ENSG00000064309

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263577 ENSG00000064309 HEK293_OSMI2_6hA HEK293_TMG_6hB CDON protein_coding protein_coding 6.113964 4.814878 8.871472 0.6905381 0.612074 0.8803063 1.0589207 0.0000000 2.314458 0.0000000 0.39761057 7.86075075 0.1347583 0.0000000 0.25870000 0.25870000 8.796238e-13 8.796238e-13 FALSE TRUE
ENST00000531738 ENSG00000064309 HEK293_OSMI2_6hA HEK293_TMG_6hB CDON protein_coding protein_coding 6.113964 4.814878 8.871472 0.6905381 0.612074 0.8803063 1.8824838 2.0950454 1.833877 0.3327636 0.14720418 -0.19110907 0.3496958 0.4337667 0.20950000 -0.22426667 2.725176e-03 8.796238e-13 FALSE TRUE
ENST00000683597 ENSG00000064309 HEK293_OSMI2_6hA HEK293_TMG_6hB CDON protein_coding retained_intron 6.113964 4.814878 8.871472 0.6905381 0.612074 0.8803063 0.7638959 0.7870456 0.823794 0.1847117 0.07850436 0.06502876 0.1499667 0.1621000 0.09306667 -0.06903333 3.418990e-01 8.796238e-13 FALSE TRUE
MSTRG.6524.5 ENSG00000064309 HEK293_OSMI2_6hA HEK293_TMG_6hB CDON protein_coding   6.113964 4.814878 8.871472 0.6905381 0.612074 0.8803063 1.5637122 1.5102892 2.634534 0.2810643 0.22094840 0.79866766 0.2336125 0.3103667 0.29773333 -0.01263333 9.690915e-01 8.796238e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000064309 E001 0.7805771 0.257670360 5.105046e-02   11 125955796 125956820 1025 - 0.000 0.432 20.738
ENSG00000064309 E002 16.1226280 0.197034218 8.180700e-02 2.483946e-01 11 125956821 125957213 393 - 1.006 1.431 1.507
ENSG00000064309 E003 16.5046310 0.133297001 2.365291e-02 1.080164e-01 11 125957214 125957451 238 - 0.978 1.463 1.721
ENSG00000064309 E004 5.8533168 0.005389882 2.253699e-06 5.795426e-05 11 125957452 125957459 8 - 0.405 1.131 3.022
ENSG00000064309 E005 393.8060731 1.614673030 3.566510e-01 5.930842e-01 11 125957460 125960678 3219 - 2.389 2.780 1.304
ENSG00000064309 E006 71.1760285 0.765521336 3.448854e-01 5.824679e-01 11 125960679 125961105 427 - 1.718 1.995 0.933
ENSG00000064309 E007 2.5779655 0.008523072 5.423618e-01 7.307815e-01 11 125961655 125961723 69 - 0.553 0.535 -0.083
ENSG00000064309 E008 72.1973293 0.004769740 5.469250e-01 7.340993e-01 11 125961724 125961998 275 - 1.793 1.931 0.466
ENSG00000064309 E009 39.5290278 0.005253728 3.406159e-01 5.785786e-01 11 125978304 125978383 80 - 1.574 1.624 0.169
ENSG00000064309 E010 72.2655401 0.015950323 1.401514e-01 3.477278e-01 11 125981049 125981329 281 - 1.846 1.868 0.072
ENSG00000064309 E011 4.6183769 0.006005448 7.077315e-03 4.497253e-02 11 125981330 125981947 618 - 0.840 0.535 -1.284
ENSG00000064309 E012 0.0000000       11 125982027 125982037 11 -      
ENSG00000064309 E013 0.6072928 0.019665148 8.437448e-01   11 125982038 125982146 109 - 0.180 0.257 0.655
ENSG00000064309 E014 15.3342038 0.149523048 6.511747e-02 2.141615e-01 11 125982147 125983871 1725 - 1.284 1.043 -0.861
ENSG00000064309 E015 57.8120424 0.010079040 1.017540e-01 2.849258e-01 11 125983872 125984093 222 - 1.757 1.772 0.052
ENSG00000064309 E016 41.8933230 0.001031528 4.567332e-01 6.708104e-01 11 125989637 125989759 123 - 1.600 1.669 0.236
ENSG00000064309 E017 0.3032425 0.027442404 1.553764e-01   11 125989760 125989983 224 - 0.000 0.257 19.709
ENSG00000064309 E018 0.1723744 0.044539368 4.094683e-01   11 125989984 125990708 725 - 0.000 0.148 18.713
ENSG00000064309 E019 0.1308682 0.031223367 4.107970e-01   11 125992319 125994283 1965 - 0.000 0.147 18.708
