ENSG00000065057

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000219066 ENSG00000065057 HEK293_OSMI2_6hA HEK293_TMG_6hB NTHL1 protein_coding protein_coding 91.54439 141.1987 38.50916 32.55691 0.7707103 -1.874181 16.52715 28.47635 0.00000 7.495509 0.0000000 -11.476055 0.1197625 0.2233667 0.0000000 -0.2233667 4.374931e-12 4.374931e-12 FALSE TRUE
ENST00000651570 ENSG00000065057 HEK293_OSMI2_6hA HEK293_TMG_6hB NTHL1 protein_coding protein_coding 91.54439 141.1987 38.50916 32.55691 0.7707103 -1.874181 58.99526 89.17353 29.54595 28.730930 0.6346198 -1.593329 0.6798000 0.5940333 0.7673667 0.1733333 5.141033e-01 4.374931e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000065057 E001 1.245048 0.0532126386 0.208304124   16 2039814 2039814 1 - 0.000 0.314 10.368
ENSG00000065057 E002 1.709518 0.0188504652 0.096862030 0.27622375 16 2039815 2039817 3 - 0.000 0.399 12.483
ENSG00000065057 E003 2.221104 0.0281407938 0.306600851 0.54724188 16 2039818 2039819 2 - 0.229 0.449 1.384
ENSG00000065057 E004 5.404231 0.0049418754 0.041935015 0.15977587 16 2039820 2039820 1 - 0.377 0.764 1.794
ENSG00000065057 E005 5.868702 0.0046898617 0.026359488 0.11636506 16 2039821 2039822 2 - 0.377 0.796 1.923
ENSG00000065057 E006 49.027469 0.0091173482 0.134253151 0.33851927 16 2039823 2039851 29 - 1.478 1.611 0.455
ENSG00000065057 E007 461.264215 0.0031104476 0.637636580 0.79547887 16 2039852 2040047 196 - 2.535 2.551 0.054
ENSG00000065057 E008 556.402541 0.0010924567 0.368677006 0.60296316 16 2040133 2040238 106 - 2.649 2.627 -0.074
ENSG00000065057 E009 17.047520 0.0026146544 0.627159408 0.78863025 16 2040239 2040241 3 - 1.192 1.139 -0.189
ENSG00000065057 E010 25.237000 0.1293742099 0.563187168 0.74553437 16 2040242 2040468 227 - 1.404 1.280 -0.432
ENSG00000065057 E011 12.833633 0.1218221854 0.076125136 0.23698990 16 2042002 2042146 145 - 1.305 0.943 -1.305
ENSG00000065057 E012 11.207899 0.1362831984 0.150205552 0.36264369 16 2043484 2043566 83 - 1.211 0.905 -1.115
ENSG00000065057 E013 678.219797 0.0001371566 0.994027727 0.99862029 16 2043567 2043726 160 - 2.720 2.719 -0.004
ENSG00000065057 E014 2.949553 0.0788377317 0.427034975 0.64875530 16 2043727 2043803 77 - 0.652 0.486 -0.756
ENSG00000065057 E015 1.028709 0.1808687616 0.908758684   16 2044050 2044079 30 - 0.230 0.246 0.126
ENSG00000065057 E016 696.064251 0.0001190413 0.510790364 0.70857085 16 2044630 2044800 171 - 2.723 2.732 0.032
ENSG00000065057 E017 18.895925 0.0385626798 0.726055001 0.85177065 16 2044801 2044803 3 - 1.245 1.174 -0.250
ENSG00000065057 E018 6.984998 0.1340028765 0.785317523 0.88770911 16 2044804 2044826 23 - 0.859 0.783 -0.297
ENSG00000065057 E019 744.520678 0.0001731796 0.382484194 0.61422802 16 2046128 2046279 152 - 2.748 2.760 0.039
ENSG00000065057 E020 648.699867 0.0003180039 0.174951884 0.39710280 16 2046280 2046366 87 - 2.722 2.693 -0.096
ENSG00000065057 E021 16.655470 0.0130669821 0.003422234 0.02589094 16 2046367 2046391 25 - 1.379 1.069 -1.098
ENSG00000065057 E022 37.469972 0.0291874774 0.063653760 0.21094904 16 2046937 2047708 772 - 1.643 1.424 -0.748
ENSG00000065057 E023 521.512509 0.0001314251 0.059155575 0.20089142 16 2047709 2047866 158 - 2.576 2.612 0.120