ENSG00000064763

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000536681 ENSG00000064763 HEK293_OSMI2_6hA HEK293_TMG_6hB FAR2 protein_coding protein_coding 7.769684 3.500084 10.52217 0.7825421 0.1426885 1.585225 3.7309103 1.3619861 5.9261531 0.2588242 0.08513016 2.1132624 0.46004583 0.40343333 0.56363333 0.16020000 0.2711832082 0.0008094867 FALSE TRUE
ENST00000549080 ENSG00000064763 HEK293_OSMI2_6hA HEK293_TMG_6hB FAR2 protein_coding processed_transcript 7.769684 3.500084 10.52217 0.7825421 0.1426885 1.585225 0.4231276 0.4206117 0.2294572 0.1148175 0.06120125 -0.8466197 0.08094583 0.11650000 0.02166667 -0.09483333 0.0008094867 0.0008094867   FALSE
ENST00000551451 ENSG00000064763 HEK293_OSMI2_6hA HEK293_TMG_6hB FAR2 protein_coding protein_coding 7.769684 3.500084 10.52217 0.7825421 0.1426885 1.585225 1.4386463 0.1657138 1.7228661 0.1657138 0.86878302 3.3018604 0.15460000 0.08253333 0.16270000 0.08016667 0.7430087037 0.0008094867 FALSE TRUE
ENST00000686419 ENSG00000064763 HEK293_OSMI2_6hA HEK293_TMG_6hB FAR2 protein_coding protein_coding 7.769684 3.500084 10.52217 0.7825421 0.1426885 1.585225 1.1563856 0.9939678 1.2676583 0.5830336 0.77498378 0.3477891 0.16173750 0.23300000 0.12140000 -0.11160000 0.8091026239 0.0008094867 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000064763 E001 0.0000000       12 29149016 29149037 22 +      
ENSG00000064763 E002 0.0000000       12 29149038 29149049 12 +      
ENSG00000064763 E003 0.0000000       12 29149050 29149081 32 +      
ENSG00000064763 E004 0.0000000       12 29149082 29149096 15 +      
ENSG00000064763 E005 0.4702677 0.0217681645 8.394662e-01   12 29149097 29149102 6 + 0.149 0.179 0.317
ENSG00000064763 E006 2.0114412 0.0109057559 1.696952e-01 3.901003e-01 12 29149103 29149132 30 + 0.385 0.608 1.098
ENSG00000064763 E007 2.0114412 0.0109057559 1.696952e-01 3.901003e-01 12 29149133 29149134 2 + 0.385 0.608 1.098
ENSG00000064763 E008 6.5884842 0.0047015273 2.837761e-01 5.242389e-01 12 29149135 29149198 64 + 0.813 0.937 0.473
ENSG00000064763 E009 6.7075361 0.0181039479 5.225763e-01 7.167471e-01 12 29149199 29149209 11 + 0.838 0.910 0.275
ENSG00000064763 E010 11.4015896 0.0080722292 5.585652e-01 7.422385e-01 12 29149210 29149262 53 + 1.049 1.103 0.196
ENSG00000064763 E011 12.8939297 0.0027578832 7.526835e-01 8.683934e-01 12 29149263 29149277 15 + 1.102 1.121 0.071
ENSG00000064763 E012 20.8740393 0.0019028314 1.509134e-01 3.636134e-01 12 29149278 29149302 25 + 1.335 1.198 -0.481
ENSG00000064763 E013 24.4354565 0.0021924383 1.526073e-01 3.660527e-01 12 29149303 29149319 17 + 1.393 1.264 -0.450
ENSG00000064763 E014 30.3510384 0.0103585269 4.570379e-01 6.710549e-01 12 29149320 29149351 32 + 1.469 1.392 -0.266
ENSG00000064763 E015 35.7862196 0.0048828184 3.415979e-01 5.794352e-01 12 29149352 29149407 56 + 1.541 1.457 -0.286
ENSG00000064763 E016 0.6901176 0.1962764674 7.033456e-02   12 29151396 29151874 479 + 0.080 0.409 2.946
ENSG00000064763 E017 5.7724836 0.0062813478 4.420309e-08 1.784336e-06 12 29171378 29172050 673 + 0.483 1.168 2.750
ENSG00000064763 E018 0.0000000       12 29223665 29223744 80 +      
ENSG00000064763 E019 0.1426347 0.0325001033 1.000000e+00   12 29223745 29223894 150 + 0.081 0.000 -11.277
