ENSG00000060339

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265872 ENSG00000060339 HEK293_OSMI2_6hA HEK293_TMG_6hB CCAR1 protein_coding protein_coding 86.03207 49.30684 142.6262 9.558104 4.722736 1.532188 12.577488 7.583500 19.066628 1.994436 1.3651348 1.3289692 0.15377083 0.14893333 0.13390000 -0.01503333 9.250996e-01 8.294391e-19 FALSE TRUE
ENST00000480627 ENSG00000060339 HEK293_OSMI2_6hA HEK293_TMG_6hB CCAR1 protein_coding retained_intron 86.03207 49.30684 142.6262 9.558104 4.722736 1.532188 25.698110 17.163116 39.032663 4.634634 2.7961291 1.1848996 0.31981250 0.33513333 0.27340000 -0.06173333 7.469368e-01 8.294391e-19 FALSE FALSE
ENST00000538031 ENSG00000060339 HEK293_OSMI2_6hA HEK293_TMG_6hB CCAR1 protein_coding protein_coding 86.03207 49.30684 142.6262 9.558104 4.722736 1.532188 3.286272 0.000000 8.070983 0.000000 0.7908047 9.6583869 0.02655000 0.00000000 0.05703333 0.05703333 8.294391e-19 8.294391e-19 FALSE FALSE
ENST00000539539 ENSG00000060339 HEK293_OSMI2_6hA HEK293_TMG_6hB CCAR1 protein_coding protein_coding 86.03207 49.30684 142.6262 9.558104 4.722736 1.532188 18.864806 8.836867 38.849701 1.959546 1.4953593 2.1350362 0.18151250 0.17860000 0.27313333 0.09453333 4.468040e-02 8.294391e-19 FALSE TRUE
ENST00000543706 ENSG00000060339 HEK293_OSMI2_6hA HEK293_TMG_6hB CCAR1 protein_coding protein_coding 86.03207 49.30684 142.6262 9.558104 4.722736 1.532188 6.135619 5.512961 6.074209 1.030562 1.0074661 0.1396277 0.09473333 0.11266667 0.04223333 -0.07043333 1.165413e-03 8.294391e-19 FALSE TRUE
MSTRG.4089.22 ENSG00000060339 HEK293_OSMI2_6hA HEK293_TMG_6hB CCAR1 protein_coding   86.03207 49.30684 142.6262 9.558104 4.722736 1.532188 4.281371 2.546292 5.543196 1.422394 1.4148193 1.1192658 0.05285000 0.05376667 0.03910000 -0.01466667 9.955902e-01 8.294391e-19 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000060339 E001 0.6188717 0.0377087717 3.923383e-01   10 68721012 68721136 125 + 0.149 0.305 1.317
ENSG00000060339 E002 0.8216059 0.1495953116 1.880590e-01   10 68721137 68721143 7 + 0.148 0.405 1.927
ENSG00000060339 E003 0.8216059 0.1495953116 1.880590e-01   10 68721144 68721156 13 + 0.148 0.405 1.927
ENSG00000060339 E004 0.0000000       10 68721157 68721158 2 +      
ENSG00000060339 E005 0.9500890 0.0572896357 4.960046e-01   10 68721159 68721172 14 + 0.307 0.178 -1.018
ENSG00000060339 E006 4.6071062 0.1210686968 7.330266e-01 8.560126e-01 10 68721173 68721215 43 + 0.692 0.802 0.444
ENSG00000060339 E007 10.0190807 0.0422263361 9.790635e-01 9.913073e-01 10 68721216 68721225 10 + 1.008 1.021 0.047
ENSG00000060339 E008 12.0178141 0.0031225026 6.189650e-01 7.830808e-01 10 68721226 68721226 1 + 1.058 1.120 0.224
ENSG00000060339 E009 21.1344372 0.0113729245 3.766969e-01 6.096267e-01 10 68721227 68721238 12 + 1.328 1.249 -0.275
ENSG00000060339 E010 28.6844481 0.0019492845 3.384654e-01 5.766200e-01 10 68721239 68721241 3 + 1.448 1.387 -0.209
ENSG00000060339 E011 73.0490928 0.0008266450 8.126379e-07 2.373660e-05 10 68721242 68721251 10 + 1.884 1.646 -0.807
ENSG00000060339 E012 81.1040916 0.0005844092 3.297033e-08 1.373006e-06 10 68721252 68721254 3 + 1.932 1.679 -0.855
ENSG00000060339 E013 154.0162483 0.0002653166 4.296809e-03 3.081751e-02 10 68721255 68721282 28 + 2.174 2.093 -0.270
ENSG00000060339 E014 32.2855420 0.0012206116 1.580759e-03 1.418195e-02 10 68721283 68721288 6 + 1.536 1.318 -0.753
ENSG00000060339 E015 24.2083126 0.0227127194 5.665976e-03 3.806949e-02 10 68721289 68721406 118 + 1.429 1.119 -1.089
ENSG00000060339 E016 4.5157527 0.0425011620 1.530982e-01 3.667544e-01 10 68721407 68721663 257 + 0.632 0.876 0.985
ENSG00000060339 E017 260.6611421 0.0002179131 7.054148e-07 2.098365e-05 10 68722455 68722577 123 + 2.410 2.297 -0.380
ENSG00000060339 E018 302.4549313 0.0010035531 1.476666e-03 1.345287e-02 10 68736876 68737048 173 + 2.466 2.391 -0.251