ENSG00000064309 E020 41.6253301 0.001974474 1.402100e-01 3.478277e-01 11 125994284 125994389 106 - 1.614 1.642 0.095
ENSG00000064309 E021 0.3040503 0.024441170 2.611211e-01   11 125994390 125994870 481 - 0.180 0.000 -18.435
ENSG00000064309 E022 51.2103654 0.003513988 7.222494e-04 7.629669e-03 11 125994871 125995052 182 - 1.740 1.665 -0.255
ENSG00000064309 E023 49.6130567 0.020177955 9.300232e-03 5.508527e-02 11 125997207 125997410 204 - 1.731 1.638 -0.316
ENSG00000064309 E024 0.0000000       11 125999125 125999131 7 -      
ENSG00000064309 E025 0.1779838 0.065670756 5.780420e-01   11 125999132 125999472 341 - 0.100 0.000 -17.439
ENSG00000064309 E026 0.3228314 0.251923124 3.287704e-01   11 126001385 126001718 334 - 0.181 0.000 -18.440
ENSG00000064309 E027 37.4311484 0.011772239 4.351892e-02 1.639022e-01 11 126001719 126001850 132 - 1.589 1.553 -0.123
ENSG00000064309 E028 43.0992003 0.006134872 5.266511e-02 1.858943e-01 11 126003902 126004076 175 - 1.637 1.627 -0.033
ENSG00000064309 E029 0.7193800 0.045242465 5.183137e-01   11 126004077 126005043 967 - 0.180 0.344 1.238
ENSG00000064309 E030 0.7743180 0.017653085 2.456668e-01   11 126005393 126005674 282 - 0.307 0.147 -1.347
ENSG00000064309 E031 58.2308750 0.013542554 3.163687e-01 5.564014e-01 11 126005759 126006057 299 - 1.742 1.790 0.165
ENSG00000064309 E032 79.3717768 0.022325766 2.540693e-02 1.134626e-01 11 126010341 126010694 354 - 1.915 1.857 -0.192
ENSG00000064309 E033 0.0000000       11 126010811 126010918 108 -      
ENSG00000064309 E034 0.0000000       11 126014293 126014305 13 -      
ENSG00000064309 E035 2.0725363 0.010137376 3.058938e-01 5.465544e-01 11 126014306 126014817 512 - 0.520 0.418 -0.513
ENSG00000064309 E036 4.9883558 0.005658343 8.839724e-01 9.433427e-01 11 126014818 126015240 423 - 0.750 0.824 0.292
ENSG00000064309 E037 65.2508432 0.020838025 9.447856e-02 2.720444e-01 11 126015241 126015510 270 - 1.815 1.802 -0.044
ENSG00000064309 E038 0.3206185 0.025688912 2.589383e-01   11 126016281 126017087 807 - 0.180 0.000 -18.436
ENSG00000064309 E039 66.0374814 0.020815883 3.246324e-03 2.487931e-02 11 126017088 126017375 288 - 1.860 1.742 -0.397
ENSG00000064309 E040 16.9404584 0.019567013 3.268696e-02 1.351891e-01 11 126018330 126018336 7 - 1.284 1.170 -0.404
ENSG00000064309 E041 30.5237291 0.015797718 1.499540e-02 7.806290e-02 11 126018337 126018473 137 - 1.521 1.425 -0.331
ENSG00000064309 E042 0.0000000       11 126018769 126018866 98 -      
ENSG00000064309 E043 37.1776012 0.018225953 8.646346e-03 5.224881e-02 11 126019619 126019765 147 - 1.607 1.501 -0.362
ENSG00000064309 E044 54.3439464 0.013990606 5.526520e-03 3.735295e-02 11 126021248 126021520 273 - 1.763 1.679 -0.284
ENSG00000064309 E045 0.3503582 0.061744671 8.906140e-01   11 126021521 126022002 482 - 0.100 0.148 0.654
ENSG00000064309 E046 24.4276608 0.011102720 5.226278e-03 3.581134e-02 11 126023401 126023537 137 - 1.444 1.317 -0.439
ENSG00000064309 E047 0.3503582 0.061744671 8.906140e-01   11 126059233 126059427 195 - 0.100 0.148 0.654
ENSG00000064309 E048 0.3228314 0.251923124 3.287704e-01   11 126062288 126062578 291 - 0.181 0.000 -18.440
ENSG00000064309 E049 7.3271225 0.003904004 6.149307e-01 7.802503e-01 11 126062579 126062866 288 - 0.900 0.939 0.149
ENSG00000064309 E050 0.0000000       11 126063226 126063271 46 -      
ENSG00000064309 E051 0.6190593 0.019913779 4.192592e-01   11 126063272 126063335 64 - 0.248 0.148 -0.927