ENSG00000065357

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000394147 ENSG00000065357 HEK293_OSMI2_6hA HEK293_TMG_6hB DGKA protein_coding protein_coding 3.660498 5.594884 1.576422 0.4496549 0.4254669 -1.820908 0.08838878 0.2261618 0.1421833 0.07355108 0.1125633 -0.6339659 0.03699167 0.03870000 0.1733000 0.13460000 9.759707e-01 7.292024e-06 FALSE TRUE
ENST00000546878 ENSG00000065357 HEK293_OSMI2_6hA HEK293_TMG_6hB DGKA protein_coding protein_coding 3.660498 5.594884 1.576422 0.4496549 0.4254669 -1.820908 0.58124091 0.7633382 0.1128664 0.08450707 0.1128664 -2.6540094 0.15282917 0.13623333 0.0623000 -0.07393333 6.014863e-01 7.292024e-06   FALSE
ENST00000546995 ENSG00000065357 HEK293_OSMI2_6hA HEK293_TMG_6hB DGKA protein_coding retained_intron 3.660498 5.594884 1.576422 0.4496549 0.4254669 -1.820908 0.13573159 0.1591077 0.3678498 0.08126604 0.1266815 1.1598706 0.05244167 0.03026667 0.2203333 0.19006667 8.053584e-02 7.292024e-06 FALSE FALSE
ENST00000549079 ENSG00000065357 HEK293_OSMI2_6hA HEK293_TMG_6hB DGKA protein_coding processed_transcript 3.660498 5.594884 1.576422 0.4496549 0.4254669 -1.820908 0.44808325 0.2793989 0.4448867 0.27939893 0.2294309 0.6524476 0.13777500 0.05933333 0.2225000 0.16316667 5.364775e-01 7.292024e-06 FALSE TRUE
ENST00000552903 ENSG00000065357 HEK293_OSMI2_6hA HEK293_TMG_6hB DGKA protein_coding protein_coding 3.660498 5.594884 1.576422 0.4496549 0.4254669 -1.820908 0.45749764 1.1000298 0.0000000 0.55033888 0.0000000 -6.7944546 0.09086250 0.18220000 0.0000000 -0.18220000 5.060807e-01 7.292024e-06 FALSE FALSE
MSTRG.7433.17 ENSG00000065357 HEK293_OSMI2_6hA HEK293_TMG_6hB DGKA protein_coding   3.660498 5.594884 1.576422 0.4496549 0.4254669 -1.820908 0.98358201 1.7299088 0.0000000 0.28088970 0.0000000 -7.4428678 0.23822083 0.31610000 0.0000000 -0.31610000 7.292024e-06 7.292024e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000065357 E001 10.9940625 0.027786037 0.143696866 0.35293675 12 55927319 55927619 301 + 1.132 0.917 -0.790
ENSG00000065357 E002 2.3675811 0.075893571 0.057225070 0.19653238 12 55928255 55928334 80 + 0.735 0.354 -1.817
ENSG00000065357 E003 0.0000000       12 55930428 55930643 216 +      
ENSG00000065357 E004 0.1723744 0.033372226 1.000000000   12 55931089 55931161 73 + 0.000 0.057 10.959
ENSG00000065357 E005 0.1723744 0.033372226 1.000000000   12 55931162 55931163 2 + 0.000 0.057 10.959
ENSG00000065357 E006 0.1723744 0.033372226 1.000000000   12 55931164 55931171 8 + 0.000 0.057 10.959
ENSG00000065357 E007 0.5059767 0.021386953 1.000000000   12 55931172 55931191 20 + 0.000 0.152 12.381
ENSG00000065357 E008 0.5059767 0.021386953 1.000000000   12 55931192 55931214 23 + 0.000 0.152 12.381
ENSG00000065357 E009 0.8810853 0.017267182 0.445387682   12 55931215 55931298 84 + 0.000 0.230 13.005
ENSG00000065357 E010 0.9225915 0.152211107 0.484475417   12 55931299 55931344 46 + 0.000 0.235 12.951
ENSG00000065357 E011 0.0000000       12 55931453 55931471 19 +      
ENSG00000065357 E012 0.0000000       12 55931472 55931496 25 +      
ENSG00000065357 E013 0.2027342 0.042706070 1.000000000   12 55931789 55932027 239 + 0.000 0.057 10.954
