ENSG00000062650

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000298767 ENSG00000062650 HEK293_OSMI2_6hA HEK293_TMG_6hB WAPL protein_coding protein_coding 21.46918 9.965259 31.9433 2.729478 1.535573 1.679539 11.030784 5.228197 16.7632332 1.4104528 0.4787494 1.679019 0.4872958 0.5265000 0.526133333 -0.0003666667 1.000000000 0.001945307 FALSE TRUE
ENST00000372075 ENSG00000062650 HEK293_OSMI2_6hA HEK293_TMG_6hB WAPL protein_coding protein_coding 21.46918 9.965259 31.9433 2.729478 1.535573 1.679539 2.391716 2.938029 0.1536899 0.9109301 0.1536899 -4.170713 0.2069167 0.2931333 0.005333333 -0.2878000000 0.001945307 0.001945307 FALSE TRUE
MSTRG.4295.4 ENSG00000062650 HEK293_OSMI2_6hA HEK293_TMG_6hB WAPL protein_coding   21.46918 9.965259 31.9433 2.729478 1.535573 1.679539 6.634846 1.251226 12.8092276 0.3330715 1.6039597 3.345410 0.2354333 0.1376667 0.398000000 0.2603333333 0.003818948 0.001945307 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000062650 E001 397.9435886 0.0014158853 9.754103e-05 1.464607e-03 10 86435256 86437009 1754 - 2.514 2.615 0.335
ENSG00000062650 E002 165.2988199 0.0039251052 8.801219e-05 1.342902e-03 10 86437010 86437271 262 - 2.114 2.286 0.576
ENSG00000062650 E003 294.2743437 0.0002243323 1.342114e-06 3.670830e-05 10 86437272 86437608 337 - 2.382 2.495 0.377
ENSG00000062650 E004 132.9002987 0.0018423949 4.914983e-03 3.417525e-02 10 86437920 86438015 96 - 2.035 2.149 0.383
ENSG00000062650 E005 136.1207091 0.0003286524 2.649401e-03 2.126521e-02 10 86443275 86443363 89 - 2.053 2.157 0.347
ENSG00000062650 E006 1.8858227 0.0110248784 4.601123e-01 6.732116e-01 10 86443364 86444032 669 - 0.460 0.323 -0.774
ENSG00000062650 E007 229.9285384 0.0003223756 6.250767e-03 4.095860e-02 10 86446242 86446449 208 - 2.289 2.364 0.250
ENSG00000062650 E008 197.6373633 0.0002745302 1.935096e-01 4.214800e-01 10 86451967 86452131 165 - 2.233 2.273 0.134
ENSG00000062650 E009 144.7151277 0.0002821454 2.664216e-01 5.059185e-01 10 86453220 86453335 116 - 2.096 2.136 0.133
ENSG00000062650 E010 168.3318785 0.0004475490 9.092337e-02 2.653737e-01 10 86453656 86453831 176 - 2.157 2.212 0.184
ENSG00000062650 E011 127.6955318 0.0004131247 2.768453e-01 5.168666e-01 10 86458989 86459065 77 - 2.041 2.082 0.138
ENSG00000062650 E012 139.5525787 0.0004322216 3.755806e-01 6.086728e-01 10 86460399 86460496 98 - 2.082 2.115 0.108
ENSG00000062650 E013 160.5057132 0.0028104666 6.020941e-01 7.715482e-01 10 86461176 86461287 112 - 2.146 2.164 0.061
ENSG00000062650 E014 0.7367559 0.0552611205 8.186092e-01   10 86467053 86467278 226 - 0.243 0.190 -0.450
ENSG00000062650 E015 223.0071328 0.0002980998 6.910425e-01 8.297562e-01 10 86467279 86467506 228 - 2.296 2.287 -0.028
ENSG00000062650 E016 151.7225531 0.0014752265 1.968780e-01 4.256340e-01 10 86470992 86471103 112 - 2.141 2.095 -0.152
ENSG00000062650 E017 156.5364882 0.0006021445 1.842708e-03 1.600768e-02 10 86472208 86472344 137 - 2.168 2.064 -0.348
ENSG00000062650 E018 157.2197613 0.0003394159 1.268633e-01 3.267952e-01 10 86472612 86472764 153 - 2.153 2.107 -0.155
ENSG00000062650 E019 118.1621380 0.0003658898 9.230866e-02 2.680185e-01 10 86473878 86473973 96 - 2.034 1.974 -0.201
ENSG00000062650 E020 125.1008917 0.0003597595 1.559090e-01 3.707529e-01 10 86497201 86497301 101 - 2.055 2.006 -0.163
ENSG00000062650 E021 52.6985766 0.0006858953 4.204367e-01 6.439958e-01 10 86497302 86497319 18 - 1.663 1.710 0.157
ENSG00000062650 E022 1.3931897 0.0125896407 6.135169e-01 7.792766e-01 10 86497320 86497337 18 - 0.328 0.424 0.550
ENSG00000062650 E023 587.4498018 0.0001707629 7.613665e-24 3.429643e-21 10 86499718 86500743 1026 - 2.753 2.580 -0.576
ENSG00000062650 E024 268.1149468 0.0016467176 1.051724e-10 7.429574e-09 10 86517571 86518091 521 - 2.419 2.214 -0.687
ENSG00000062650 E025 0.5365243 0.0306635091 1.362709e-01   10 86518583 86518637 55 - 0.075 0.324 2.555
ENSG00000062650 E026 73.0748997 0.0123344682 9.512955e-01 9.776268e-01 10 86521365 86521792 428 - 1.814 1.826 0.041