ENSG00000065883

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000340829 ENSG00000065883 HEK293_OSMI2_6hA HEK293_TMG_6hB CDK13 protein_coding protein_coding 18.24333 16.0038 22.01066 3.04169 0.380024 0.4595419 2.2393733 2.7863090 1.2501928 0.6313379 0.2516550 -1.1498793 0.11191667 0.17660000 0.05706667 -0.119533333 0.01218748 0.01218748 FALSE TRUE
ENST00000478563 ENSG00000065883 HEK293_OSMI2_6hA HEK293_TMG_6hB CDK13 protein_coding processed_transcript 18.24333 16.0038 22.01066 3.04169 0.380024 0.4595419 1.2660310 0.1974230 3.0088378 0.1974230 0.3808401 3.8633456 0.06158333 0.01986667 0.13633333 0.116466667 0.15379120 0.01218748 FALSE FALSE
ENST00000642626 ENSG00000065883 HEK293_OSMI2_6hA HEK293_TMG_6hB CDK13 protein_coding protein_coding 18.24333 16.0038 22.01066 3.04169 0.380024 0.4595419 1.0377112 1.3502025 1.5428618 0.4547957 0.3126695 0.1911080 0.05959167 0.07843333 0.07046667 -0.007966667 0.95896648 0.01218748 FALSE FALSE
ENST00000643859 ENSG00000065883 HEK293_OSMI2_6hA HEK293_TMG_6hB CDK13 protein_coding protein_coding 18.24333 16.0038 22.01066 3.04169 0.380024 0.4595419 5.0074808 3.1908841 8.2335122 0.9985498 0.9223545 1.3647887 0.25730417 0.18830000 0.37460000 0.186300000 0.12997183 0.01218748 FALSE TRUE
ENST00000643915 ENSG00000065883 HEK293_OSMI2_6hA HEK293_TMG_6hB CDK13 protein_coding protein_coding 18.24333 16.0038 22.01066 3.04169 0.380024 0.4595419 0.9752385 1.0037769 0.0000000 1.0037769 0.0000000 -6.6635963 0.05806250 0.05170000 0.00000000 -0.051700000 0.86913627 0.01218748 FALSE TRUE
ENST00000644561 ENSG00000065883 HEK293_OSMI2_6hA HEK293_TMG_6hB CDK13 protein_coding retained_intron 18.24333 16.0038 22.01066 3.04169 0.380024 0.4595419 0.9256136 0.8080738 0.5018066 0.1832758 0.5018066 -0.6766323 0.06198750 0.06060000 0.02303333 -0.037566667 0.40016429 0.01218748 FALSE TRUE
ENST00000645826 ENSG00000065883 HEK293_OSMI2_6hA HEK293_TMG_6hB CDK13 protein_coding retained_intron 18.24333 16.0038 22.01066 3.04169 0.380024 0.4595419 2.4304530 2.9156252 1.9842034 0.7036696 0.7771838 -0.5529324 0.14839583 0.17816667 0.08900000 -0.089166667 0.36806641 0.01218748 FALSE TRUE
MSTRG.29772.1 ENSG00000065883 HEK293_OSMI2_6hA HEK293_TMG_6hB CDK13 protein_coding   18.24333 16.0038 22.01066 3.04169 0.380024 0.4595419 3.0153350 2.4274077 3.8724845 0.5150278 0.2057970 0.6716326 0.16315000 0.15056667 0.17616667 0.025600000 0.78221470 0.01218748 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000065883 E001 22.0278250 0.0018545025 4.924156e-01 0.6956277148 7 39950088 39950120 33 + 1.337 1.396 0.206
ENSG00000065883 E002 45.7272053 0.0133237519 7.983975e-01 0.8953821105 7 39950121 39950255 135 + 1.676 1.673 -0.010
