 -0.233233333 1.011831e-03 1.591455e-06 FALSE TRUE
MSTRG.11179.2 ENSG00000067141 HEK293_OSMI2_6hA HEK293_TMG_6hB NEO1 protein_coding   17.63303 18.58345 17.30311 2.114095 0.8363493 -0.1029301 2.088739 0.000000 2.919521 0.0000000 1.0753823 8.1945209 0.11755000 0.0000000 0.1729667 0.172966667 1.591455e-06 1.591455e-06 FALSE TRUE
MSTRG.11179.6 ENSG00000067141 HEK293_OSMI2_6hA HEK293_TMG_6hB NEO1 protein_coding   17.63303 18.58345 17.30311 2.114095 0.8363493 -0.1029301 5.387397 5.622758 4.982613 0.5469824 0.7235547 -0.1740464 0.30501667 0.3047667 0.2896667 -0.015100000 9.648669e-01 1.591455e-06 FALSE TRUE
MSTRG.11179.7 ENSG00000067141 HEK293_OSMI2_6hA HEK293_TMG_6hB NEO1 protein_coding   17.63303 18.58345 17.30311 2.114095 0.8363493 -0.1029301 1.582259 2.331572 2.128684 0.3733821 0.1445833 -0.1307546 0.09017083 0.1271333 0.1237667 -0.003366667 1.000000e+00 1.591455e-06 FALSE TRUE
MSTRG.11179.9 ENSG00000067141 HEK293_OSMI2_6hA HEK293_TMG_6hB NEO1 protein_coding   17.63303 18.58345 17.30311 2.114095 0.8363493 -0.1029301 1.234904 1.663988 1.868984 0.4426320 0.3937983 0.1666634 0.06880417 0.0862000 0.1075333 0.021333333 8.710561e-01 1.591455e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000067141 E001 1.2447579 0.0162484454 7.126292e-01   15 73051710 73051841 132 + 0.317 0.389 0.426
ENSG00000067141 E002 1.0420237 0.0226311333 9.530408e-01   15 73051842 73051910 69 + 0.317 0.333 0.102
ENSG00000067141 E003 2.3456408 0.0094138487 5.457879e-02 1.904169e-01 15 73051911 73051964 54 + 0.318 0.650 1.687
ENSG00000067141 E004 1.7688955 0.0109438942 7.377923e-02 2.323273e-01 15 73051965 73051992 28 + 0.235 0.557 1.858
ENSG00000067141 E005 3.1045066 0.1660730379 2.671970e-01 5.068072e-01 15 73052463 73052483 21 + 0.445 0.731 1.294
ENSG00000067141 E006 10.3162772 0.0634772976 1.501791e-02 7.814644e-02 15 73052484 73052609 126 + 0.781 1.198 1.554
ENSG00000067141 E007 25.6780504 0.0588616105 7.052642e-02 2.257640e-01 15 73052610 73052805 196 + 1.277 1.519 0.838
ENSG00000067141 E008 108.7880199 0.6141396156 5.309652e-01 7.227427e-01 15 73116540 73116857 318 + 2.006 2.061 0.183
ENSG00000067141 E009 104.9052099 0.0358015347 5.868567e-01 7.615248e-01 15 73122525 73122633 109 + 2.057 1.995 -0.207
ENSG00000067141 E010 151.3232641 0.0013769655 3.670025e-04 4.406807e-03 15 73122634 73122800 167 + 2.239 2.130 -0.363
ENSG00000067141 E011 140.2255331 0.0003758434 3.252459e-07 1.059548e-05 15 73126417 73126570 154 + 2.224 2.078 -0.487
ENSG00000067141 E012 0.1723744 0.0362408389 5.980027e-01   15 73126571 73126623 53 + 0.000 0.111 10.892
ENSG00000067141 E013 125.0418989 0.0004341286 1.550996e-04 2.159504e-03 15 73135891 73135984 94 + 2.155 2.042 -0.378
ENSG00000067141 E014 91.0462277 0.0043734625 4.631523e-02 1.708308e-01 15 73135985 73136027 43 + 2.003 1.917 -0.289
ENSG00000067141 E015 138.6566744 0.0007838725 2.424084e-03 1.984407e-02 15 73176403 73176557 155 + 2.187 2.098 -0.296
ENSG00000067141 E016 123.6817541 0.0032849885 1.141559e-04 1.668213e-03 15 73178307 73178427 121 + 2.171 2.018 -0.513
ENSG00000067141 E017 0.2852693 0.2608819726 2.029394e-01   15 73221693 73221735 43 + 0.232 0.000 -11.844
ENSG00000067141 E018 0.0000000       15 73221919 73222087 169 +      
