ENSG00000066468

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000346997 ENSG00000066468 HEK293_OSMI2_6hA HEK293_TMG_6hB FGFR2 protein_coding protein_coding 10.57292 8.461693 15.03164 0.2987159 0.3895462 0.8282398 0.1070344 0.0000000 0.8562755 0.0000000 0.8562755 6.43675402 0.007283333 0.00000000 0.05826667 0.05826667 0.938895135 0.002129934 FALSE TRUE
ENST00000358487 ENSG00000066468 HEK293_OSMI2_6hA HEK293_TMG_6hB FGFR2 protein_coding protein_coding 10.57292 8.461693 15.03164 0.2987159 0.3895462 0.8282398 2.5137625 1.9739767 1.8912757 0.2239692 0.9800845 -0.06142738 0.250287500 0.23510000 0.12923333 -0.10586667 0.797669579 0.002129934 FALSE TRUE
ENST00000369061 ENSG00000066468 HEK293_OSMI2_6hA HEK293_TMG_6hB FGFR2 protein_coding protein_coding 10.57292 8.461693 15.03164 0.2987159 0.3895462 0.8282398 0.1622751 0.0000000 0.7898648 0.0000000 0.3046196 6.32168428 0.011016667 0.00000000 0.05180000 0.05180000 0.002129934 0.002129934 FALSE TRUE
ENST00000613048 ENSG00000066468 HEK293_OSMI2_6hA HEK293_TMG_6hB FGFR2 protein_coding protein_coding 10.57292 8.461693 15.03164 0.2987159 0.3895462 0.8282398 1.1616226 0.6325964 2.7767819 0.3998697 0.6372698 2.11661538 0.098370833 0.07400000 0.18433333 0.11033333 0.651087724 0.002129934 FALSE TRUE
ENST00000638709 ENSG00000066468 HEK293_OSMI2_6hA HEK293_TMG_6hB FGFR2 protein_coding protein_coding 10.57292 8.461693 15.03164 0.2987159 0.3895462 0.8282398 0.5200252 0.6543502 0.0000000 0.6543502 0.0000000 -6.05387207 0.065462500 0.07403333 0.00000000 -0.07403333 0.855181048 0.002129934 FALSE TRUE
ENST00000682904 ENSG00000066468 HEK293_OSMI2_6hA HEK293_TMG_6hB FGFR2 protein_coding processed_transcript 10.57292 8.461693 15.03164 0.2987159 0.3895462 0.8282398 1.1388890 1.2741459 1.3868384 0.6375297 0.6934940 0.12135598 0.115791667 0.15420000 0.09136667 -0.06283333 0.967610395 0.002129934 FALSE TRUE
MSTRG.4742.25 ENSG00000066468 HEK293_OSMI2_6hA HEK293_TMG_6hB FGFR2 protein_coding   10.57292 8.461693 15.03164 0.2987159 0.3895462 0.8282398 1.0408203 0.9191365 1.2837631 0.1868885 0.2382978 0.47761101 0.097000000 0.10743333 0.08613333 -0.02130000 0.867761382 0.002129934 FALSE TRUE
MSTRG.4742.26 ENSG00000066468 HEK293_OSMI2_6hA HEK293_TMG_6hB FGFR2 protein_coding   10.57292 8.461693 15.03164 0.2987159 0.3895462 0.8282398 1.7445059 0.7040189 3.0897066 0.3932917 0.6993928 2.11809751 0.136341667 0.08650000 0.20370000 0.11720000 0.657264872 0.002129934 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000066468 E001 0.2617363 0.2012041386 0.1555224437   10 121478332 121478333 2 - 0.000 0.245 13.424
ENSG00000066468 E002 0.7547291 0.0172671820 0.3970950158   10 121478334 121478346 13 - 0.186 0.336 1.126
ENSG00000066468 E003 2.4155543 0.0125501550 0.1479949340 0.359457315 10 121478347 121478356 10 - 0.416 0.653 1.126
ENSG00000066468 E004 2.5769700 0.0095214854 0.2266307914 0.461336839 10 121478357 121478363 7 - 0.458 0.653 0.904
ENSG00000066468 E005 3.4281434 0.0077561115 0.5420771138 0.730554414 10 121478364 121478367 4 - 0.596 0.690 0.404
ENSG00000066468 E006 147.0132774 0.0006012176 0.0002635115 0.003358877 10 121478368 121479071 704 - 2.112 2.224 0.373
ENSG00000066468 E007 39.8323099 0.0021383433 0.9885775532 0.996061184 10 121479072 121479217 146 - 1.599 1.602 0.009
ENSG00000066468 E008 13.1213872 0.0023534465 0.8135058599 0.904345503 10 121479218 121479226 9 - 1.149 1.129 -0.072