ENSG00000064763 E020 28.1597600 0.0022579589 1.542276e-02 7.968659e-02 12 29270412 29270448 37 + 1.468 1.264 -0.710
ENSG00000064763 E021 48.5471603 0.0248309975 8.908706e-01 9.470988e-01 12 29270449 29270638 190 + 1.649 1.653 0.013
ENSG00000064763 E022 0.2027342 0.0324075017 1.803606e-01   12 29291416 29291494 79 + 0.000 0.179 13.888
ENSG00000064763 E023 34.3247147 0.8034913028 3.807260e-01 6.127919e-01 12 29293300 29293475 176 + 1.451 1.621 0.580
ENSG00000064763 E024 0.0000000       12 29293476 29294388 913 +      
ENSG00000064763 E025 49.6679543 0.0362059940 7.942735e-01 8.928939e-01 12 29297021 29297200 180 + 1.664 1.665 0.006
ENSG00000064763 E026 0.1779838 0.0361166926 1.000000e+00   12 29297201 29297929 729 + 0.081 0.000 -11.280
ENSG00000064763 E027 0.0000000       12 29302317 29302429 113 +      
ENSG00000064763 E028 53.1907480 0.0006910225 9.765990e-01 9.900567e-01 12 29307658 29307835 178 + 1.697 1.685 -0.041
ENSG00000064763 E029 20.0437519 0.0024595537 3.125702e-01 5.529039e-01 12 29309186 29309206 21 + 1.259 1.330 0.248
ENSG00000064763 E030 23.0657097 0.0038241724 8.297244e-01 9.136055e-01 12 29309207 29309230 24 + 1.335 1.341 0.017
ENSG00000064763 E031 1.7984859 0.0115666801 4.559652e-01 6.702316e-01 12 29309231 29311027 1797 + 0.453 0.305 -0.850
ENSG00000064763 E032 45.5991174 0.0009876674 7.374633e-01 8.589303e-01 12 29311028 29311146 119 + 1.622 1.627 0.017
ENSG00000064763 E033 1.1740047 0.2624105321 5.446894e-01   12 29311147 29311882 736 + 0.351 0.180 -1.280
ENSG00000064763 E034 41.4854909 0.0011220103 9.504823e-01 9.772389e-01 12 29311883 29311950 68 + 1.593 1.582 -0.036
ENSG00000064763 E035 1.8740065 0.0110799193 1.065984e-02 6.093802e-02 12 29311951 29313721 1771 + 0.537 0.000 -14.862
ENSG00000064763 E036 0.0000000       12 29316711 29316840 130 +      
ENSG00000064763 E037 61.4705189 0.0006261332 8.748350e-01 9.386644e-01 12 29316841 29317012 172 + 1.758 1.752 -0.020
ENSG00000064763 E038 0.6434498 0.0195803234 2.321751e-01   12 29317775 29318471 697 + 0.259 0.000 -13.279
ENSG00000064763 E039 0.0000000       12 29319887 29320020 134 +      
ENSG00000064763 E040 53.6816852 0.0059593646 3.240043e-01 5.633198e-01 12 29321795 29321924 130 + 1.681 1.735 0.183
ENSG00000064763 E041 0.3088520 0.0262814193 4.870508e-01   12 29321925 29321955 31 + 0.081 0.179 1.316
ENSG00000064763 E042 0.7063259 0.7296333430 8.712161e-01   12 29331234 29331370 137 + 0.216 0.181 -0.311
ENSG00000064763 E043 48.2393536 0.0011759825 6.091035e-02 2.048542e-01 12 29332600 29332727 128 + 1.628 1.715 0.298
ENSG00000064763 E044 0.8807956 0.0171173582 2.608105e-01   12 29332728 29332844 117 + 0.207 0.403 1.319
ENSG00000064763 E045 1.0837175 0.0605493498 4.056570e-01   12 29332845 29332908 64 + 0.259 0.403 0.909
ENSG00000064763 E046 3.9559584 0.0065553480 9.964986e-01 9.999456e-01 12 29332909 29333631 723 + 0.670 0.660 -0.043
ENSG00000064763 E047 37.6972797 0.0053288424 1.921255e-01 4.195308e-01 12 29333632 29333734 103 + 1.527 1.598 0.244
ENSG00000064763 E048 192.0162664 0.0249482560 1.027639e-01 2.867134e-01 12 29333735 29335633 1899 + 2.280 2.145 -0.450
ENSG00000064763 E049 1.5007649 0.0433355281 9.598658e-02 2.747144e-01 12 29340808 29341121 314 + 0.258 0.552 1.659