ENSG00000067141 E019 69.4623665 0.0009720080 1.846675e-02 9.059796e-02 15 73236287 73236346 60 + 1.894 1.799 -0.318
ENSG00000067141 E020 171.5556227 0.0011510825 4.115239e-05 7.052090e-04 15 73236347 73236506 160 + 2.294 2.177 -0.393
ENSG00000067141 E021 160.0412416 0.0026589555 6.762560e-04 7.236536e-03 15 73244344 73244498 155 + 2.264 2.148 -0.388
ENSG00000067141 E022 133.1474542 0.0003796776 2.756028e-02 1.199800e-01 15 73249060 73249208 149 + 2.157 2.098 -0.200
ENSG00000067141 E023 116.4269974 0.0004211600 7.468503e-03 4.687599e-02 15 73249583 73249721 139 + 2.108 2.027 -0.270
ENSG00000067141 E024 82.3891609 0.0033698735 5.343250e-04 5.987112e-03 15 73253400 73253449 50 + 1.999 1.843 -0.525
ENSG00000067141 E025 77.6296053 0.0044019536 1.071160e-01 2.941918e-01 15 73254682 73254716 35 + 1.935 1.862 -0.248
ENSG00000067141 E026 133.4691513 0.0025890740 5.111297e-01 7.088522e-01 15 73254717 73254829 113 + 2.135 2.120 -0.052
ENSG00000067141 E027 138.7820900 0.0019254701 8.408873e-01 9.199382e-01 15 73258766 73258876 111 + 2.137 2.140 0.010
ENSG00000067141 E028 0.0000000       15 73258877 73259111 235 +      
ENSG00000067141 E029 196.7284060 0.0019576783 6.298712e-01 7.903697e-01 15 73260271 73260465 195 + 2.293 2.289 -0.015
ENSG00000067141 E030 134.8597047 0.0004689565 2.953572e-01 5.358236e-01 15 73266316 73266411 96 + 2.143 2.119 -0.079
ENSG00000067141 E031 2.4470973 0.0086830554 8.492259e-02 2.544651e-01 15 73270010 73270057 48 + 0.662 0.389 -1.311
ENSG00000067141 E032 216.0447660 0.0021905544 4.067191e-01 6.335665e-01 15 73270058 73270233 176 + 2.342 2.326 -0.055
ENSG00000067141 E033 213.3845798 0.0002986844 2.587525e-02 1.149014e-01 15 73270316 73270454 139 + 2.353 2.307 -0.153
ENSG00000067141 E034 192.5077406 0.0003015517 1.979774e-02 9.519809e-02 15 73272455 73272562 108 + 2.310 2.259 -0.172
ENSG00000067141 E035 221.3438186 0.0013768145 5.131428e-01 7.103597e-01 15 73273811 73274005 195 + 2.346 2.337 -0.030
ENSG00000067141 E036 14.9009476 0.0023699788 4.210190e-01 6.444561e-01 15 73274692 73274724 33 + 1.155 1.236 0.285
ENSG00000067141 E037 120.8001435 0.0016825421 1.087153e-01 2.969541e-01 15 73278131 73278199 69 + 2.037 2.107 0.237
ENSG00000067141 E038 193.8159659 0.0005300134 3.090564e-02 1.300642e-01 15 73282964 73283111 148 + 2.243 2.312 0.230
ENSG00000067141 E039 280.5467587 0.0002030794 5.984771e-01 7.692350e-01 15 73288313 73288551 239 + 2.432 2.453 0.068
ENSG00000067141 E040 0.3032425 0.0274424043 2.717677e-01   15 73289074 73289145 72 + 0.000 0.198 12.016
ENSG00000067141 E041 172.0171039 0.0005875694 4.462373e-02 1.666660e-01 15 73289146 73289238 93 + 2.197 2.264 0.224
ENSG00000067141 E042 198.3685319 0.0006359414 1.850407e-05 3.575805e-04 15 73293390 73293548 159 + 2.222 2.349 0.426
ENSG00000067141 E043 1.1050873 0.0291564410 9.511920e-01   15 73298299 73298347 49 + 0.318 0.334 0.099
ENSG00000067141 E044 277.7300234 0.0004349730 7.925315e-08 3.015686e-06 15 73298348 73298611 264 + 2.362 2.496 0.445
ENSG00000067141 E045 225.4273058 0.0002404143 7.967521e-05 1.237261e-03 15 73301321 73301457 137 + 2.288 2.393 0.352
ENSG00000067141 E046 0.6479912 0.2665187977 1.097912e-01   15 73301458 73301550 93 + 0.000 0.335 11.834
ENSG00000067141 E047 880.0245188 0.0015196723 1.484335e-11 1.238086e-09 15 73302613 73305205 2593 + 2.853 2.999 0.487