ENSG00000066651

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000334379 ENSG00000066651 HEK293_OSMI2_6hA HEK293_TMG_6hB TRMT11 protein_coding protein_coding 11.73844 5.169088 20.9241 0.7076204 0.573377 2.015085 3.7399716 2.1620836 5.4418489 0.6345304 0.4703627 1.3276659 0.40542083 0.4015333 0.25970000 -0.1418333 3.863912e-01 6.00871e-20 FALSE TRUE
MSTRG.28923.13 ENSG00000066651 HEK293_OSMI2_6hA HEK293_TMG_6hB TRMT11 protein_coding   11.73844 5.169088 20.9241 0.7076204 0.573377 2.015085 1.7008293 1.4278815 3.5366779 0.2355049 0.5541910 1.3025236 0.13515833 0.2741333 0.16786667 -0.1062667 2.666496e-01 6.00871e-20 TRUE TRUE
MSTRG.28923.20 ENSG00000066651 HEK293_OSMI2_6hA HEK293_TMG_6hB TRMT11 protein_coding   11.73844 5.169088 20.9241 0.7076204 0.573377 2.015085 2.4250979 0.0000000 5.4039342 0.0000000 0.1857042 9.0805335 0.13054583 0.0000000 0.25856667 0.2585667 6.008710e-20 6.00871e-20 TRUE TRUE
MSTRG.28923.5 ENSG00000066651 HEK293_OSMI2_6hA HEK293_TMG_6hB TRMT11 protein_coding   11.73844 5.169088 20.9241 0.7076204 0.573377 2.015085 0.5329854 0.8741886 0.5085926 0.2610940 0.5085926 -0.7697525 0.05483333 0.1697667 0.02313333 -0.1466333 1.660465e-01 6.00871e-20 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000066651 E001 0.3559677 0.4940556467 0.8455129392   6 125986012 125986054 43 + 0.146 0.000 -8.872
ENSG00000066651 E002 0.3559677 0.4940556467 0.8455129392   6 125986055 125986058 4 + 0.146 0.000 -10.789
ENSG00000066651 E003 0.3559677 0.4940556467 0.8455129392   6 125986059 125986138 80 + 0.146 0.000 -10.789
ENSG00000066651 E004 0.4868358 0.2532815379 0.8177552007   6 125986139 125986431 293 + 0.145 0.184 0.416
ENSG00000066651 E005 0.4646582 0.0217681645 0.1511799616   6 125986432 125986460 29 + 0.077 0.316 2.462
ENSG00000066651 E006 0.8288081 0.0195717228 0.1223873572   6 125986461 125986463 3 + 0.143 0.416 2.049
ENSG00000066651 E007 1.5795434 0.0149001334 0.8090918376 0.901661569 6 125986464 125986478 15 + 0.373 0.416 0.244
ENSG00000066651 E008 4.7494173 0.0054716760 0.4266032513 0.648506805 6 125986479 125986506 28 + 0.689 0.803 0.464
ENSG00000066651 E009 7.0059068 0.0046230536 0.2817620814 0.522089881 6 125986507 125986525 19 + 0.821 0.956 0.515
ENSG00000066651 E010 10.7563545 0.0043334881 0.4437549564 0.661183853 6 125986526 125986539 14 + 1.005 1.088 0.303
ENSG00000066651 E011 16.7780898 0.0020107421 0.8299469030 0.913747529 6 125986540 125986550 11 + 1.208 1.189 -0.068
ENSG00000066651 E012 16.7968709 0.0020651174 0.8294562487 0.913489704 6 125986551 125986552 2 + 1.208 1.189 -0.068
ENSG00000066651 E013 32.6083943 0.0014006129 0.4505970599 0.666138733 6 125986553 125986622 70 + 1.495 1.444 -0.178
ENSG00000066651 E014 2.4834420 0.0106698928 0.2209202780 0.454562845 6 125986623 125986690 68 + 0.547 0.317 -1.236
ENSG00000066651 E015 3.1648298 0.0408944314 0.3025074054 0.543092143 6 125986691 125986773 83 + 0.616 0.417 -0.960
ENSG00000066651 E016 0.0000000       6 125986914 125987189 276 +      
ENSG00000066651 E017 36.2933366 0.0011630877 0.2793125437 0.519428532 6 125993757 125993792 36 + 1.546 1.476 -0.241
ENSG00000066651 E018 28.9527457 0.0013240752 0.1933785636 0.421340584 6 125993793 125993800 8 + 1.456 1.361 -0.329
ENSG00000066651 E019 36.8504612 0.0010497075 0.0710518353 0.226833963 6 125993801 125993822 22 + 1.563 1.444 -0.409
ENSG00000066651 E020 49.9889820 0.0007644921 0.4144392129 0.639412946 6 125995967 125996040 74 + 1.671 1.626 -0.153
ENSG00000066651 E021 59.3093203 0.0007750292 0.1422453136 0.350781125 6 125998053 125998134 82 + 1.753 1.677 -0.255
ENSG00000066651 E022 69.8924968 0.0006329134 0.4449445096 0.662105640 6 125998223 125998315 93 + 1.812 1.777 -0.118
ENSG00000066651 E023 85.8055882 0.0005681843 0.2190737517 0.452329625 6 125998550 125998684 135 + 1.904 1.852 -0.176
ENSG00000066651 E024 101.4629233 0.0032517446 0.0377933316 0.149062736 6 125999457 125999613 157 + 1.990 1.891 -0.332
