ENSG00000065615

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369679 ENSG00000065615 HEK293_OSMI2_6hA HEK293_TMG_6hB CYB5R4 protein_coding protein_coding 6.583297 1.423772 11.83583 0.2554679 1.689024 3.046492 0.2796517 0.2010895 0.6382445 0.201089459 0.6382445 1.618683 0.04432917 0.1694667 0.04390000 -0.12556667 0.89344156 0.01804871 FALSE FALSE
ENST00000369681 ENSG00000065615 HEK293_OSMI2_6hA HEK293_TMG_6hB CYB5R4 protein_coding protein_coding 6.583297 1.423772 11.83583 0.2554679 1.689024 3.046492 0.3681050 0.1963581 0.4049418 0.006293311 0.0468154 1.007759 0.10167917 0.1468333 0.03586667 -0.11096667 0.01804871 0.01804871 FALSE TRUE
ENST00000479164 ENSG00000065615 HEK293_OSMI2_6hA HEK293_TMG_6hB CYB5R4 protein_coding processed_transcript 6.583297 1.423772 11.83583 0.2554679 1.689024 3.046492 1.0982976 0.2724941 2.3823681 0.272494071 1.2530410 3.082147 0.11510000 0.1408667 0.17633333 0.03546667 0.82841983 0.01804871 FALSE FALSE
MSTRG.28594.2 ENSG00000065615 HEK293_OSMI2_6hA HEK293_TMG_6hB CYB5R4 protein_coding   6.583297 1.423772 11.83583 0.2554679 1.689024 3.046492 3.7238283 0.7192717 5.5310911 0.172265919 2.7863367 2.925642 0.49996667 0.5186667 0.53630000 0.01763333 1.00000000 0.01804871 TRUE TRUE
MSTRG.28594.4 ENSG00000065615 HEK293_OSMI2_6hA HEK293_TMG_6hB CYB5R4 protein_coding   6.583297 1.423772 11.83583 0.2554679 1.689024 3.046492 0.8600480 0.0000000 2.5515883 0.000000000 2.5515883 8.000895 0.20191250 0.0000000 0.17550000 0.17550000 1.00000000 0.01804871 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000065615 E001 0.1614157 0.0321573413 8.291661e-01   6 83859656 83859659 4 + 0.050 0.000 -7.762
ENSG00000065615 E002 1.1148852 0.0393565942 9.278255e-01   6 83859660 83859673 14 + 0.239 0.267 0.215
ENSG00000065615 E003 3.2179851 0.0074604542 7.997894e-01 8.962515e-01 6 83859674 83859685 12 + 0.489 0.550 0.289
ENSG00000065615 E004 4.6584781 0.0055660306 9.038437e-01 9.538317e-01 6 83859686 83859688 3 + 0.609 0.643 0.148
ENSG00000065615 E005 31.1092422 0.0014257752 4.955131e-01 6.978266e-01 6 83859689 83859857 169 + 1.334 1.408 0.256
ENSG00000065615 E006 57.3213978 0.0084882148 3.310803e-01 5.699565e-01 6 83864175 83864328 154 + 1.604 1.542 -0.211
ENSG00000065615 E007 52.2519458 0.0547107115 2.944505e-01 5.350280e-01 6 83893522 83893622 101 + 1.569 1.455 -0.391
ENSG00000065615 E008 44.9327105 0.0008316390 5.245739e-04 5.899650e-03 6 83909009 83909090 82 + 1.523 1.234 -1.005
ENSG00000065615 E009 0.1723744 0.0346491030 5.157566e-02   6 83910068 83910296 229 + 0.000 0.267 13.306
ENSG00000065615 E010 39.2404096 0.0047434705 2.580231e-04 3.303797e-03 6 83914416 83914448 33 + 1.473 1.110 -1.273
ENSG00000065615 E011 42.4873653 0.0106796303 1.102592e-01 2.994154e-01 6 83918005 83918065 61 + 1.488 1.347 -0.488
ENSG00000065615 E012 37.6808421 0.0019761178 4.595399e-01 6.728031e-01 6 83919397 83919454 58 + 1.427 1.379 -0.165
ENSG00000065615 E013 40.6132093 0.0009310887 2.168031e-01 4.496511e-01 6 83921082 83921175 94 + 1.437 1.543 0.366
ENSG00000065615 E014 35.9913343 0.0013270033 2.975644e-01 5.380642e-01 6 83922438 83922470 33 + 1.390 1.487 0.336
ENSG00000065615 E015 56.1399564 0.0009230568 6.828816e-01 8.244867e-01 6 83924470 83924592 123 + 1.586 1.574 -0.040
ENSG00000065615 E016 1.7187273 0.1909521986 2.126095e-01 4.447919e-01 6 83926136 83926268 133 + 0.275 0.551 1.538
ENSG00000065615 E017 1.4343360 0.0128884778 8.774521e-01 9.399503e-01 6 83926269 83926331 63 + 0.297 0.267 -0.211
ENSG00000065615 E018 0.1614157 0.0321573413 8.291661e-01   6 83929420 83929510 91 + 0.050 0.000 -7.757
ENSG00000065615 E019 56.6311175 0.0013860050 8.764553e-01 9.394413e-01 6 83934595 83934735 141 + 1.586 1.612 0.089
ENSG00000065615 E020 64.4475624 0.0043327990 5.202028e-01 7.150859e-01 6 83936224 83936376 153 + 1.649 1.621 -0.096
ENSG00000065615 E021 62.0273189 0.0091382284 8.543843e-02 2.554114e-01 6 83940056 83940206 151 + 1.645 1.522 -0.417
ENSG00000065615 E022 45.1376357 0.0009170912 8.923391e-01 9.477866e-01 6 83940515 83940601 87 + 1.494 1.499 0.020
ENSG00000065615 E023 57.6025433 0.0007337648 8.530918e-01 9.267082e-01 6 83955298 83955462 165 + 1.593 1.621 0.096
ENSG00000065615 E024 90.7776674 0.0136756490 4.677027e-01 6.784951e-01 6 83959824 83961274 1451 + 1.781 1.852 0.239
ENSG00000065615 E025 42.6227236 0.0221219006 2.612688e-10 1.695432e-08 6 83961275 83967423 6149 + 1.341 1.904 1.920
ENSG00000065615 E026 0.0000000       6 83982529 83982560 32 +      
ENSG00000065615 E027 0.0000000       6 83983267 83983310 44 +