ENSG00000065060

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000192788 ENSG00000065060 HEK293_OSMI2_6hA HEK293_TMG_6hB UHRF1BP1 protein_coding protein_coding 7.753769 9.327308 9.194901 2.169744 0.2506964 -0.02060439 5.281814 5.177049 7.958720 0.8453785 0.3988097 0.6194338 0.6988208 0.5802 0.8644667 0.2842667 0.001246990 0.00124699 FALSE TRUE
ENST00000516297 ENSG00000065060 HEK293_OSMI2_6hA HEK293_TMG_6hB UHRF1BP1 protein_coding misc_RNA 7.753769 9.327308 9.194901 2.169744 0.2506964 -0.02060439 2.471955 4.150259 1.236182 1.3252746 0.1559583 -1.7391587 0.3011792 0.4198 0.1355333 -0.2842667 0.001253353 0.00124699   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000065060 E001 26.06936 0.0180303739 9.686680e-01 9.861646e-01 6 34792083 34792294 212 + 1.416 1.450 0.119
ENSG00000065060 E002 51.44261 0.0010005840 1.605977e-01 3.776613e-01 6 34821653 34821815 163 + 1.733 1.698 -0.119
ENSG00000065060 E003 32.50763 0.0012988291 1.117492e-02 6.309675e-02 6 34821917 34821955 39 + 1.577 1.453 -0.423
ENSG00000065060 E004 40.40512 0.0008705546 3.143919e-02 1.316206e-01 6 34823257 34823348 92 + 1.652 1.566 -0.290
ENSG00000065060 E005 49.42976 0.0062354922 9.904822e-04 9.839524e-03 6 34834217 34834406 190 + 1.772 1.601 -0.578
ENSG00000065060 E006 45.30399 0.0208827481 3.597313e-02 1.441503e-01 6 34834721 34834861 141 + 1.725 1.580 -0.493
ENSG00000065060 E007 47.99522 0.0095660727 1.022053e-02 5.906206e-02 6 34835294 34835464 171 + 1.750 1.604 -0.497
ENSG00000065060 E008 43.67144 0.0010130391 7.073784e-03 4.496019e-02 6 34836156 34836348 193 + 1.695 1.583 -0.382
ENSG00000065060 E009 31.70952 0.0298967160 6.693456e-01 8.158291e-01 6 34855617 34855703 87 + 1.515 1.500 -0.051
ENSG00000065060 E010 49.43512 0.0020526496 7.265127e-01 8.521149e-01 6 34856239 34856409 171 + 1.693 1.707 0.048
ENSG00000065060 E011 43.26067 0.0100067355 8.430313e-01 9.211681e-01 6 34856790 34856929 140 + 1.642 1.659 0.059
ENSG00000065060 E012 41.50833 0.0121733137 2.167283e-01 4.495597e-01 6 34857329 34857470 142 + 1.659 1.598 -0.209
ENSG00000065060 E013 52.93479 0.0119605180 1.083038e-01 2.962124e-01 6 34857724 34857917 194 + 1.769 1.695 -0.253
ENSG00000065060 E014 272.08703 0.0002694563 2.647127e-05 4.841084e-04 6 34858124 34859571 1448 + 2.460 2.406 -0.181
ENSG00000065060 E015 81.88012 0.0088729109 2.206860e-01 4.542735e-01 6 34864002 34864198 197 + 1.938 1.901 -0.121
ENSG00000065060 E016 63.90125 0.0041199562 6.863140e-01 8.266854e-01 6 34867225 34867379 155 + 1.807 1.821 0.046
ENSG00000065060 E017 54.79989 0.0007003424 5.436227e-01 7.316620e-01 6 34867466 34867616 151 + 1.713 1.776 0.214
ENSG00000065060 E018 69.42977 0.0006798028 5.958757e-01 7.676635e-01 6 34870854 34871116 263 + 1.815 1.872 0.194
ENSG00000065060 E019 50.46304 0.0008376302 2.743525e-01 5.143103e-01 6 34871584 34871692 109 + 1.715 1.695 -0.069
ENSG00000065060 E020 55.15912 0.0006627460 3.846944e-01 6.162506e-01 6 34871819 34871925 107 + 1.751 1.744 -0.023
ENSG00000065060 E021 317.19406 0.0013462580 8.327887e-01 9.153712e-01 6 34872313 34873830 1518 + 2.487 2.515 0.093
ENSG00000065060 E022 872.89240 0.0032605257 2.188342e-07 7.465465e-06 6 34873831 34877514 3684 + 2.865 3.013 0.492