ENSG00000066651 E025 9.0227465 0.0223779207 0.4157009444 0.640322734 6 126006842 126006954 113 + 0.982 0.869 -0.425
ENSG00000066651 E026 76.4435590 0.0005644383 0.0001595555 0.002213511 6 126008392 126008472 81 + 1.885 1.706 -0.605
ENSG00000066651 E027 1.3166394 0.0295647635 0.3474932320   6 126008473 126008480 8 + 0.373 0.186 -1.345
ENSG00000066651 E028 4.6239367 0.0058320551 0.0073592196 0.046357979 6 126008657 126008745 89 + 0.795 0.316 -2.289
ENSG00000066651 E029 2.3326251 0.0501485233 0.0817806244 0.248354974 6 126009335 126009434 100 + 0.550 0.187 -2.246
ENSG00000066651 E030 12.2554353 0.1057273220 0.0872799740 0.258757499 6 126010925 126011252 328 + 0.970 1.274 1.095
ENSG00000066651 E031 112.1659513 0.0003830150 0.8888366779 0.946078366 6 126011253 126011417 165 + 2.007 2.003 -0.015
ENSG00000066651 E032 91.1333864 0.0006889173 0.3090726224 0.549562759 6 126012771 126012843 73 + 1.904 1.946 0.140
ENSG00000066651 E033 57.5683089 0.0032522339 0.4961420017 0.698266576 6 126012844 126012852 9 + 1.710 1.748 0.129
ENSG00000066651 E034 56.4944348 0.0016171653 0.4468848100 0.663367987 6 126012970 126012974 5 + 1.700 1.741 0.137
ENSG00000066651 E035 116.4458710 0.0003417839 0.0014832650 0.013497616 6 126012975 126013101 127 + 1.990 2.100 0.367
ENSG00000066651 E036 100.7931277 0.0004692613 0.0087034522 0.052498628 6 126021160 126021265 106 + 1.931 2.029 0.331
ENSG00000066651 E037 64.5681285 0.0006492763 0.6998077582 0.835503480 6 126021266 126021280 15 + 1.766 1.785 0.065
ENSG00000066651 E038 123.2291753 0.0003503980 0.2963146117 0.536843616 6 126038705 126038925 221 + 2.038 2.075 0.122
ENSG00000066651 E039 25.6332818 0.0014634864 0.1086957910 0.296924372 6 126038926 126039276 351 + 1.350 1.468 0.408
ENSG00000066651 E040 2.9045687 0.0086546784 0.3230473867 0.562329606 6 126040795 126040845 51 + 0.593 0.416 -0.859
ENSG00000066651 E041 0.6953672 0.2629209826 0.3341091417   6 126042670 126042778 109 + 0.254 0.000 -12.037
ENSG00000066651 E042 1.4021232 0.1120609165 0.6632647438 0.811919618 6 126048201 126048265 65 + 0.334 0.416 0.471
ENSG00000066651 E043 0.1614157 0.0333834380 1.0000000000   6 126052587 126052643 57 + 0.077 0.000 -10.717
ENSG00000066651 E044 0.9279113 0.0155299099 0.7208025558   6 126053123 126053190 68 + 0.250 0.316 0.464
ENSG00000066651 E045 0.8344176 0.0191724048 0.5232205282   6 126054811 126054872 62 + 0.200 0.316 0.878
ENSG00000066651 E046 1.1134572 0.1488926450 0.1410118552   6 126059619 126059799 181 + 0.199 0.498 1.885
ENSG00000066651 E047 0.0000000       6 126072676 126072707 32 +      
ENSG00000066651 E048 0.6544085 0.0189253333 1.0000000000   6 126077238 126077368 131 + 0.199 0.186 -0.121
ENSG00000066651 E049 1.2970505 0.0134768903 0.5093212692   6 126077369 126077529 161 + 0.295 0.416 0.726
ENSG00000066651 E050 2.1881375 0.0361039262 0.7986652783 0.895542704 6 126112866 126112954 89 + 0.470 0.417 -0.271
ENSG00000066651 E051 1.8130289 0.0175537333 0.1535041922 0.367338478 6 126114705 126114739 35 + 0.469 0.186 -1.860
ENSG00000066651 E052 1.3383691 0.0136968632 0.1658396036   6 126115345 126115493 149 + 0.250 0.498 1.464
ENSG00000066651 E053 2.0564615 0.2300962252 0.6529093009 0.805338611 6 126115743 126115855 113 + 0.412 0.506 0.478
ENSG00000066651 E054 5.4739742 0.0051395823 0.3312524386 0.570108080 6 126174825 126174911 87 + 0.738 0.871 0.524
ENSG00000066651 E055 0.0000000       6 126177193 126177193 1 +      
ENSG00000066651 E056 1.6820433 0.0461217028 0.1691961031 0.389499659 6 126177194 126177335 142 + 0.468 0.186 -1.857
ENSG00000066651 E057 1.5184484 0.0128895194 0.1239284749 0.321945594 6 126198799 126198875 77 + 0.294 0.565 1.464
ENSG00000066651 E058 1.1603853 0.0146504580 0.0935424122   6 126199750 126199900 151 + 0.199 0.498 1.880
ENSG00000066651 E059 1.5522497 0.2224546621 0.1678875828 0.387759397 6 126202028 126203817 1790 + 0.251 0.575 1.817
ENSG00000066651 E060 1.0652262 0.2730202025 0.0166114589   6 126247873 126247929 57 + 0.076 0.580 3.862