ENSG00000062598

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000290246 ENSG00000062598 HEK293_OSMI2_6hA HEK293_TMG_6hB ELMO2 protein_coding protein_coding 19.19483 23.06245 14.51943 1.885655 0.8362708 -0.6671932 8.7406726 10.9757963 6.558999 1.4689656 0.1136625 -0.7418940 0.45907500 0.4724667 0.4543333 -0.01813333 9.523217e-01 1.858059e-11 FALSE TRUE
ENST00000372176 ENSG00000062598 HEK293_OSMI2_6hA HEK293_TMG_6hB ELMO2 protein_coding protein_coding 19.19483 23.06245 14.51943 1.885655 0.8362708 -0.6671932 0.4569411 0.1642147 0.929611 0.1642147 0.4339820 2.4311975 0.02610833 0.0076000 0.0611000 0.05350000 3.406225e-01 1.858059e-11 FALSE TRUE
ENST00000396391 ENSG00000062598 HEK293_OSMI2_6hA HEK293_TMG_6hB ELMO2 protein_coding protein_coding 19.19483 23.06245 14.51943 1.885655 0.8362708 -0.6671932 2.6801542 3.8709110 2.183120 0.8396025 0.2674361 -0.8234103 0.14213333 0.1717333 0.1492667 -0.02246667 9.591616e-01 1.858059e-11 FALSE TRUE
ENST00000452857 ENSG00000062598 HEK293_OSMI2_6hA HEK293_TMG_6hB ELMO2 protein_coding protein_coding 19.19483 23.06245 14.51943 1.885655 0.8362708 -0.6671932 2.3487305 2.8241091 0.000000 0.7606765 0.0000000 -8.1467515 0.10338750 0.1194333 0.0000000 -0.11943333 1.858059e-11 1.858059e-11 FALSE TRUE
MSTRG.20796.1 ENSG00000062598 HEK293_OSMI2_6hA HEK293_TMG_6hB ELMO2 protein_coding   19.19483 23.06245 14.51943 1.885655 0.8362708 -0.6671932 1.4818810 2.1065614 1.232283 0.2504087 0.6433973 -0.7687286 0.07820000 0.0908000 0.0904000 -0.00040000 9.302831e-01 1.858059e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000062598 E001 0.0000000       20 46365870 46366049 180 -      
ENSG00000062598 E002 0.8701267 0.0172671820 5.177452e-01   20 46366050 46366053 4 - 0.163 0.283 1.014
ENSG00000062598 E003 0.8701267 0.0172671820 5.177452e-01   20 46366054 46366054 1 - 0.163 0.283 1.014
ENSG00000062598 E004 584.6008292 0.0001624842 2.288519e-08 9.906786e-07 20 46366055 46367359 1305 - 2.672 2.764 0.306
ENSG00000062598 E005 176.8268329 0.0006369660 4.229532e-03 3.042751e-02 20 46367360 46367560 201 - 2.152 2.245 0.312
ENSG00000062598 E006 129.2550676 0.0026841704 3.035857e-01 5.441511e-01 20 46368891 46368968 78 - 2.047 2.098 0.172
ENSG00000062598 E007 10.6133611 0.1677865932 6.001698e-01 7.703242e-01 20 46368969 46370442 1474 - 1.065 1.024 -0.150
ENSG00000062598 E008 133.8069223 0.0014201159 6.377339e-01 7.955345e-01 20 46370443 46370513 71 - 2.079 2.104 0.083
ENSG00000062598 E009 86.9496127 0.0005067722 1.885980e-01 4.151860e-01 20 46370514 46370525 12 - 1.870 1.929 0.199
ENSG00000062598 E010 144.8419214 0.0038182146 8.718873e-01 9.369460e-01 20 46371352 46371459 108 - 2.122 2.140 0.061
ENSG00000062598 E011 154.7646152 0.0130608482 4.376133e-01 6.569557e-01 20 46371579 46371691 113 - 2.120 2.183 0.210
ENSG00000062598 E012 164.2746442 0.0054611574 9.925763e-01 9.979448e-01 20 46371806 46371969 164 - 2.180 2.193 0.044
ENSG00000062598 E013 0.8265952 0.0169218293 7.560504e-01   20 46372835 46373240 406 - 0.281 0.227 -0.403
ENSG00000062598 E014 0.6486114 0.0188879762 7.285717e-01   20 46373241 46373398 158 - 0.163 0.227 0.598
