ENSG00000060237

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000315939 ENSG00000060237 HEK293_OSMI2_6hA HEK293_TMG_6hB WNK1 protein_coding protein_coding 38.46055 54.91887 35.50144 10.85286 0.674553 -0.6292806 3.1865410 4.908595 2.780006 0.9276001 0.39169742 -0.8179782 0.08370417 0.09046667 0.078300000 -0.012166667 8.610681e-01 4.629961e-20 FALSE TRUE
ENST00000535572 ENSG00000060237 HEK293_OSMI2_6hA HEK293_TMG_6hB WNK1 protein_coding protein_coding 38.46055 54.91887 35.50144 10.85286 0.674553 -0.6292806 2.6218030 3.295901 2.426293 0.3446249 0.33620724 -0.4403557 0.07130417 0.06380000 0.068566667 0.004766667 9.705530e-01 4.629961e-20 FALSE TRUE
ENST00000540885 ENSG00000060237 HEK293_OSMI2_6hA HEK293_TMG_6hB WNK1 protein_coding retained_intron 38.46055 54.91887 35.50144 10.85286 0.674553 -0.6292806 5.2400051 5.658344 0.157369 2.4099575 0.09217778 -5.0818228 0.12739583 0.09090000 0.004433333 -0.086466667 2.018611e-02 4.629961e-20 FALSE FALSE
ENST00000545285 ENSG00000060237 HEK293_OSMI2_6hA HEK293_TMG_6hB WNK1 protein_coding protein_coding 38.46055 54.91887 35.50144 10.85286 0.674553 -0.6292806 3.8930807 6.349918 5.168814 0.8824425 0.40927221 -0.2963864 0.10262083 0.11940000 0.145400000 0.026000000 7.016049e-01 4.629961e-20 FALSE FALSE
ENST00000676347 ENSG00000060237 HEK293_OSMI2_6hA HEK293_TMG_6hB WNK1 protein_coding protein_coding 38.46055 54.91887 35.50144 10.85286 0.674553 -0.6292806 12.0913260 22.019552 9.561790 4.4865358 0.84491742 -1.2025795 0.30690000 0.40003333 0.270033333 -0.130000000 9.384942e-02 4.629961e-20 FALSE TRUE
MSTRG.6611.10 ENSG00000060237 HEK293_OSMI2_6hA HEK293_TMG_6hB WNK1 protein_coding   38.46055 54.91887 35.50144 10.85286 0.674553 -0.6292806 5.7081538 7.261697 6.727582 1.5801876 0.34376738 -0.1100612 0.15211250 0.13196667 0.189366667 0.057400000 1.886108e-01 4.629961e-20 FALSE TRUE
MSTRG.6611.15 ENSG00000060237 HEK293_OSMI2_6hA HEK293_TMG_6hB WNK1 protein_coding   38.46055 54.91887 35.50144 10.85286 0.674553 -0.6292806 0.3843481 0.000000 2.260517 0.0000000 0.25653740 7.8268769 0.01123750 0.00000000 0.063966667 0.063966667 4.629961e-20 4.629961e-20 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000060237 E001 1.4947277 0.0595294338 3.797891e-01 6.120094e-01 12 752579 752592 14 + 0.268 0.465 1.169
ENSG00000060237 E002 62.6060115 0.0042358685 3.561056e-02 1.432139e-01 12 752593 752922 330 + 1.846 1.755 -0.308
ENSG00000060237 E003 9.6632510 0.0036720162 2.353196e-04 3.061337e-03 12 752923 753055 133 + 0.646 1.135 1.885
ENSG00000060237 E004 9.2344550 0.0777291788 2.738937e-02 1.194552e-01 12 753056 753154 99 + 0.687 1.112 1.628
ENSG00000060237 E005 11.4324719 0.0672771393 1.277444e-02 6.952960e-02 12 753155 753213 59 + 0.756 1.199 1.654
ENSG00000060237 E006 26.8841953 0.0216305823 1.724049e-02 8.632292e-02 12 753214 753351 138 + 1.239 1.511 0.944
ENSG00000060237 E007 106.5017080 0.0107531052 9.051311e-01 9.546087e-01 12 753352 753693 342 + 2.005 2.023 0.062
ENSG00000060237 E008 67.1719345 0.0008716578 5.145421e-01 7.113634e-01 12 753694 753782 89 + 1.823 1.820 -0.008
ENSG00000060237 E009 101.2640813 0.0070251334 6.442856e-01 7.996384e-01 12 753783 753958 176 + 1.964 2.013 0.165