ENSG00000065883 E003 45.1473535 0.0013381904 2.263887e-01 0.4610896721 7 39950256 39950359 104 + 1.631 1.706 0.254
ENSG00000065883 E004 84.1236080 0.0114057892 5.334246e-03 0.0363572476 7 39950360 39950753 394 + 1.835 2.016 0.610
ENSG00000065883 E005 31.6693764 0.0012501171 3.786641e-05 0.0006582555 7 39950754 39951017 264 + 1.372 1.640 0.921
ENSG00000065883 E006 20.4509876 0.0020880986 3.678552e-03 0.0273596466 7 39951018 39951301 284 + 1.210 1.441 0.806
ENSG00000065883 E007 78.6948313 0.0135633927 1.598931e-01 0.3766300721 7 39951302 39951750 449 + 1.851 1.961 0.372
ENSG00000065883 E008 51.6322821 0.0025386610 1.982708e-01 0.4274373238 7 39951751 39951852 102 + 1.686 1.767 0.275
ENSG00000065883 E009 2.4402027 0.0092574076 7.517753e-01 0.8678306223 7 39951853 39952918 1066 + 0.573 0.530 -0.199
ENSG00000065883 E010 1.1901250 0.0989347801 2.308624e-01   7 39984105 39987152 3048 + 0.207 0.435 1.493
ENSG00000065883 E011 82.2017245 0.0029641274 2.580215e-01 0.4967467711 7 39987599 39987768 170 + 1.945 1.905 -0.134
ENSG00000065883 E012 53.0064139 0.0009082377 4.715032e-01 0.6812095196 7 39987769 39987835 67 + 1.751 1.726 -0.086
ENSG00000065883 E013 143.4379422 0.0004395135 5.182776e-02 0.1840634405 7 39987836 39988073 238 + 2.183 2.132 -0.169
ENSG00000065883 E014 145.9322444 0.0013778248 1.774847e-01 0.4004115823 7 39988074 39988258 185 + 2.187 2.149 -0.128
ENSG00000065883 E015 135.9671988 0.0003823852 5.397277e-02 0.1890287991 7 39997494 39997664 171 + 2.163 2.114 -0.165
ENSG00000065883 E016 11.6873303 0.0042526088 2.977129e-01 0.5382061812 7 39997665 39997983 319 + 1.043 1.156 0.407
ENSG00000065883 E017 2.1165138 0.2382130316 9.408287e-01 0.9726766334 7 39998044 39998134 91 + 0.527 0.481 -0.223
ENSG00000065883 E018 2.8270076 0.0086070893 9.636086e-01 0.9837146380 7 39998250 39998836 587 + 0.573 0.572 -0.004
ENSG00000065883 E019 1.6352173 0.0402779228 6.746766e-01 0.8193042691 7 39998837 39999345 509 + 0.451 0.375 -0.409
ENSG00000065883 E020 0.6058878 0.0910852363 6.147038e-02   7 39999346 39999360 15 + 0.345 0.000 -11.973
ENSG00000065883 E021 58.2816875 0.0006724033 2.671762e-04 0.0033973903 7 39999361 39999388 28 + 1.842 1.680 -0.550
ENSG00000065883 E022 103.4115115 0.0004316919 1.025320e-03 0.0101087332 7 39999389 39999500 112 + 2.069 1.963 -0.356
ENSG00000065883 E023 109.0921030 0.0035129901 2.236273e-01 0.4577736735 7 40001861 40002031 171 + 2.064 2.019 -0.153
ENSG00000065883 E024 0.1723744 0.0641835598 4.378999e-01   7 40002032 40002249 218 + 0.000 0.128 9.696
ENSG00000065883 E025 77.0960611 0.0092492406 8.877679e-01 0.9454541187 7 40045836 40045929 94 + 1.892 1.895 0.010
ENSG00000065883 E026 73.1094060 0.0009620106 9.915162e-01 0.9975309748 7 40045930 40046025 96 + 1.866 1.874 0.027
