ENSG00000063169

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000396720 ENSG00000063169 HEK293_OSMI2_6hA HEK293_TMG_6hB BICRA protein_coding protein_coding 5.282438 8.391878 3.700754 1.361674 0.03364747 -1.178999 0.3547626 0.5956458 0.2136849 0.5087698 0.059108794 -1.437006 0.07218750 0.06080000 0.05786667 -2.933333e-03 9.054494e-01 7.863109e-15 FALSE TRUE
ENST00000594866 ENSG00000063169 HEK293_OSMI2_6hA HEK293_TMG_6hB BICRA protein_coding protein_coding 5.282438 8.391878 3.700754 1.361674 0.03364747 -1.178999 1.3558936 2.6628433 1.1015590 0.3941186 0.299045737 -1.265791 0.24594583 0.32223333 0.29636667 -2.586667e-02 9.524543e-01 7.863109e-15 FALSE TRUE
ENST00000602258 ENSG00000063169 HEK293_OSMI2_6hA HEK293_TMG_6hB BICRA protein_coding retained_intron 5.282438 8.391878 3.700754 1.361674 0.03364747 -1.178999 0.6023807 0.7754874 0.3688679 0.1799183 0.004723473 -1.051893 0.11476667 0.09963333 0.09970000 6.666667e-05 9.930128e-01 7.863109e-15 FALSE TRUE
MSTRG.17409.1 ENSG00000063169 HEK293_OSMI2_6hA HEK293_TMG_6hB BICRA protein_coding   5.282438 8.391878 3.700754 1.361674 0.03364747 -1.178999 0.2021951 0.5688820 0.0000000 0.1145924 0.000000000 -5.855197 0.03879583 0.07043333 0.00000000 -7.043333e-02 3.252394e-04 7.863109e-15 FALSE TRUE
MSTRG.17409.3 ENSG00000063169 HEK293_OSMI2_6hA HEK293_TMG_6hB BICRA protein_coding   5.282438 8.391878 3.700754 1.361674 0.03364747 -1.178999 2.2766349 3.6302543 1.2394456 0.7360217 0.197950233 -1.542751 0.42795417 0.42570000 0.33570000 -9.000000e-02 7.243041e-01 7.863109e-15 FALSE TRUE
MSTRG.17409.4 ENSG00000063169 HEK293_OSMI2_6hA HEK293_TMG_6hB BICRA protein_coding   5.282438 8.391878 3.700754 1.361674 0.03364747 -1.178999 0.4138350 0.0000000 0.7321949 0.0000000 0.059580752 6.213726 0.08579583 0.00000000 0.19820000 1.982000e-01 7.863109e-15 7.863109e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000063169 E001 0.4341107 0.0244411696 3.674887e-01   19 47607884 47608195 312 + 0.000 0.204 9.027
ENSG00000063169 E002 2.7563613 0.1610418571 8.263809e-01 0.9117210708 19 47608196 47608282 87 + 0.486 0.584 0.461
ENSG00000063169 E003 1.4064633 0.0517594491 3.192988e-01 0.5590132213 19 47609115 47609115 1 + 0.182 0.383 1.445
ENSG00000063169 E004 1.7400657 0.0676346865 1.994946e-01 0.4290895740 19 47609116 47609123 8 + 0.182 0.451 1.811
ENSG00000063169 E005 6.8514991 0.0055695907 5.851167e-01 0.7603960394 19 47609124 47609133 10 + 0.890 0.821 -0.266
ENSG00000063169 E006 26.9304240 0.0047182736 8.742802e-02 0.2590247805 19 47609134 47609168 35 + 1.486 1.356 -0.450
ENSG00000063169 E007 51.6179134 0.0008008853 1.931362e-05 0.0003712811 19 47670443 47670544 102 + 1.819 1.607 -0.719
ENSG00000063169 E008 48.5933382 0.0043784322 5.686759e-04 0.0062968148 19 47673570 47673615 46 + 1.786 1.582 -0.692
ENSG00000063169 E009 49.2066862 0.0009263244 1.094540e-03 0.0106337573 19 47673720 47673762 43 + 1.768 1.600 -0.570
ENSG00000063169 E010 51.9033647 0.0051409773 2.409907e-03 0.0197460999 19 47675851 47675916 66 + 1.797 1.618 -0.607
ENSG00000063169 E011 2.2795540 0.0677147849 7.028648e-01 0.8373797051 19 47678962 47679320 359 + 0.409 0.482 0.377
ENSG00000063169 E012 230.0405989 0.0022840359 7.801120e-01 0.8848344969 19 47679321 47681276 1956 + 2.320 2.313 -0.024
ENSG00000063169 E013 12.7156389 0.0026484808 3.173603e-01 0.5573316573 19 47681976 47682152 177 + 1.162 1.065 -0.348
ENSG00000063169 E014 40.0572265 0.0108816908 5.814016e-01 0.7580858056 19 47694115 47694663 549 + 1.601 1.563 -0.127
ENSG00000063169 E015 21.1668106 0.0149347673 8.523763e-01 0.9263842661 19 47694664 47694726 63 + 1.293 1.316 0.080
ENSG00000063169 E016 41.9549096 0.0009201972 2.964773e-04 0.0036950440 19 47694900 47695080 181 + 1.405 1.644 0.818
ENSG00000063169 E017 22.0806211 0.0030968326 4.977035e-03 0.0345029536 19 47695365 47695385 21 + 1.112 1.370 0.911
ENSG00000063169 E018 45.7955200 0.0010438595 1.091024e-02 0.0619875997 19 47695386 47695474 89 + 1.500 1.660 0.543
ENSG00000063169 E019 48.0607930 0.0033245243 7.164802e-01 0.8459161132 19 47696451 47696512 62 + 1.624 1.648 0.083
ENSG00000063169 E020 69.3622461 0.0006770054 9.738917e-01 0.9888150940 19 47698634 47698782 149 + 1.798 1.804 0.019
ENSG00000063169 E021 64.5073663 0.0011940562 9.451642e-01 0.9748711767 19 47698965 47699059 95 + 1.768 1.768 0.001
ENSG00000063169 E022 68.9164456 0.0029361700 8.728404e-01 0.9375134808 19 47699303 47699405 103 + 1.801 1.798 -0.010
ENSG00000063169 E023 18.6694512 0.0754195853 2.537113e-01 0.4920516214 19 47699965 47701327 1363 + 1.360 1.200 -0.561
ENSG00000063169 E024 368.2759172 0.0012892462 4.384907e-05 0.0007442115 19 47701328 47703277 1950 + 2.451 2.545 0.314