ENSG00000060237 E010 58.2412126 0.0032868224 1.058872e-01 2.921446e-01 12 753959 753990 32 + 1.682 1.799 0.395
ENSG00000060237 E011 61.9524436 0.0036270190 1.155179e-01 3.083476e-01 12 753991 754018 28 + 1.711 1.824 0.381
ENSG00000060237 E012 207.9335789 0.0008919971 1.739865e-03 1.529264e-02 12 754019 754324 306 + 2.346 2.282 -0.212
ENSG00000060237 E013 189.6144782 0.0002554449 1.048041e-09 6.093169e-08 12 813642 813814 173 + 2.345 2.209 -0.453
ENSG00000060237 E014 230.2019998 0.0002410570 6.263709e-11 4.625650e-09 12 827042 827262 221 + 2.426 2.294 -0.442
ENSG00000060237 E015 1.9225615 0.0126406876 9.281450e-01 9.660888e-01 12 827263 827501 239 + 0.433 0.469 0.183
ENSG00000060237 E016 3.3909412 0.0076557680 4.619542e-01 6.744538e-01 12 829925 830002 78 + 0.686 0.593 -0.398
ENSG00000060237 E017 204.0124043 0.0010097202 3.477345e-09 1.804257e-07 12 830003 830160 158 + 2.381 2.234 -0.491
ENSG00000060237 E018 0.0000000       12 851424 851782 359 +      
ENSG00000060237 E019 153.3481247 0.0005163749 2.049277e-11 1.673396e-09 12 857161 857249 89 + 2.276 2.099 -0.593
ENSG00000060237 E020 223.5515302 0.0042438534 9.056526e-09 4.299711e-07 12 859245 859464 220 + 2.454 2.247 -0.692
ENSG00000060237 E021 140.9555721 0.0071313387 2.810238e-05 5.096095e-04 12 861013 861123 111 + 2.249 2.059 -0.637
ENSG00000060237 E022 220.9727724 0.0037025042 2.421644e-05 4.497986e-04 12 861124 861343 220 + 2.413 2.276 -0.460
ENSG00000060237 E023 172.7165785 0.0045113837 9.156793e-05 1.387928e-03 12 862083 862173 91 + 2.311 2.165 -0.488
ENSG00000060237 E024 163.4554050 0.0049409143 4.599277e-05 7.745568e-04 12 862174 862234 61 + 2.296 2.136 -0.536
ENSG00000060237 E025 126.5949028 0.0009314414 7.642956e-07 2.248700e-05 12 862235 862270 36 + 2.179 2.034 -0.486
ENSG00000060237 E026 0.0000000       12 865110 865364 255 +      
ENSG00000060237 E027 2.0423983 0.0104568748 3.671964e-01 6.017117e-01 12 867866 868525 660 + 0.358 0.535 0.922
ENSG00000060237 E028 0.4054685 0.4770957208 5.508671e-01   12 868526 868567 42 + 0.000 0.180 9.382
ENSG00000060237 E029 1.5354939 0.0195970693 9.118974e-01 9.581029e-01 12 868568 869104 537 + 0.359 0.392 0.191
ENSG00000060237 E030 1.4941753 0.0284919138 5.823481e-01 7.586223e-01 12 869105 871264 2160 + 0.433 0.346 -0.489
ENSG00000060237 E031 124.1828975 0.0035235691 1.054934e-03 1.032993e-02 12 871265 871348 84 + 2.154 2.035 -0.399
ENSG00000060237 E032 1.1490667 0.1307622538 1.406339e-02   12 877094 878014 921 + 0.557 0.094 -3.431
ENSG00000060237 E033 1.2577572 0.2081915946 2.295110e-01   12 878015 878211 197 + 0.500 0.235 -1.593
ENSG00000060237 E034 71.1344665 0.0106285693 5.425045e-02 1.896571e-01 12 878212 878214 3 + 1.908 1.806 -0.343
ENSG00000060237 E035 237.0826810 0.0003556777 4.132270e-06 9.765578e-05 12 878215 878361 147 + 2.416 2.329 -0.291
ENSG00000060237 E036 29.2629118 0.0054595870 6.968660e-03 4.449519e-02 12 879573 879660 88 + 1.572 1.402 -0.583
ENSG00000060237 E037 65.3545755 0.0042190080 1.088541e-03 1.059062e-02 12 879661 880031 371 + 1.898 1.748 -0.504
ENSG00000060237 E038 121.1870726 0.0003491018 2.361263e-03 1.945264e-02 12 880721 880999 279 + 2.117 2.042 -0.252