ENSG00000065357 E014 0.0000000       12 55932028 55932048 21 +      
ENSG00000065357 E015 0.0000000       12 55932049 55932050 2 +      
ENSG00000065357 E016 0.0000000       12 55932051 55932051 1 +      
ENSG00000065357 E017 0.0000000       12 55932052 55932057 6 +      
ENSG00000065357 E018 0.3032425 0.024441170 1.000000000   12 55932058 55932062 5 + 0.000 0.107 11.868
ENSG00000065357 E019 0.3032425 0.024441170 1.000000000   12 55932063 55932063 1 + 0.000 0.107 11.868
ENSG00000065357 E020 1.4875703 0.012426291 0.164945257 0.38390322 12 55932064 55932094 31 + 0.000 0.354 13.690
ENSG00000065357 E021 1.9631872 0.012198908 0.086498864 0.25741493 12 55932095 55932107 13 + 0.000 0.428 14.016
ENSG00000065357 E022 2.3686557 0.009850848 0.056323656 0.19438397 12 55932108 55932123 16 + 0.000 0.471 14.192
ENSG00000065357 E023 0.0000000       12 55932124 55932134 11 +      
ENSG00000065357 E024 0.3447487 0.374315821 1.000000000   12 55932135 55932162 28 + 0.000 0.109 11.641
ENSG00000065357 E025 0.3447487 0.374315821 1.000000000   12 55932163 55932180 18 + 0.000 0.109 11.641
ENSG00000065357 E026 1.4578306 0.012082104 0.695984462 0.83292227 12 55932181 55932255 75 + 0.242 0.326 0.585
ENSG00000065357 E027 0.0000000       12 55932561 55932706 146 +      
ENSG00000065357 E028 0.4514866 0.022276194 0.047554593   12 55932707 55932909 203 + 0.396 0.057 -3.418
ENSG00000065357 E029 0.0000000       12 55933505 55933608 104 +      
ENSG00000065357 E030 0.5352391 0.363114405 0.581638321   12 55935305 55935335 31 + 0.240 0.145 -0.894
ENSG00000065357 E031 0.7379733 0.068235314 0.805785819   12 55935336 55935404 69 + 0.241 0.191 -0.425
ENSG00000065357 E032 0.5363366 0.081582982 1.000000000   12 55935405 55935833 429 + 0.000 0.153 12.348
ENSG00000065357 E033 0.1308682 0.032253721 1.000000000   12 55935834 55935958 125 + 0.000 0.057 10.957
ENSG00000065357 E034 0.3926045 0.579526861 1.000000000   12 55935959 55936146 188 + 0.000 0.143 11.941
ENSG00000065357 E035 0.4644705 0.025984206 1.000000000   12 55936147 55936422 276 + 0.000 0.152 12.376
ENSG00000065357 E036 7.1138124 0.008336631 0.763917382 0.87501596 12 55936423 55936447 25 + 0.738 0.782 0.177
ENSG00000065357 E037 11.2346804 0.008627511 0.573109294 0.75240338 12 55936448 55936567 120 + 0.887 0.961 0.279
ENSG00000065357 E038 0.0000000       12 55936568 55936652 85 +      
ENSG00000065357 E039 0.0000000       12 55936653 55936856 204 +      
ENSG00000065357 E040 0.0000000       12 55936857 55937016 160 +      
ENSG00000065357 E041 6.9935951 0.004434312 0.021557787 0.10114368 12 55937017 55937030 14 + 0.396 0.828 1.941
ENSG00000065357 E042 10.2764092 0.008583113 0.079944205 0.24471178 12 55937031 55937090 60 + 0.675 0.947 1.076
ENSG00000065357 E043 14.5084544 0.003439275 0.226443968 0.46115667 12 55937408 55937524 117 + 0.927 1.076 0.549
ENSG00000065357 E044 8.2556564 0.003589716 0.207448284 0.43875073 12 55937525 55937543 19 + 0.674 0.871 0.786
ENSG00000065357 E045 0.3336024 0.027442404 1.000000000   12 55937544 55937557 14 + 0.000 0.107 11.867
