ENSG00000065000

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000586370 ENSG00000065000 HEK293_OSMI2_6hA HEK293_TMG_6hB AP3D1 protein_coding protein_coding 117.562 189.1873 78.03017 31.91791 2.806177 -1.277603 16.39573 26.68304 0.1492582 8.2126808 0.1492582 -7.3889526 0.1009917 0.13330000 0.001933333 -0.131366667 0.002000210 0.00200021 FALSE TRUE
ENST00000643010 ENSG00000065000 HEK293_OSMI2_6hA HEK293_TMG_6hB AP3D1 protein_coding protein_coding 117.562 189.1873 78.03017 31.91791 2.806177 -1.277603 10.84848 14.95260 17.5636784 0.3539376 1.0663183 0.2320549 0.1176167 0.08553333 0.225500000 0.139966667 0.007122277 0.00200021 FALSE TRUE
ENST00000643116 ENSG00000065000 HEK293_OSMI2_6hA HEK293_TMG_6hB AP3D1 protein_coding protein_coding 117.562 189.1873 78.03017 31.91791 2.806177 -1.277603 28.18217 44.69466 17.7336732 10.2114743 0.5041292 -1.3331205 0.2452500 0.23030000 0.227900000 -0.002400000 1.000000000 0.00200021 FALSE TRUE
ENST00000644728 ENSG00000065000 HEK293_OSMI2_6hA HEK293_TMG_6hB AP3D1 protein_coding protein_coding 117.562 189.1873 78.03017 31.91791 2.806177 -1.277603 28.63902 52.42396 17.8215544 8.6070246 1.5981464 -1.5560689 0.2260000 0.27756667 0.228333333 -0.049233333 0.541820591 0.00200021 FALSE TRUE
MSTRG.16102.5 ENSG00000065000 HEK293_OSMI2_6hA HEK293_TMG_6hB AP3D1 protein_coding   117.562 189.1873 78.03017 31.91791 2.806177 -1.277603 25.04044 38.42780 16.1723570 5.4160646 1.0870785 -1.2481038 0.2276583 0.20680000 0.208533333 0.001733333 1.000000000 0.00200021 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000065000 E001 1.458018 0.0724157019 8.037048e-01 8.984633e-01 19 2100988 2100988 1 - 0.319 0.370 0.307
ENSG00000065000 E002 2.125411 0.0650086108 8.178241e-01 9.068642e-01 19 2100989 2100994 6 - 0.420 0.466 0.238
ENSG00000065000 E003 13.456995 0.0029973128 2.242878e-02 1.040064e-01 19 2100995 2100995 1 - 1.252 1.039 -0.761
ENSG00000065000 E004 354.882520 0.0021007463 2.541102e-01 4.925328e-01 19 2100996 2101112 117 - 2.459 2.504 0.150
ENSG00000065000 E005 2016.510393 0.0009633024 4.221013e-12 3.900028e-10 19 2101113 2101620 508 - 3.147 3.276 0.428
ENSG00000065000 E006 2728.841834 0.0010720013 5.754563e-12 5.187140e-10 19 2101621 2102236 616 - 3.281 3.406 0.418
ENSG00000065000 E007 619.636002 0.0004331217 6.085534e-01 7.759315e-01 19 2102237 2102268 32 - 2.722 2.741 0.062
ENSG00000065000 E008 829.731925 0.0025116316 7.518800e-01 8.679191e-01 19 2108687 2108766 80 - 2.847 2.865 0.060
ENSG00000065000 E009 18.255943 0.0063315297 5.762764e-01 7.546129e-01 19 2108767 2108876 110 - 1.180 1.246 0.234
ENSG00000065000 E010 674.118760 0.0021982479 3.419064e-01 5.796271e-01 19 2109086 2109125 40 - 2.745 2.779 0.113
ENSG00000065000 E011 904.196002 0.0014575794 4.986132e-01 6.998537e-01 19 2109126 2109207 82 - 2.880 2.905 0.081
ENSG00000065000 E012 53.092543 0.1103352686 3.654034e-01 6.002578e-01 19 2109208 2109872 665 - 1.766 1.638 -0.436
ENSG00000065000 E013 928.661058 0.0001108793 3.619760e-03 2.704080e-02 19 2109873 2109958 86 - 2.874 2.925 0.170
ENSG00000065000 E014 913.284548 0.0001344825 8.302664e-05 1.281104e-03 19 2110136 2110224 89 - 2.855 2.923 0.224
ENSG00000065000 E015 1054.882984 0.0004402445 7.832822e-04 8.141216e-03 19 2110707 2110896 190 - 2.919 2.983 0.213
ENSG00000065000 E016 20.905633 0.2030170569 9.738884e-01 9.888151e-01 19 2110897 2111284 388 - 1.226 1.303 0.272
ENSG00000065000 E017 431.804226 0.0001480155 2.667124e-02 1.172718e-01 19 2111285 2111332 48 - 2.540 2.595 0.185
ENSG00000065000 E018 23.561071 0.0861767870 6.173842e-01 7.820245e-01 19 2111333 2111678 346 - 1.381 1.314 -0.234
ENSG00000065000 E019 608.644578 0.0001271612 4.919532e-02 1.776721e-01 19 2111679 2111790 112 - 2.698 2.742 0.147
ENSG00000065000 E020 387.144494 0.0013185191 5.919748e-01 7.650368e-01 19 2111791 2111828 38 - 2.537 2.531 -0.020
ENSG00000065000 E021 22.245648 0.2104881941 8.488382e-02 2.543893e-01 19 2111829 2112823 995 - 1.522 1.203 -1.110