ENSG00000060339 E019 126.1581890 0.0004706956 1.162782e-01 3.095873e-01 10 68737845 68737889 45 + 2.080 2.036 -0.149
ENSG00000060339 E020 142.5604114 0.0032317596 3.644227e-04 4.381716e-03 10 68740629 68740661 33 + 2.158 2.012 -0.490
ENSG00000060339 E021 167.8169325 0.0026711569 2.141759e-05 4.051686e-04 10 68742376 68742427 52 + 2.231 2.073 -0.531
ENSG00000060339 E022 269.3454278 0.0005283938 4.848413e-08 1.939628e-06 10 68742428 68742569 142 + 2.429 2.294 -0.450
ENSG00000060339 E023 272.3267397 0.0006714279 2.100727e-04 2.785165e-03 10 68747161 68747275 115 + 2.422 2.333 -0.299
ENSG00000060339 E024 417.4532646 0.0006649000 1.133074e-02 6.372433e-02 10 68747374 68747566 193 + 2.596 2.548 -0.163
ENSG00000060339 E025 345.3667102 0.0019517889 3.179575e-01 5.578957e-01 10 68749136 68749265 130 + 2.507 2.480 -0.090
ENSG00000060339 E026 401.9573770 0.0006472594 2.895300e-02 1.242231e-01 10 68749524 68749685 162 + 2.577 2.537 -0.133
ENSG00000060339 E027 438.9402085 0.0014288714 6.180393e-02 2.068858e-01 10 68753852 68754077 226 + 2.616 2.574 -0.139
ENSG00000060339 E028 321.2043587 0.0001581719 2.320717e-02 1.066116e-01 10 68754714 68754827 114 + 2.481 2.443 -0.128
ENSG00000060339 E029 0.0000000       10 68755172 68755181 10 +      
ENSG00000060339 E030 6.7610616 0.0304954559 6.626795e-01 8.115657e-01 10 68755182 68755285 104 + 0.878 0.817 -0.234
ENSG00000060339 E031 351.1581307 0.0001851015 5.021182e-02 1.802132e-01 10 68755370 68755475 106 + 2.518 2.489 -0.099
ENSG00000060339 E032 345.2803712 0.0001642425 3.649028e-02 1.455797e-01 10 68755476 68755536 61 + 2.511 2.478 -0.110
ENSG00000060339 E033 541.7736760 0.0001516776 8.310769e-05 1.282005e-03 10 68756273 68756483 211 + 2.713 2.657 -0.188
ENSG00000060339 E034 17.7373329 0.2474307594 6.605492e-01 8.103069e-01 10 68756526 68756632 107 + 1.241 1.215 -0.090
ENSG00000060339 E035 292.9746790 0.0002878784 2.902032e-01 5.307999e-01 10 68757294 68757349 56 + 2.434 2.419 -0.047
ENSG00000060339 E036 236.6302239 0.0011703414 8.770905e-01 9.397675e-01 10 68757350 68757377 28 + 2.334 2.349 0.048
ENSG00000060339 E037 9.8328941 0.1006658619 1.492032e-01 3.610861e-01 10 68760810 68761006 197 + 0.906 1.152 0.902
ENSG00000060339 E038 547.8870287 0.0001903041 1.766812e-01 3.993417e-01 10 68761007 68761192 186 + 2.692 2.726 0.114
ENSG00000060339 E039 537.9121436 0.0001308387 8.640000e-03 5.222162e-02 10 68765888 68766079 192 + 2.678 2.733 0.185
ENSG00000060339 E040 344.3095581 0.0046230299 5.854665e-03 3.902720e-02 10 68771206 68771445 240 + 2.465 2.573 0.359
ENSG00000060339 E041 102.7510048 0.0029416570 1.031337e-04 1.535204e-03 10 68772988 68772991 4 + 1.918 2.097 0.598
ENSG00000060339 E042 245.0426056 0.0012894426 1.671201e-04 2.301398e-03 10 68772992 68773058 67 + 2.316 2.434 0.393
ENSG00000060339 E043 268.0767471 0.0002646364 1.768793e-05 3.444350e-04 10 68773059 68773099 41 + 2.358 2.470 0.376
ENSG00000060339 E044 4.0981718 0.0496190817 1.336069e-04 1.904608e-03 10 68774952 68775019 68 + 0.388 1.022 2.725
ENSG00000060339 E045 358.2162294 0.0001895048 1.694993e-07 5.959603e-06 10 68786136 68786218 83 + 2.480 2.598 0.393
ENSG00000060339 E046 493.7061433 0.0005176285 2.304678e-04 3.006739e-03 10 68786546 68786692 147 + 2.630 2.714 0.281
ENSG00000060339 E047 5.1113290 0.1957428197 4.150157e-01 6.398013e-01 10 68786693 68786986 294 + 0.677 0.868 0.767
ENSG00000060339 E048 3.1958571 0.0078615942 5.937618e-01 7.662131e-01 10 68787836 68787926 91 + 0.564 0.658 0.416
ENSG00000060339 E049 554.5804970 0.0075367993 3.867497e-01 6.179285e-01 10 68787927 68788047 121 + 2.688 2.740 0.172
ENSG00000060339 E050 667.2357118 0.0061753990 2.272506e-01 4.620957e-01 10 68788143 68788328 186 + 2.766 2.828 0.207
ENSG00000060339 E051 606.0617639 0.0005742416 1.830217e-05 3.542835e-04 10 68789710 68789915 206 + 2.716 2.807 0.301
ENSG00000060339 E052 485.4435223 0.0027178888 2.433653e-03 1.990418e-02 10 68791207 68792377 1171 + 2.615 2.715 0.333