ENSG00000065357 E046 11.0491817 0.003226476 0.095251881 0.27339470 12 55937978 55938024 47 + 0.738 0.979 0.932
ENSG00000065357 E047 10.6774876 0.003663342 0.576817014 0.75500640 12 55938025 55938052 28 + 0.887 0.959 0.271
ENSG00000065357 E048 0.6951069 0.553841084 0.536760525   12 55938053 55938258 206 + 0.245 0.155 -0.818
ENSG00000065357 E049 1.3734580 0.022747179 0.816651721   12 55938259 55938510 252 + 0.242 0.297 0.395
ENSG00000065357 E050 11.6427555 0.003443577 0.672764955 0.81807089 12 55938511 55938552 42 + 0.927 0.979 0.193
ENSG00000065357 E051 8.2722972 0.006823344 0.678482429 0.82177384 12 55938553 55938560 8 + 0.794 0.854 0.235
ENSG00000065357 E052 1.7127849 1.107458599 0.775256048 0.88189974 12 55938561 55938637 77 + 0.243 0.365 0.815
ENSG00000065357 E053 1.4691646 0.283310558 0.569242970 0.74968048 12 55938638 55938651 14 + 0.394 0.299 -0.579
ENSG00000065357 E054 1.6415390 0.353475910 0.614480339 0.77987620 12 55938652 55938689 38 + 0.394 0.330 -0.378
ENSG00000065357 E055 1.2967903 0.217104173 0.506637312   12 55938690 55938698 9 + 0.395 0.266 -0.810
ENSG00000065357 E056 1.2012713 0.589137105 0.335506101   12 55938699 55938747 49 + 0.401 0.236 -1.070
ENSG00000065357 E057 2.0521844 0.902154463 0.315534910 0.55555267 12 55938748 55938802 55 + 0.517 0.365 -0.798
ENSG00000065357 E058 2.5058839 0.622280004 0.268542255 0.50820707 12 55938803 55938914 112 + 0.681 0.386 -1.405
ENSG00000065357 E059 8.2909761 0.004369445 0.322027272 0.56145354 12 55938915 55938937 23 + 0.964 0.827 -0.520
ENSG00000065357 E060 5.6434979 0.006467476 0.839806306 0.91926485 12 55938938 55938938 1 + 0.738 0.703 -0.145
ENSG00000065357 E061 10.0260001 0.029678604 0.364136912 0.59914373 12 55938939 55938989 51 + 1.029 0.898 -0.489
ENSG00000065357 E062 0.9708226 0.189324386 0.352369448   12 55938990 55939185 196 + 0.397 0.193 -1.417
ENSG00000065357 E063 11.8675154 0.027947369 0.550950595 0.73700361 12 55939186 55939280 95 + 1.058 0.978 -0.291
ENSG00000065357 E064 6.7234571 0.009267965 0.940905784 0.97270634 12 55939281 55939305 25 + 0.793 0.779 -0.057
ENSG00000065357 E065 9.4419936 0.013168840 0.865603874 0.93349488 12 55939415 55939474 60 + 0.926 0.900 -0.099
ENSG00000065357 E066 6.9896303 0.008324983 0.423903122 0.64648853 12 55939475 55939486 12 + 0.887 0.769 -0.459
ENSG00000065357 E067 9.7022676 0.038037043 0.224085147 0.45825430 12 55939487 55939529 43 + 1.056 0.882 -0.650
ENSG00000065357 E068 2.8103102 0.621188597 0.230516715 0.46573260 12 55939530 55939914 385 + 0.746 0.407 -1.558
ENSG00000065357 E069 2.8321119 0.396215273 0.037771153 0.14901639 12 55939915 55940081 167 + 0.850 0.359 -2.244
ENSG00000065357 E070 12.0440893 0.003346854 0.081442765 0.24770497 12 55940082 55940168 87 + 1.159 0.958 -0.730
ENSG00000065357 E071 6.6589182 0.015355432 0.597446606 0.76861179 12 55940169 55940170 2 + 0.842 0.758 -0.332
ENSG00000065357 E072 1.5051340 0.014888361 0.203426273 0.43383463 12 55940171 55940251 81 + 0.510 0.265 -1.414
ENSG00000065357 E073 1.6657418 0.015258925 0.729393474 0.85387783 12 55940252 55940313 62 + 0.396 0.326 -0.416