ENSG00000065883 E027 66.4165645 0.0008817344 4.917506e-01 0.6951739754 7 40047821 40047877 57 + 1.842 1.821 -0.070
ENSG00000065883 E028 1.6776512 0.0117843335 8.868212e-01 0.9450426411 7 40047878 40049206 1329 + 0.451 0.432 -0.097
ENSG00000065883 E029 1.1364427 0.0140181470 6.629682e-02   7 40059215 40059279 65 + 0.451 0.128 -2.418
ENSG00000065883 E030 11.0143967 0.2576516375 6.807887e-01 0.8231863204 7 40060820 40062510 1691 + 1.090 1.063 -0.098
ENSG00000065883 E031 3.7600959 0.0822553537 5.567566e-01 0.7410368630 7 40062511 40062825 315 + 0.724 0.610 -0.484
ENSG00000065883 E032 92.7963955 0.0004042012 4.253437e-02 0.1613319286 7 40062826 40062927 102 + 2.004 1.938 -0.220
ENSG00000065883 E033 78.7549990 0.0004884039 5.848064e-02 0.1993688039 7 40063023 40063100 78 + 1.933 1.866 -0.225
ENSG00000065883 E034 2.0481954 0.0129462907 3.279580e-01 0.5669837983 7 40066693 40066882 190 + 0.402 0.572 0.842
ENSG00000065883 E035 1.1603853 0.0153787590 6.148117e-01   7 40067260 40067973 714 + 0.282 0.374 0.583
ENSG00000065883 E036 4.7676278 0.0163445348 9.035591e-01 0.9536794909 7 40069310 40073143 3834 + 0.770 0.761 -0.036
ENSG00000065883 E037 0.0000000       7 40073618 40073692 75 +      
ENSG00000065883 E038 78.7116429 0.0005676753 4.121790e-01 0.6377437098 7 40078005 40078100 96 + 1.914 1.889 -0.082
ENSG00000065883 E039 47.2923867 0.0008666737 8.587331e-01 0.9296962147 7 40078101 40078121 21 + 1.677 1.695 0.058
ENSG00000065883 E040 5.3647649 0.2584714396 3.731336e-01 0.6066234308 7 40078414 40078719 306 + 0.888 0.684 -0.813
ENSG00000065883 E041 98.9352442 0.0117150113 3.419959e-01 0.5797336055 7 40078720 40078851 132 + 1.968 2.026 0.194
ENSG00000065883 E042 0.7249894 0.0288932902 7.290282e-01   7 40085699 40085746 48 + 0.282 0.226 -0.423
ENSG00000065883 E043 162.1075586 0.0023958211 9.321857e-01 0.9682358992 7 40088126 40088331 206 + 2.206 2.215 0.028
ENSG00000065883 E044 1.8917920 0.0103711338 1.128129e-01 0.3038576808 7 40092247 40092784 538 + 0.573 0.306 -1.419
ENSG00000065883 E045 29.9389748 0.0013993157 2.016907e-01 0.4317461398 7 40092785 40092964 180 + 1.522 1.447 -0.257
ENSG00000065883 E046 203.2972666 0.0002581552 6.035541e-02 0.2036344525 7 40092965 40093237 273 + 2.285 2.340 0.185
ENSG00000065883 E047 614.3923639 0.0012290986 9.307478e-03 0.0551166253 7 40094130 40095555 1426 + 2.760 2.818 0.191
ENSG00000065883 E048 139.9379441 0.0010896057 5.022757e-02 0.1802387205 7 40095556 40096966 1411 + 2.178 2.125 -0.178
ENSG00000065883 E049 22.2754969 0.0213843014 5.240603e-01 0.7178869566 7 40096967 40099580 2614 + 1.388 1.349 -0.136
ENSG00000065883 E050 1.0539778 0.0206587115 3.179701e-01   7 40103294 40103383 90 + 0.401 0.226 -1.154