ENSG00000065000 E022 346.129844 0.0004985663 6.643618e-01 8.126007e-01 19 2112860 2112931 72 - 2.470 2.489 0.065
ENSG00000065000 E023 62.912707 0.0006390649 2.594907e-01 4.984560e-01 19 2112932 2112967 36 - 1.699 1.767 0.233
ENSG00000065000 E024 15.458375 0.1271747522 5.049959e-01 7.043126e-01 19 2112968 2113335 368 - 1.238 1.131 -0.382
ENSG00000065000 E025 242.049058 0.0033285533 1.183711e-04 1.719747e-03 19 2113336 2113413 78 - 2.205 2.362 0.526
ENSG00000065000 E026 787.090249 0.0002147184 7.658964e-02 2.379300e-01 19 2114125 2114302 178 - 2.812 2.849 0.125
ENSG00000065000 E027 657.482421 0.0001073556 4.350194e-01 6.549861e-01 19 2114748 2114821 74 - 2.746 2.769 0.076
ENSG00000065000 E028 878.165894 0.0001423690 6.641593e-01 8.124875e-01 19 2115219 2115346 128 - 2.877 2.893 0.054
ENSG00000065000 E029 634.978979 0.0001765668 1.373512e-01 3.434651e-01 19 2115347 2115418 72 - 2.760 2.745 -0.051
ENSG00000065000 E030 738.580187 0.0005097884 4.534311e-01 6.682957e-01 19 2115538 2115613 76 - 2.817 2.811 -0.020
ENSG00000065000 E031 688.805473 0.0014565690 7.205476e-02 2.289218e-01 19 2116207 2116278 72 - 2.744 2.793 0.162
ENSG00000065000 E032 902.260026 0.0014600331 1.569608e-01 3.721999e-01 19 2116605 2116746 142 - 2.868 2.908 0.133
ENSG00000065000 E033 4.755995 0.0057614408 3.567168e-02 1.433748e-01 19 2116747 2116766 20 - 0.420 0.789 1.659
ENSG00000065000 E034 3.916228 0.0067935314 2.751642e-02 1.198308e-01 19 2116767 2116796 30 - 0.320 0.732 2.012
ENSG00000065000 E035 5.430434 0.1115884668 9.810702e-01 9.923092e-01 19 2116797 2117221 425 - 0.767 0.762 -0.019
ENSG00000065000 E036 661.667799 0.0022019461 3.170010e-01 5.570001e-01 19 2117222 2117367 146 - 2.736 2.774 0.126
ENSG00000065000 E037 827.015356 0.0019302899 2.668461e-01 5.063987e-01 19 2118601 2118820 220 - 2.835 2.870 0.114
ENSG00000065000 E038 386.875458 0.0020932679 6.403114e-01 7.970884e-01 19 2118821 2118832 12 - 2.517 2.538 0.070
ENSG00000065000 E039 970.127305 0.0002415273 8.153354e-01 9.053992e-01 19 2120862 2121048 187 - 2.928 2.934 0.018
ENSG00000065000 E040 603.871593 0.0002953388 1.110111e-01 3.006352e-01 19 2121049 2121092 44 - 2.742 2.723 -0.062
ENSG00000065000 E041 1025.845298 0.0001738995 4.088779e-06 9.676264e-05 19 2121163 2121311 149 - 2.996 2.942 -0.178
ENSG00000065000 E042 981.015583 0.0002308286 1.765772e-07 6.171409e-06 19 2121734 2121879 146 - 2.984 2.918 -0.220
ENSG00000065000 E043 648.714486 0.0004756738 1.777822e-07 6.210965e-06 19 2123358 2123406 49 - 2.820 2.731 -0.297
ENSG00000065000 E044 636.018646 0.0001930254 3.657413e-07 1.173494e-05 19 2123830 2123879 50 - 2.803 2.727 -0.251
ENSG00000065000 E045 656.765828 0.0005283761 9.798779e-07 2.791575e-05 19 2127152 2127201 50 - 2.822 2.738 -0.280
ENSG00000065000 E046 694.558531 0.0006224328 3.816053e-04 4.555097e-03 19 2129090 2129163 74 - 2.829 2.769 -0.201
ENSG00000065000 E047 838.382160 0.0014414353 4.185710e-02 1.595828e-01 19 2129318 2129457 140 - 2.895 2.857 -0.125
ENSG00000065000 E048 761.537492 0.0031120941 2.162243e-03 1.815657e-02 19 2130408 2130521 114 - 2.886 2.802 -0.280
ENSG00000065000 E049 416.140969 0.0011347466 3.319995e-07 1.078859e-05 19 2130522 2130537 16 - 2.650 2.532 -0.390
ENSG00000065000 E050 698.275656 0.0005954382 1.085489e-10 7.649001e-09 19 2132471 2132578 108 - 2.869 2.757 -0.374
ENSG00000065000 E051 6.899789 0.1031066866 6.087652e-01 7.760795e-01 19 2133397 2133484 88 - 0.910 0.819 -0.351
ENSG00000065000 E052 633.788768 0.0020760705 2.039289e-07 7.013330e-06 19 2137011 2137091 81 - 2.842 2.706 -0.451
ENSG00000065000 E053 488.100347 0.0019290142 6.996061e-05 1.108916e-03 19 2137727 2137807 81 - 2.708 2.603 -0.351
ENSG00000065000 E054 459.194392 0.0012635441 4.784681e-07 1.489276e-05 19 2138619 2138714 96 - 2.692 2.571 -0.402
ENSG00000065000 E055 301.965405 0.0001695583 1.730229e-06 4.593288e-05 19 2151239 2151566 328 - 2.498 2.399 -0.330
ENSG00000065000 E056 0.000000       19 2164356 2164468 113 -