ENSG00000065357 E074 12.9147276 0.002868989 0.396860555 0.62580532 12 55940314 55940433 120 + 0.927 1.032 0.390
ENSG00000065357 E075 0.6673924 0.018990236 0.625336601   12 55940434 55940623 190 + 0.242 0.152 -0.830
ENSG00000065357 E076 11.9908656 0.070819386 0.337246304 0.57562484 12 55940624 55940722 99 + 1.137 0.957 -0.655
ENSG00000065357 E077 0.6791589 0.019387492 0.115334788   12 55940723 55940896 174 + 0.396 0.107 -2.412
ENSG00000065357 E078 11.3375954 0.078226855 0.117617199 0.31187611 12 55940897 55940974 78 + 1.200 0.913 -1.047
ENSG00000065357 E079 7.8231268 0.099356738 0.345825462 0.58340569 12 55940975 55940980 6 + 0.995 0.796 -0.758
ENSG00000065357 E080 1.6797212 0.266596033 0.432373660 0.65301235 12 55940981 55941251 271 + 0.511 0.301 -1.168
ENSG00000065357 E081 9.7875365 0.003601180 0.441923335 0.66004773 12 55941252 55941284 33 + 0.997 0.894 -0.387
ENSG00000065357 E082 9.2826395 0.017519980 0.951510499 0.97771975 12 55941285 55941325 41 + 0.887 0.874 -0.049
ENSG00000065357 E083 1.3988286 0.019257858 0.804479735 0.89890490 12 55941326 55941326 1 + 0.242 0.297 0.399
ENSG00000065357 E084 10.7058586 0.030025220 0.784872042 0.88745479 12 55941510 55941584 75 + 0.964 0.924 -0.151
ENSG00000065357 E085 17.2551485 0.002378831 0.702032976 0.83685831 12 55941998 55942083 86 + 1.159 1.115 -0.157
ENSG00000065357 E086 0.0000000       12 55942084 55942173 90 +      
ENSG00000065357 E087 19.2623200 0.002415963 0.724073755 0.85060618 12 55942174 55942263 90 + 1.202 1.163 -0.138
ENSG00000065357 E088 0.1723744 0.033372226 1.000000000   12 55942264 55942648 385 + 0.000 0.057 10.959
ENSG00000065357 E089 0.5059767 0.021386953 1.000000000   12 55943297 55943420 124 + 0.000 0.152 12.381
ENSG00000065357 E090 27.5146550 0.002145615 0.775569963 0.88209825 12 55951623 55951783 161 + 1.340 1.311 -0.102
ENSG00000065357 E091 1.3271501 0.023769581 0.518072329   12 55951784 55952034 251 + 0.396 0.265 -0.826
ENSG00000065357 E092 18.9186461 0.004722948 0.402399607 0.63030196 12 55952035 55952099 65 + 1.085 1.173 0.314
ENSG00000065357 E093 1.7300931 0.278124633 0.225203825 0.45960989 12 55952100 55952340 241 + 0.000 0.400 13.745
ENSG00000065357 E094 20.7332292 0.003160439 0.214830491 0.44732246 12 55952341 55952431 91 + 1.085 1.215 0.463
ENSG00000065357 E095 1.8379285 0.011172589 0.521125522 0.71565504 12 55952432 55952733 302 + 0.242 0.380 0.906
ENSG00000065357 E096 29.7369218 0.004083791 0.003866449 0.02839403 12 55952734 55952927 194 + 1.086 1.378 1.033
ENSG00000065357 E097 10.9317311 0.017862473 0.022153953 0.10311543 12 55952928 55952932 5 + 0.600 0.987 1.549
ENSG00000065357 E098 21.1601513 0.015282197 0.204261082 0.43498484 12 55953040 55953160 121 + 1.084 1.231 0.526
ENSG00000065357 E099 0.4812263 0.021223133 0.422967605   12 55953204 55953349 146 + 0.242 0.107 -1.419
ENSG00000065357 E100 13.2226249 0.029128544 0.626643791 0.78829726 12 55953350 55953410 61 + 1.084 1.021 -0.231
ENSG00000065357 E101 1.5402229 0.276963299 0.301736861 0.54228206 12 55953411 55953684 274 + 0.000 0.360 13.564
ENSG00000065357 E102 16.2419172 0.011957688 0.776545676 0.88265822 12 55953685 55954027 343 + 1.085 1.117 0.114