ENSG00000060237 E039 1.1733692 0.0147058710 2.252751e-01   12 881471 881691 221 + 0.155 0.391 1.772
ENSG00000060237 E040 149.8718052 0.0002662455 8.030476e-04 8.306996e-03 12 881692 881763 72 + 2.208 2.134 -0.246
ENSG00000060237 E041 113.5431432 0.0004269754 1.401879e-04 1.981945e-03 12 881764 881789 26 + 2.109 2.004 -0.351
ENSG00000060237 E042 234.7503527 0.0002231126 4.419098e-10 2.740922e-08 12 881911 882073 163 + 2.431 2.308 -0.410
ENSG00000060237 E043 214.0673093 0.0012919935 5.301458e-11 3.966121e-09 12 882943 883059 117 + 2.415 2.248 -0.557
ENSG00000060237 E044 283.5485643 0.0020246508 9.349260e-05 1.413442e-03 12 883395 883568 174 + 2.494 2.402 -0.306
ENSG00000060237 E045 159.4983773 0.0003042684 8.869263e-01 9.450645e-01 12 883774 883831 58 + 2.171 2.201 0.104
ENSG00000060237 E046 235.0876335 0.0002722297 6.820406e-01 8.239676e-01 12 884121 884243 123 + 2.348 2.365 0.057
ENSG00000060237 E047 964.3249028 0.0006868117 9.383851e-01 9.714843e-01 12 884649 885704 1056 + 2.953 2.975 0.074
ENSG00000060237 E048 537.5651137 0.0001136417 1.362319e-01 3.417274e-01 12 885705 886084 380 + 2.681 2.732 0.171
ENSG00000060237 E049 234.1291806 0.0002304840 1.919791e-01 4.193487e-01 12 887221 887304 84 + 2.315 2.375 0.200
ENSG00000060237 E050 245.0952342 0.0017221937 3.191876e-01 5.589050e-01 12 889140 889223 84 + 2.334 2.390 0.188
ENSG00000060237 E051 216.0484348 0.0004111711 3.546565e-01 5.914113e-01 12 890453 890510 58 + 2.284 2.335 0.171
ENSG00000060237 E052 124.9913717 0.0004007332 9.659520e-01 9.848748e-01 12 890511 890513 3 + 2.063 2.091 0.094
ENSG00000060237 E053 241.9216571 0.0007818937 6.233530e-01 7.861435e-01 12 894562 894635 74 + 2.341 2.380 0.130
ENSG00000060237 E054 759.8324036 0.0002082217 4.140370e-01 6.390275e-01 12 896071 896622 552 + 2.839 2.877 0.127
ENSG00000060237 E055 283.4881189 0.0002196642 7.458547e-02 2.339558e-01 12 896623 896732 110 + 2.391 2.459 0.225
ENSG00000060237 E056 370.2988929 0.0002142452 5.968168e-04 6.551598e-03 12 897479 897681 203 + 2.489 2.587 0.324
ENSG00000060237 E057 0.9349259 0.0214568578 4.517853e-01   12 900473 900475 3 + 0.359 0.238 -0.819
ENSG00000060237 E058 286.9698787 0.0001784104 7.979669e-09 3.835639e-07 12 900476 900596 121 + 2.335 2.495 0.534
ENSG00000060237 E059 285.9560461 0.0001705369 1.190482e-06 3.303451e-05 12 900597 900670 74 + 2.347 2.486 0.461
ENSG00000060237 E060 9.1999661 0.0364304810 1.252851e-01 3.242496e-01 12 900671 901074 404 + 0.820 1.059 0.896
ENSG00000060237 E061 5.5083622 0.0068801407 7.668313e-01 8.767216e-01 12 901561 901632 72 + 0.817 0.802 -0.059
ENSG00000060237 E062 2.3063586 0.4162353786 8.150868e-01 9.052828e-01 12 904453 904494 42 + 0.503 0.505 0.011
ENSG00000060237 E063 4.4925618 0.0088503307 8.265751e-01 9.118108e-01 12 907720 907846 127 + 0.723 0.711 -0.048
ENSG00000060237 E064 417.9525312 0.0001694885 3.514927e-09 1.822642e-07 12 907847 908034 188 + 2.511 2.651 0.468
ENSG00000060237 E065 27.1957040 0.0012325495 5.200068e-01 7.149899e-01 12 908035 908201 167 + 1.446 1.428 -0.064
ENSG00000060237 E066 2532.9119718 0.0030956201 5.071642e-12 4.613184e-10 12 908475 911452 2978 + 3.252 3.445 0.640