ENSG00000066468 E009 71.5751954 0.0049179251 0.2629362733 0.502135890 10 121479227 121479618 392 - 1.824 1.885 0.203
ENSG00000066468 E010 43.2054094 0.0012624166 0.0991207920 0.280218246 10 121479619 121479670 52 - 1.597 1.689 0.314
ENSG00000066468 E011 62.4955596 0.0108073345 0.8692589493 0.935503223 10 121479671 121479784 114 - 1.790 1.802 0.038
ENSG00000066468 E012 63.2122330 0.0146341226 0.5602261460 0.743478957 10 121479785 121479854 70 - 1.781 1.829 0.161
ENSG00000066468 E013 38.9437140 0.0159929184 0.4622449523 0.674681133 10 121479855 121479856 2 - 1.565 1.634 0.236
ENSG00000066468 E014 97.6959045 0.0004844163 0.1355527810 0.340663272 10 121479857 121480021 165 - 1.963 2.019 0.189
ENSG00000066468 E015 11.7048969 0.0330988377 0.7435082489 0.862688412 10 121480022 121480113 92 - 1.071 1.119 0.172
ENSG00000066468 E016 2.9496732 0.3750396614 0.4282576203 0.649647109 10 121480226 121480485 260 - 0.456 0.716 1.174
ENSG00000066468 E017 0.9034506 0.1639036701 0.4369716681   10 121481835 121481855 21 - 0.188 0.341 1.139
ENSG00000066468 E018 4.1827297 0.0998423062 0.1476376682 0.358898234 10 121481856 121482103 248 - 0.571 0.837 1.107
ENSG00000066468 E019 4.4242639 0.0066228995 0.0607433633 0.204500529 10 121482104 121482177 74 - 0.595 0.860 1.085
ENSG00000066468 E020 5.9864672 0.5027303512 0.9244928968 0.964565815 10 121482178 121483697 1520 - 0.858 0.815 -0.167
ENSG00000066468 E021 44.5567314 0.0008750252 0.0780034544 0.240819907 10 121483698 121483717 20 - 1.611 1.706 0.324
ENSG00000066468 E022 70.0985628 0.0005222073 0.0643963215 0.212563686 10 121483718 121483803 86 - 1.810 1.891 0.271
ENSG00000066468 E023 8.7655537 0.0066593155 0.8000133384 0.896348607 10 121483804 121485394 1591 - 0.968 0.999 0.114
ENSG00000066468 E024 79.6866642 0.0004820720 0.7628002697 0.874257429 10 121485395 121485532 138 - 1.893 1.908 0.048
ENSG00000066468 E025 47.0412668 0.0010628217 0.0352799562 0.142327995 10 121487354 121487424 71 - 1.716 1.606 -0.375
ENSG00000066468 E026 71.0180660 0.0007497059 0.0279396394 0.121114800 10 121487991 121488113 123 - 1.889 1.796 -0.313
ENSG00000066468 E027 87.1968934 0.0014278160 0.7285906842 0.853373342 10 121496532 121496722 191 - 1.929 1.946 0.056
ENSG00000066468 E028 0.0000000       10 121496723 121496806 84 -      
ENSG00000066468 E029 69.3009398 0.0006419534 0.8539224555 0.927067925 10 121498495 121498605 111 - 1.837 1.847 0.035
ENSG00000066468 E030 83.5188134 0.0007524149 0.8692066279 0.935503223 10 121500826 121500947 122 - 1.921 1.916 -0.014
ENSG00000066468 E031 80.7218315 0.0046046207 0.4117042947 0.637311163 10 121503790 121503941 152 - 1.920 1.880 -0.133
ENSG00000066468 E032 5.9096214 0.0049646102 0.0007381308 0.007766518 10 121503942 121506241 2300 - 0.595 1.031 1.729
ENSG00000066468 E033 0.4514866 0.0230548109 0.8006273308   10 121510187 121510293 107 - 0.186 0.143 -0.459
ENSG00000066468 E034 19.8610711 0.0124475594 0.4199002279 0.643611833 10 121515117 121515122 6 - 1.343 1.268 -0.261
ENSG00000066468 E035 60.2958711 0.0008512688 0.0654521435 0.214912594 10 121515123 121515226 104 - 1.814 1.729 -0.286
ENSG00000066468 E036 61.7144602 0.0014664744 0.0398286578 0.154287784 10 121515227 121515319 93 - 1.824 1.727 -0.330
ENSG00000066468 E037 2.2852491 0.0420613115 0.7041458374 0.838217851 10 121517212 121517318 107 - 0.533 0.470 -0.306
