ENSG00000064995

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361288 ENSG00000064995 HEK293_OSMI2_6hA HEK293_TMG_6hB TAF11 protein_coding protein_coding 25.43263 12.09082 31.5543 1.035771 1.388558 1.383189 20.2033667 9.584547 24.101831 1.1718352 1.1260350 1.3294546 0.79843750 0.78750000 0.7638667 -0.02363333 8.993130e-01 8.785531e-07 FALSE  
ENST00000420584 ENSG00000064995 HEK293_OSMI2_6hA HEK293_TMG_6hB TAF11 protein_coding protein_coding 25.43263 12.09082 31.5543 1.035771 1.388558 1.383189 2.3427230 1.173909 1.903126 0.2602854 0.4971712 0.6923742 0.08947083 0.09553333 0.0595000 -0.03603333 5.819099e-01 8.785531e-07 FALSE  
ENST00000689560 ENSG00000064995 HEK293_OSMI2_6hA HEK293_TMG_6hB TAF11 protein_coding retained_intron 25.43263 12.09082 31.5543 1.035771 1.388558 1.383189 0.5393134 0.000000 1.656136 0.0000000 0.4202633 7.3803622 0.01786667 0.00000000 0.0516000 0.05160000 8.785531e-07 8.785531e-07 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000064995 E001 2.558752 0.0135060031 0.669768298 0.81613316 6 34877462 34877607 146 - 0.506 0.583 0.360
ENSG00000064995 E002 7.233370 0.0185115212 0.379687042 0.61194082 6 34877608 34877777 170 - 0.930 0.821 -0.419
ENSG00000064995 E003 11.570298 0.0032972431 0.254988898 0.49358954 6 34877778 34877792 15 - 1.030 1.153 0.445
ENSG00000064995 E004 10.767645 0.0042934711 0.118981816 0.31420204 6 34877793 34877797 5 - 0.982 1.153 0.618
ENSG00000064995 E005 12.341133 0.0037275928 0.029957067 0.12722314 6 34877798 34877802 5 - 1.011 1.232 0.792
ENSG00000064995 E006 272.024148 0.0032366019 0.025942686 0.11512660 6 34877803 34878128 326 - 2.379 2.464 0.282
ENSG00000064995 E007 129.665364 0.0098208385 0.049686722 0.17888379 6 34878129 34878148 20 - 2.046 2.170 0.415
ENSG00000064995 E008 378.937290 0.0048448866 0.367794587 0.60224432 6 34878149 34878338 190 - 2.538 2.580 0.141
ENSG00000064995 E009 665.497352 0.0001037859 0.904073190 0.95394841 6 34878339 34878720 382 - 2.792 2.802 0.033
ENSG00000064995 E010 52.757430 0.0858307574 0.927190424 0.96564614 6 34878721 34879548 828 - 1.693 1.719 0.087
ENSG00000064995 E011 10.497643 0.0270874222 0.522582967 0.71675045 6 34879549 34879625 77 - 1.056 0.979 -0.282
ENSG00000064995 E012 18.802587 0.0221717867 0.401425353 0.62950017 6 34879626 34879736 111 - 1.292 1.208 -0.299
ENSG00000064995 E013 32.586078 0.0384448884 0.784160334 0.88699144 6 34879737 34879966 230 - 1.502 1.484 -0.063
ENSG00000064995 E014 296.005483 0.0002009876 0.684976718 0.82591823 6 34879967 34880063 97 - 2.445 2.444 -0.001
ENSG00000064995 E015 34.856033 0.0239980660 0.017194550 0.08615691 6 34880064 34880288 225 - 1.587 1.359 -0.784
ENSG00000064995 E016 233.789769 0.0002856366 0.184599565 0.40995890 6 34880289 34880348 60 - 2.352 2.328 -0.082
ENSG00000064995 E017 162.750593 0.0002718584 0.350324465 0.58753446 6 34880349 34880376 28 - 2.193 2.174 -0.064
ENSG00000064995 E018 4.740943 0.0058791389 0.006364644 0.04152055 6 34882772 34882931 160 - 0.828 0.383 -2.017
ENSG00000064995 E019 312.933811 0.0015657792 0.228900587 0.46388914 6 34882932 34883080 149 - 2.475 2.450 -0.083
ENSG00000064995 E020 10.761153 0.1213900121 0.338671926 0.57682138 6 34883081 34883610 530 - 0.956 1.176 0.800
ENSG00000064995 E021 20.431053 0.1973023612 0.538943887 0.72828528 6 34883611 34885281 1671 - 1.316 1.267 -0.173
ENSG00000064995 E022 3.822375 0.0975873408 0.631324478 0.79123981 6 34887714 34887786 73 - 0.680 0.586 -0.407
ENSG00000064995 E023 322.579487 0.0002944011 0.001355027 0.01257183 6 34887787 34889192 1406 - 2.499 2.438 -0.202