ENSG00000062598 E015 160.1922845 0.0004627818 3.053260e-01 5.459304e-01 20 46373399 46373535 137 - 2.193 2.168 -0.085
ENSG00000062598 E016 81.3423976 0.0004904568 4.281693e-01 6.495653e-01 20 46374332 46374350 19 - 1.906 1.878 -0.094
ENSG00000062598 E017 113.1711453 0.0005315145 8.980193e-01 9.508226e-01 20 46374351 46374437 87 - 2.019 2.029 0.033
ENSG00000062598 E018 55.2081153 0.0011273768 2.376063e-01 4.738148e-01 20 46374438 46374440 3 - 1.671 1.738 0.228
ENSG00000062598 E019 120.0327764 0.0005025931 6.639513e-01 8.123442e-01 20 46374536 46374640 105 - 2.057 2.048 -0.033
ENSG00000062598 E020 98.8632145 0.0034637147 9.147408e-03 5.448374e-02 20 46375236 46375285 50 - 2.039 1.930 -0.366
ENSG00000062598 E021 128.4099256 0.0039694252 6.434438e-04 6.948906e-03 20 46375286 46375370 85 - 2.168 2.030 -0.460
ENSG00000062598 E022 133.2176598 0.0003613536 2.808121e-04 3.537449e-03 20 46375668 46375790 123 - 2.168 2.057 -0.372
ENSG00000062598 E023 8.1836881 0.1045855510 2.773609e-01 5.173992e-01 20 46376704 46376967 264 - 1.054 0.873 -0.676
ENSG00000062598 E024 4.3084568 0.0073966144 2.305950e-03 1.908957e-02 20 46379919 46380252 334 - 0.941 0.517 -1.753
ENSG00000062598 E025 76.5319873 0.0020169373 3.597545e-02 1.441522e-01 20 46380253 46380303 51 - 1.920 1.829 -0.305
ENSG00000062598 E026 83.8030177 0.0005781041 4.067720e-03 2.955607e-02 20 46383416 46383467 52 - 1.969 1.858 -0.375
ENSG00000062598 E027 70.6191430 0.0006498356 3.201267e-02 1.332538e-01 20 46383468 46383494 27 - 1.886 1.795 -0.304
ENSG00000062598 E028 116.4777348 0.0009195594 2.691738e-01 5.089393e-01 20 46386124 46386275 152 - 2.067 2.032 -0.119
ENSG00000062598 E029 86.7465476 0.0004898557 3.056123e-01 5.462396e-01 20 46387338 46387426 89 - 1.939 1.902 -0.123
ENSG00000062598 E030 48.1025470 0.0104361125 4.528175e-01 6.677631e-01 20 46387427 46387431 5 - 1.697 1.648 -0.167
ENSG00000062598 E031 46.6565325 0.0057758385 3.573390e-01 5.935485e-01 20 46387432 46387437 6 - 1.686 1.633 -0.183
ENSG00000062598 E032 5.5368636 0.0866573529 3.762782e-01 6.092290e-01 20 46387505 46387622 118 - 0.889 0.735 -0.607
ENSG00000062598 E033 119.7327246 0.0031816961 8.659108e-02 2.575632e-01 20 46389039 46389220 182 - 2.098 2.034 -0.216
ENSG00000062598 E034 75.7244982 0.0064600618 7.055578e-01 8.390693e-01 20 46393093 46393143 51 - 1.873 1.854 -0.064
ENSG00000062598 E035 76.0775542 0.6760237585 4.476338e-01 6.640253e-01 20 46393529 46393601 73 - 1.790 1.892 0.342
ENSG00000062598 E036 3.6868341 0.5190030973 1.144724e-01 3.065832e-01 20 46393981 46394048 68 - 0.945 0.395 -2.399
ENSG00000062598 E037 64.6429985 0.6253391505 4.461262e-01 6.628099e-01 20 46394049 46394089 41 - 1.725 1.820 0.323
ENSG00000062598 E038 90.0172683 0.7271912911 4.402181e-01 6.588742e-01 20 46394405 46394503 99 - 1.854 1.967 0.379
ENSG00000062598 E039 44.9601055 0.5196754620 5.025210e-01 7.025243e-01 20 46394504 46394532 29 - 1.598 1.654 0.192
ENSG00000062598 E040 43.7170930 0.1083375431 3.679124e-01 6.023519e-01 20 46398697 46398771 75 - 1.554 1.656 0.349
ENSG00000062598 E041 42.9093328 0.1566899219 4.144441e-01 6.394129e-01 20 46406548 46406709 162 - 1.556 1.645 0.302
ENSG00000062598 E042 0.0000000       20 46432894 46432985 92 -