ENSG00000066468 E038 39.5761869 0.0086109441 0.4842398007 0.689984022 10 121517319 121517333 15 - 1.618 1.569 -0.166
ENSG00000066468 E039 64.1800831 0.0027588813 0.1187376028 0.313793587 10 121517334 121517463 130 - 1.835 1.758 -0.260
ENSG00000066468 E040 2.9778399 0.0424006726 0.3019444825 0.542495128 10 121518682 121518829 148 - 0.652 0.470 -0.836
ENSG00000066468 E041 76.3624762 0.0011465561 0.1725174340 0.393820078 10 121519979 121520169 191 - 1.902 1.845 -0.191
ENSG00000066468 E042 0.3447487 0.3250706945 0.1795920501   10 121526155 121526194 40 - 0.000 0.253 13.569
ENSG00000066468 E043 0.1723744 0.0318968740 0.3410233754   10 121526195 121526250 56 - 0.000 0.143 12.550
ENSG00000066468 E044 0.5885118 0.0297225743 0.7154175920   10 121526729 121526954 226 - 0.186 0.250 0.545
ENSG00000066468 E045 0.0000000       10 121527676 121528003 328 -      
ENSG00000066468 E046 0.0000000       10 121530322 121530458 137 -      
ENSG00000066468 E047 0.1723744 0.0318968740 0.3410233754   10 121531267 121531354 88 - 0.000 0.143 12.550
ENSG00000066468 E048 0.1723744 0.0318968740 0.3410233754   10 121537966 121538410 445 - 0.000 0.143 12.550
ENSG00000066468 E049 70.4367000 0.0006023291 0.0063796375 0.041594394 10 121538592 121538715 124 - 1.890 1.774 -0.392
ENSG00000066468 E050 83.0284138 0.0006374433 0.0045092639 0.031980652 10 121551290 121551459 170 - 1.956 1.843 -0.380
ENSG00000066468 E051 0.4764247 0.0227133647 0.8021402569   10 121551460 121554260 2801 - 0.186 0.143 -0.455
ENSG00000066468 E052 0.0000000       10 121564324 121564324 1 -      
ENSG00000066468 E053 0.0000000       10 121564325 121564334 10 -      
ENSG00000066468 E054 1.5492856 0.0189681436 0.1260927522 0.325640218 10 121564335 121564501 167 - 0.256 0.525 1.550
ENSG00000066468 E055 53.1851389 0.0007838848 0.8423945148 0.920823468 10 121564502 121564579 78 - 1.727 1.720 -0.026
ENSG00000066468 E056 54.3369084 0.0006811690 0.9164153221 0.960408280 10 121565438 121565636 199 - 1.734 1.741 0.025
ENSG00000066468 E057 33.9400678 0.0054772533 0.6444265418 0.799748969 10 121565637 121565704 68 - 1.553 1.526 -0.095
ENSG00000066468 E058 0.3206185 0.0274424043 0.3222442814   10 121565705 121565911 207 - 0.186 0.000 -12.497
ENSG00000066468 E059 0.0000000       10 121583302 121583574 273 -      
ENSG00000066468 E060 84.1730815 0.0004887882 0.8617026790 0.931240114 10 121593709 121593967 259 - 1.926 1.922 -0.014
ENSG00000066468 E061 0.6182515 0.0212984826 0.1719866582   10 121593968 121594111 144 - 0.103 0.336 2.129
ENSG00000066468 E062 0.3150090 0.0263730965 0.7854419291   10 121594112 121594554 443 - 0.103 0.143 0.546
ENSG00000066468 E063 0.1308682 0.0309015964 0.3415950416   10 121594555 121594763 209 - 0.000 0.143 12.545
ENSG00000066468 E064 0.0000000       10 121594764 121595690 927 -      
ENSG00000066468 E065 0.7143205 0.0508631564 0.1781528431   10 121595691 121596476 786 - 0.103 0.337 2.131
ENSG00000066468 E066 0.1308682 0.0309015964 0.3415950416   10 121596477 121596811 335 - 0.000 0.143 12.545
ENSG00000066468 E067 47.7300052 0.0022796800 0.2643630102 0.503577256 10 121597962 121598102 141 - 1.701 1.642 -0.201
ENSG00000066468 E068 32.8444268 0.0184099216 0.8628572569 0.931934243 10 121598103 121598224 122 - 1.526 1.517 -0.032
ENSG00000066468 E069 13.8370991 0.0593914678 0.2126817865 0.444888329 10 121598225 121598458 234 - 1.080 1.260 0.641