ENSG00000060491

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000290291 ENSG00000060491 HEK293_OSMI2_6hA HEK293_TMG_6hB OGFR protein_coding protein_coding 43.74492 65.49442 18.49751 12.5387 0.8750772 -1.823481 27.7356135 39.2802293 9.729667 8.6033734 1.20214158 -2.0122262 0.60359583 0.591833333 0.52300000 -0.06883333 0.73605509 0.02602172 FALSE TRUE
ENST00000370461 ENSG00000060491 HEK293_OSMI2_6hA HEK293_TMG_6hB OGFR protein_coding protein_coding 43.74492 65.49442 18.49751 12.5387 0.8750772 -1.823481 1.7180340 1.8844032 1.673144 0.4859736 0.05165771 -0.1705851 0.05402917 0.034966667 0.09116667 0.05620000 0.21434898 0.02602172 FALSE TRUE
ENST00000450048 ENSG00000060491 HEK293_OSMI2_6hA HEK293_TMG_6hB OGFR protein_coding protein_coding 43.74492 65.49442 18.49751 12.5387 0.8750772 -1.823481 0.5372574 0.2621697 1.130309 0.1449647 0.50573160 2.0668463 0.01858333 0.003333333 0.06043333 0.05710000 0.02602172 0.02602172   FALSE
MSTRG.20967.2 ENSG00000060491 HEK293_OSMI2_6hA HEK293_TMG_6hB OGFR protein_coding   43.74492 65.49442 18.49751 12.5387 0.8750772 -1.823481 3.2140270 6.1530430 1.652927 1.3391650 0.02671776 -1.8899178 0.07662917 0.093000000 0.08990000 -0.00310000 0.96889157 0.02602172 FALSE TRUE
MSTRG.20967.3 ENSG00000060491 HEK293_OSMI2_6hA HEK293_TMG_6hB OGFR protein_coding   43.74492 65.49442 18.49751 12.5387 0.8750772 -1.823481 9.6926543 16.8934568 3.742124 2.9274502 0.28075652 -2.1715387 0.22313750 0.260566667 0.20453333 -0.05603333 0.61478122 0.02602172 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000060491 E001 0.000000       20 62804341 62804499 159 +      
ENSG00000060491 E002 4.599347 0.0205823826 0.227530484 0.46238793 20 62804796 62804812 17 + 0.777 0.653 -0.511
ENSG00000060491 E003 9.304692 0.0895838735 0.061238168 0.20557136 20 62804813 62804818 6 + 1.112 0.872 -0.889
ENSG00000060491 E004 16.139732 0.0026187404 0.093127835 0.26955819 20 62804819 62804823 5 + 1.219 1.136 -0.294
ENSG00000060491 E005 29.904803 0.0169900555 0.279211116 0.51935437 20 62804824 62804834 11 + 1.414 1.408 -0.020
ENSG00000060491 E006 31.970836 0.0058419777 0.376001563 0.60899103 20 62804835 62804836 2 + 1.424 1.442 0.065
ENSG00000060491 E007 243.726514 0.0515476871 0.944147359 0.97442218 20 62804837 62805030 194 + 2.224 2.316 0.308
ENSG00000060491 E008 69.916248 0.1296488701 0.003516089 0.02644432 20 62805886 62807272 1387 + 2.053 1.636 -1.406
ENSG00000060491 E009 20.968992 0.0774555512 0.001083417 0.01055225 20 62807273 62807536 264 + 1.541 1.137 -1.406
ENSG00000060491 E010 107.421681 0.0261818673 0.277091184 0.51712096 20 62807537 62807541 5 + 1.944 1.947 0.011
ENSG00000060491 E011 228.809332 0.0244616415 0.124814238 0.32344567 20 62807542 62807605 64 + 2.286 2.268 -0.061
ENSG00000060491 E012 42.758555 0.1457180844 0.015119438 0.07854850 20 62807606 62808246 641 + 1.805 1.452 -1.201
ENSG00000060491 E013 310.521984 0.0121340002 0.002801341 0.02219418 20 62808247 62808325 79 + 2.456 2.389 -0.223
ENSG00000060491 E014 354.930729 0.0136335912 0.003086992 0.02394128 20 62809585 62809663 79 + 2.519 2.445 -0.245
ENSG00000060491 E015 289.451926 0.0127764289 0.014491554 0.07620846 20 62810499 62810565 67 + 2.409 2.363 -0.151
ENSG00000060491 E016 7.144224 0.0224790366 0.339191260 0.57726011 20 62811363 62811461 99 + 0.894 0.832 -0.241
ENSG00000060491 E017 367.805644 0.0002399308 0.562532596 0.74506679 20 62811462 62811610 149 + 2.424 2.498 0.248
ENSG00000060491 E018 1120.267687 1.5803074557 0.446183854 0.66286080 20 62812230 62813182 953 + 2.730 3.004 0.909
ENSG00000060491 E019 217.694740 0.3274779104 0.163506690 0.38195794 20 62813183 62813362 180 + 1.985 2.299 1.052
ENSG00000060491 E020 410.746309 0.6215060933 0.221062452 0.45476171 20 62813363 62814000 638 + 2.232 2.577 1.149